CN103545165B - A kind of mass ions method based on cold-plasma jet and ion source device - Google Patents
A kind of mass ions method based on cold-plasma jet and ion source device Download PDFInfo
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Abstract
Based on mass ions method and the ion source device of cold-plasma jet, belong to analytical technique of mass spectrum field.The present invention uses the conductive metal pipe such as copper pipe, stainless steel tube or outer surface to be covered with the quartz ampoule of sparking electrode as discharge cavity, uses high voltage source as discharge power supply; Pass into discharge gas at discharge cavity air inlet, adjusting gas flow, stable cold-plasma jet can be produced in gas outlet; This jet can make sample ionization, and then realizes ion detection.This technology can adopt sample gas and discharge gas mixing (when sample be gas or volatile substances time) and jet flow direct spray sample two kinds of modes make sample generation ionization.The invention still further relates to corresponding ion source device, this device can be applied in open type environment, have build conveniently, the advantage such as volume is little, cheap, low energy consumption.
Description
Technical field
The invention belongs to mass spectral analysis field, particularly a kind of ioning method of open type and ion source device, specifically, relate to a kind of mass ions method based on atmosphere cold plasma jet and ion source device.
Background technology
Mass spectrum alanysis instrument is widely used a kind of chemical analysis instrument on our times, its general principle makes each composition in sample in an ion source ionization occur, produce the charged ion of various different mass-to-charge ratio, then utilize electric field or the magnetic field ion motion on different mass-to-charge ratio to produce different impacts, thus realize the detection of material.
Ion source is mass spectrum alanysis instrument sampling ion, and its key is ionization techniques.Ionized essence is that molecule loses electronics or proton, generates the molecular ion of band positive and negative charge.Through the development of last 100 years, Ionized technology is of a great variety.And the study hotspot of ionization techniques is normal pressure open type ionization techniques in recent years.Maximum different of this kind of technology and conventional ionizing technology are in the past exactly do not need numerous and diverse sample pretreatment program, make the rapid analysis of sample obtain realization; And can carry out under the atmospheric pressure environment of opening wide, the sample making mass spectrum alanysis instrument analyze spatially obtains great expansion; Sample can keep primary characteristic simultaneously, and the possibility that Non-Destructive Testing is realized is greatly improved.The methods such as the existing electron spray desorption ionization (DESI) based on electro-spray ionization (ESI) of this kind of technology, electron spray extraction ionization (EESI), neutral desorption electrospray extraction ionization (ND-EESI), also comprise based on the Atmosphere Pressure Chemical Ionization (APCI) (APCI) of plasma, directly real-time analysis technology (DART), method such as dielectric barrier discharge ionization (DBDI), low temperature plasma probe (LTP), microwave plasma torch (MPT) etc.Wherein ESI and APCI is the two kinds of ion sources be the most often equipped with in LC/MS equipment, and this two classes ion source range of application is comparatively wide, more stable, belongs to soft ionomer source.It should be noted that most that ESI makes the mankind can intactly measure protein macromolecule first, for life science brings revolution, therefore its inventor JohnFenn also obtains 2002 years Nobel chemistry Prizes.But these two kinds of ion sources need institute's test sample product to dissolve in specific solvent, make sample treatment program comparatively complicated, and define testing sample kind.
2004, the achievement in research of Cooks teach problem group delivered by " Science " magazine, i.e. DESI.It can at the ionized solid sample of open type environment, and the blank of field of mass spectrometry for sample site Direct Analysis has been filled up in its appearance greatly.After this, many open type ionization techniques without the need to sample pretreatment occur thereupon.As EESI, ND-EESI, DART, DBDI, LTP, MPT plasma method.Wherein based on the method such as DESI, EESI, ND-EESI of ESI in the important tool analyzing polar substances, and in analysis apolar substance, there is absolute predominance based on the method such as DART, DBDI, LTP, MPT of plasma.
Based on the ionization techniques of plasma because principle is novel, apolar substance ionising effect excellence is obtained to everybody extensive concern.Plasma, refer to when mass temperature raises or is subject to ionizing, electronics is separated with cation, forms the state of matter be made up of electronics and cation.This ionization material is macroscopically keeping electric neutrality.Plasma divides by temperature can be divided into high-temperature plasma and low temperature plasma, the plasma that high-temperature plasma produces as the fixed stars such as the sun and atom bomb, hydrogen bomb, and they have been full-ionized, and gas temperature can reach 10
4-10
9k.Low temperature plasma is partially ionized, and gas temperature is generally lower than 10
4k.Low temperature plasma can be divided into again hot plasma (also known as thermal equilibrium plasma) and cold plasma (also known as nonthermal plasma).Electronics and ion temperature approximately equal in hot plasma, macro-temperature is higher; And electronics and ion temperature differ greatly in cold plasma, electron temperature is ion temperature 10-100 times, and macro-temperature is close to room temperature.Containing a large amount of electronics, metastable state ion, free radical isoreactivity particle in cold plasma, there is extremely strong reactivity, therefore can make sample molecule ionization, use as ion source.
The plasma that DART utilizes glow discharge to produce makes sample produce ionization, and this technology realizes commercialization, and Technical comparing is ripe.But also there is electrode fouling and loss, need periodic cleaning and replacing, the shortcomings such as price is very high, have certain obstruction for the universal of technology.The plasma that DBDI applicating medium barrier discharge produces makes sample ionization, and dielectric impedance can softening strength of discharge, prevents electrode fouling.But also define working space, greatly reduce the advantage of open type ionization techniques.In order to make this technology be more widely used, introduce atmosphere cold plasma fluidics.
Atmosphere cold plasma jet is a kind of new atmos low-temperature plasma discharge technology of rising in recent years, is one of study hotspot of plasma science and engineering field in the world at present.It is supplementary to of atmospheric non-equilibrium plasma, is a kind of new form producing cold plasma under atmospheric pressure.In atmosphere cold plasma jet production process, by introducing air-flow, the plasma that region of discharge is produced is from jet pipe or middle ejection of eating dishes without rice or wine, achieve being separated of region of discharge and working region, in turn ensure that most of active material simultaneously and carry and can be transported in more wide space by air-flow by a charged particle.Therefore there is higher practicality.The characteristic of atmosphere cold plasma jet and advantage, just meeting the ionogenic requirement of a high-quality normal pressure open type.
And LTP and MPT just this technology in the application in mass spectral analysis field.MPT uses microwave generated plasma jet.Its shortcoming is that device compares bulky complex, needs professional person to build, and the adjustment of a lot of parameter is not facilitate very much in testing process.And LTP structure is relatively simple, but also there is internal and external electrode relative position and need to optimize, excitation power supply parameter also needs the shortcomings such as optimization.And when regulating power parameter, easy generating electrodes and mass spectrum taper hole generation discharge breakdown phenomenon, can damage mass spectrographic circuit board time serious.
Summary of the invention
The problems such as the present invention aims to provide a kind of mass ions method based on cold-plasma jet and ion source device, solves existing method step numerous and diverse, and left-hand seat is comparatively slow, efficiency is low.The method utilizes atmosphere cold plasma jet to realize the ionization of sample, and step is simpler, easy to operate, efficiency is higher.The present invention is simultaneously according to having built an easy ion source for method, the advantages such as volume is little, cheap, low energy consumption that it has, are conducive to the portability of mass spectrum alanysis instrument.
Technical scheme of the present invention is as follows:
A kind of mass ions method based on cold-plasma jet provided by the invention, is characterized in that the method comprises the steps:
1) sample is put on sample stage;
2) center line of adjustment cold plasma fluid generator discharge cavity and the angle of mass spectrum taper hole axis are at 0 ° ~ 90 °, and the distance of cold-plasma jet outlet and mass spectrum taper hole is at 1mm ~ 100mm;
3) introduce in cold plasma fluid generator by discharge gas, controlled discharge gas flow is at 0.1L/min ~ 10L/min;
4) start high voltage source, make cold plasma fluid generator produce cold-plasma jet and make this jet inject directly on sample, by sample ionization.
Another kind provided by the invention, based on the mass ions method of cold-plasma jet, is characterized in that the method comprises the steps:
1) sample is put in mixed gas cylinder;
2) center line of adjustment cold plasma fluid generator discharge cavity and the angle of mass spectrum taper hole axis are at 0 ° ~ 90 °, and the distance of cold-plasma jet outlet and mass spectrum taper hole is at 1mm ~ 100mm;
3) first discharge gas is passed into in mixed gas cylinder, enter after discharge gas is mixed with sample gas in cold plasma fluid generator, discharge gas flow is controlled at 0.1L/min ~ 10L/min;
4) start high voltage source, make cold plasma fluid generator produce cold-plasma jet, by sample ionization.
In said method, it is characterized in that: the frequency of described high voltage source is within the scope of 1kHz ~ 100kHz, and Voltage Peak peak value is within the scope of 1kV ~ 10kV, and power is within the scope of 0.1W ~ 100W.Described discharge gas uses the mist of one or more in helium, argon gas, nitrogen, hydrogen and air.
A kind of ion source device based on cold-plasma jet provided by the invention, is characterized in that: described device comprises manometric discharge gas bottle, pressure-reducing valve, flowmeter, flow control valve, plasma fluid generator, sample stage and high voltage source are housed; The outlet of described discharge gas bottle is connected with described pressure-reducing valve, flowmeter, flow control valve and plasma fluid generator successively by gas piping; Described sample stage is arranged on the jet exit of plasma fluid generator; The discharge cavity of cold plasma fluid generator adopts internal diameter at 0.1mm ~ 5mm, and length is the metal tube of 5mm ~ 200mm, or adopts internal diameter at 0.1mm ~ 5mm, and wall thickness 0.1mm ~ 5mm, length is 5mm ~ 200mm, and outer surface is covered with the quartz ampoule of sparking electrode.
The second provided by the invention, based on the ion source device of cold-plasma jet, is characterized in that: described device comprises manometric discharge gas bottle, pressure-reducing valve, flowmeter, flow control valve, mixed gas cylinder, plasma fluid generator and high voltage source are housed; The outlet of described discharge gas bottle is connected with described pressure-reducing valve, flowmeter, flow control valve and mixed gas cylinder import successively by gas piping, and the outlet of mixed gas cylinder is connected with plasma fluid generator by gas piping; The discharge cavity of cold plasma fluid generator adopts internal diameter at 0.1mm ~ 5mm, and length is the metal tube of 5mm ~ 200mm, or adopts internal diameter at 0.1mm ~ 5mm, and wall thickness 0.1mm ~ 5mm, length is 5mm ~ 200mm, and outer surface is covered with the quartz ampoule of sparking electrode.
It is characterized in that in ion source device of the present invention: be provided with insulation screen at the outer wall of described discharge cavity; Described metal tube material is copper, aluminium, copper alloy, aluminium alloy or stainless steel.Sparking electrode (703) material of described quartz ampoule outer surface is gold, silver, copper, iron, aluminium, stainless steel, copper alloy, ferroalloy or aluminium alloy.
The present invention compared with prior art, have the following advantages and the technique effect of high-lighting: this method is based on atmosphere cold plasma principle, the ioning method related to realizes in atmospheric pressure open type environment, do not need the pre-treatment of sample or only need simple process, enormously simplify analysis process, is a kind of easy ioning method; In analytic process, the parameter of required adjustment is little, greatly reduces the workload of staff.The present invention, owing to have employed a kind of simple discharging structure form, makes to build device and simple.Compared with existing ion source device, the ion source device built has the advantages such as cost is low, easy to use, energy consumption is little.And the funtion part volume of device is smaller, comprises high voltage source and can accomplish that weight is no more than 300g, very portable, be beneficial to the portability of mass spectrum alanysis instrument.
Accompanying drawing explanation
Fig. 1 is the structural representation of the main part-cold plasma fluid generator of intermediate ion source apparatus of the present invention, and wherein Fig. 1 a is metal tube electric discharge cavate cold plasma fluid generator, and Fig. 1 b is quartz ampoule electric discharge cavate cold plasma fluid generator.
Fig. 2 is the single unit system schematic diagram adopting intermediate ion source apparatus of the present invention and mass spectrometry to realize solid, difficult volatile liquid sample detection.
Fig. 3 is the single unit system schematic diagram adopting intermediate ion source apparatus of the present invention and mass spectrometry to realize gas or volatile substances sample detection.
Ion source and mass spectrometry are realized the mass spectrogram that in medicine, the fast detecting of active component obtains in embodiment one by Fig. 4.Wherein Fig. 4 a is the spectrogram that detection Azithromycin dispersible tablet obtains, and Fig. 4 b is the spectrogram that detection erythromycin ointment obtains.
Caffeine in ion source and mass spectrometry fast detecting beverage is obtained mass spectrogram in embodiment two by Fig. 5.Wherein Fig. 5 a detects the laughable spectrogram obtained, and Fig. 5 b is the spectrogram that the unified green tea of detection obtains.
In figure: 1-Pressure gauge; 2-discharge gas bottle; 3-pressure-reducing valve; 4-flowmeter; 5-flow control valve; 6-high voltage source; 7-plasma fluid generator; 8-sample stage; 9-solid sample; 10-mass spectrum taper hole; 11-mixes gas cylinder; 701-insulation screen; 702-discharge cavity; 703-sparking electrode.
Embodiment
Below in conjunction with accompanying drawing, the present invention will be further described.
As shown in Figure 1, be the structural representation of main part-cold plasma fluid generator of intermediate ion source apparatus of the present invention.
Wherein, Fig. 1 a is metal tube electric discharge cavate cold plasma fluid generator, and it comprises insulation screen 701, discharge cavity 702 two parts.Insulation screen is opened an aperture, lead-in conductor is connected with discharge cavity.
Fig. 1 b is quartz ampoule electric discharge cavate cold plasma fluid generator, wraps up in deposited layer of metal sparking electrode 703, be connected by electrode with high voltage source at the outer surface of quartz ampoule.The material of sparking electrode can use gold, silver, copper, iron, aluminium, stainless steel, copper alloy, ferroalloy or aluminium alloy.
When with mass spectrometer coupling, kind can adopt two kinds of modes shown in Fig. 2 and Fig. 3 per sample.When sample be solid and not volatile material time, shown ion source device as shown in Figure 2 can be adopted to detect, and this device comprises discharge gas bottle 2, pressure-reducing valve 3, flowmeter 4, flow control valve 5, plasma fluid generator 7, sample stage 8 and high voltage source 6 that Pressure gauge 1 is housed; The outlet of described discharge gas bottle 2 is connected with described pressure-reducing valve 3, flowmeter 4, flow control valve 5 and plasma fluid generator 7 successively by gas piping; Described sample stage 8 is arranged on the jet exit of plasma fluid generator; The discharge cavity 702 of cold plasma fluid generator adopts internal diameter at 0.1mm ~ 5mm, length is the metal tube of 5mm ~ 200mm, or adopts internal diameter at 0.1mm ~ 5mm, wall thickness 0.1mm ~ 5mm, length is 5mm ~ 200mm, and outer surface is covered with the quartz ampoule of sparking electrode 703.The discharge gas be equipped with in the discharge gas bottle 2 of Pressure gauge 1 introduces cold plasma fluid generator 7 through pressure-reducing valve 3, flowmeter 4, flow control valve 5.First the sample stage 8 being placed with solid sample 9 is above placed on 1mm ~ 25mm place, mass spectrum taper hole 10 front.Regulate the angle of cold plasma generator 7 center line and mass spectrum taper hole axis at 0 ° ~ 90 °, the distance of cold-plasma jet outlet and mass spectrum taper hole is at 1mm ~ 100mm.Then discharge gas flow is regulated, by flow control at 0.1L/min ~ 10L/min.More stable plasma jet can be produced in this range of flow.Start high voltage source 6, cold plasma fluid generator 7 produces cold-plasma jet, and jet flow direct spray sample, by sample ionization.Again finely tune angle and the distance of jet and taper hole, make to obtain optimum mass signal.Described discharge gas uses the mist of one or more in helium, argon gas, nitrogen, hydrogen and air.The frequency of high voltage source is within the scope of 1kHz ~ 100kHz, and Voltage Peak peak value is within the scope of 1kV ~ 10kV, and power is within the scope of 0.1W ~ 100W.
When sample be volatile substances or gas time, ion source device shown in Fig. 3 can be adopted to detect, this device comprise Pressure gauge 1 is housed discharge gas bottle 2, pressure-reducing valve 3, flowmeter 4, flow control valve 5, mixed gas cylinder 11, plasma fluid generator 7 and high voltage source 6; The outlet of described discharge gas bottle 2 is connected with described pressure-reducing valve 3, flowmeter 4, flow control valve 5 and mixed gas cylinder 11 import successively by gas piping, and the outlet of mixed gas cylinder 11 is connected with plasma fluid generator 7 by gas piping; The discharge cavity 702 of cold plasma fluid generator adopts internal diameter at 0.1mm ~ 5mm, length is the metal tube of 5mm ~ 200mm, or adopts internal diameter at 0.1mm ~ 5mm, wall thickness 0.1mm ~ 5mm, length is 5mm ~ 200mm, and outer surface is covered with the quartz ampoule of sparking electrode 703.Same discharge gas flows into through pressure-reducing valve 3, flowmeter 4, flow control valve 5 the mixed gas cylinder 11 that air inlet pipeline and outlet pipe are housed.First sample is placed in mixed gas cylinder or by syringe and gas inject to be measured is mixed gas cylinder 11.After passing into discharge gas, sample volatilizes sample gas and mixes with discharge gas, then enters cold plasma fluid generator 7.Regulate cold plasma generator 7 center line with mass spectrum taper hole axis to overlapping, the distance of cold-plasma jet outlet and mass spectrum taper hole is at 1mm ~ 100mm.Then discharge gas flow is regulated, by flow control at 0.1L/min ~ 10L/min.More stable plasma jet can be produced in this range of flow.Start high voltage source 6, cold plasma fluid generator 7 produces the cold-plasma jet containing sample ions, again finely tunes the distance of jet and taper hole, makes to obtain optimum mass signal.Described discharge gas uses the mist of one or more in helium, argon gas, nitrogen, hydrogen and air.The frequency of high voltage source is within the scope of 1kHz ~ 100kHz, and Voltage Peak peak value is within the scope of 1kV ~ 10kV, and power is within the scope of 0.1W ~ 100W.
Lift several embodiment below to be again further described effect of the present invention.
The fast detecting of active component in embodiment one, medicine
Adopt mode shown in Fig. 2, ion source and mass spectrometer coupling are detected the active component in Azithromycin dispersible tablet (active ingredient: azithromycin, Mw, 748.88) and erythromycin ointment (active ingredient: erythromycin, Mw, 733.93).Testing the source parameters that uses is: high-voltage power voltage 4kV(peak-to-peak value), frequency 20kHz, power 5W; Discharge gas is helium; Discharge cavity is the stainless steel tube of a length 80mm, internal diameter 0.5mm, external diameter 1/16in.During experiment, first tablet is placed on (or being coated on sample stage by ointment) on sample stage, regulate the angle (about 30 °) of cold plasma generator 7 center line and mass spectrum taper hole axis, the distance (about 20mm) of cold-plasma jet outlet and mass spectrum taper hole, constant gas flow rate is at 1.6L/min.After parameter mixes up, in several seconds, just can obtain the spectrogram of sample.If use automatic sampling apparatus continuous sample introduction instead, the detection speed of 2s/ sheet can be realized.This is to quality on-line monitoring important in inhibiting in pharmaceutical production.The mass spectrogram that Fig. 4 obtains for experiment.Show very strong quasi-molecular ion peak (m/z749.9) in Fig. 4 a, show in Fig. 4 b very strong [M+H]
+peak (m/z734.9) and [M+H-H
2o]
+peak (m/z716.9), illustrates that the method effectively can detect the active ingredient in medicine.
The fast detecting of caffeine in embodiment two, beverage
Adopt mode shown in Fig. 2, ion source and mass spectrometer coupling are carried out fast detecting to caffeine (Mw, 194.19) in beverage (laughable, unified green tea).Testing the source parameters that uses is: high-voltage power voltage 4kV(peak-to-peak value), frequency 20kHz, power 5W; Discharge gas is helium; Discharge cavity is the quartz ampoule of a length 80mm, internal diameter 1mm, external diameter 3mm, and quartz ampoule outer surface wraps up one deck copper electrode.During experiment, first drop on sample stage by beverage, regulate the angle (about 30 °) of cold plasma generator 7 center line and mass spectrum taper hole axis, the distance (about 20mm) of cold-plasma jet outlet and mass spectrum taper hole, constant gas flow rate is at 1.6L/min.After parameter mixes up, in several seconds, just can obtain the spectrogram of sample.The mass spectrogram that Fig. 5 obtains for experiment, wherein Fig. 5 a detects the laughable spectrogram obtained, and Fig. 5 b is the spectrogram that the unified green tea of detection obtains.Show very strong quasi-molecular ion peak (m/z195) in figure, illustrate that the method can realize the detection of caffeine in beverage.The method can be used for field of food safety.
Claims (6)
1. based on a mass ions method for cold-plasma jet, it is characterized in that the ion source device that the method adopts comprises: the discharge gas bottle (2) of Pressure gauge (1), pressure-reducing valve (3), flowmeter (4), flow control valve (5), metal tube electric discharge cavate cold plasma fluid generator (7), sample stage (8) and high voltage source (6) are housed; The outlet of described discharge gas bottle (2) is connected by the gas piping cavate cold plasma fluid generator (7) that discharges with described pressure-reducing valve (3), flowmeter (4), flow control valve (5) and metal tube successively; Described sample stage (8) is arranged on the jet exit of cold plasma fluid generator; The discharge cavity (702) of cold plasma fluid generator adopts internal diameter at 0.1mm ~ 5mm, length is the metal tube of 5mm ~ 200mm, or adopt internal diameter at 0.1mm ~ 5mm, wall thickness 0.1mm ~ 5mm, length is 5mm ~ 200mm, and outer surface is covered with the quartz ampoule of sparking electrode (703); The outer wall of described discharge cavity (702) is provided with insulation screen (701); Described ioning method comprises the steps:
1) sample is put on sample stage;
2) center line of adjustment metal tube electric discharge cavate cold plasma fluid generator (7) discharge cavity and the angle of mass spectrum taper hole (10) axis are at 0 ° ~ 90 °, and the distance of cold-plasma jet outlet and mass spectrum taper hole is at 1mm ~ 100mm;
3) introduced by discharge gas in cold plasma fluid generator (7), controlled discharge gas flow is at 0.1L/min ~ 10L/min;
4) start high voltage source (6), make cold plasma fluid generator (7) produce cold-plasma jet and make this jet inject directly on sample, by sample ionization.
2. based on a mass ions method for cold-plasma jet, it is characterized in that the ion source device that the method adopts comprises: the discharge gas bottle (2) of Pressure gauge (1), pressure-reducing valve (3), flowmeter (4), flow control valve (5), mixed gas cylinder (11), metal tube electric discharge cavate cold plasma fluid generator (7) and high voltage source (6) are housed; The outlet of described discharge gas bottle (2) is connected with described pressure-reducing valve (3), flowmeter (4), flow control valve (5) and mixed gas cylinder (11) import successively by gas piping, and the outlet of mixed gas cylinder (11) is connected with plasma fluid generator (7) by gas piping; The discharge cavity (702) of cold plasma fluid generator adopts internal diameter at 0.1mm ~ 5mm, length is the metal tube of 5mm ~ 200mm, or adopt internal diameter at 0.1mm ~ 5mm, wall thickness 0.1mm ~ 5mm, length is 5mm ~ 200mm, and outer surface is covered with the quartz ampoule of sparking electrode (703); The outer wall of described discharge cavity (702) is provided with insulation screen (701); Described ioning method comprises the steps:
1) sample is put in mixed gas cylinder (11);
2) center line of adjustment cold plasma fluid generator discharge cavity and the angle of mass spectrum taper hole (10) axis are at 0 ° ~ 90 °, and the distance of cold-plasma jet outlet and mass spectrum taper hole is at 1mm ~ 100mm;
3) first discharge gas is passed into in mixed gas cylinder (11), enter after discharge gas is mixed with sample gas in cold plasma fluid generator (7), discharge gas flow is controlled at 0.1L/min ~ 10L/min;
4) start high voltage source (6), make cold plasma fluid generator (7) produce cold-plasma jet, by sample ionization.
3. a kind of mass ions method based on cold-plasma jet as claimed in claim 1 or 2, it is characterized in that: the frequency of described high voltage source is within the scope of 1kHz ~ 100kHz, Voltage Peak peak value is within the scope of 1kV ~ 10kV, and power is within the scope of 0.1W ~ 100W.
4. a kind of mass ions method based on cold-plasma jet as claimed in claim 1 or 2, is characterized in that: described discharge gas uses the mist of one or more in helium, argon gas, nitrogen, hydrogen and air.
5. a kind of mass ions method based on cold-plasma jet as claimed in claim 1 or 2, is characterized in that: described metal tube material is copper, aluminium, copper alloy, aluminium alloy or stainless steel.
6. a kind of mass ions method based on cold-plasma jet as claimed in claim 1 or 2, is characterized in that: sparking electrode (703) material of described quartz ampoule outer surface is gold, silver, copper, iron, aluminium, stainless steel, copper alloy, ferroalloy or aluminium alloy.
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| CN103760221B (en) * | 2014-02-14 | 2015-12-02 | 厦门大学 | A kind of needle point electric discharge device degraded for solid surface |
| CN105355535B (en) * | 2015-09-18 | 2018-05-22 | 宁波华仪宁创智能科技有限公司 | Ion source and ioning method |
| CN108463046B (en) * | 2018-05-04 | 2023-10-10 | 安徽工业大学 | Hand-held air electric spark cold plasma shock wave jet device |
| CN112683991B (en) * | 2020-08-04 | 2022-10-28 | 浙江大学 | Organic matter quality detection device and method based on arc plasma |
| CN113588772A (en) * | 2021-06-25 | 2021-11-02 | 浙江大学 | Unsaturated fatty acid carbon-carbon double bond epoxidation and positioning method based on arc plasma |
| CN115274399B (en) * | 2022-07-20 | 2023-08-25 | 苏州大学 | Low-pressure discharge plasma ion source device based on membrane sample injection |
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