CN103537015B - A kind of intensity-regulation compensator preparation method based on 3D printing technique - Google Patents
A kind of intensity-regulation compensator preparation method based on 3D printing technique Download PDFInfo
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- CN103537015B CN103537015B CN201310488300.4A CN201310488300A CN103537015B CN 103537015 B CN103537015 B CN 103537015B CN 201310488300 A CN201310488300 A CN 201310488300A CN 103537015 B CN103537015 B CN 103537015B
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- 238000000034 method Methods 0.000 title claims abstract description 43
- 238000010146 3D printing Methods 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 239000006260 foam Substances 0.000 claims abstract description 49
- 230000004907 flux Effects 0.000 claims abstract description 17
- 239000002184 metal Substances 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 238000000465 moulding Methods 0.000 claims abstract description 6
- 238000013461 design Methods 0.000 claims description 9
- 229920003023 plastic Polymers 0.000 claims description 8
- 239000004033 plastic Substances 0.000 claims description 8
- 230000004927 fusion Effects 0.000 claims description 6
- 239000013049 sediment Substances 0.000 claims description 6
- 238000007493 shaping process Methods 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 5
- 239000000463 material Substances 0.000 abstract description 6
- 239000002131 composite material Substances 0.000 abstract 1
- 238000005516 engineering process Methods 0.000 description 8
- 238000007639 printing Methods 0.000 description 5
- 229920000122 acrylonitrile butadiene styrene Polymers 0.000 description 3
- 230000003044 adaptive effect Effects 0.000 description 3
- 238000012423 maintenance Methods 0.000 description 3
- 238000010276 construction Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000006261 foam material Substances 0.000 description 2
- 238000001959 radiotherapy Methods 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000003325 tomography Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- -1 wherein Polymers 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/103—Treatment planning systems
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y50/00—Data acquisition or data processing for additive manufacturing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
- A61N2005/1095—Elements inserted into the radiation path within the system, e.g. filters or wedges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
- A61N2005/1096—Elements inserted into the radiation path placed on the patient, e.g. bags, bolus, compensators
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Materials Engineering (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
The invention discloses a kind of intensity-regulation compensator preparation method based on 3D printing technique, including: A, treatment planning systems, according to adjusting strong planning data, are derived the intensity distribution of each irradiation field, thus are obtained the gray scale flux pattern adjusting intense irradiation wild；B, according to X-ray attenuation characteristic in metal and the gray scale flux pattern that obtains, rebuild the three-dimensional foam model for pouring into a mould compensator, and the three-dimensional foam model of reconstruction be sent to 3D printer；C, 3D printer prints the three-dimensional foam model of reconstruction；D, the three-dimensional foam model printed carried out lead water cast and cools down moulding process, thus obtaining intensity-regulation compensator.The present invention uses based on 3D printing technique, the linear accelerator being particularly suitable for not equipping multi-diaphragm collimator, has the advantage that preparation method is simple and quick, input cost is low, consumptive material is few, the short and applicable small-middle hospital of machine spill time uses.The composite can be widely applied to medical field.
Description
Technical field
The present invention relates to medical field, a kind of intensity-regulation compensator preparation method based on 3D printing technique.
Background technology
In tumour radiotherapy field, there is 10 the method adjusting intense irradiation wild that obtains of planting at present more, wherein the most universal with the strong technology of tune based on multi-diaphragm collimator.This technology realizes the intensity adjustment of irradiation field by controlling the relative motion of two groups of blades, make the technical staff can be by MLC(multi-leaf optical grating in machine room control room) control software and complete whole treatment plan, operation is very simple, but this technology there is also the weak points such as capacity usage ratio low, blade leakage is penetrated, in-placing precision is low, the step device rapid wear of blade.
For using the strong technology of tune of multi-diaphragm collimator, the regular hour need to be consumed owing to blade moves to predeterminated position, in order to realize the intensity distribution of complexity, treatment planning systems may produce more Ziye (static intensity modulating) or reduce the translational speed (dynamically adjusting strong) of blade, so can increase the time for the treatment of, reduce the utilization rate of X-ray.But, if using compensator technology, the most only needing accelerator disposably to go out bundle and just can obtain meeting the tune intense irradiation open country of clinical requirement, substantially reducing the time for the treatment of.It addition, the price of a current multi-diaphragm collimator product and does not the most include follow-up maintenance cost more than 1,000,000, need to put into is relatively costly, and general small-middle hospital is difficult to undertake.Therefore for cost and the consideration for the treatment of time, the intensity adjustment using compensator technology to realize irradiation field has become a good selection.
Make intensity-regulation compensator adaptive heated-wire cutting-machine to be used.But, current adaptive heated-wire cutting-machine can only make two dimension intensity-regulation compensator, and for being similar to mountain range shape, the making of up-and-down three-dimensional intensity-regulation compensator is the most helpless.
In recent years, 3D printing technique quickly grows, it has also become the focus of current every profession and trade research.3D printer can generate the part of arbitrary shape, but it has a premise, that is, 3D must be provided to print the stl file of function identification.The superposition process of 3D printing technique has kind more than 10 at present, wherein fusion sediment quick shaping process is widely used in desktop level 3D printer, its printing precision, generally between 0.1mm to 0.3mm, has the features such as simple in construction, making and maintenance cost are low, materials are few.And 3D prints raw material and generally includes ABS plastic and PLA plastics, wherein, ABS plastic intensity is higher, is used for industry making field, but has certain toxicity, and its heat-shrinkable is relatively big, affects finished product accuracy；And PLA plastics are degradable biological material, environmental protection, printing precision is higher than ABS plastic, and the low cost (about 0.2 yuan/gram) of PLA plastics.Although 3D printing technique is widely used, but 3D printing technique is not used to make three-dimensional intensity-regulation compensator, to realize the intensity adjustment of irradiation field at present.
In sum, the most also do not have a kind of based on 3D printing technique, the intensity-regulation compensator preparation method that preparation method is simple and quick, low cost, consumptive material are few, the short and applicable small-middle hospital of machine spill time uses.
Summary of the invention
In order to solve above-mentioned technical problem, it is an object of the invention to: provide a kind of based on 3D printing technique, the intensity-regulation compensator preparation method that preparation method is simple and quick, low cost, consumptive material are few, the short and applicable small-middle hospital of machine spill time uses.
The technical solution adopted for the present invention to solve the technical problems is: a kind of intensity-regulation compensator preparation method based on 3D printing technique, including:
A, treatment planning systems, according to adjusting strong planning data, are derived the intensity distribution of each irradiation field, thus are obtained the gray scale flux pattern adjusting intense irradiation wild；
B, according to X-ray attenuation characteristic in metal and the gray scale flux pattern that obtains, rebuild the three-dimensional foam model for pouring into a mould compensator, and the three-dimensional foam model of reconstruction be sent to 3D printer；
C, 3D printer prints the three-dimensional foam model of reconstruction；
D, the three-dimensional foam model printed carried out lead water cast and cools down moulding process, thus obtaining intensity-regulation compensator.
Further, described step A, comprising:
A1, treatment planning systems require to design the strong plan of tune according to clinical treatment；
A2, treatment planning systems, according to the strong planning data of tune of design, derive the intensity distribution of each irradiation field.
Further, described step B, comprising:
B1, according to X-ray attenuation characteristic in metal, the gray scale flux pattern obtained is processed, thus obtain a series of faultage images of three-dimensional foam model；
B2, a series of faultage images obtained are carried out three-dimensional reconstruction process, thus obtain the stl file of three-dimensional foam model；
B3, the stl file of three-dimensional foam model is sent to 3D printer.
Further, described step B1, itself particularly as follows:
To the gray scale flux pattern obtained, along transmitted intensity from strong to weak direction, sequentially generate the two-dimensional cross-section image of three-dimensional foam model according to default interval, thus obtain a series of faultage images of three-dimensional foam model.
Further, described step B2, it is particularly as follows: use three-dimensional reconstruction software that a series of faultage images obtained are carried out three-dimensional reconstruction process, thus obtains the stl file of three-dimensional foam model.
Further, described step C, itself particularly as follows:
3D printer, according to the stl file received, with PLA plastics as raw material, with fusion sediment rapid shaping technique as superposition process, prints described three-dimensional foam model.
The invention has the beneficial effects as follows: based on 3D printing technique, according to X-ray attenuation characteristic in metal, the three-dimensional foam model for pouring into a mould compensator is rebuild from the gray scale flux pattern adjusting intense irradiation wild, and the three-dimensional foam model of reconstruction is sent to 3D printer prints, then the three-dimensional foam model printed carried out lead water cast and cool down moulding process, finally give the intensity-regulation compensator meeting clinical treatment requirement, the linear accelerator being particularly suitable for not equipping multi-diaphragm collimator uses, there is preparation method simple and quick, input cost is low, consumptive material is few, the advantage that the short and applicable small-middle hospital of machine spill time uses.
Accompanying drawing explanation
The invention will be further described with embodiment below in conjunction with the accompanying drawings.
Fig. 1 is the flow chart of steps of a kind of intensity-regulation compensator preparation method based on 3D printing technique of the present invention；
Fig. 2 is sigmatron attenuation characteristic curve in metal；
Fig. 3 is the three-dimensional foam model for pouring into a mould compensator；
Fig. 4 is the schematic diagram of intensity-regulation compensator；
Fig. 5 is the flow chart of step A of the present invention；
Fig. 6 is the flow chart of step B of the present invention.
Detailed description of the invention
Reference Fig. 1, a kind of intensity-regulation compensator preparation method based on 3D printing technique, including:
A, treatment planning systems, according to adjusting strong planning data, are derived the intensity distribution of each irradiation field, thus are obtained the gray scale flux pattern adjusting intense irradiation wild；
B, according to X-ray attenuation characteristic in metal and the gray scale flux pattern that obtains, rebuild the three-dimensional foam model for pouring into a mould compensator, and the three-dimensional foam model of reconstruction be sent to 3D printer；
C, 3D printer prints the three-dimensional foam model of reconstruction；
D, the three-dimensional foam model printed carried out lead water cast and cools down moulding process, thus obtaining intensity-regulation compensator.
Wherein, the gray scale flux pattern adjusting intense irradiation wild can reflect the intensity distribution of irradiation field.For cost-effective consideration, 3D printer is only to print monochromatic printer.
Fig. 2 is sigmatron attenuation characteristic curve in metal, and sigmatron energy conventional in radiotherapy has 6MV, 10MV and 15MV.
Fig. 3 is for pouring into a mould the three-dimensional foam model of compensator (the three-dimensional foam model i.e. rebuild), and Fig. 4 is the intensity-regulation compensator schematic diagram finally given.
With reference to Fig. 5, it is further used as preferred embodiment, described step A, comprising:
A1, treatment planning systems require to design the strong plan of tune according to clinical treatment；
A2, treatment planning systems, according to the strong planning data of tune of design, derive the intensity distribution of each irradiation field.
With reference to Fig. 6, it is further used as preferred embodiment, described step B, comprising:
B1, according to X-ray attenuation characteristic in metal, the gray scale flux pattern obtained is processed, thus obtain a series of faultage images of three-dimensional foam model；
B2, a series of faultage images obtained are carried out three-dimensional reconstruction process, thus obtain the stl file of three-dimensional foam model；
B3, the stl file of three-dimensional foam model is sent to 3D printer.
Wherein, the gray scale flux pattern obtained is processed mainly carry out binary conversion treatment.Faultage image is binary picture, i.e. gray scale 0 represents air, and gray scale 255 represents foam material.
The right of Fig. 3 is the three-dimensional foam model binary picture at some tomography of reconstruction, and black represents air, and white represents foam material.
Be further used as preferred embodiment, described step B1, itself particularly as follows:
To the gray scale flux pattern obtained, along transmitted intensity from strong to weak direction, sequentially generate the two-dimensional cross-section image of three-dimensional foam model according to default interval, thus obtain a series of faultage images of three-dimensional foam model.
Being further used as preferred embodiment, described step B2, it is particularly as follows: use three-dimensional reconstruction software that a series of faultage images obtained are carried out three-dimensional reconstruction process, thus obtains the stl file of three-dimensional foam model.
Be further used as preferred embodiment, described step C, itself particularly as follows:
3D printer, according to the stl file received, with PLA plastics as raw material, with fusion sediment rapid shaping technique as superposition process, prints described three-dimensional foam model.
As shown in Figures 1 to 6, the specifically comprising the following steps that of a kind of intensity-regulation compensator preparation method based on 3D printing technique of the present invention
A. adjust and plan by force design: design meets the tune of clinical treatment requirement and plans by force in treatment planning systems, and derives the intensity distribution of each irradiation field according to the strong plan of adjusting of design.
B. reconstruction is for pouring into a mould the bubbles model of compensator: the attenuation characteristic (as shown in Figure 2) utilizing X-ray in metal, along transmitted intensity from strong to weak direction, generate the two-dimensional cross-section image of bubbles model according to default interval, thus obtain being similar to a series of faultage images (as shown in Figure 3) of CT machine scanning bubbles model.
C. the stl file of three-dimensional foam model is generated: the three-dimensional reconstruction software that a series of faultage images obtained import to specialty carries out three-dimensional reconstruction, and derives the stl file after three-dimensional reconstruction.When implementing, the vtkSTLWriter class of three-dimensional visualization instrument such as VTK can be used to rewrite the stl file of three-dimensional foam model.
D.3D print bubbles model: the stl file of bubbles model is imported to 3D printer, and with PLA plastics as raw material, with fusion sediment rapid shaping technique as superposition process, print this three-dimensional foam model.
E. pour into a mould moulding: in three-dimensional foam model, pour into a mould low melting point lead water, after lead water cools down, disassemble foam and i.e. can get the intensity-regulation compensator shown in Fig. 4.
Compared with prior art, the invention have the advantages that
(1) using compensator technology, accelerator disposably goes out bundle just can obtain meeting the tune intense irradiation open country of clinical requirement, substantially reduces treatment time.
(2) use and only print a monochromatic 3D printer, cost need only 1-2 ten thousand yuan, and have employed PLA plastics and the metal of repeatable utilization of low cost, be greatly saved cost, be suitable for small-middle hospital and use.
(3) have employed fusion sediment quick shaping process, printing precision generally at 0.1mm-0.3mm, can meet the former requirement printing intensity-regulation compensator, have the advantage that simple in construction, making and maintenance cost are low, materials are few.
(4) based on 3D printing technique, can print the intensity-regulation compensator of arbitrary shape, compensate for adaptive heated-wire cutting-machine and cannot be similar to mountain range shape by printing and making, the defect of up-and-down three-dimensional intensity-regulation compensator, function is more diversified.
It is above the preferably enforcement of the present invention is illustrated, but the invention is not limited to described embodiment, those of ordinary skill in the art also can make all equivalent variations or replacement on the premise of spirit of the present invention, and deformation or the replacement of these equivalents are all contained in the application claim limited range.
Claims (5)
1. an intensity-regulation compensator preparation method based on 3D printing technique, it is characterised in that: including:
A, treatment planning systems, according to adjusting strong planning data, are derived the intensity distribution of each irradiation field, thus are obtained the gray scale flux pattern adjusting intense irradiation wild；
B, according to X-ray attenuation characteristic in metal and the gray scale flux pattern that obtains, rebuild the three-dimensional foam model for pouring into a mould compensator, and the three-dimensional foam model of reconstruction be sent to 3D printer；
C, 3D printer prints the three-dimensional foam model of reconstruction；
D, the three-dimensional foam model printed carried out lead water cast and cools down moulding process, thus obtaining intensity-regulation compensator；
Described step B, comprising:
B1, according to X-ray attenuation characteristic in metal, the gray scale flux pattern obtained is processed, thus obtain a series of faultage images of three-dimensional foam model；
B2, a series of faultage images obtained are carried out three-dimensional reconstruction process, thus obtain the stl file of three-dimensional foam model；
B3, the stl file of three-dimensional foam model is sent to 3D printer.
A kind of intensity-regulation compensator preparation method based on 3D printing technique the most according to claim 1, it is characterised in that: described step A, comprising:
A1, treatment planning systems require to design the strong plan of tune according to clinical treatment；
A2, treatment planning systems, according to the strong planning data of tune of design, derive the intensity distribution of each irradiation field.
A kind of intensity-regulation compensator preparation method based on 3D printing technique the most according to claim 1, it is characterised in that: described step B1, itself particularly as follows:
To the gray scale flux pattern obtained, along transmitted intensity from strong to weak direction, sequentially generate the two-dimensional cross-section image of three-dimensional foam model according to default interval, thus obtain a series of faultage images of three-dimensional foam model.
A kind of intensity-regulation compensator preparation method based on 3D printing technique the most according to claim 1, it is characterized in that: described step B2, it is particularly as follows: use three-dimensional reconstruction software that a series of faultage images obtained are carried out three-dimensional reconstruction process, thus obtains the stl file of three-dimensional foam model.
A kind of intensity-regulation compensator preparation method based on 3D printing technique the most according to claim 1, it is characterised in that: described step C, itself particularly as follows:
3D printer, according to the stl file received, with PLA plastics as raw material, with fusion sediment rapid shaping technique as superposition process, prints described three-dimensional foam model.
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| CN103934415B (en) * | 2014-03-11 | 2015-07-29 | 宁波通达精密铸造有限公司 | Based on the preparation method of the dispellable mould casting bubbles model that 3D prints |
| CN104759038B (en) * | 2015-04-23 | 2017-12-22 | 中国科学院近代物理研究所 | The conformal intensity modulated device and method of heavy particle radiotherapy multifunction three-dimensional |
| CN105148390B (en) * | 2015-07-30 | 2018-08-10 | 西南医科大学附属医院 | The design method of applicating device |
| JP6835553B2 (en) * | 2016-12-02 | 2021-02-24 | 株式会社日立製作所 | Ridge filter and its manufacturing method |
| CN107693960A (en) * | 2017-10-31 | 2018-02-16 | 德阳市人民医院 | Two-dimentional radiotherapy physical compensation lead preparation method |
| CN110237443A (en) * | 2019-06-13 | 2019-09-17 | 武汉大学 | Using the method for 3D printing technique production low melting point gear lead |
| KR200490657Y1 (en) * | 2019-09-16 | 2019-12-12 | 고려대학교 산학협력단 | Radiotherapy Apparatus for Companion animal Using Kilovoltage X-ray |
| US11751997B2 (en) * | 2019-10-15 | 2023-09-12 | b-ONE Medical (Suzhou) Co., Ltd. | Implant and a method of making the implant and a method of calculating porosity of a porous material |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2001346892A (en) * | 2000-06-07 | 2001-12-18 | Hitachi Ltd | Radiotherapeutic porus and production method thereof |
| EP2810693A2 (en) * | 2012-02-02 | 2014-12-10 | Samsung Life Public Welfare Foundation | Method and apparatus for manufacturing radiation intensity bolus |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2001346892A (en) * | 2000-06-07 | 2001-12-18 | Hitachi Ltd | Radiotherapeutic porus and production method thereof |
| EP2810693A2 (en) * | 2012-02-02 | 2014-12-10 | Samsung Life Public Welfare Foundation | Method and apparatus for manufacturing radiation intensity bolus |
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