CN103505638A - Qihuang granules used for treating coronary heart disease and hypertension - Google Patents
Qihuang granules used for treating coronary heart disease and hypertension Download PDFInfo
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Abstract
The invention provides Qihuang granules used for treating coronary heart disease and hypertension. The granules are composed of 16 traditional Chinese medicines which are Mongolian milkvetch root, Szechwan lovage rhizome, Chinese taxillus herb, achyranthes bidentata, tree peony root-bark, golden thread, tall gastrodia rhizome, spine date seed, prepared rehmannia, creeping liriope, raw oyster, stir-fried ovate atractylodes root, pilose asiabell root, ligusticum, prepared pinellia, and cassia bark with a weight ratio of 11.67:5.84:5.84:3.89:3.89:2.33:3.89:84:11.67:5.84:11.67:3.89:11.67:5.84:3.89:2.34. The medicine has good qi-benefiting, yin-nourishing, blood-circulation-activating, phlegm-dissipating, liver-soothing, wind-evil-dispelling, and tranquilizing functions. With the medicine, a coronary heart disease angina pectoris treatment total effective rate is 94%, and a blood pressure reduction total effective rate is 77%. The granules have good lipid regulation and insulin resistance amelioration effects. The medicine is suitable for middle-aged and senior patients. The medicine has no toxic or side effect.
Description
Technical field
The present invention relates to a kind of coronary heart disease and hypertensive Chinese medicinal granule for the treatment of, is a kind of coronary heart disease, hypertensive Qihuang granular for the treatment of.
Background technology
According to the recent statistics of Ministry of Public Health, the patients with hypertension of China has surpassed 1.3 hundred million people at present, and wherein mild hypertension accounts for 70%.More than annual newly-increased hypertension 3,000,000 people.The existing patients with coronary heart disease of China approximately 1,000 ten thousand people, wherein 65% patient has hypertension history.Hypertension is one of the most common risk factor of incidence of coronary heart disease, and hypertension can cause the cardiovascular events such as left ventricular hypertrophy, arrhythmia, arteriosclerosis, sudden death.The treatment of actively developing coronary heart disease with hypertension has important practical significance.The Chinese patent medicine kind for the treatment of in the market coronary heart disease is more, treats hypertensive Chinese patent medicine less.The Chinese patent medicine that can treat coronary heart disease with hypertension is few.On market, have now the Chinese patent medicine of many treatment coronary heart disease to contain Radix Ginseng, Radix Glycyrrhizae etc. and can rise hypertensive Chinese medicine ingredients, this treatment for coronary heart disease with hypertension is disadvantageous.
Summary of the invention
The technical problem to be solved in the present invention is, a kind of coronary heart disease, hypertensive Qihuang granular for the treatment of is provided, and can treat coronary heart disease and can treat hypertension again, by hypertension and coronary heart disease Comprehensive Treatment, patient got well early.
Summary of the invention of the present invention is: it is by the Radix Astragali, Rhizoma Chuanxiong, Herba Taxilli, Radix Achyranthis Bidentatae, Cortex Moutan, Rhizoma Coptidis, Rhizoma Gastrodiae, Semen Ziziphi Spinosae, Radix Rehmanniae Preparata, Radix Ophiopogonis, Concha Ostreae, Rhizoma Atractylodis Macrocephalae (parched), Radix Codonopsis, Radix Angelicae Sinensis, Rhizoma Pinelliae Preparata, Cortex Cinnamomi ten Six-element Chinese medicines form, the percentage by weight of each taste Chinese medicine is: the Radix Astragali: Rhizoma Chuanxiong: Herba Taxilli: Radix Achyranthis Bidentatae: Cortex Moutan: Rhizoma Coptidis: Rhizoma Gastrodiae: Semen Ziziphi Spinosae: Radix Rehmanniae Preparata: Radix Ophiopogonis: Concha Ostreae: Rhizoma Atractylodis Macrocephalae (parched): Radix Codonopsis: Radix Angelicae Sinensis: Rhizoma Pinelliae Preparata: Cortex Cinnamomi=11.67: 5.84: 5.84: 3.89: 3.89: 2.33: 3.89: 84: 11.67: 5.84: 11.67: 3.89: 11.67: 5.84: 3.89: 2.34.
The theory of Chinese medical science foundation of this formula and the medicinal efficacy of each taste Chinese medicine:
The formation of hypertension, coronary heart disease is the multifactor result causing, and its pathogenesis is deficiency in origin and excess in superficiality, simulataneous insufficiency and excessive.Visceral-qi loss, deficiency of both QI and YIN are it, and heat in blood liver-yang hyperactivity, stirring-up of pathogenic wind in the interior resulting from deficiency, the mind are disturbed as its mark.
The age of onset of hypertension, coronary heart disease is generally after 40 years old, and through cloud " Nian Sishi and half of YIN QI consumed ", Kidney-Yin one is lost, and first evaporation source is not enough, occurs the pathomechanism of QIYINLIANGXU.In the pathogenic process of hypertension, coronary heart disease, heat in blood liver-yang hyperactivity is another the important pathogenesis.Its " heat " derives from the deficiency of YIN first, and the raw interior-heat of the deficiency of YIN; Second derive from " five excessive emotions converting into internal fire ", feelings will is too drastic, is worried angry, causes the too drastic raw interior-heat of five will; Moreover drinking and eating irregularly, surfeit delicious food savoury, overnutrition, fat raw interior-heat.Heat is at blood vessels, and consumption impairing the liver is cloudy, disturbance liver-yang, the pathomechanism of formation hyperactivity of YANG due to deficiency of YIN, liver-wind stirring up internally.Another hyperpietic is often associated with neurasthenia, insomnia, anxiety, nervous etc.And have a sleepless night, angry, psychentonia and feelings will freely can not cause elevation of the blood pressure.The pathogenesis of this pathology circulation is that deficiency of both QI and YIN, heat in blood liver-yang hyperactivity, the mind are disturbed.
This formula is with supplementing QI and nourishing YIN, dissipating blood stasis and clearing away heat, endogenous wind stopping calm the nerves for tcm treatment method, at prescription, send in medicine, both followed the traditional Chinese medical science tradition principles of formulating prescriptions, again in conjunction with modern pharmacological research screening of medicaments, in treatment hypertension, coronary heart disease, obtained good result.
In side Radix Astragali QI invigorating consolidate, Radix Rehmanniae Preparata kidney tonifying, essence replenishing, two medicines are monarch drug altogether; Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Radix Ophiopogonis, replenishing QI to invigorate the spleen, YIN nourishing and the production of body fluid promoting were ministerial drug; Rhizoma Chuanxiong, Cortex Moutan, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Rhizoma Coptidis phlegm reduction of blood circulation promoting, heat-clearing and toxic substances removing, Rhizoma Gastrodiae, Semen Ziziphi Spinosae, Radix Achyranthis Bidentatae, Concha Ostreae suppressing the hyperactive liver and subsiding YANG, tranquilizing by nourishing the heart are adjuvant drug, Herba Taxilli, Cortex Cinnamomi conditioning lifting, priming enter Liver Channel, GUIXIN kidney altogether for making medicine.Full side's giving consideration to both the incidental and fundamental, the precise and appropriate ，Xiao of compatibility GSMC is special.Selected medicine meets the requirement of modern Chinese medicine preparation.
In prescription, Cortex Moutan has clearing away heat and cooling blood, the effect of blood circulation promoting and blood stasis dispelling." detailed outline " said: " Cortex Moutan is controlled the few the moon of brothers, fainted cloudy four through blood system volt fire.Gai Fuhuo be YIN-fire also, YIN-fire mutually fire also, ancient prescription is only controlled mutually fire with this, therefore Zhong Jing shenqi pill is used it.Descendant specially controls fire mutually with yellow tiller, does not know that the merit of Cortex Moutan more wins also.
" not Lu " cloud: " the vexatious insomnia of Semen Ziziphi Spinosae master ... chronic diarrhea, sweating due to debility excessive thirst, invigorating middle warmer, the liver benefiting gas, hard muscles and bones, helps cloudy gas.”
Rhizoma Gastrodiae has the effect of suppressing the hyperactive liver, endogenous wind stopping, relieving convulsion.Cure mainly headache dizzy, numb limbs and tense tendons, infantile convulsion, epilepsy clonus, is treatment excessive rising of liver-YANG, liver-wind stirring up internally key medicine.It is kind controls dizzyly, can be used for again the card of wind-phlegm, and spasmolytic power is good, and again can tonneau meridians and pain relieving." detailed outline " cloud: " Rhizoma Gastrodiae enter to faint the moon through and control all diseases.' pupil dizziness, does in wind syndrome caused by deficiency, and non-Rhizoma Gastrodiae can not be controlled to press Luo Tianyi cloud.' Rhizoma Gastrodiae is the grass of subduing the wind syndrome, therefore for controlling the refreshing medicine of wind.”。
Concha Ostreae nature and flavor are salty and bitter, cool.Merit is arrogated to oneself yin fluid astringing, YANG hyperactivity suppressing, and hidroschesis, arresting seminal emission, reduces phlegm, softening the hard mass." Bencao Jingshu ": " Concha Ostreae salty in the mouth is flat, and feeble QI is cold, nontoxic, enters the few the moon of foot, the moon of fainting, shaoyang channel.The cards such as that voluminous, the frightened gas ,Liu Re joint of being enraged of its main typhoid fever cold and heat, pyrexial malaria is gone is indefinite, stuffy sensation with restlessness, depressed pained, the lower painful abdominal mass heat of the heart side of body, all liver and gall two are through being disease.Two are subject to cold-evil through the winter, are typhoid fever cold and heat; Being attacked by pathogenic heat in summer is that pyrexial malaria is voluminous; It is indefinite that evil Fu Bu Chu，Re goes in joint; Two is not strongly fragrant loose through heresy, heart side of body painful abdominal mass; Pathogenic heat is very vehement, shies the gas of being enraged, and stuffy sensation with restlessness is depressed pained.The salty gas of these flavour of a drug is cold, enter two through and except cold and heat pathogen, battalion defends logically, arrest and relax, and all cards Liao invariably.”
The effective ingredient of Radix Rehmanniae Preparata is mainly containing catalpol, rehmanin, and modern pharmacological research confirms that Radix Rehmanniae Preparata has significant hypotensive effect; Pharmacological research shows that the Radix Astragali all has hypotensive effect to many animals, and its antihypertensive compositions is γ-aminobutyric acid and Astragalus Saponin I, and hypotensive effect is mainly direct expansion peripheral blood vessel, reduces Peripheral resistance.
The main component berberine of Rhizoma Coptidis is very extensive to Cardiovascular.Berberine intravenously administrable, all can produce obvious hypotensive effect to anesthetized dog and Conscious Rat, and the key link of its blood pressure lowering is the reduction of slowing down of heart rate and Peripheral resistance.The effects such as berberine has antiplatelet aggregation simultaneously, resists myocardial ischemia, arrhythmia, blood pressure lowering, blood fat reducing.Animal experiment study is found the myocardial infarct size that berberine lumbar injection can significantly dwindle after rat coronary ligation 24 hours, suppresses increasing of serum free fatty acid, reduces the incidence rate of pathologic Q ripple after infarction, and ischemic myocardial is had to protective effect.In addition, the antipathogen of berberine, antibacterium toxin, antiinflammatory etc. are very useful to the inhibitory action of active chronic inflammation to preventing and treating atherosclerosis.In addition, the chemical composition of Rhizoma Chuanxiong, Semen Ziziphi Spinosae all has definite hypotensive effect.And the Radix Astragali, Radix Ophiopogonis have good nutrition protective effect to myocardial cell.
Research finds, hypertension, coronary heart disease and insulin resistant (IR), fat, lipid metabolism is abnormal, generation type 2 diabetes mellitus is closely related, i.e. soil theory jointly.We find by clinical observation, and Qihuang granular, in blood pressure lowering, allevating angina pectoris, also has the effect of adjusting fat, improving insulin resistant and improving sleep quality.The mechanism that treatment coronary heart disease, hypertensive Qihuang granular are obtained curative effect is to play therapeutical effect by too many levels, many target spots comprehensively regulating.
The composition of each herbal medicine and effect in formula:
The Radix Astragali mainly contains the flavone compounds such as flavone, isoflavone, flavanone; In the Radix Astragali and congener thereof, isolated more than 40 and planted triterpene saponin, structure is tetracyclic triterpene and pentacyclic triterpene glycoside.In the Radix Astragali, also contain in addition riboflavin, folic acid, organic acid, coumarin, β mono-sitosterol, daucosterol, the Multiple components such as lupeol, monosaccharide, polysaccharide, aminoacid, protein, trace element, Citrin, cetyl alcohol, choline, sweet fragrant alkali.Pharmacological research shows that the Radix Astragali has cardiac nutrition, resists myocardial ischemia, hypotensive effect, and its antihypertensive compositions is γ-aminobutyric acid and Astragalus Saponin I, and hypotensive effect is mainly direct expansion peripheral blood vessel, reduces Peripheral resistance.
Rhizoma Chuanxiong is mainly containing volatile ingredient, phthalide derivant, two phthalide derivant, alkaloid, organic acid, organic acid ester and other composition.Modern pharmacological research shows, the equal energy of Rhizoma Chuanxiong and extract thereof coronary artery dilator, and increase coronary artery blood flow, improves myocardium blood oxygen supply and reduces myocardium oxygen consumption, and anticoagulant and antithrombotic form, and reduce blood pressure and sedation.
Herba Taxilli is mainly containing compositions such as oleanolic acid, β mono-Amyrin, flavone compounds.Modern pharmacological research shows, Herba Taxilli has the effects such as blood pressure lowering, diuresis, antiviral.
Radix Achyranthis Bidentatae mainly contains triterpenes, steroid, polysaccharide and other composition.Modern pharmacological research shows, Radix Achyranthis Bidentatae has blood pressure lowering, analgesia and slight diuresis.
Cortex Moutan is mainly containing paeonol, terpenoid, glycoside etc.Modern pharmacology research shows, Cortex Moutan has significant protective effect to expeirmental myocardial ischemia, and the persistent period is longer, reduces myocardial oxygen consumption simultaneously, has diuresis, blood pressure lowering, hypoglycemic effect simultaneously.
Rhizoma Coptidis main component is berberine, coptisine, palmatine etc.Berberine is very extensive to Cardiovascular.The multiple cardiovascular pharmacological effects such as Rhizoma Coptidis has blood pressure lowering, resists myocardial ischemia, antiplatelet aggregation, arrhythmia blood sugar lowering, blood fat reducing; In addition, the antipathogen of berberine, antibacterium toxin, effects such as antiinflammatory and be useful to preventing and treating atherosclerosis to the inhibitory action of active chronic inflammation.
Rhizoma Gastrodiae is containing gastrodine, gastrodia elata genin, cephrol, vanillin, gastrodia elata polysaccharide and various trace elements.Modern pharmacological research shows, Rhizoma Gastrodiae have resist myocardial ischemia, the pharmacological action such as antiplatelet aggregation, antithrombotic, blood pressure lowering, calmness.
Semen Ziziphi Spinosae mainly, containing multiple Saponin class and flavones ingredient, comprises jujuboside A, B, B
1deng.Modern pharmacological research show Semen Ziziphi Spinosae have resist myocardial ischemia, the effect such as blood pressure lowering, arrhythmia, blood fat reducing, calmness.
Radix Rehmanniae Preparata is mainly containing main catalpol, Radix Rehmanniae, plain glycoside, saccharide, the aminoacid etc. of containing.Modern pharmacological research confirmation, Radix Rehmanniae Preparata has significant hypotensive effect; And have the effect of expanding renal blood vessels and diuresis, also have in addition slight hypoglycemic activity.Radix Rehmanniae water decoction can not only pass through the regulating action to general, improves deficiency of YIN symptom, and can abnormal thyroxine state be played regulatory role.
Radix Ophiopogonis is mainly containing volatile oil, steroidal saponin, flavonoid etc.Modern pharmacological research shows, can make Radix Ophiopogonis the myocardial cell of significantly infringement obtain faster its healing of repairing accelerant, the corresponding necrosis that reduces myocardial cell, Radix Ophiopogonis, injection can significantly improve myocardial contraction and heart pump function, also had certain calmness, hypoglycemic activity Radix Ophiopogonis.
The Rhizoma Atractylodis Macrocephalae is mainly containing atractylone, atractylodes lactone etc., and pharmacological research shows the effects such as Rhizoma Atractylodis Macrocephalae diuresis, blood pressure lowering, blood sugar lowering.
Concha Ostreae is mainly containing calcium carbonate, calcium phosphate and calcium sulfate, magnesium, aluminum, silicon and ferrum oxide etc.Modern pharmacological research shows, the nourishing YIN of Concha Ostreae YANG hyperactivity suppressing, hard masses softening and resolving.From Concha Ostreae, isolate the material with antibacterial action, be called distillations " C ", can suppress the growth of streptococcus pyogenes.Someone thinks why cancerous cell can breed rapidly in large quantities without limit, and its reason is relevant with calcium ion deficiency in cell membrane, when dropping into calcium ion, can stop the division of cancerous cell.In Concha Ostreae, contain calcium, research finds that this medicine is that tumor has obvious inhibition active function to mice.
Radix Codonopsis is mainly containing sterols, glucosides class, alkaloid and volatile ingredient, triterpenes.Modern pharmacological research shows, Radix Codonopsis resists myocardial ischemia, improves the effects such as hemorheology, expansion peripheral vessels.Radix Codonopsis is all improved effect to mouse memory acquisition, memory consolidation, memory represents process.Radix Codonopsis and polysaccharide can make the increase of macrophage quantity, cell volume increase, pseudopodium is many, phagocytic activity is strong, and after medication, in macrophage, various chemical composition contents obviously increase.
Radix Angelicae Sinensis mainly contains volatile ingredient, saccharide, aminoacid, inorganic elements and other compositions.Modern pharmacological research shows, Radix Angelicae Sinensis energy coronary artery dilator increases crown moving swimming blood flow, reduces myocardial oxygen consumption; Reduce platelet aggregation, antithrombotic forms, and has quinidine-like arrhythmia and effect for reducing blood fat.
The Rhizoma Pinelliae is mainly containing compositions such as β mono-sitosterol, choline, daucosterols.Pharmacological research confirms that the Rhizoma Pinelliae has the effects such as blood fat reducing, arrhythmia.
Cortex Cinnamomi is mainly containing volatile oil (Oleum Cinnamomi), cinnamic aldehyde and glucosides etc.Modern pharmacological research shows, Cortex Cinnamomi has dilating effect to animal peripheral blood vessel, can make arteria coronaria and cerebral blood flow obviously increase, and vascular resistance declines, blood pressure drops.Cortex Cinnamomi also has the effects such as calmness, antiinflammatory, stomach invigorating antiulcer.
Production technology is:
Get the Radix Astragali in this formula, Rhizoma Chuanxiong, Herba Taxilli, Radix Achyranthis Bidentatae, Cortex Moutan, Rhizoma Coptidis, Rhizoma Gastrodiae, Semen Ziziphi Spinosae, Radix Rehmanniae Preparata, Radix Ophiopogonis, Concha Ostreae, Rhizoma Atractylodis Macrocephalae (parched), Radix Codonopsis, Radix Angelicae Sinensis, Rhizoma Pinelliae Preparata, Cortex Cinnamomi ten Six-element Chinese medicines, percentage by weight by each taste Chinese medicine is: the Radix Astragali: Rhizoma Chuanxiong: Herba Taxilli: Radix Achyranthis Bidentatae: Cortex Moutan: Rhizoma Coptidis: Rhizoma Gastrodiae: Semen Ziziphi Spinosae: Radix Rehmanniae Preparata: Radix Ophiopogonis: Concha Ostreae: Rhizoma Atractylodis Macrocephalae (parched): Radix Codonopsis: Radix Angelicae Sinensis: Rhizoma Pinelliae Preparata: Cortex Cinnamomi=11.67: 5.84: 5.84: 3.89: 3.89: 2.33: 3.89: 84: 11.67: 5.84: 11.67: 3.89: 11.67: select materials at 5.84: 3.89: 2.34.
First get Rhizoma Coptidis, Cortex Moutan, the Radix Astragali, Semen Ziziphi Spinosae, Radix Ophiopogonis, Concha Ostreae, Rhizoma Pinelliae Preparata seven flavor medicine, decoct with water 2 times, add for the first time 8 times of water gagings and decoct 2.0 hours; Add for the second time 6 times of water gagings and decoct 1.5 hours, filter, collecting decoction, is concentrated into relative density and is the clear paste of 1.35～1.40 (60 ℃), standby; All the other nine taste medicine Rhizoma Chuanxiongs, Herba Taxilli, Radix Achyranthis Bidentatae, Rhizoma Gastrodiae, Radix Rehmanniae Preparata, Rhizoma Atractylodis Macrocephalae (parched), Radix Codonopsis, Radix Angelicae Sinensis, Cortex Cinnamomi decoct with water 2 times, add for the first time 9 times of water gagings and decoct 2.0 hours; Add for the second time 7 times of water gagings and decoct 1.5 hours, filter collecting decoction, being concentrated into relative density is 1.10～1.15 (60 ℃), add ethanol to make to reach 60% containing alcohol amount, standing 24 hours, filter, reclaim ethanol, being concentrated into relative density is the clear paste of 1.30～1.35 (60 ℃), mixes with above-mentioned clear paste, adds appropriate amount of auxiliary materials, make 1000g granule, obtain.
Quality control standard: the thin layer of the aminoacid in finished product in Radix Ophiopogonis, paeonol, berberine, Semen Ziziphi Spinosae glycoside, ligustrazine is differentiated the qualitative index that can be used as Radix Ophiopogonis, Cortex Moutan, Rhizoma Coptidis, Semen Ziziphi Spinosae, Rhizoma Chuanxiong, and physiologically active ingredient astragaloside is as assay index.
Advantage of the present invention is: 1. treatment coronary heart disease, hypertensive Qihuang granular can be treated angina pectoris and can be reduced blood pressure again, for the patient of coronary heart disease with hypertension, is a kind of very suitable Chinese traditional treatment method.Through the clinical research observation for the treatment of coronary heart disease, hypertensive Qihuang granular Qihuang granular is confirmed, this medical instrument has good supplementing QI and nourishing YIN, phlegm reduction of blood circulation promoting, the effect that suppressing the hyperactive liver to relieve the wind syndrome is calmed the nerves.Treatment angina pectoris has been obtained total effective rate 94%, the good efficacy of blood pressure lowering total effective rate 77%.And there is good tune fat, improve the effect of insulin resistant.
Treatment coronary heart disease, hypertensive Qihuang granular prescription compatibility rigorous, select medicine fastidious, wherein the medicine such as Rhizoma Gastrodiae, Semen Ziziphi Spinosae, the Radix Astragali, Radix Ophiopogonis, Radix Rehmanniae Preparata, Radix Codonopsis is the rare Chinese medicine with the effect of taking a tonic or nourishing food to build up one's health, very suitable for the middle-older patient of coronary heart disease with hypertension.
3. preparation process is reasonable, and quality control standard is reliable.
4. treatment coronary heart disease, hypertensive Qihuang granular are pure Chinese medicinal preparation, by safety, are detected and are confirmed that this medicine has no side effect.
Accompanying drawing explanation
Fig. 1 is treatment coronary heart disease of the present invention, hypertensive Qihuang granular technological process of production schematic diagram.Below in conjunction with accompanying drawing, by the specific embodiment, the present invention is described in more detail:
The specific embodiment
Get the Radix Astragali in this formula, Rhizoma Chuanxiong, Herba Taxilli, Radix Achyranthis Bidentatae, Cortex Moutan, Rhizoma Coptidis, Rhizoma Gastrodiae, Semen Ziziphi Spinosae, Radix Rehmanniae Preparata, Radix Ophiopogonis, Concha Ostreae, Rhizoma Atractylodis Macrocephalae (parched), Radix Codonopsis, Radix Angelicae Sinensis, Rhizoma Pinelliae Preparata, Cortex Cinnamomi ten Six-element Chinese medicines, percentage by weight by each taste Chinese medicine is: the Radix Astragali: Rhizoma Chuanxiong: Herba Taxilli: Radix Achyranthis Bidentatae: Cortex Moutan: Rhizoma Coptidis: Rhizoma Gastrodiae: Semen Ziziphi Spinosae: Radix Rehmanniae Preparata: Radix Ophiopogonis: Concha Ostreae: Rhizoma Atractylodis Macrocephalae (parched): Radix Codonopsis: Radix Angelicae Sinensis: Rhizoma Pinelliae Preparata: Cortex Cinnamomi=11.67: 5.84: 5.84: 3.89: 3.89: 2.33: 3.89: 84: 11.67: 5.84: 11.67: 3.89: 11.67: 5.84: 3.89: 2.34 feedings.
First get Rhizoma Coptidis 30g, Cortex Moutan 50g, Radix Astragali 150g, Semen Ziziphi Spinosae 75g, Radix Ophiopogonis 75g, Concha Ostreae 150g, Rhizoma Pinelliae Preparata 50g seven flavor medicine, decoct with water 2 times, add for the first time 8 times of water gagings and decoct 2.0 hours; Add for the second time 6 times of water gagings and decoct 1.5 hours, filter, collecting decoction, is concentrated into relative density and is the clear paste of 1.35～1.40 (60 ℃), standby; Again all the other nine taste medicines are got to Rhizoma Chuanxiong 75g, Herba Taxilli 75g, Radix Achyranthis Bidentatae 50g, Rhizoma Gastrodiae 50g, Radix Rehmanniae Preparata 150g, Rhizoma Atractylodis Macrocephalae (parched) 50g, Radix Codonopsis 150g, Radix Angelicae Sinensis 75g, Cortex Cinnamomi 30g decocts with water 2 times, add for the first time 9 times of water gagings and decoct 2.0 hours; Add for the second time 7 times of water gagings and decoct 1.5 hours, filter collecting decoction, being concentrated into relative density is 1.10～1.15 (60 ℃), add ethanol to make to reach 60% containing alcohol amount, standing 24 hours, filter, reclaim ethanol, being concentrated into relative density is the clear paste of 1.30～1.35 (60 ℃), mixes with above-mentioned clear paste, adds appropriate amount of auxiliary materials, make 1000g granule, obtain.
Quality control standard: the thin layer of the aminoacid in finished product in Radix Ophiopogonis, paeonol, berberine, Semen Ziziphi Spinosae glycoside, ligustrazine is differentiated the qualitative index that can be used as Radix Ophiopogonis, Cortex Moutan, Rhizoma Coptidis, Semen Ziziphi Spinosae, Rhizoma Chuanxiong, and physiologically active ingredient astragaloside is as assay index.
Claims (1)
1. treatment coronary heart disease, a hypertensive Qihuang granular, is characterized in that: it is comprised of the Radix Astragali, Rhizoma Chuanxiong, Herba Taxilli, Radix Achyranthis Bidentatae, Cortex Moutan, Rhizoma Coptidis, Rhizoma Gastrodiae, Semen Ziziphi Spinosae, Radix Rehmanniae Preparata, Radix Ophiopogonis, Concha Ostreae, Rhizoma Atractylodis Macrocephalae (parched), Radix Codonopsis, Radix Angelicae Sinensis, Rhizoma Pinelliae Preparata, Cortex Cinnamomi ten Six-element Chinese medicines; The percentage by weight of each taste Chinese medicine ingredients is: the Radix Astragali: Rhizoma Chuanxiong: Herba Taxilli: Radix Achyranthis Bidentatae: Cortex Moutan: Rhizoma Coptidis: Rhizoma Gastrodiae: Semen Ziziphi Spinosae: Radix Rehmanniae Preparata: Radix Ophiopogonis: Concha Ostreae: Rhizoma Atractylodis Macrocephalae (parched): Radix Codonopsis: Radix Angelicae Sinensis: Rhizoma Pinelliae Preparata: Cortex Cinnamomi=11.67: 5.84: 5.84: 3.89: 3.89: 2.33: 3.89: 84: 11.67: 5.84: 11.67: 3.89: 11.67: 5.84: 3.89: 2.34.
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| CN1628760A (en) * | 2004-10-13 | 2005-06-22 | 于云龙 | Traditional Chinese medicinal formulation for treating cardiovascular and cerebrovascular disease |
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| CN1628760A (en) * | 2004-10-13 | 2005-06-22 | 于云龙 | Traditional Chinese medicinal formulation for treating cardiovascular and cerebrovascular disease |
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Application publication date: 20140115 |