CN103503895A - Antifungal composition containing pyrazole compound and triazole compound - Google Patents
Antifungal composition containing pyrazole compound and triazole compound Download PDFInfo
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- CN103503895A CN103503895A CN201210208204.5A CN201210208204A CN103503895A CN 103503895 A CN103503895 A CN 103503895A CN 201210208204 A CN201210208204 A CN 201210208204A CN 103503895 A CN103503895 A CN 103503895A
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Abstract
The invention discloses an antifungal composition containing an active component A and an active component B. The component A is a compound represented by a formula I as described in the specification; in the formula I, R1 is selected from the group consisting of H, 2-Cl, 2-CH3, 2-OH, 4-Cl, 4-CH3, 4-OCH3, 4-OH, 2,4-2Cl and 2,4-2CH3, R2 is selected from the group consisting of CH3 and C2H5, R3 is selected from the group consisting of H, Cl, CH3 and C2H5, and Q is selected from the group consisting of Q1, Q2 and Q3 represented by formulas as described in the specification. The component B is a triazole bactericide or a salt thereof. The antifungal composition provided by the invention has an obvious synergistic effect and is especially applicable to prevention and treatment of a plurality of plant pathogenic fungal diseases, e.g., powdery mildew, a rust disease and sheath blight.
Description
Technical field
The invention belongs to disinfectant use in agriculture field, relate to the research containing the double activated component agricultural bactericidal mixture preparation of pyrazole compound, be specifically related to a kind of Fungicidal composition containing pyrazole compound and triazole class compounds.
Background technology
Bactericide azoles bacterium ester has efficiently, the bactericidal activity of wide spectrum, and structural formula of compound is as follows:
In the further research process of this compound, inventor finds that the isomer and the analog (compound as shown in general formula I) thereof that in the preparation process of above-claimed cpd (and general formula compound), generate have good control efficiency to fungal diseases such as rice blast, powdery mildew, rust, banded sclerotial blight, downy mildew.
In formula: R
1be selected from H, 2-Cl, 2-CH
3, 2-OH, 4-Cl, 4-CH
3, 4-OCH
3, 4-OH, 2,4-2Cl or 2,4-2CH
3; R
2be selected from CH
3or C
2h
5; R
3be selected from H, Cl, CH
3or C
2h
5; Q is selected from structure Q as follows
1, Q
2or Q
3:
Bactericide is used history to show, reuses for a long time same class medicament, very easily makes the part bacterial strain of disease develop immunity to drugs, and drug effect is obviously declined.By the bactericide with the different mechanisms of action being used in combination, sometimes can being expanded the fungicidal spectrum of medicament, delay the drug-fast generation of pathogen, the synergistic effect of performance combination medicament, the service life of prolongation medicament.
Summary of the invention
The object of the present invention is to provide a kind of Fungicidal composition that the pyrazole compound shown in general formula A is one of active component that contains, to improve the control efficiency to corps diseases.
By large quantity research and test, inventor has determined take the suitable mixed ratio of Fungicidal composition that pyrazole compound and triazole class compounds or its salt be active component, obtained a kind of Fungicidal composition with outstanding synergistic effect, thereby realized object of the present invention, completed the present invention.
Technical scheme of the present invention is as follows:
, containing A, two kinds of active components of B, the weight ratio between component A and B component two components is 1:100 ~ 100:1; In composition, the weight content of active component is 0.1 ~ 95%;
Component A is selected from the compound shown in following general formula I:
In formula: R
1be selected from H, 2-Cl, 2-CH
3, 2-OH, 4-Cl, 4-CH
3, 4-OCH
3, 4-OH, 2,4-2Cl or 2,4-2CH
3; R
2be selected from CH
3or C
2h
5; R
3be selected from H, Cl, CH
3or C
2h
5; Q is selected from structure Q as follows
1, Q
2or Q
3:
B component is selected from triazole bactericidal agent or its salt, described triazole bactericidal agent is selected from Tebuconazole B1, propiconazole B2, Difenoconazole B3, epoxiconazole B4, triazolone B5, Flusilazole B6, efficient alkene azoles alcohol B7, nitrile bacterium azoles B8, alkene azoles alcohol B9, penconazole B10, own azoles alcohol B11, Triadimenol B12, Cyproconazole B13, Fluquinconazole B14, Flutriafol B15, metconazole B16, glyoxalin B17, prothioconazoles B18, plant bacterium azoles B19, triticonazole B20, bitertanol B21, oxygen ring azoles B22, tetraconazole B23, imazalil B24 or efficient imazalil B25.
The demonstration of biological activity test result, the compd A 1(in component A is R in general formula I
1=H, R
2=CH
3, R
3=CH
3, Q=Q
1compound) various crop disease is shown to more excellent bactericidal effect.Partial test the results are shown in Table 1-table 6.
Table 1 pyrazole compound A1 prevents and treats cucumber downy mildew effect (potted plant seedling)
Table 2 pyrazole compound A1 is to tomato late blight bacterium sporangium Germination suppression effect
Table 3 pyrazole compound A1 prevents and treats wheat powdery mildew effect (potted plant seedling)
Table 4 pyrazole compound A1 prevents and treats cucumber anthracnose effect (potted plant seedling)
Table 5 pyrazole compound A1 prevents and treats Bean rust disease effect (potted plant seedling)
Table 6 pyrazole compound A1 is to magnaporthe grisea spore Germination suppression effect
Therefore, the present invention more preferably technical scheme is: in above-mentioned Fungicidal composition, active component A is selected from compd A 1, and structural formula is as follows:
The further preferred technical scheme of the present invention is: in described Fungicidal composition,
Active component A is selected from compd A 1;
Active component B is selected from triazole bactericidal agent or its salt; Described triazole bactericidal agent is selected from Tebuconazole B1, propiconazole B2, Difenoconazole B3, epoxiconazole B4, triazolone B5, Flusilazole B6, efficient alkene azoles alcohol B7, nitrile bacterium azoles B8, alkene azoles alcohol B9, penconazole B10 or own azoles alcohol B11;
Weight ratio between A, two kinds of active components of B is 1:50 ~ 50:1.
The present invention further preferred technical scheme is: in described Fungicidal composition,
Active component A is selected from compd A 1;
Active component B is selected from Tebuconazole B1, propiconazole B2, Difenoconazole B3, epoxiconazole B4, triazolone B5, Flusilazole B6, efficient alkene azoles alcohol B7 or nitrile bacterium azoles B8;
Weight ratio between A, two kinds of active components of B is 1:20 ~ 20:1.
Present composition synergistic function is obvious, and the disease that multiple disease fungus is caused especially powdery mildew, rust, banded sclerotial blight, root rot, scab, (silk) smut etc. in Cereal (barley, wheat, corn, dogstail etc.), vegetables (as cucumber, beans etc.), fruit (apple, pears, strawberry etc.), ornamental plants, lawn and grape vine has good control efficiency.Therefore, technical scheme of the present invention also comprises that said composition is used as the purposes of fungicide, as preparing fungicide medicine, for preventing and treating various plants pathogenic epiphyte disease.
When preparing the present composition, can add wherein other to the effective active substance of pest, or there is active substance or the fertilizer of herbicide effect and growth regulating effect.
The present invention also comprises the using method of above-mentioned composition control harmful fungoid.Component A and at least one B component prepare in advance according to appropriate proportioning provided by the invention or using on-the-spot preparation or using successively separately, all present significant protection effect or obviously expand disease control kind.
Fungicidal composition of the present invention is particularly suitable for preventing and treating following plants disease: powdery mildew of wheat and barley, wheat rust, Wheat sheath blight, stinking smut, wheat class root rot, maize head smut, head smut of sorghum, cucurbits powdery mildew, pepper powdery mildew, root rot, cotton seedling blight, apple mildew, pear scab, grape powdery mildew, Peanut Rust, powdery mildew of strawberry, coffee rust, oranges and tangerines powdery mildew, oranges and tangerines root rot, lawn powdery mildew, lawn fusarium wilt.
According to the occurrence degree of corps diseases, the working concentration of the present composition is 5 ~ 1500g/hm in proportion of crop planting region
2, preferred 20 ~ 500g/hm
2.
Process kind of a period of the day from 11 p.m. to 1 a.m, the using dosage of composition is generally 1 ~ 1000g/100kg seed, preferably 5 ~ 200g/100kg seed.
Fungicidal composition of the present invention can be processed into direct use or be watered water-based or the oily suspensions of rear use, the multiple formulations such as powder, emulsion, oil dispersion, paste, paste, particle, fumicants.In all cases, use and guarantee the meticulous and equally distributed preparation of the present composition.Above-mentioned various preparation all can be prepared in a known manner.For example active component is mixed and prepared with solvent and/or carrier, if desired can add auxiliary agent and the surfactants such as emulsifier, dispersant, wetting agent.
Suitable solvent or auxiliary agent are mainly water, benzene, dimethylbenzene, toluene, alkylbenzene, aliphatic hydrocarbon, alcohols, ester class, ketone, also have vegetable oil and the molten fiber of methyl.Meanwhile, the mixture of different liquids is also suitable for.
Suitable surfactant is alkali metal salt, alkali salt and the ammonium salt of lignin sulfonic acid, naphthalene sulfonic acids, phenolsulfonic acid, dibutyl naphthalene sulfonic acids, alkylaryl sulfonates, alkyl sulfate, alkylsulfonate, aliphatic alcohol sulfate etc.
Suitable wetting agent is sldium lauryl sulfate, lauryl sodium sulfate, dodecyl sodium sulfate, sodium alkyl benzene sulfonate, Negel, sorbitan fatty acid ester polyoxyethylene ether etc.
Powder formulation active substance and solid carrier can be mixed or together with grind and prepare.
Granular preparation can be prepared by active component and solid carrier are adhered to.
The present composition can be made into and contains 0.1 ~ 95%(weight) preparation of active component, preferably contain 5 ~ 80%(weight) preparation of active component.
The example of preparing of part preparation is listed below, and wherein said active component is pyrazole compound A and the triazole class compounds B in Fungicidal composition of the present invention, and the suitable proportion between A, two kinds of active components of B as previously mentioned.
Soluble liquid (SL)
10 parts of (weight ratio, lower with) active components, in water-soluble or water-soluble solvent, are mixed with to liquid preparation.Dilute with water obtains dispersion, for cauline leaf spraying or soil pouring.
Dispersible agent (DC)
20 parts of active components be dissolved in cyclohexanone and add PEF base pyrrolidones, being mixed with liquid preparation.Dilute with water obtains dispersion.
Missible oil (EC)
30 parts of active components are dissolved in dimethylbenzene and add calcium dodecyl benzene sulfonate and castor oil ethoxylate, be mixed with homogeneous liquid preparation.Dilute with water obtains emulsion, for cauline leaf spraying or soil pouring.
Aqueous emulsion (EW)
25 parts of active components be dissolved in dimethylbenzene and add calcium dodecyl benzene sulfonate and castor oil ethoxylate, by emulsifier, said composition is introduced in water, being mixed with liquid preparation.Dilute with water obtains emulsion, for cauline leaf spraying or soil pouring.
Suspending agent (SC)
In the ball mill stirring, 20 parts of active components are pulverized and added dispersant, wetting agent and water or organic solvent, obtain active component suspension in small, broken bits.Dilute with water obtains suspension, for cauline leaf spraying or soil pouring.
Water dispersible granules (WG)
By 50 parts of active component grindings in small, broken bits and add dispersant and wetting agent, by extruder, spray tower, fluid bed, make water dispersible or water-soluble granular.Dilute with water obtains dispersion or solution, for cauline leaf spraying or soil pouring.
Wetting powder (WP)
75 parts of active components in rotor-stator grinding machine for grinding and add dispersant, wetting agent and silica gel, are made to powder preparation.Dilute with water obtains dispersion or solution, for cauline leaf spraying or soil pouring.
Example 8: pulvis (DP)
By 5 parts of active component grindings in small, broken bits and with the kaolin in small, broken bits of 95 parts, be fully mixed to get the pulvis that can directly use.
Example 9: granule (GR)
By 0.5 part of active component grinding in small, broken bits and in conjunction with the carrier of 99.5 parts, through extruder, spray dryer, obtain granule.
Active component can be directly or with its preparation by spraying, atomization, dusting, broadcast sowing or pouring type is used.In addition, polytype oil, wetting agent, adjuvant, weed killer herbicide, fungicide, other agricultural chemicals can add in the present composition.These compositions mix with the weight ratio of 1:30 ~ 30:1 with the present composition conventionally.
Fungicidal composition of the present invention has good synergistic function, obviously improves the control efficiency to corps diseases.The present invention is used in combination the bactericide with the different mechanisms of action, so not only expands the fungicidal spectrum of medicament, and can delay the drug-fast generation of pathogen, extends the service life of medicament.In agricultural production, the suitable proportion that two kinds of bactericide are proposed according to the present invention is used together, also can reach the effect of saving of work and time.
Embodiment
The present composition can be described further by the following example the synergistic function of harmful fungoid, but the present invention only limits to absolutely not this.Wherein said active component is the compd A 1 and triazole type part bactericide B of one of pyrazole compound in Fungicidal composition of the present invention.
Method of testing and evaluation method are as follows:
By active ingredient acetone solution (volume ratio of amounts of acetone and spouting liquid is equal to or less than 0.05) for matter sample, the water dilution with containing 0.1% Tween 80, is mixed with desired concn liquid to be measured, separately by the liquid to be measured of preset proportion compositions formulated.On crops sprayer, liquid to be measured is sprayed on disease host plant, after 24 hours, carry out disease inoculation.According to disease feature, will need be placed in climatic chamber after the disease plant inoculating cultivated of temperature control moisturizing and cultivate, after disease completes and infects, move into hot-house culture, will not need disease plant that moisturizing cultivates directly at warm indoor inoculation and cultivate.After contrasting abundant morbidity, measure pathogen and infect Crop leaf area percentage, use Abbot formula to calculate, obtain observing effect (W):
W=（1-α/β）×100
In formula:
α: the fungal infection percentage of processing crop;
β: the fungal infection percentage of untreated (blank) crop;
Effect is identical with the level that infects of untreated control crop for " 0 " represents to process the level that infects of crop; Effect is infected for " 100 " represent to process crop.
The expection effect of composition (calculating effect) use Colby formula (see R.S.Colby, weeds (Weeds), 1967,15,20-22) determine, and with observe effect comparison.
E=X+Y–XY/100
In formula:
E: expection effect when working concentration is the active component A of a and b and the composition of B (the calculating effect in following table), represents with the % of untreated control;
X: effect during active component A that working concentration is a, represents with the % of untreated control;
Y: effect during active component B that working concentration is b, represents with the % of untreated control.
When observation effect value is greater than calculating effect value, represent that composition has synergistic effect; When observation effect value equals to calculate effect value, expression composition is adduction; When observation effect value is less than calculating effect value, expression composition is antagonism.
Embodiment 1 control wheat powdery mildew (Blumeria graminis) test
The potted plant two leaf phase wheat seedlings that by kind are " the Liao Dynasty's spring 10 " are processed with the aqueous solution (concentration the is as described below) spraying of active component, after 24 hours, by the spore suspension inoculation test plants of wheat powdery mildew.It is that the climatic chamber that 24 ± 2 ℃ and relative moisture are 50 ± 5% is cultivated that test plants is placed in to temperature, within 5 days, estimates afterwards the development degree of infection process on blade.The activity data of each independent active component and present composition control wheat powdery mildew the results are shown in Table 7 and table 8.The observation effect value of composition is all greater than calculates effect value, and composition shows as synergistic effect in test ratio range.
Table 7 is the activity of active component separately
The activity of table 8 present composition
| Tested number | Composition | Concentration (mg/L) | Proportioning | Observe effect (%) | Calculate effect (%) |
| 9 | Compd A 1+ Tebuconazole B1 | 1.25 | 4:1 | 92.63 | 72.35 |
| 10 | Compd A 1+ Tebuconazole B1 | 0.5 | 1:1 | 69.47 | 55.05 |
| 11 | Compd A 1+ Tebuconazole B1 | 0.3125 | 1:4 | 44.21 | 33.45 |
| 12 | Compd A 1+ propiconazole B2 | 1.25 | 4:1 | 87.37 | 71.64 |
| 13 | Compd A 1+ propiconazole B2 | 0.5 | 1:1 | 76.84 | 53.90 |
| 14 | Compd A 1+ propiconazole B2 | 0.3125 | 1:4 | 54.74 | 31.75 |
| 15 | Compd A 1+ Difenoconazole B3 | 1.25 | 4:1 | 89.47 | 71.28 |
| 16 | Compd A 1+ Difenoconazole B3 | 0.5 | 1:1 | 70.53 | 53.32 |
| 17 | Compd A 1+ Difenoconazole B3 | 0.3125 | 1:4 | 48.42 | 30.89 |
| 18 | Compd A 1+ triazolone B5 | 1.25 | 4:1 | 83.16 | 68.80 |
| 19 | Compd A 1+ triazolone B5 | 0.5 | 1:1 | 70.53 | 49.29 |
| 20 | Compd A 1+ triazolone B5 | 0.3125 | 1:4 | 40.00 | 24.92 |
| 21 | The efficient alkene azoles of compd A 1+ alcohol B7 | 1.25 | 4:1 | 85.26 | 70.22 |
| 22 | The efficient alkene azoles of compd A 1+ alcohol B7 | 0.5 | 1:1 | 69.47 | 51.59 |
| 23 | The efficient alkene azoles of compd A 1+ alcohol B7 | 0.3125 | 1:4 | 38.95 | 28.34 |
| 24 | Compd A 1+ nitrile bacterium azoles B8 | 1.25 | 4:1 | 86.32 | 69.51 |
| 25 | Compd A 1+ nitrile bacterium azoles B8 | 0.5 | 1:1 | 68.42 | 50.44 |
| 26 | Compd A 1+ nitrile bacterium azoles B8 | 0.3125 | 1:4 | 38.95 | 26.63 |
Embodiment 2 prevents and treats powdery mildew of cucumber (Erysiphe cucurbitacearum) test
By the close thorn in kind Wei“ Shandong " potted plant two leaf phase cucumber seedlings with the aqueous solution (concentration the is as described below) spraying of active component, process, after 24 hours, by the spore suspension inoculation test plants of powdery mildew of cucumber bacterium.It is that 24 ± 2 ℃ and relative moisture are that 50±5% greenhouse is cultivated that test plants is placed in to temperature, within 8 days, estimates afterwards the development degree of infection process on blade.The activity data that each independent active component and the present composition are prevented and treated powdery mildew of cucumber the results are shown in Table 9 and table 10.The observation effect value of composition is all greater than calculates effect value, and composition shows as synergistic effect in test ratio range.
Table 9 is the activity of active component separately
The activity of table 10 present composition
| Tested number | Composition | Concentration (mg/L) | Proportioning | Observe effect (%) | Calculate effect (%) |
| 35 | Compd A 1+ Tebuconazole B1 | 21 | 20:1 | 78.49 | 53.94 |
| 36 | Compd A 1+ Tebuconazole B1 | 6 | 5:1 | 55.91 | 35.70 |
| 37 | Compd A 1+ Tebuconazole B1 | 2 | 1:1 | 38.71 | 25.15 |
| 38 | Compd A 1+ Tebuconazole B1 | 1.2 | 1:5 | 29.03 | 14.59 |
| 39 | Compd A 1+ Tebuconazole B1 | 1.05 | 1:20 | 18.28 | 10.75 |
| 40 | Compd A 1+ propiconazole B2 | 21 | 20:1 | 76.34 | 51.72 |
| 41 | Compd A 1+ propiconazole B2 | 6 | 5:1 | 52.69 | 32.61 |
| 42 | Compd A 1+ propiconazole B2 | 2 | 1:1 | 32.26 | 21.54 |
| 43 | Compd A 1+ propiconazole B2 | 1.2 | 1:5 | 24.73 | 10.47 |
| 44 | Compd A 1+ propiconazole B2 | 1.05 | 1:20 | 15.05 | 6.45 |
| 45 | Compd A 1+ Difenoconazole B3 | 21 | 20:1 | 77.42 | 52.83 |
| 46 | Compd A 1+ Difenoconazole B3 | 6 | 5:1 | 51.61 | 34.15 |
| 47 | Compd A 1+ Difenoconazole B3 | 2 | 1:1 | 37.63 | 23.34 |
| 48 | Compd A 1+ Difenoconazole B3 | 1.2 | 1:5 | 25.81 | 12.53 |
| 49 | Compd A 1+ Difenoconazole B3 | 1.05 | 1:20 | 17.20 | 8.60 |
| 50 | Compd A 1+ epoxiconazole B4 | 21 | 20:1 | 82.80 | 54.49 |
| 51 | Compd A 1+ epoxiconazole B4 | 6 | 5:1 | 58.06 | 36.48 |
| 52 | Compd A 1+ epoxiconazole B4 | 2 | 1:1 | 39.78 | 26.05 |
| 53 | Compd A 1+ epoxiconazole B4 | 1.2 | 1:5 | 29.03 | 15.62 |
| 54 | Compd A 1+ epoxiconazole B4 | 1.05 | 1:20 | 19.35 | 11.83 |
| 55 | The efficient alkene azoles of compd A 1+ alcohol B7 | 21 | 20:1 | 75.27 | 50.61 |
| 56 | The efficient alkene azoles of compd A 1+ alcohol B7 | 6 | 5:1 | 51.61 | 31.06 |
| 57 | The efficient alkene azoles of compd A 1+ alcohol B7 | 2 | 1:1 | 29.03 | 19.74 |
| 58 | The efficient alkene azoles of compd A 1+ alcohol B7 | 1.2 | 1:5 | 18.28 | 8.42 |
| 59 | The efficient alkene azoles of compd A 1+ alcohol B7 | 1.05 | 1:20 | 12.90 | 4.30 |
| 60 | Compd A 1+ nitrile bacterium azoles B8 | 21 | 20:1 | 79.57 | 53.38 |
| 61 | Compd A 1+ nitrile bacterium azoles B8 | 6 | 5:1 | 54.84 | 34.93 |
| 62 | Compd A 1+ nitrile bacterium azoles B8 | 2 | 1:1 | 36.56 | 24.45 |
| 63 | Compd A 1+ nitrile bacterium azoles B8 | 1.2 | 1:5 | 24.73 | 13.56 |
| 64 | Compd A 1+ nitrile bacterium azoles B8 | 1.05 | 1:20 | 16.13 | 9.68 |
Embodiment 3 prevents and treats wheat rust (Puccinia recondita tritici) test
The potted plant two leaf phase wheat seedlings that by kind are " the Liao Dynasty's spring 10 " are processed with the aqueous solution (concentration the is as described below) spraying of active component, after 24 hours, with the spore suspension of wheat rust bacterium, are inoculated in test plants.It is that 85 ~ 90% climatic chambers are cultivated 20 hours with relative moisture that test plants is placed in to 22 ~ 24 ℃, then moves into hot-house culture (temperature is 24 ± 2 ℃, and relative moisture is 50 ± 5%), within 7 days, estimates afterwards the development degree of infection process on blade.The activity data that the active component that each is independent and the present composition are prevented and treated wheat rust the results are shown in Table 11 and table 12.The observation effect value of composition is all greater than calculates effect value, and composition shows as synergistic effect in test ratio range.
Table 11 is the activity of active component separately
The activity of table 12 present composition
| Tested number | Composition | Concentration (mg/L) | Proportioning | Observe effect (%) | Calculate effect (%) |
| 72 | Compd A 1+ Tebuconazole B1 | 2.5 | 4:1 | 87.50 | 77.14 |
| 73 | Compd A 1+ Tebuconazole B1 | 1 | 1:1 | 76.14 | 62.67 |
| 74 | Compd A 1+ Tebuconazole B1 | 0.625 | 1:4 | 55.68 | 45.90 |
| 75 | Compd A 1+ propiconazole B2 | 2.5 | 4:1 | 81.82 | 72.50 |
| 76 | Compd A 1+ propiconazole B2 | 1 | 1:1 | 69.32 | 55.08 |
| 77 | Compd A 1+ propiconazole B2 | 0.625 | 1:4 | 44.32 | 34.91 |
| 78 | Compd A 1+ epoxiconazole B4 | 2.5 | 4:1 | 90.91 | 78.69 |
| 79 | Compd A 1+ epoxiconazole B4 | 1 | 1:1 | 78.41 | 65.20 |
| 80 | Compd A 1+ epoxiconazole B4 | 0.625 | 1:4 | 57.95 | 49.58 |
| 81 | Compd A 1+ triazolone B5 | 2.5 | 4:1 | 80.68 | 70.95 |
| 82 | Compd A 1+ triazolone B5 | 1 | 1:1 | 63.64 | 52.54 |
| 83 | Compd A 1+ triazolone B5 | 0.625 | 1:4 | 48.86 | 31.24 |
| 84 | The efficient alkene azoles of compd A 1+ alcohol B7 | 2.5 | 4:1 | 82.95 | 73.66 |
| 85 | The efficient alkene azoles of compd A 1+ alcohol B7 | 1 | 1:1 | 65.91 | 56.98 |
| 86 | The efficient alkene azoles of compd A 1+ alcohol B7 | 0.625 | 1:4 | 54.55 | 37.66 |
Embodiment 4 control wheat sharp eyespot (Rhizoctonia cereas) tests
The potted plant two leaf phase wheat seedlings that by kind are " the Liao Dynasty's spring 10 " are processed with the aqueous solution (concentration the is as described below) spraying of active component, after 24 hours, with wheat sharp eyespot mycelium, are inoculated in test plants.It is that 80 ~ 85% climatic chambers are cultivated with relative moisture that test plants is placed in to 24 ~ 26 ℃.After 5 days, the development degree of infection process on range estimation leaf sheath.The activity data of the active component that each is independent and present composition control wheat sharp eyespot the results are shown in Table 13 and table 14.The observation effect value of composition is all greater than calculates effect value, and composition shows as synergistic effect in test ratio range.
Table 13 is the activity of active component separately
The activity of table 14 present composition
| Tested number | Composition | Concentration (mg/L) | Proportioning | Observe effect (%) | Calculate effect (%) |
| 92 | Compd A 1+ Difenoconazole B3 | 5 | 4:1 | 82.14 | 63.82 |
| 93 | Compd A 1+ Difenoconazole B3 | 2 | 1:1 | 63.10 | 45.24 |
| 94 | Compd A 1+ Difenoconazole B3 | 1.25 | 1:4 | 39.29 | 29.60 |
| 95 | Compd A 1+ epoxiconazole B4 | 5 | 4:1 | 86.90 | 65.91 |
| 96 | Compd A 1+ epoxiconazole B4 | 2 | 1:1 | 67.86 | 48.41 |
| 97 | Compd A 1+ epoxiconazole B4 | 1.25 | 1:4 | 46.43 | 33.68 |
| 98 | Compd A 1+ triazolone B5 | 5 | 4:1 | 77.38 | 60.14 |
| 99 | Compd A 1+ triazolone B5 | 2 | 1:1 | 52.38 | 39.68 |
| 100 | Compd A 1+ triazolone B5 | 1.25 | 1:4 | 33.33 | 22.45 |
Embodiment 5 prevents and treats scab of cucumber (Scolicotrichum melophthorum) test
By the close thorn in kind Wei“ Shandong " potted plant two leaf phase cucumber seedlings with the aqueous solution (concentration the is as described below) spraying of active component, process, after 24 hours, by the spore suspension inoculation test plants of dosporium cucumerinumand its.It is that 24 ± 2 ℃ and relative moisture are that 85 ~ 90% climatic chambers are cultivated 24 hours that test plants is placed in to temperature, then moves into hot-house culture (temperature is 24 ± 2 ℃, and relative moisture is 50 ± 5%), within 6 days, estimates afterwards the development degree of infection process on blade.The activity data that the active component that each is independent and the present composition are prevented and treated scab of cucumber the results are shown in Table 15 and table 16.The observation effect value of composition is all greater than calculates effect value, and composition shows as synergistic effect in test ratio range.
Table 15 is the activity of active component separately
The activity of table 16 present composition
| Tested number | Composition | Concentration (mg/L) | Proportioning | Observe effect (%) | Calculate effect (%) |
| 105 | Compd A 1+ Flusilazole B6 | 21 | 20:1 | 85.39 | 66.37 |
| 106 | Compd A 1+ Flusilazole B6 | 6 | 5:1 | 68.54 | 49.10 |
| 107 | Compd A 1+ Flusilazole B6 | 2 | 1:1 | 52.81 | 37.28 |
| 108 | Compd A 1+ Flusilazole B6 | 1.2 | 1:5 | 44.94 | 30.92 |
| 109 | Compd A 1+ Flusilazole B6 | 1.05 | 1:20 | 35.96 | 24.55 |
| 110 | Compd A 1+ nitrile bacterium azoles B8 | 21 | 20:1 | 83.15 | 65.44 |
| 111 | Compd A 1+ nitrile bacterium azoles B8 | 6 | 5:1 | 65.17 | 47.68 |
| 112 | Compd A 1+ nitrile bacterium azoles B8 | 2 | 1:1 | 47.19 | 35.54 |
| 113 | Compd A 1+ nitrile bacterium azoles B8 | 1.2 | 1:5 | 39.33 | 29.00 |
| 114 | Compd A 1+ nitrile bacterium azoles B8 | 1.05 | 1:20 | 31.46 | 22.46 |
Claims (7)
1. a Fungicidal composition, contains A, two kinds of active components of B, and the weight ratio between component A and B component two components is 1:100 ~ 100:1; In composition, the weight content of active component is 0.1 ~ 95%;
Component A is selected from the compound shown in following general formula I:
In formula: R
1be selected from H, 2-Cl, 2-CH
3, 2-OH, 4-Cl, 4-CH
3, 4-OCH
3, 4-OH, 2,4-2Cl or 2,4-2CH
3; R
2be selected from CH
3or C
2h
5; R
3be selected from H, Cl, CH
3or C
2h
5; Q is selected from structure Q as follows
1, Q
2or Q
3:
B component is selected from triazole bactericidal agent or its salt, described triazole bactericidal agent is selected from Tebuconazole B1, propiconazole B2, Difenoconazole B3, epoxiconazole B4, triazolone B5, Flusilazole B6, efficient alkene azoles alcohol B7, nitrile bacterium azoles B8, alkene azoles alcohol B9, penconazole B10, own azoles alcohol B11, Triadimenol B12, Cyproconazole B13, Fluquinconazole B14, Flutriafol B15, metconazole B16, glyoxalin B17, prothioconazoles B18, plant bacterium azoles B19, triticonazole B20, bitertanol B21, oxygen ring azoles B22, tetraconazole B23, imazalil B24 or efficient imazalil B25.
2. Fungicidal composition according to claim 1, is characterized in that: active component A is selected from A1, and structural formula is as follows:
3. Fungicidal composition according to claim 1 and 2, is characterized in that: active component A is selected from compd A 1; Active component B is selected from triazole bactericidal agent or its salt; Described triazole bactericidal agent is selected from Tebuconazole B1, propiconazole B2, Difenoconazole B3, epoxiconazole B4, triazolone B5, Flusilazole B6, efficient alkene azoles alcohol B7, nitrile bacterium azoles B8, alkene azoles alcohol B9, penconazole B10 or own azoles alcohol B11; Weight ratio between A, two kinds of active components of B is 1:50 ~ 50:1.
4. Fungicidal composition according to claim 3, is characterized in that: active component A is selected from compd A 1; Active component B is selected from triazole bactericidal agent or its salt; Described triazole bactericidal agent is selected from Tebuconazole B1, propiconazole B2, Difenoconazole B3, epoxiconazole B4, triazolone B5, Flusilazole B6, efficient alkene azoles alcohol B7 or nitrile bacterium azoles B8; Weight ratio between A, two kinds of active components of B is 1:20 ~ 20:1.
5. Fungicidal composition according to claim 1, is characterized in that: composition is mixed with water-based or oily suspensions, powder, emulsion, oil dispersion, paste, paste, particle, fumicants.
6. the purposes of Fungicidal composition according to claim 1, is characterized in that: as preparing fungicide medicine, for preventing and treating plant pathogenic fungi disease.
7. the purposes of Fungicidal composition according to claim 6, is characterized in that: for preventing and treating plant powdery mildew, rust, banded sclerotial blight, root rot, scab, head smut.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104186485A (en) * | 2014-09-22 | 2014-12-10 | 江苏省绿盾植保农药实验有限公司 | Microbicide composition for preventing and controlling wheat powdery mildew and application of composition |
| CN104336036A (en) * | 2014-10-14 | 2015-02-11 | 沈阳化工研究院有限公司 | Fungicidal composition and application thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1657524A (en) * | 2004-02-20 | 2005-08-24 | 沈阳化工研究院 | Substituted azole compounds and their preparation and application |
| CN1869034A (en) * | 2005-05-26 | 2006-11-29 | 沈阳化工研究院 | An arylether kind compound and its preparation and application |
| CN101406191A (en) * | 2007-10-09 | 2009-04-15 | 中国中化集团公司 | Fungicidal compositions |
| WO2010021121A1 (en) * | 2008-08-18 | 2010-02-25 | 三井化学アグロ株式会社 | Plant disease control agent comprising d-tagatose as active ingredient, and plant disease control method |
| CN102106355A (en) * | 2009-12-23 | 2011-06-29 | 中国中化股份有限公司 | Antifungal composition containing pyraoxystrobin |
-
2012
- 2012-06-19 CN CN201210208204.5A patent/CN103503895B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1657524A (en) * | 2004-02-20 | 2005-08-24 | 沈阳化工研究院 | Substituted azole compounds and their preparation and application |
| CN1869034A (en) * | 2005-05-26 | 2006-11-29 | 沈阳化工研究院 | An arylether kind compound and its preparation and application |
| CN101406191A (en) * | 2007-10-09 | 2009-04-15 | 中国中化集团公司 | Fungicidal compositions |
| WO2010021121A1 (en) * | 2008-08-18 | 2010-02-25 | 三井化学アグロ株式会社 | Plant disease control agent comprising d-tagatose as active ingredient, and plant disease control method |
| CN102106355A (en) * | 2009-12-23 | 2011-06-29 | 中国中化股份有限公司 | Antifungal composition containing pyraoxystrobin |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104186485A (en) * | 2014-09-22 | 2014-12-10 | 江苏省绿盾植保农药实验有限公司 | Microbicide composition for preventing and controlling wheat powdery mildew and application of composition |
| CN104336036A (en) * | 2014-10-14 | 2015-02-11 | 沈阳化工研究院有限公司 | Fungicidal composition and application thereof |
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|---|---|
| CN103503895B (en) | 2015-10-21 |
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Effective date of registration: 20160128 Address after: 110021 Liaodong Road, Tiexi District, Liaoning, No. 8-1, No. Patentee after: SHENYANG SINOCHEM PESTICIDE CHEMICAL RESEARCH AND DEVELOPMENT CO., LTD. Address before: 100031 Beijing, Xicheng District, the door of the revitalization of the main street, No. 28 Patentee before: Sinochem Corporation Patentee before: Shenyang Research Institute of Chemical Industry |