CN103536468A - Traditional Chinese medicine composition with whitening effect and application of traditional Chinese medicine composition in cosmetics - Google Patents
Traditional Chinese medicine composition with whitening effect and application of traditional Chinese medicine composition in cosmetics Download PDFInfo
- Publication number
- CN103536468A CN103536468A CN201310474006.8A CN201310474006A CN103536468A CN 103536468 A CN103536468 A CN 103536468A CN 201310474006 A CN201310474006 A CN 201310474006A CN 103536468 A CN103536468 A CN 103536468A
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- medicine composition
- whitening
- parts
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Landscapes
- Cosmetics (AREA)
Abstract
The invention discloses a whitening traditional Chinese medicine composition extract which is characterized by comprising the following raw materials in parts by weight: 10-50 parts of ginseng; 10-50 parts of liquorice; 10-40 parts of angelica; 5-30 parts of scutellaria; 1-10 parts of safflower. The preparation method comprises pulverizing the Chinese medicinal composition, adding extraction solvent, heating and extracting at 50-80 deg.C for 0.5-2 hr, extracting for 1-3 times, filtering, mixing filtrates, concentrating under reduced pressure at 60 deg.C, purifying with D101 or AB-8 type macroporous resin column, collecting 40% -70% ethanol eluate, concentrating under reduced pressure at 60 deg.C until the ratio of medicinal liquid to medicinal materials is 1: 2-1: 10, adding 10 to 60 percent of butanediol for dissolving, and filtering to obtain the active part extract of the traditional Chinese medicine. The Chinese medicinal composition extract obtained by the method has health whitening effect, and can be used in skin care cosmetics to achieve whitening and skin care effects.
Description
Technical field
The present invention relates to a kind of Skin-care Chinese medicine compositions, a kind of specifically have the Chinese medicine composition of white-skinned face function and an application in cosmetics thereof.
Background technology
Everybody has a love of beauty, and due to the tradition thought attractive in appearance of " a white screening three is ugly ", the skin of having deep love for pale health that Asia women is natural, makes whitening become focus and the trend of beauty treatment.The depth of skin color is regulated and controled by many factors, but depends primarily on melanic content and distribution, so whitening is mainly generation, the distribution of modulating melanin.For melanin generation, distribution mechanism, its whitening Regulation Mechanism mainly contains: check melanin forms, and check melanin transfer of granules makes containing the more skin exfoliation of melanin, ability signal transduction pathway in blocking-up melanin production process, reduces the extrinsic factor that melanin is formed.
Based on melanic Regulation Mechanism, the whitening agent of market mainly contains following a few class at present: 1. check melanin forms class, mainly contain tyrosinase inhibitor as kojic acid and derivant, hydroquinone and derivant thereof, dopachrome isomerase inhibitors is as chromocor compounds such as glycyrrhizins, and oxidation reaction inhibitor is as L-AA and derivant thereof; Check melanin transfer of granules to horn cell as nicotiamide; 3. skin exfoliation agent is as fruit acid and nicotiamide; 4. UV absorbent is as benzophenone, paraaminobenzoic acid esters, cinnamate derivative.These chemical whitening agents mostly economical but exist certain zest, character is unstable, skin absorption is poor, especially skin exfoliation agent is the directly a kind of infringement to human body skin, sometimes causes a kind of unsound white.
So exploitation whitening effect obviously, the whitening agent of safety, stable, good absorbing, become the focus of current beauty industry, and plant origin, natural, Chinese medicine whitening thing are its mains direction of studying.Especially based on traditional Chinese medical science Overall View, can bring healthy white natural whiting Chinese medicine composition, be expected to become the main flow in following whitening market.
Summary of the invention
Technical problem to be solved by this invention is exactly in order to overcome the deficiency of the chemical whitening agent of appeal, a kind of the have Chinese medicine composition of healthy whitening, natural safety, monarch, Synergistic and the preparation technology of this Chinese medicine composition extract and the application in cosmetics thereof to be provided.
The technical scheme that the present invention will solve the employing of appeal technical problem is a kind of whitening Chinese medicament compositions, it is characterized in that: its raw material forms and proportioning is: Radix Ginseng 10-50 part; Radix Glycyrrhizae 10-50 part; Radix Angelicae Sinensis 10-40 part; Radix Scutellariae 5-30 part; Flos Carthami 1-10 part.
The preparation technology of the above-mentioned whitening Chinese medicament compositions of the present invention extract, is characterized in that: taking raw material of Chinese medicine and proportioning is: Radix Ginseng 10-50 part; Radix Glycyrrhizae 10-50 part; Radix Angelicae Sinensis 10-40 part; Radix Scutellariae 5-30 part; Flos Carthami 1-10 part.Above-mentioned Chinese medicine is suitably pulverized, add extraction solvent, 50-80 ℃ of heating extraction 0.5-2h, extracts 1-3 time, filter, merging filtrate is evaporated to without alcohol taste under 60 ℃ of conditions, upper D101 type or AB-8 type macroporous resin column purification, collects 40%-70% ethanol eluting part, under 60 ℃ of conditions, being evaporated to medicinal liquid is 1:2～1:10 with medical material ratio, add 10%-60% butanediol and dissolve, filter, make Chinese medicine composition extract.The extraction solvent using in the present invention can adopt water, ethanol, ethanol water.
The second object of the present invention be by above-mentioned whitening Chinese medicament compositions extract for skin-lightening cosmetic, make stable in properties, respond well skin-lightening cosmetic.
For realizing the second object of the present invention, the present invention has adopted following technical scheme: above-mentioned Chinese medicine composition extract is used for preparing skin-lightening cosmetic, it is characterized in that containing above-mentioned Chinese medicine composition extract in skin-lightening cosmetic, its consumption is 0.1-20%, and preferable amount is 1-10%.
According to traditional Chinese medical science Overall View, considering constitution theory in traditional Chinese medicine, say, skin is a part for human body, and embodies human body constitution state, and the colour of skin that good body constitution embodies is healthy, moist, and skin condition is that nutrition is fair and clear, and poor body constitution is that lusterless complexion, the colour of skin are withered.In the present invention, Radix Ginseng is monarch, strongly invigorating primordial QI, promotes the production of body fluid and nourishes blood, and has very strong nourishing effects; Radix Glycyrrhizae is minister, QI invigorating invigorating middle warmer, the mitigation property of medicine; When being classified as minister, enrich blood and invigorate blood circulation, be the panacea of enriching blood, invigorate blood circulation it is foster to the honor of skin to strengthen blood simultaneously; Radix Scutellariae is assistant, and clearing away heat-fire removing toxic substances, removes skin pyretic toxicity; Flos Carthami is for making, and blood-activating and qi-promoting, increases the absorption of overall activity thing.Modern medicine study proves: Radix Ginseng has very strong enhancing function of human body, the effect of slow down aging; The contained licoflavone class material of Radix Glycyrrhizae, the phenylpropionic acid material in Radix Angelicae Sinensis have good white-skinned face function, and Radix Angelicae Sinensis can also be accelerated the renewal of skin surface cell simultaneously, and Radix Scutellariae and above all taste medical materials be restraint of tyrosinase activity well.
All medicines share above, and Synergistic is played qi-supplementing, blood-engendering altogether, flourish merit of supporting skin, and originally, skin natural health is white for strong body constitution.The present invention effectively restraint of tyrosinase is active, removes free radical, reduces melanin and produces, and accelerates skin surface cell and upgrades, and makes an addition in cosmetics, and white-skinned face function is remarkable, natural non-stimulated, the healthy good colour of skin.
Accompanying drawing explanation
Fig. 1 is that Chinese medicine composition of the present invention is to tyrosinase inhibition test result figure.
The specific embodiment
By specific embodiment, come below that the present invention is further illustrated, but these embodiment are just in order to illustrate, are not limitations of the present invention.
The preparation of embodiment 1 Chinese medicine composition extract (I)
Get Radix Ginseng 25g, Radix Glycyrrhizae 25g, Radix Angelicae Sinensis 20g, Radix Scutellariae 15g, Flos Carthami 5g, suitably pulverize, add 70% ethanol 2L, 80 ℃ of hot refluxs twice, each 1.5h, filters, and merging filtrate is evaporated to without alcohol taste under 60 ℃ of conditions.Above aqueous solution is gone up AB-8 macroporous resin column purification again, collect 70% ethanol eluting part, under 60 ℃ of conditions, concentrating under reduced pressure obtains 50ml concentrated solution, add again 50ml butanediol, filter, make 100ml traditional Chinese medicine composition extract liquid, its solid content is 8%-11%, can directly add in skin protection cosmetics.
The preparation of embodiment 2 Chinese medicine composition extracts (II)
Get Radix Ginseng 100g, Radix Glycyrrhizae 90g, Radix Angelicae Sinensis 80g, Radix Scutellariae 50g, Flos Carthami 20g, suitably pulverize, add 70% ethanol 7L, 80 ℃ of hot refluxs twice, each 1.5h, filters, and merging filtrate is evaporated to without alcohol taste under 60 ℃ of conditions.Above aqueous solution is gone up AB-8 macroporous resin column purification again, collect 70% ethanol eluting part, under 60 ℃ of conditions, concentrating under reduced pressure obtains 200ml concentrated solution, add again 150ml butanediol, filter, make 350ml traditional Chinese medicine composition extract liquid, its solid content is 8%-11%, can directly add in skin protection cosmetics.
Embodiment 3 is containing the preparation of the protective skin cream of Chinese medicine composition extract
Table 1 provides the prescription for skin cream that contains Chinese medicine composition extract of the present invention, the consumption of each material mass fraction table:
Table 1 whitening skin-protection cream formula table
Preparation method: A mutually 80 ℃ dissolve mix homogeneously, B mutually 80 ℃ dissolve mix homogeneously, before Cyclomethicone emulsifying, add B phase, during emulsifying, B is added to A mutually and homogenizing 5 minutes, adds C mutually and homogenizing 2 minutes while being cooled to 50 ℃, after ageing 24h, pack.
Embodiment 4 is containing the preparation of the emulsion of Chinese medicine composition extract
Table 2 provides the emulsion formulations that contains Chinese medicine composition extract of the present invention, and the consumption of each material represents with mass fraction:
Table 2 whitening and skin-protecting emulsion formulations table
Preparation method: A mutually 80 ℃ dissolve mix homogeneously, B mutually 80 ℃ dissolve mix homogeneously, before emulsifying, C is added to B phase, during emulsifying, A is added to B mutually and homogenizing 5 minutes, adds D homogenizing 2 minutes while being cooled to 50 ℃, after ageing 24h, pack.
Embodiment 5 restraint of tyrosinase active testings
(1) material
1. solution preparation
(1) PBS solution (pH=6.8,0.1mol/L): 1. 17.91g disodium hydrogen phosphate is dissolved in deionized water, is settled to 500ml with deionized water.2. 7.8g ten sodium dihydrogen phosphate dihydrates are dissolved in deionized water, with deionized water, are settled to 500ml.3. get respectively 92.6ml and be 1. 2. mixed with the phosphate buffer solution of 200ml pH=6.8 with 107.4ml.
(2) TYR solution: 0.05g is dissolved in the HCl of 35ml0.1mol/L, with PBS (0.1mol/L) buffer of pH6.8, is settled to 100mL.
(3) tryrosinase: enzyme is lived as 100U/ml.
2. sample preparation
Above-mentioned traditional Chinese medicine composition extract liquid is diluted with deionized water, be made into concentration and be 0.05%, 0.1%, 0.2%, 0.4%, 0.8% sample solution, carry out test below.
(2) test method
1. according to table 3 application of sample, do not add tryrosinase.
Table 3 tyrosinase inhibition test preparation table
2. solution is placed in to 37 ℃ of water-bath constant temperature 10min.
3. add tryrosinase, solution is placed in after 37 ℃ of water-bath constant temperature 10min, under 475nm, measure its absorbance, and compare with arbutin.
Tyrosinase activity suppression ratio calculates according to formula (1):
Tyrosinase activity suppression ratio=(the same product absorbance of blank absorbency value)/blank absorbency value * 100 (1)
(3) experimental result
Experimental result is shown in accompanying drawing 1.This routine Chinese medicine composition extract, just shows tyrosinase inhibitory activity in concentration 0.05%, to tyrosinase activity suppression ratio, is 42%; When concentration reaches 0.2%, tyrosinase activity suppression ratio is reached more than 90%.
Embodiment 6 human bodies are tried out evaluation experimental
(1) experimental technique
The cream frost emulsion of embodiment 3 and embodiment 4 preparations is carried out respectively human body evaluation on probation.Choose 60 volunteers that the colour of skin is darker, men and women half and half.Be divided at random 3 groups, every group of 10 male, 10 women.3 groups are used respectively commercially available skin-lightening cosmetic, this routine whitening skin-protection cream, this routine whitening and skin-protecting emulsion.Using method is to use after clean of every day, and once a day, experimental period is one month, according to sensory evaluation, fills in evaluation table on probation.Use the 3rd day, the 7th day, the 14th day, the 28th day each statistics once.
(2) experimental result
Human body evaluation result statistics on probation is in Table 4.
Table 4 human body is tried out evaluation result
This table adopts volunteer to evaluate scoring mechanism, and wherein best result is 5, represents that effect is remarkable, is minimumly divided into 1 expression and there is no effect.
From table 4 result, this routine skin-lightening cosmetic white-skinned face function is obvious, and more remarkable than commercially available skin-lightening cosmetic effect.This routine skin-lightening cosmetic is used skinfeel comfortable, there is no zest, and not only white-skinned face function is remarkable, and after whitening, skin health is saturating clearly.
Claims (3)
1. a whitening Chinese medicament compositions, is characterized in that its raw material forms and proportioning is: Radix Ginseng 10-50 part; Radix Glycyrrhizae 10-50 part; Radix Angelicae Sinensis 10-40 part; Radix Scutellariae 5-30 part; Flos Carthami 1-10 part.
2. the preparation method of the extract of the Chinese medicine composition of claim 1 is characterized in that: Chinese medicine composition is pulverized, add extraction solvent, 50-80 ℃ of heating extraction 0.5-2h, extracts 1-3 time, filter, merging filtrate is concentrating under reduced pressure under 60 ℃ of conditions, upper macroporous resin column purification, collects 40%-70% ethanol eluting part, under 60 ℃ of conditions, being evaporated to medicinal liquid is 1:2～1:10 with medical material ratio, add 10%-60% butanediol and dissolve, filter, make whitening Chinese medicament compositions extract.
3. the cosmetics that contain the extract of claim 1 whitening Chinese medicament compositions, is characterized in that the extract that skin protection contains whitening Chinese medicament compositions claimed in claim 1 in applying some make up, and its consumption is 0.1-25%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310474006.8A CN103536468B (en) | 2013-10-12 | 2013-10-12 | Traditional Chinese medicine composition with whitening effect and application of traditional Chinese medicine composition in cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310474006.8A CN103536468B (en) | 2013-10-12 | 2013-10-12 | Traditional Chinese medicine composition with whitening effect and application of traditional Chinese medicine composition in cosmetics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103536468A true CN103536468A (en) | 2014-01-29 |
| CN103536468B CN103536468B (en) | 2015-09-02 |
Family
ID=49960586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310474006.8A Active CN103536468B (en) | 2013-10-12 | 2013-10-12 | Traditional Chinese medicine composition with whitening effect and application of traditional Chinese medicine composition in cosmetics |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103536468B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104013562A (en) * | 2014-06-13 | 2014-09-03 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine composition with skin-whitening effect and application of traditional Chinese medicine composition in cosmetics |
| CN105125436A (en) * | 2015-08-18 | 2015-12-09 | 广东轻工职业技术学院 | Compound whitening composition and preparation method |
| CN109481366A (en) * | 2018-12-17 | 2019-03-19 | 温州古木生物科技有限公司 | It is a kind of to have effects that repair the Chinese medicine composition of skin sunburn and its water extract and fermentation material and application |
| CN109846762A (en) * | 2018-09-17 | 2019-06-07 | 上海珈凯生物科技有限公司 | A kind of composition with white-skinned face function and preparation method thereof, application |
| CN109846772A (en) * | 2018-10-29 | 2019-06-07 | 上海珈凯生物科技有限公司 | A kind of composition with white-skinned face function, skin care item and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1342474A (en) * | 2000-09-08 | 2002-04-03 | 俞宝明 | Functional additive for cosmetics |
| CN101062002A (en) * | 2006-04-24 | 2007-10-31 | 王筑平 | Skin-care combination including plant extracts |
| CN101467941A (en) * | 2007-12-27 | 2009-07-01 | 天津天阜康生物技术发展有限公司 | Chinese medicine mask with whitening and spot-eliminating functions and technique for preparing the same |
-
2013
- 2013-10-12 CN CN201310474006.8A patent/CN103536468B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1342474A (en) * | 2000-09-08 | 2002-04-03 | 俞宝明 | Functional additive for cosmetics |
| CN101062002A (en) * | 2006-04-24 | 2007-10-31 | 王筑平 | Skin-care combination including plant extracts |
| CN101467941A (en) * | 2007-12-27 | 2009-07-01 | 天津天阜康生物技术发展有限公司 | Chinese medicine mask with whitening and spot-eliminating functions and technique for preparing the same |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104013562A (en) * | 2014-06-13 | 2014-09-03 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine composition with skin-whitening effect and application of traditional Chinese medicine composition in cosmetics |
| CN105125436A (en) * | 2015-08-18 | 2015-12-09 | 广东轻工职业技术学院 | Compound whitening composition and preparation method |
| CN105125436B (en) * | 2015-08-18 | 2018-03-13 | 广东轻工职业技术学院 | A kind of composite whitening composition and preparation method |
| CN109846762A (en) * | 2018-09-17 | 2019-06-07 | 上海珈凯生物科技有限公司 | A kind of composition with white-skinned face function and preparation method thereof, application |
| CN109846772A (en) * | 2018-10-29 | 2019-06-07 | 上海珈凯生物科技有限公司 | A kind of composition with white-skinned face function, skin care item and preparation method thereof |
| CN109481366A (en) * | 2018-12-17 | 2019-03-19 | 温州古木生物科技有限公司 | It is a kind of to have effects that repair the Chinese medicine composition of skin sunburn and its water extract and fermentation material and application |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103536468B (en) | 2015-09-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103536468B (en) | Traditional Chinese medicine composition with whitening effect and application of traditional Chinese medicine composition in cosmetics | |
| CN104013560B (en) | A kind of whitening Chinese medicament compositions and the application in cosmetics thereof | |
| CN104814908A (en) | Mask with effects of resisting wrinkle and tendering skin | |
| KR20070095588A (en) | Nature room composite and the manufacture method for atopiseong skin disease treatment | |
| KR101569431B1 (en) | Skin enhancement method comprising six steps using cosmetic composition, especially cosmetic composition comprising illite eluate haved skin whitening function and anti-wrinkles effect | |
| KR100894628B1 (en) | Cosmetic Compositions containing ginseng extract and deep sea water | |
| CN103083213A (en) | Acer truncatum oil skincare cream and preparation method thereof | |
| CN103751552B (en) | A kind of Chinese medicine composition and preparation method and application with senile-resistant efficacy | |
| CN104027280A (en) | Anti-aging traditional Chinese medicine composition and application of anti-aging traditional Chinese medicine composition in cosmetics | |
| CN110787119A (en) | Antibacterial skin-care traditional Chinese medicine composition and preparation method and application thereof | |
| CN105769691A (en) | Herbal skin care product | |
| CN106890120A (en) | A kind of Chinese medicine Whitening, spot breast and preparation method thereof | |
| CN106924134A (en) | A kind of Chinese medicine whitening spot-relieving cream and preparation method thereof | |
| KR101948597B1 (en) | Hair cosmetic composition with excellent cleansing effect and soothing effect | |
| CN105748374A (en) | Traditional Chinese medicine toner with effect of tendering and caring skin | |
| CN105902475A (en) | Rose and egg white facial mask and preparation method thereof | |
| CN105796409A (en) | Bath salt and preparation method thereof | |
| KR100890234B1 (en) | Cosmetic Compositions containing ginseng and siberian ginseng extracts and deep sea water | |
| KR101282488B1 (en) | Liquefied making method for a facewashing soup | |
| KR20160010909A (en) | Natural beauty soap for the improvement and treatment of the Eczema.acne, psoriasis, seborrheic skin using White Ionic Minerals, SY2220, and White Ionic Minerals distilled water, SY2216, extracted from white clay of Yang Gu Bangsan region and manufacturing method and that compositions. | |
| CN104721744A (en) | Pharmaceutical composition with whitening function and preparation method thereof | |
| CN105687052A (en) | Bath salt and preparation method | |
| CN104083313A (en) | Facial mask capable of whitening, lightening spots and tendering skin | |
| CN102488852B (en) | A kind of acne-removing composition and preparation method thereof | |
| CN105616300A (en) | Bath salt with whitening and moistening functions and preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 510663 No. 15, Colin Road, Guangzhou Science City, Guangzhou high tech Industrial Development Zone, Guangdong Province Patentee after: Guangzhou Huanya cosmetics technology Co.,Ltd. Address before: 510663 No. 15, Colin Road, Guangzhou Science City, Guangzhou high tech Industrial Development Zone, Guangdong Province Patentee before: GUANGZHOU HUANYA COSMETICS TECHNOLOGY Co.,Ltd. |
|
| CP01 | Change in the name or title of a patent holder |