CN103505574A - Traditional Chinese medicine ointment used for treating leucoderma, and preparation method thereof - Google Patents

Abstract

The invention relates to a traditional Chinese medicine ointment used for treating leucoderma, and a preparation method thereof. The traditional Chinese medicine ointment comprises following raw materials, herba siegesbeckiae, fructus psoraleae, zaocys dhumnade, cinnamon, crocus sativus and radix astragali. The traditional Chinese medicine ointment is capable of adjusting immunologic functions, activating tyrosinase, promoting growth of black cells, improving light sensitivity, promoting blood circulation and removing blood stasis, and improving microcirculation. The traditional Chinese medicine ointment is developed based on traditional Chinese medicine treatment which is based on syndrome differentiation, and by combination of modern latest scientific research achievements. The traditional Chinese medicine ointment used for treating leucoderma, and the preparation method thereof are provided in the invention. The traditional Chinese medicine ointment possesses characteristics of accurate curative effects, safety and convenience, and low cost, and no toxic or side effect is caused.

Description

A kind of leukodermic Chinese medicinal ointment and preparation method thereof for the treatment of

Technical field

The present invention relates to a kind of leukodermic Chinese medicinal ointment and preparation method thereof for the treatment of, is that a kind of vitiligo for the treatment of be take the Chinese patent medicine that Chinese herbal medicine is raw material.Belong to the field of Chinese medicines.

Background technology

Vitiligo is a kind of posteriority limitation depigmentation dermatosis.With skin color, go down, bleach, boundary is distinct, and no conscious sympton is feature.The same with other pigment anomalies, leukodermic sickness rate is with area, the ethnic group colour of skin and different.The darker people's sickness rate of general colour is higher, and in population of China, prevalence is about 0.1～2%.Men and women about equally, all can fall ill from newborn baby to old age, but take teenager as many, has data to show that age of onset is in the majority 10～30 years old group, accounts for 62.65% of sum, and women's age of onset is done sth. in advance about 5 years compared with male.

Leukodermic clinical manifestation is: the skin at any position all can occur, and is subject to solar radiation and frictionally damage position, as facial area, cervical region, trunk and extremity etc. but be apt to occur in.Inside lip, labia, glans penis and foreskin, mucosa also can involve.Most of leukasmus is symmetrical, also have some patients were white macula to distribute along nerve segment.Skin lesion is limitation depigmentation speckle, and milky is big or small to coin from fingernail, circle, ellipse or irregular type.White macula place hair also can bleach.In progressive stage, decolouring speckle is divided a word with a hyphen at the end of a line to normal skin, and development is very fast, and has isomorphic response, after pressure, friction, wound, can form secondary vitiligo.

According to leukoderma scope and distribution, can divide three types: 1, topical type skin lesion is confined to Yi Ge position, can be divided into 1. segmental pattern again: skin lesion is pressed dermatomere and distributed; 2. mucosa type: only involve mucosa.2, general hair style is the most common, shows as skin lesion and is distributed widely in body surface, can be divided into 1. homeliness type: skin lesion is dispersed in and is distributed in body surface many places; 2. face acra type: skin lesion is distributed in face and far-end of limb; 3. mixed type: above-mentioned several various combinations form.As face acra type+segmental pattern etc.3, whole body type, whole skin all decolours completely or almost, also has hair to bleach.

Primary disease is equivalent to leucoderma, the vitiligo of the traditional Chinese medical science.As " General Treatise on the Cause and Symptoms of Diseases " leucoderma is recorded: " leucoderma person, face and neck health skin and flesh complexion changed are white, different from meat, the pain of also not itching, the leucoderma of meaning." and for example " the Yizong Jinjian surgery heart shows " vitiligo record: " vitiligo is face collar humorously, and the ailment said due to cold or exposure white point speckle of fighting is mutually even all over, without the pain of itching, controls and should fully recover from an illness by pathogenic wind expelling fat liquoring.”

The traditional Chinese medical science thinks that leukodermic morbidity is outer because experience ailment said due to cold or exposure, injury from falling down; Interior because of feelings will internal injury, hemorrhagic disorder and consumption of essence etc., these can make qi-blood disharmony, obstruction of collaterals by blood stasis, deficiency of the liver and kindey leads to this disease.So the treatment of the traditional Chinese medical science is to be divided into the disease types such as disharmony between QI and blood, retention of damp-heat in the interior, obstruction of collaterals by blood stasis, deficiency of the liver and kindey, stagnation of QI due to depression of the liver to carry out Coryza Treated by Syndrome Differentiation.The leukodermic method of western medical treatment is a lot, but great majority can only reach Short Term Clinical effect, and can not prevent recurrence, and has toxic and side effects in various degree.

Summary of the invention

The present invention develops in conjunction with latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The object of this invention is to provide a kind of leukodermic Chinese medicinal ointment and preparation method thereof for the treatment of, there is determined curative effect, safe ready, have no side effect, cheap feature.

The present invention is made by the raw material of following weight proportioning:

1.5～6 parts of 1.5～6 parts of Zaocyss of 1.5～6 parts of Fructus Psoraleaes of Herba Siegesbeckiae

1.5～6 parts of 0.1～0.6 part of Radixs Astragali of 2～4 parts of Stigma Crocis of Cortex Cinnamomi.

The weight proportion of each raw material of optimization formula of the present invention is:

2.5～3.5 parts of 2.5～3.5 parts of Zaocyss of 2.5～3.5 parts of Fructus Psoraleaes of Herba Siegesbeckiae

2.5～3.5 parts of 0.2～0.4 part of Radixs Astragali of 0.5～1.5 part of Stigma Croci of Cortex Cinnamomi.

The weight proportion of each raw material of optimum formula of the present invention is:

3 parts of 3 parts of Zaocyss of 3 parts of Fructus Psoraleaes of Herba Siegesbeckiae

3 parts of 0.3 part of Radixs Astragali of 1 part of Stigma Croci of Cortex Cinnamomi.

Drug action mechanism in the present invention is as follows:

Herba Siegesbeckiae nature and flavor bitter, acrid, cold.Slightly poisonous.Return liver, kidney channel.There is wind-damp dispelling, the meridian dredging, the effect of heat clearing away poison.Can treat hemiplegia, deviation of the eye and mouth, mental disorder is stopped up Sheng, numb hand and foot, flaccidity syndrome and arthralgia syndrome is meciless, bones and muscles pain, the dampness tuberculosis of bone and joint, paralysis flaccidity is soft, rheumatism phlegm-fire, red, vitiligo, man comes off.Radical cure married woman leucorrhea etc.(the 3588th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Fructus Psoraleae nature and flavor are pungent, bitter, temperature.Return kidney, spleen channel.There is kidney invigorating and YANG supporting, controlling nocturnal emission with astringent drugs reducing urination, warming spleen and stopping diarrha, the effect of improving inspiration by invigorating kidney-QI.Can treat that osteosarcoma, neoplastic bone shift, leukopenia, hemorrhagic illness, vitiligo, the cold diarrhea of suffering from a deficiency of the kidney, the enuresis, spermatorrhea, frequent micturition, sexual impotence, chills and pain of the waist and kness, frequent micturition, deficiency and coldness are breathed heavily and are coughed etc. after chemotherapy radiotherapy.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 714th page).

The Zaocys property of medicine is sweet, flat.Return lung, spleen, Liver Channel.There is wind-damp dispelling, the meridian dredging, the effect of relieving convulsion.Can treat rheumatoid arthritis stubborn, numbness of the skin, the contracture of muscle arteries and veins, quadriplegia, tetanus, leprosy, rubella scabies etc.(the 667th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Cortex Cinnamomi property of medicine is pungent, sweet, heat.Return kidney, spleen, the heart, Liver Channel.There is the fire of benefit supporing yang, dispersing cold for relieving pain, the effect of warming the meridian and promoting blood circulation.Can treat insufficiency of kidney-YANG, the aversion to cold and cold limbs of decline of the fire from the gate of life, soreness of the waist and knees, impotence and seminal emission, dysuria or frequency, the dyspnea with rapid and short breath of losing heart, all diseases of edema oliguria; Decline of the fire from the gate of life ，Huo Bugui source, floating YANG, refusing yang, and heat in the upper and cold in the lower, flushed complexion cold foot, dizziness and tinnitus, dispute is rotten broken; Spleen-kidney vacuity cold, coldness and pain in the epigastrium, decreased food intake loose stool; Lumbago due to renal deficiency; Arthralgia due to cold-dampnes; Colic of cold type pain; Cold womb is infertile, dysmenorrhea amenorrhea, the stagnant stomachache of the stasis of blood in puerperal; Carbuncle of yin nature multiple abscess, or deficiency and coldness carbuncle and ulcer difficulty in discharging of pus, or do not hold back after bursting etc.(the 1223rd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Stigma Croci nature and flavor are sweet, flat.GUIXIN, Liver Channel.There is blood circulation promoting and blood stasis dispelling, the effect of dispersing stagnation and relieving accumulation of pathogens.Can treat dysmenorrhea, amenorrhea, menoxenia, post partum longtime lochia, enclosed mass pain in abdomen, injury from falling down, melancholy painful abdominal mass is vexed, palpitation with fear, epidemic febrile disease is sent out speckle, measles etc.(the 3367th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Radix Astragali nature and flavor are sweet, warm.Return lung, spleen channel.There is benefit and defend consolidating superficial resistance, inducing diuresis to remove edema, poison holding, the effect of granulation promoting.That for internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, metrorrhagia and leukorrhagia, spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle, does not burst or burst does not hold back and the disease of all weakness of QI blood deficiency.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 1074th page).

For showing that medicine of the present invention is to treating leukodermic therapeutic effect, as follows through clinical test results; Treatment patients with vitiligo 47 examples.External embodiment unguentum, each 1 pastes, and once-a-day, is affixed on umbilicus place.Within three months, be a course for the treatment of, use continuously three the course for the treatment of observe the curative effect.34 examples of fully recovering account for 77.19%, and 9 examples that take a turn for the better account for 15.79%, and more 4 examples do not account for 7%, and total effective rate reaches 93%.After three course of therapy, patient is without any untoward reaction, and three large routine tests and hepatic and renal function detect no abnormal.

The specific embodiment

Embodiment unguentum takes raw material by following weight:

3 parts of 3 parts of Zaocyss of 3 parts of Fructus Psoraleaes of Herba Siegesbeckiae

3 parts of 0.3 part of Radixs Astragali of 1 part of Stigma Croci of Cortex Cinnamomi.

Preparation method is to get above-mentioned raw materials to clean roguing, dries, and is ground into granule, soaks 1 hour, puts in multi-function extractor and decocts with water secondary, adds up for the first time the water of 10 times of amounts of medical material, decocts 1.5～2 hours, gets decocting liquid, filters.Add up for the second time the water of 7 times of amounts of medical material, decoct 1～1.2 hour, get decocting liquid twice, filter.The relative density that lixiviating solution is concentrated into regulation, obtains clear paste.The sugar refinery or the refined honey that in clear paste, add ormal weight, constantly stir, and continues heating and temper to specified standard.

Case 1 Zhang, man 21 years old, student, 2 years medical histories, face, cervical region have lamellar irregular type vitiligo, lean type area 10% left and right, adopt oral medicine to add that after 2 courses for the treatment of of external patch umbilicus method treatment, speckle pigment appears in patient, continual cure is after 2 courses for the treatment of, the most of primary colors that recovers of patient skin, cure area more than 90%, remainder presents kermesinus, after 2 courses for the treatment of of after treatment, white macula all disappears, recurrence that so far there are no.

Case 2 Zhao so-and-so, man, 39 years old, suffer from vitiligo, cervical region and hand have white macula, white macula area 20% left and right, adopting external umbilicus to paste therapy after 5 courses for the treatment of, there is speckle pigment in patient, and continual cure is after 5 courses for the treatment of, the most of primary colors that recovers of patient skin, cure area more than 90%, remainder presents kermesinus, after 5 courses for the treatment of of after treatment, white macula all disappears, recurrence that so far there are no.

Case 3 high certain, female, 23 years old, there is small particles in face and cervical region, coming hospital to make a definite diagnosis is vitiligo, enlarged areas in a few days, and her situation belongs to period of expansion, adopt melanin site-specific delivery of drugs and external umbilicus subsides method to treat after 1 course for the treatment of, the state of an illness is controlled, and white macula rubicundity, after the external umbilicus subsides treatment of 3 courses for the treatment of, patient's white macula all disappears, recurrence that so far there are no.

Claims (3)

1. treat leukodermic Chinese medicinal ointment and preparation method thereof for one kind, it is characterized in that it is to be made by the raw material of following weight proportioning:

1.5～6 parts of 1.5～6 parts of Zaocyss of 1.5～6 parts of Fructus Psoraleaes of Herba Siegesbeckiae

1.5～6 parts of 0.1～0.6 part of Radixs Astragali of 2～4 parts of Stigma Crocis of Cortex Cinnamomi.

2. treat leukodermic Chinese medicinal ointment and preparation method thereof for one kind, wherein the weight proportion of each raw material is:

2.5～3.5 parts of 2.5～3.5 parts of Zaocyss of 2.5～3.5 parts of Fructus Psoraleaes of Herba Siegesbeckiae

2.5～3.5 parts of 0.2～0.4 part of Radixs Astragali of 0.5～1.5 part of Stigma Croci of Cortex Cinnamomi.

3. a kind of leukodermic Chinese medicinal ointment and preparation method thereof for the treatment of according to claim 1, wherein the weight proportion of each raw material is:

3 parts of 3 parts of Zaocyss of 3 parts of Fructus Psoraleaes of Herba Siegesbeckiae

3 parts of 0.3 part of Radixs Astragali of 1 part of Stigma Croci of Cortex Cinnamomi.