CN103535520A - Application of polyaspartic acid and salts thereof as animal feed additive - Google Patents
Application of polyaspartic acid and salts thereof as animal feed additive Download PDFInfo
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- CN103535520A CN103535520A CN201210236282.6A CN201210236282A CN103535520A CN 103535520 A CN103535520 A CN 103535520A CN 201210236282 A CN201210236282 A CN 201210236282A CN 103535520 A CN103535520 A CN 103535520A
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Abstract
The invention discloses application of polyaspartic acid and salts thereof as an animal feed additive, an animal oral preparation and a liquid admixture for animals. The molecular formula of the polyaspartic acid and salts thereof is C4H5NO3M(C4H4NO3M)m(C4H4NO3M)nC4H4NO3M2, wherein M is hydrogen, ammonium or a metal element, and the molecular weight is 363-30000. The polyaspartic acid and salts thereof used as the animal feed additive can improve the gastrointestinal functions, promote absorption of copper, iron, manganese, zinc and other microelements, improve the utilization of nutrient substances, and reduce the emission. The polyaspartic acid and salts thereof act as a safe efficient environment-friendly feed additive.
Description
Technical field
The present invention relates to the purposes of poly-aspartic-acid and salt thereof, be specifically related to poly-aspartic-acid and salt thereof as the application of animal feed additive.
Background technology
Along with the fast development of China's aquaculture, feed resource relatively lacks and problem of environmental pollution becomes increasingly conspicuous.How to improve animal gastrointestinal tract function, improve the key problem that efficiency of feed utilization is modern efficient and healthful cultivation.
Grice diarrhoea and functional disturbances of gastrointestinal tract have a strong impact on sound development ，Gei China pig-breeding industry of China's live pig industry and bring massive losses.Diarrhea of weaned piglets is mainly because intestines and stomach grow due to complete, intestinal mucosa is impaired and micro-ecological disorder causes inflammation reaction and digestion and absorption function obstacle.At present, the main path that solves grice diarrhoea is that antibiotic, zinc, the copper by add high dose in feed is alleviated.Yet these solutions not only do not meet animal physiological feature, also brought the problems such as microorganism drug resistance and contaminated environment, new science, safety method are still among finding.
Mineral matter element is body health and the essential nutriment growing.Improve absorbing of mineral matter element and can reduce feed interpolation and ight soil discharge.Studies confirm that, compare with inorganic microelement, organic trace element and relevant complex compound improve absorbing, reduce and add and discharge, promote body health and improve aspect feed process to there is good superiority.But body absorbs effect difference to different organic forms, different complex status or different ions form trace element, safety, trace mineral supplement needs further exploitation efficiently.
Ruminant has unique digestive physiology feature, can utilize inorganic nitrogen and protein feed inferior to meet body requirement by lumen fermentation, destroys the direct utilization that high-quality protein feed stops body simultaneously.How to bring into play maximizes favourable factors and minimizes unfavourable ones makes full use of the key point that lumen fermentation is the efficient cultivation of ruminant.Utilize different urease inhibitors, inorganic nitrogen sustained release agent or slowly-releasing measure guaranteeing the stable fermentation of cud, reduce utilization that ammonia poisoning greatly promoted nonprotein nitrogen, saved a large amount of protein feed resources, but still potential for not giving full play to; Lasting, the stable supplying of cud trace element are also the key factors that improves microorganism fermentation efficiency, in widespread attention and research, and slow release effect has much room for improvement.The rumen-protected of high-quality protein feed mainly realized by protected dose of various chemical treatments or physical package, but effect is still undesirable.
Poly-aspartate is a kind of water-soluble polypeptide, amino acid polymer, in the natural shell that is present in mollusk and snail class in mucus, include peptide bond and carboxyl isoreactivity group, there is the effects such as extremely strong chelating, dispersion and absorption, to animal have no side effect, biodegradable.Polyaspartic acid salts is poly-aspartate ion and cation combining form.
Poly-aspartic-acid meets following general structure I:
Wherein: 1) in general structure I, m, n value are respectively 0-200, and m+n sum value is not less than 1.
Salt of poly aspartic acid meets following general structure II:
Wherein: 1) in general structure II, m, n value are respectively 0-200, and m+n sum value is not less than 1; 2) in general structure II, M can be the cation replacements such as sodium, potassium, ammonium, copper, iron, manganese, zinc.
Poly-aspartate and salt thereof is for water treatment and metal inhibitor, also for the synergist of vegetable fertilizer, or does the household chemicals fields such as cleaning agent, water absorbing agent, or at field of medicaments as pharmaceutical carrier.The technical scheme that the existing open feed addictive using and disclosed document, patent all do not have poly-aspartate or its salt to apply as animal feed additive.
Summary of the invention
The object of the invention is newly to provide a class animal feed additive, be used for promoting growth of animal, improve health, improve feed conversion, reduce discharge, improve human body immune function, improve animal reproduction performance etc., reduce or replace completely the use of antibiotic and other nutrition improvement agent, growth accelerator, save feed resource, reduce environmental pollution, reduce aquaculture cost, improve animal product quality.
The technical problem that will solve required for the present invention is to provide the new purposes of a class poly-aspartic-acid and salt thereof, as the new application in animal feed additive.
The invention provides the application of the water intermixture that oral agents that a class poly-aspartic-acid takes as animal feed additive, animal and animal take, described poly-aspartic-acid meets following structural formula I:
Wherein: 1) in general structure I, m, n value are respectively 0-200, and m+n sum value is not less than 1.
The invention provides the application of the water intermixture that oral agents that a class salt of poly aspartic acid takes as animal feed additive, animal and animal take, described salt of poly aspartic acid meets following formula II:
Wherein: 1) in general structure II, m, n value are respectively 0-200, and m+n sum value is not less than 1; 2) in general structure II, M can be the cation replacements such as sodium, potassium, ammonium, copper, iron, manganese, zinc.
When a class poly-aspartic-acid of the present invention and salt thereof are prepared the water intermixture that oral agents that animal feed additive, animal take and animal take, can adopt one of them that meets general structure I, also can adopt the mixture of a plurality of compounds that meet general structure I.
The object of the invention is to realize by the following method: the using method of a described class poly-aspartic-acid and salt thereof, similar to other feeds interpolation usings method, can directly add in feed, or be made into and contain premix, pre-mixing agent, concentrate feed and the functional additive that such poly-aspartic-acid and salt weight content thereof are 0.0001-99.99%, then add in animal feed or feeding animals; Or be made into oral agents or the water intermixture that such poly-aspartic-acid and salt weight content thereof are 0.0001-99.99% that contain of taking to animal; Or as feed and feedstuff protective agent or carrier, then add in animal feed or feeding animals.Application comprises pig, poultry, ruminant, plant-eating animal, aquatic livestock, economic animal or animal for display.
The invention provides the application of the water intermixture that oral agents that a class poly-aspartic-acid and salt thereof takes as animal feed additive, animal and animal take, tool has the following advantages: (1) such material is a kind of water-soluble polypeptide and salt thereof, partly or completely by body digestibility and utilization, stay in grade, use cost is low, safety non-toxic is a class green, safety and environmentally friendly feed addictive; (2) such material can be used for improving intestines function of piglings, by forming physical barriers obstruction pathogen, at intestinal mucosa, adheres to and mucosa injury, suppresses harmful intestinal tract growth of microorganism, thereby partly or completely replaces the use of antibiotic and the high zinc of high-copper; (3) such material promotes body to micro-as the absorption of copper, iron, manganese, zinc in chyme by the formation of complex compound, reduces discharge, thereby saves feed resource, reduces environmental pollution; (4) such substance, for ruminant tumor gastric fermentation provides stable nitrogenous source and trace element, improves fermentation efficiency, avoids ammonia poisoning; (5) utilize such material to be coated with high-quality protein feed, can thoroughly improve the ratio of rumen bypass protein, improve breeding performonce fo animals.
The specific embodiment: the invention provides the application of the water intermixture that oral agents that a class poly-aspartic-acid and salt thereof takes as animal feed additive, animal and animal take.The present invention will be described below to enumerate specific embodiment, and required class poly-aspartic-acid and salt thereof can be obtained or be synthesized voluntarily by commercial sources.Embodiment, only for the invention will be further described, does not represent protection scope of the present invention, and the non-intrinsically safe that other people make according to the present invention is revised and adjusted, and still belongs to protection scope of the present invention.
When the present invention applies, be that a class poly-aspartic-acid or its salt are added in feedstuff, mixed feed, concentrate feed, premix, additive, oral liquid or other form animal foods, feeding animals after evenly mixing.
Embodiment 1: as additive for feed for piglets, the addition of described feed addictive poly-aspartic-acid zinc salt is according to 0.05 ‰-5 ‰ of perfect compound feed gross weight, directly add in piglet diet perfect compound feed, or be mixed after being added to again in perfect compound feed after premix, concentrate feed and feed with other feed addictive or feedstuff, to prevent and to treat its trophism and bacterial diarrhea.120 14 age in days weanling pigs are divided into control group (addition is 0) and test group (addition is that 250mg/kg is 0.25 ‰) at random.After two weeks, result is as follows: 1) control group grice diarrhoea rate is 24%, and test group is 56%.2) average daily gain of test group piglet improves 14.5% than control group piglet.
Embodiment 2: as growing and fattening feed addictive, the addition of described feed addictive sodium polyaspartate is according to 0.05 ‰-1 ‰ of perfect compound feed gross weight, directly adds in perfect compound feed; Or be added to again in perfect compound feed after being mixed and made into premix, concentrate feed with other feed addictive or feedstuff, with the discharge that promotes that mineral matter element absorbs, reduces.72 of the DLY three way cross piglets of test use body weight 20kg, (sodium polyaspartate addition is 0 to be divided at random positive controls, copper sulphate 200mg/kg,), (sodium polyaspartate addition is 0 to negative control group, copper sulphate 120mg/kg) and test group (sodium polyaspartate addition is 200mg/kg, copper sulphate 120mg/kg).Other nutritional labelings of daily ration meet NRC1998 requirement standard, and experimental period is 30 days.Result shows, add 200mg/kg sodium polyaspartate and can make low copper group pig obtain the close growth performance of high-copper group pig, and the institute's excrement copper content of draining reduction is more than 47%.
Embodiment 3: as cattle feed additive, the addition of described feed addictive poly-aspartic acid ammonium salt is according to 1.2% of perfect compound feed gross weight, directly adds in perfect compound feed; Or feed with other feed addictive, feedstuff, after being mixed and made into premix, concentrate feed.Result shows, adds 1.2% poly-aspartic acid ammonium salt and can save 1.8% bean-dregs feed, and do not affect growth performance.
Claims (8)
1. the application of the water intermixture that the oral agents that a class poly-aspartic-acid is taken as animal feed additive, animal and animal take, described poly-aspartic-acid meets following structural formula I:
Wherein: 1) in structural formula I, m, n value are respectively 0-200, and m+n sum is not less than 1.
2. the application of the water intermixture that the oral agents that a class salt of poly aspartic acid is taken as animal feed additive, animal and animal take, described salt of poly aspartic acid meets following formula II:
Wherein: 1) in formula II, m, n value are respectively 0-200, and m+n sum is not less than 1; 2) in formula II, M can be the cation replacements such as sodium, potassium, ammonium, copper, iron, manganese, zinc.
3. the application as animal feed additive according to the class poly-aspartic-acid described in claim 1 and 2 and salt thereof, is characterized in that described poly-aspartic-acid and salt thereof adopt one of them that meets general structure I or the mixture that adopts a plurality of compounds that meet general structure I while preparing the water intermixture that oral agents that animal feed additive, animal take and animal take.
4. the application as animal feed additive according to the class poly-aspartic-acid described in claim 1 and 2 and salt thereof, while it is characterized in that poly-aspartic-acid and salt thereof as animal feed additive, every kilogram of nonruminant perfect compound feed addition 0.0001-200000mg, every kilogram of ruminant perfect compound feed addition can be higher than 100g.
5. the application as animal feed additive according to the class poly-aspartic-acid described in claim 1 and 2 and salt thereof, it is characterized in that being made into and contain premix, pre-mixing agent, concentrate feed and the functional additive that such poly-aspartic-acid and salt weight content thereof are 0.0001-99.99%, then add in animal feed or feeding animals.
6. the application as animal feed additive according to the class poly-aspartic-acid described in claim 1 and 2 and salt thereof, is characterized in that being made into oral agents or the water intermixture that such poly-aspartic-acid and salt weight content thereof are .0001-99.99% that contain of taking to animal.
7. the application as animal feed additive according to the class poly-aspartic-acid described in claim 1 and 2 and salt thereof; it is characterized in that poly-aspartic-acid and salt thereof are as feed and feedstuff protective agent or carrier, then add in animal feed or feeding animals.
According to the class poly-aspartic-acid described in claim 1 and 2 and salt thereof as the application of animal feed additive, it is characterized in that described animal is any in pig, poultry, ruminant, plant-eating animal, aquatic livestock, economic animal or animal for display.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107549474A (en) * | 2017-09-22 | 2018-01-09 | 吴洪生 | Animal feed additive polyaminoacid zinc-iron method and application are produced using zinc gray cadmia Synchronos method |
| CN108887479A (en) * | 2018-06-14 | 2018-11-27 | 华南农业大学 | L-Aspartic acid zinc promotes animal intestinal tract development in preparation and alleviates the application in intestinal tract injury preparation |
| CN113142398A (en) * | 2021-04-27 | 2021-07-23 | 张自力 | Functional feed additive for ruminants and preparation method thereof |
| CN114145392A (en) * | 2021-12-06 | 2022-03-08 | 吉林大学 | Feed additive for improving nitrogen utilization rate of dairy cows and preparation method thereof |
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| JPH09132649A (en) * | 1995-11-09 | 1997-05-20 | Mitsui Toatsu Chem Inc | Artificial particle and its production |
| CN101061867A (en) * | 2005-05-16 | 2007-10-31 | 东海生物科技股份有限公司 | Gamma-polyglutamic acid (gamma-PGA, H form) and gamma-polyglutamate used as nutrition supplement in dietary product |
| CN101500430A (en) * | 2006-08-07 | 2009-08-05 | 诺维信公司 | Enzyme granules for animal feed |
| CN101505611A (en) * | 2006-08-07 | 2009-08-12 | 诺维信公司 | Enzyme granules for animal feed |
| CN101999525A (en) * | 2010-11-02 | 2011-04-06 | 河北科技大学 | Composite probiotics feed additive |
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2012
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JPH09132649A (en) * | 1995-11-09 | 1997-05-20 | Mitsui Toatsu Chem Inc | Artificial particle and its production |
| CN101061867A (en) * | 2005-05-16 | 2007-10-31 | 东海生物科技股份有限公司 | Gamma-polyglutamic acid (gamma-PGA, H form) and gamma-polyglutamate used as nutrition supplement in dietary product |
| CN101500430A (en) * | 2006-08-07 | 2009-08-05 | 诺维信公司 | Enzyme granules for animal feed |
| CN101505611A (en) * | 2006-08-07 | 2009-08-12 | 诺维信公司 | Enzyme granules for animal feed |
| CN101999525A (en) * | 2010-11-02 | 2011-04-06 | 河北科技大学 | Composite probiotics feed additive |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107549474A (en) * | 2017-09-22 | 2018-01-09 | 吴洪生 | Animal feed additive polyaminoacid zinc-iron method and application are produced using zinc gray cadmia Synchronos method |
| CN108887479A (en) * | 2018-06-14 | 2018-11-27 | 华南农业大学 | L-Aspartic acid zinc promotes animal intestinal tract development in preparation and alleviates the application in intestinal tract injury preparation |
| CN113142398A (en) * | 2021-04-27 | 2021-07-23 | 张自力 | Functional feed additive for ruminants and preparation method thereof |
| CN114145392A (en) * | 2021-12-06 | 2022-03-08 | 吉林大学 | Feed additive for improving nitrogen utilization rate of dairy cows and preparation method thereof |
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Application publication date: 20140129 |