CN103518716B - 协同抗微生物组合物 - Google Patents
协同抗微生物组合物 Download PDFInfo
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds containing nitrogen-to-oxygen bonds
- A01N33/18—Nitro compounds
- A01N33/20—Nitro compounds containing oxygen or sulfur attached to the carbon skeleton containing the nitro group
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
- A01N43/76—1,3-Oxazoles; Hydrogenated 1,3-oxazoles
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N2300/00—Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
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- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
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Abstract
一种协同抗微生物组合物。所述组合物包含至少两种组分。第一组分是邻苯基苯酚或其碱金属盐或铵盐。第二组分是4,4-二甲基噁唑烷(DMOZ),三(羟甲基)硝基甲烷或六氢-1,3,5-三(2-羟乙基)-s-三嗪。
Description
本发明专利申请是国际申请号为PCT/US2010/048845,国际申请日为2010年9月15日,进入中国国家阶段的申请号为201080043271.5,名称为“协同抗微生物组合物”的发明专利申请的分案申请。
本发明涉及杀生物剂的组合,该组合具有比单独的抗微生物化合物所观察到的活性更高的活性。
使用至少两种抗微生物化合物的组合能拓宽潜在的市场,减少使用浓度和成本,并减少废物。在一些情况下,由于市售的抗微生物化合物对某些种类的微生物的活性很差,或者较慢的抗微生物作用,或者在某些条件如高温和高pH下不稳定,所以即使采用高使用浓度,所述市售的抗微生物化合物也无法提供有效的微生物控制。有时人们使用不同抗微生物化合物的组合在具体最终应用环境中提供微生物的总体控制,或者以较低使用率提供相同水平的微生物控制。例如,美国专利第7,262,222号揭示了邻苯基苯酚和胍杀生物剂或季铵杀生物剂的组合,但是该参考文献没有暗示本发明要求保护的任何组合。而且,目前需要其它的抗微生物化合物的组合,该组合具有增强的活性,从而能有效控制微生物。本发明所解决的问题是提供这些抗微生物化合物的组合。
发明内容
本发明涉及一种协同抗微生物组合物,其包含:(a)邻苯基苯酚或其碱金属盐或铵盐;和(b)4,4-二甲基噁唑烷(DMOZ);其中邻苯基苯酚或其碱金属盐或铵盐与4,4-二甲基噁唑烷的重量比为4:1-1:15。
本发明还涉及一种协同抗微生物组合物,其包含:(a)邻苯基苯酚或其碱金属盐或铵盐;和(b)三(羟甲基)硝基甲烷(Tris Nitro);其中邻苯基苯酚或其碱金属盐或铵盐与三(羟甲基)硝基甲烷的重量比为15:1-1:15。
本发明还涉及一种协同抗微生物组合物,其包含:(a)邻苯基苯酚或其碱金属盐或铵盐;和(b)六氢-1,3,5-三(2-羟乙基)-s-三嗪(HHT);其中邻苯基苯酚或其碱金属盐或铵盐与六氢-1,3,5-三(2-羟乙基)-s-三嗪的重量比为15:1-1:15。
发明详述
在本文中,除非上下文明确有不同的说明,以下术语具有所限定的含义。根据所用的剂量,体系条件,以及所需微生物控制水平,术语"抗微生物化合物"表示能够抑制微生物生长或繁殖和/或杀灭微生物的化合物;抗微生物化合物包括杀细菌剂、细菌抑制剂(bacteristats)、杀真菌剂、真菌抑制剂、杀藻剂和藻抑制剂。术语“微生物”包括例如真菌(例如酵母菌和霉菌)、细菌和藻类。在本说明书中使用以下缩写:ppm=百万分之一重量份(重量/重量),mL=毫升。除非另外说明,温度的单位是摄氏度(℃),百分数以重量计(重量%)。本发明组合物中抗微生物化合物的百分含量是基于组合物中活性成分的总重量计,即是基于抗微生物化合物本身,而排除任何可能存在的溶剂、载体、分散剂、稳定剂或其它材料的量。邻苯基苯酚或其碱金属盐或铵盐包括锂、钠、钾、铷、铯和铵盐。如果存在不止一种形式的邻苯基苯酚,可以由这些化合物的总含量计算杀生物剂比例。在本发明的一些实施方式中,使用邻苯基苯酚钠(NaOPP)。
在本发明的一些实施方式中,邻苯基苯酚或其碱金属盐或铵盐与4,4-二甲基噁唑烷(DMOZ)的重量比为3:1-1:12;或者3:1-1:10;或者3:1-1:9;或者2:1-1:15;或者2:1-1:10;或者1:1-1:12;或者1:1-1:10;或者1:1-1:9。
在本发明的一些实施方式中,邻苯基苯酚或其碱金属盐或铵盐与三(羟甲基)硝基甲烷(Tris Nitro)的重量比为15:1-1:12;或者15:1-1:10;或者12:1-1:12;或者12:1-1:10;或者10:1-1:10;或者10:1-1:9;或者9:1-1:9。
在本发明的一些实施方式中,邻苯基苯酚或其碱金属盐或铵盐与六氢-1,3,5-三(2-羟乙基)-s-三嗪的重量比为12:1-1:15;或者10:1-1:15;或者10:1-1:12;或者10:1-1:10;或者9:1-1:10;或者9:1-1:9。
在本发明的一些实施方式中,本发明的抗微生物组合可用于油气田注水,产出流体,压裂液和其它功能流体,油气井,油气操作、分离、储存和传输***,油气管道,油气容器和燃料中。该组合特别可用于加入油气井中的水性流体或由油气井产生的水性流体中。该组合物还可用于控制其它工业用水和含水基质或水污染基质中的微生物,所述工业用水和含水基质或水污染基质的例子包括冷却水,空气洗涤器,热交换器,锅炉水,纸浆和造纸用水,其它工业处理水,压舱水,废水,金属加工流体,胶乳,漆,涂料,粘合剂,油墨,带条接缝配混物,颜料,水基浆料,个人护理产品和居家产品,例如清洁剂,过滤体系(包括反渗透和超滤体系),抽水马桶(toilet bowel),织物,皮革和皮革生产体系,或与之一起使用的体系。
通常,为控制微生物生长,本发明杀生物剂组合的量应为10ppm-5,000ppm活性成分。在本发明的一些实施方式中,组合物中活性成分的含量至少为20ppm,或者至少为50ppm,或者至少为100ppm,或者至少为150ppm,或者至少为200ppm。在一些实施方式中,组合物中活性成分的含量不超过2,000ppm,或者不超过1,000ppm,或者不超过500ppm,或者不超过400ppm,或者不超过300ppm,或者不超过250ppm,或者不超过200ppm,或者不超过100ppm,或者不超过50ppm。上述浓度是在含杀生物剂组合的液体组合物中的浓度。在高硫化物和高温环境中的杀生物剂浓度通常高于在其它环境中的浓度。
本发明还包括减少或抑制或防止上述使用区域、特别是石油或天然气生产操作中微生物生长的方法,该方法是将所述的杀生物剂组合引入所述材料中。
实施例
实施例1.NaOPP和DMOZ或Tris Nitro或HHT抵抗硫酸盐还原细菌(SRB)的协同效应
在厌氧培养室(BACTRON厌氧培养室)中,脱气的无菌盐溶液(3.1183克NaCl,1.3082毫克NaHCO3,47.70毫克KCl,72.00毫克CaCl2,54.49毫克MgSO4,172.28毫克Na2SO4,43.92毫克Na2CO3,在1升水中)被油田分离出的厌氧聚生体污染,所述厌氧聚生体主要是SRB,最终细菌浓度为106-107CFU/mL。然后用不同活性浓度的NaOPP和DMOZ,或NaOPP/DMOZ组合,NaOPP和Tris Nitro,或NaOPP/Tris Nitro组合,NaOPP和HHT,或NaOPP/HHT组合处理该被污染的水的等分样。在将混合物于40℃培育24小时后,用完全杀死等分样中细菌的最小测试杀生物剂浓度(MBC)确定杀生物效力。表1-3总结了各杀生物剂和它们的混合物的效力,以及各种组合的协同指数。
表1.NaOPP、DMOZ和NaOPP/DMOZ组合抵抗厌氧细菌的杀生物效力,以及协同指数
*协同指数=Ca/CA+Cb/CB
Ca:当与杀生物剂B组合使用时,完全杀死细菌所需的杀生物剂A的浓度
CA:单独使用时,完全杀死细菌所需的杀生物剂A的浓度
Cb:当与杀生物剂A组合使用时,完全杀死细菌所需的杀生物剂B的浓度
CB:单独使用时,完全杀死细菌所需的杀生物剂B的浓度
表2.NaOPP、Tris Nitro和NaOPP/Tris Nitro组合抵抗厌氧细菌的杀生物效力,以及协同指数
表3.NaOPP、HHT和NaOPP/HHT组合抵抗厌氧细菌的杀生物效力,以及协同指数
实施例2.NaOPP和DMOZ或Tris Nitro抵抗需氧细菌的协同效应
用铜绿假单胞菌(Psedomonas aeruginosa ATCC10145)和金黄色葡萄球菌(Staphylococcus aureus ATCC6538)污染无菌NaCl溶液(0.85%),最终细菌浓度为约106CFU/ml。然后用不同活性浓度的NaOPP和Tris Nitro,或NaOPP/TrisNitro组合,NaOPP和DMOZ或NaOPP/DMOZ组合处理该被污染的水的等分样。在将混合物于37℃培育24小时后,用完全杀死等分样中细菌所需的最小测试杀生物剂浓度确定杀生物效力。表4和5总结了各杀生物剂和它们的混合物的效力,以及各种组合的协同指数。
表4.NaOPP、DMOZ和NaOPP/DMOZ组合抵抗需氧细菌的杀生物效力,以及协同指数
*P值<0.05表示平均协同指数与1.00之间存在明显差值
表5.NaOPP、Tris Nitro和NaOPP/Tris Nitro组合抵抗需氧细菌的杀生物效力,以及协同指数
Claims (3)
1.一种协同抗微生物组合物,其包含:(a)邻苯基苯酚或其碱金属盐或铵盐;和(b)三(羟甲基)硝基甲烷;其中邻苯基苯酚或其碱金属盐或铵盐与三(羟甲基)硝基甲烷的重量比为15:1-1:15。
2.如权利要求1所述的组合物,其特征在于,所述重量比为12:1-1:12。
3.如权利要求2所述的组合物,其特征在于,所述重量比为10:1-1:10。
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US27754109P | 2009-09-25 | 2009-09-25 | |
US61/277,541 | 2009-09-25 |
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CN201310467483.1A Expired - Fee Related CN103518716B (zh) | 2009-09-25 | 2010-09-15 | 协同抗微生物组合物 |
CN201310467481.2A Pending CN103548837A (zh) | 2009-09-25 | 2010-09-15 | 协同抗微生物组合物 |
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US (1) | US8445521B2 (zh) |
EP (3) | EP2687091A1 (zh) |
JP (1) | JP5449563B2 (zh) |
CN (3) | CN102711459B (zh) |
AU (1) | AU2010298539B2 (zh) |
BR (1) | BR112012006668B1 (zh) |
IN (1) | IN2012DN01949A (zh) |
PL (1) | PL2687092T3 (zh) |
RU (1) | RU2525727C2 (zh) |
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EP2932849B1 (en) | 2012-05-24 | 2016-10-05 | Dow Global Technologies LLC | Microbicidal composition |
AR101211A1 (es) * | 2014-07-30 | 2016-11-30 | Dow Global Technologies Llc | Composición antimicrobiana sinérgica |
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- 2010-09-15 EP EP10757132A patent/EP2458984A2/en not_active Ceased
- 2010-09-15 AU AU2010298539A patent/AU2010298539B2/en not_active Ceased
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- 2010-09-15 PL PL13171884T patent/PL2687092T3/pl unknown
- 2010-09-15 US US13/496,946 patent/US8445521B2/en not_active Expired - Fee Related
- 2010-09-15 CN CN201080043271.5A patent/CN102711459B/zh not_active Expired - Fee Related
- 2010-09-15 BR BR112012006668-4A patent/BR112012006668B1/pt not_active IP Right Cessation
- 2010-09-15 WO PCT/US2010/048845 patent/WO2011037790A2/en active Application Filing
- 2010-09-15 RU RU2012116401/13A patent/RU2525727C2/ru not_active IP Right Cessation
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- 2010-09-15 CN CN201310467481.2A patent/CN103548837A/zh active Pending
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EP2687091A1 (en) | 2014-01-22 |
CN103548837A (zh) | 2014-02-05 |
WO2011037790A2 (en) | 2011-03-31 |
WO2011037790A3 (en) | 2011-09-09 |
IN2012DN01949A (zh) | 2015-08-21 |
RU2012116401A (ru) | 2013-10-27 |
CN103518716A (zh) | 2014-01-22 |
BR112012006668A8 (pt) | 2017-01-24 |
AU2010298539B2 (en) | 2013-10-10 |
RU2525727C2 (ru) | 2014-08-20 |
JP5449563B2 (ja) | 2014-03-19 |
EP2458984A2 (en) | 2012-06-06 |
BR112012006668A2 (pt) | 2015-09-08 |
US20120184436A1 (en) | 2012-07-19 |
CN102711459A (zh) | 2012-10-03 |
CN102711459B (zh) | 2014-07-09 |
PL2687092T3 (pl) | 2015-08-31 |
BR112012006668B1 (pt) | 2018-01-02 |
JP2013504624A (ja) | 2013-02-07 |
AU2010298539A1 (en) | 2012-04-12 |
EP2687092A1 (en) | 2014-01-22 |
US8445521B2 (en) | 2013-05-21 |
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