CN103494986B - The Chinese medicine for the treatment of primary trigeminal neuralgia - Google Patents
The Chinese medicine for the treatment of primary trigeminal neuralgia Download PDFInfo
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Abstract
The present invention relates to a kind of pharmaceutical formulation field, specifically a kind of Chinese medicine for the treatment of primary trigeminal neuralgia, its technical characteristic is, raw material composition is by weight percentage: Fructus Xanthii 7 ~ 11%, Fructus Forsythiae 6 ~ 9%, Radix Bupleuri 5 ~ 7%, Cortex Magnoliae Officinalis 5 ~ 8%, Pheretima 6 ~ 9%, Radix Angelicae Sinensis 10 ~ 13%, Herba Ephedrae 5 ~ 8%, Radix Gentianae 4 ~ 7%, Fructus Viticis 4 ~ 7%, Herba Asari 4 ~ 8%, Herba Schizonepetae 3 ~ 6%, Fructus Toosendan 5 ~ 9%, Fructus Trichosanthis 2 ~ 6%, Vascular aurantii 3 ~ 6%, Arisaema Cum Bile 3 ~ 6%, Sanguis Draxonis 1 ~ 3%, by medicinal for above-mentioned raw materials water soaking, to remove slag after decocting to obtain filtrate.Cost of the present invention is low, and treatment trigeminal neuralgia is high, has no side effect, has strengthening vital QI to eliminate pathogenic factors, and cold expelling disappears heat, blood circulation promoting and blood stasis dispelling, dispelling wind and removing obstruction in the collateral, the function of the kidney invigorating pain relieving.
Description
Technical field
The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of Chinese medicine for the treatment of primary trigeminal neuralgia.
Background technology
As everyone knows, primary trigeminal neuralgia shows as the of short duration repeated relapsing severe pain of nervi trigeminus areal area.Pathogenesis is still explored so far.Around theory thinks that pathological changes is positioned at position between semilunar ganglion to pons, is caused by the compressing that causes due to many reasons; Nervus centralis theory thinks that trigeminal neuralgia is the outbreak of a kind of epilepsia thalamica sample, and paradoxical discharge position may at spinal nucleus of trigeminal nerve or brain stem; More scholar thinks that the nervi trigeminus focal demyelination that a variety of causes causes produces ectopic impulse, the pseudo-Synaptic formation of adjacent axonal fibres or generation short circuit, slight pain stimulus imports maincenter into by short circuit, and maincenter efferent impulse spread is also imported into by short circuit, and so superposition causes trigeminal neuralgia to show effect.Trigeminal neuralgia is more common in adult and old people, and within more than 40 years old, patient accounts for 70 ~ 80%, and women is more than male.Trigeminal neuralgia is often confined to nervi trigeminus one or two areal area, common with ramus maxillaris, ramus of mandible.Show as during outbreak lower jaw and tongue on buccal significantly acutely shock by electricity sample, acupuncture sample, lancinate sample or tear sample pain, last for several seconds or 1 ~ 2 minute, burst stops.Patient's bicker, the wing of nose, buccal or tongue are sensitizing range, touch and can bring out.Because of pain, several cases can occur that facial muscle reflexive is twitched, bicker is led to Ipsilateral and trismus dolorificus.The course of disease is in periodically, and outbreak not can be a few days, several weeks or several months not etc., and along with course of disease delay, attack times increases gradually, and duration of seizure extends, and the intermission shortens, even for persistence is shown effect.Clinical symptomatic treatment medicine has carbamazepine, and untoward reaction has dizziness, drowsiness, xerostomia, feels sick, dyspepsia etc.Carbamazepine is invalid uses phenytoin Sodium instead, and untoward reaction has drowsiness and instability of gait, and the accidental transience of gerontal patient is mentally deranged, whole body pruritus, diplopia etc.
Summary of the invention
Technical problem to be solved by this invention is to overcome the deficiencies in the prior art, and provide a kind of Chinese medicine for the treatment of primary trigeminal neuralgia, cost is low, and treatment trigeminal neuralgia is high, have no side effect, have strengthening vital QI to eliminate pathogenic factors, cold expelling disappears heat, blood circulation promoting and blood stasis dispelling, dispelling wind and removing obstruction in the collateral, the function of the kidney invigorating pain relieving.No matter course of disease weight, the trigeminal neuralgia of duration of seizure length is all effective.
The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of Chinese medicine for the treatment of primary trigeminal neuralgia, its technical characteristic is, raw material composition is by weight percentage: Fructus Xanthii 7 ~ 11%, Fructus Forsythiae 6 ~ 9%, Radix Bupleuri 5 ~ 7%, Cortex Magnoliae Officinalis 5 ~ 8%, Pheretima 6 ~ 9%, Radix Angelicae Sinensis 10 ~ 13%, Herba Ephedrae 5 ~ 8%, Radix Gentianae 4 ~ 7%, Fructus Viticis 4 ~ 7%, Herba Asari 4 ~ 8%, Herba Schizonepetae 3 ~ 6%, Fructus Toosendan 5 ~ 9%, Fructus Trichosanthis 2 ~ 6%, Vascular aurantii 3 ~ 6%, Arisaema Cum Bile 3 ~ 6%, Sanguis Draxonis 1 ~ 3%, by medicinal for above-mentioned raw materials water soaking, to remove slag after decocting to obtain filtrate.
The invention has the beneficial effects as follows, cost is low, and treatment primary trigeminal neuralgia curative effect is high, has no side effect, has strengthening vital QI to eliminate pathogenic factors, and cold expelling disappears heat, blood circulation promoting and blood stasis dispelling, dispelling wind and removing obstruction in the collateral, the function of the kidney invigorating pain relieving.No matter course of disease weight, duration of seizure length is all applicable.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described:
Embodiment 1:
Adopt Fructus Xanthii, Fructus Forsythiae, Radix Bupleuri, Cortex Magnoliae Officinalis, Pheretima, Radix Angelicae Sinensis, Herba Ephedrae, Radix Gentianae, Fructus Viticis, Herba Asari, Herba Schizonepetae, Fructus Toosendan, Fructus Trichosanthis, Vascular aurantii, Arisaema Cum Bile, Sanguis Draxonis to be that raw material is prepared from, its component (% by weight) is often paid as Fructus Xanthii 9, Fructus Forsythiae 8, Radix Bupleuri 6, Cortex Magnoliae Officinalis 6, Pheretima 6, Radix Angelicae Sinensis 13, Herba Ephedrae 6, Radix Gentianae 6, Fructus Viticis 7, Herba Asari 6, Herba Schizonepetae 5, Fructus Toosendan 7, Fructus Trichosanthis 4, Vascular aurantii 5, Arisaema Cum Bile 4, Sanguis Draxonis 2.Get above-mentioned 16 taste raw material gross weight 233 grams, at room temperature remaining 15 taste Chinese herbal medicine are added water to about 1000ml, soak 5 hours, then boil with high heat, slow fire decocts about 60 minutes, and remove slag to obtain filtrate about 200ml, and medicinal residues add water about 300ml again, decoct 20 ~ 30 minutes, remove slag to obtain filtrate 50 ~ 70ml, is total to obtain filtrate about 250 ~ 270ml medicine juice, i.e. the Chinese medicine decoction of obtained treatment primary trigeminal neuralgia, load in sterile glass vials, seal bottle cap is for subsequent use.Every day potion, points 2 times are oral, each (medicine) being taken before meal 125 ~ 135ml.Take and disappear completely to Clinical symptom and sign, without outbreak, then interruption is taken medicine 3 weeks, and first week every day, potion took 4 days, stopped 3 days; Second week potion every day takes 3 days, stops 4 days; 3rd week every day, potion took 2 days, stopped 5 days, with consolidate curative effect.
Fructus Xanthii acrid in the mouth of the present invention, hardship, warm in nature, poisonous.Return lung meridian.There is the function of the dehumidifying of loose wind, understand things pain-stopping.Fructus Xanthii is strong with wind-repellent itching-relieving power, is usually used in itchy skin eruption and other dermatosiss; Fructus Forsythiae has the effect of heat-clearing and toxic substances removing, is mainly used in calentura from the beginning of, anemopyretic cold, heating, vexed, laryngopharynx swelling and pain, acute nephritis etc.; Radix Bupleuri clearind deficient heat Chinese medicine, comes off for cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus, menoxenia; Cortex Magnoliae Officinalis has dampness, expectorant, except effects such as full, the therapeutic method to keep the adverse QI flowing downwardss, can be used for the diseases such as treatment humidity hysteresis damaging the spleen and stomach, stagnation of QI due to dyspepsia, abdominal distention constipation; Pheretima salty in the mouth cold in nature.Its salty in the mouth, cold in nature.Function is heat clearing away, spasmolytic, Zhichuan, diuresis.Cure mainly high fanatical hot-tempered, convulsion with spasms, headache conjunctival congestion, the diseases such as expectorant heat, apoplexy, hemiplegia of panting; The inclined what of Radix Angelicae Sinensis is invigorated blood circulation, removing blood stasis; Herba Ephedrae diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.Detumescence power is strong, is used for chill exterior syndrome, uncomfortable in chestly breathes with cough, edema due to wind pathogen edema, rheumatism; Radix Gentianae nature and flavor are bitter, puckery, Great Cold, nontoxic.Cure mainly cold and heat between bone, frightened pathogenic factor gas, continue wound absolutely, determines the five internal organs, parasite killing poison; Fructus Viticis bitter in the mouth, pungent, property is put down.Effect: loose wind heat, refresh oneself.Cure mainly the diseases such as cold anemopyretic headache, wind syndrome of head headache, conjunctival congestion and swelling pain, the dim many tears of the head; Herba Asari cures mainly: dispel the wind, cold expelling, and row water, has one's ideas straightened out.Control air-cooled headache, nasal sinusitis, toothache, phlegm retention cough with dyspnea, rheumatic arthralgia; Herba Schizonepetae energy town expectorant, timid wind, removing heat from blood.Control influenza, the diaphoresis of headache cold and heat, vomiting; Fructus Toosendan soothing liver-QI promoting the circulation of QI to relieve pain, except damp and hot, anthelmintic.For the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation; Fructus Trichosanthis clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, moisturizes laxation.For cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, blocked-up chest feeling of fullness, acute mastitis, lung abscess, and acute appendicitis swells and ache, constipation; Vascular aurantii dredging collateral, regulates the flow of vital energy, and reduces phlegm, and controls blockage of meridian-QI, chronic cough chest pain, and sputum mixed with blood is got sick from drinking too much wine thirsty; Arisaema Cum Bile removing heat-phlegm, dispelling wind and relieving convulsion.For phlegm-heat cough, cough up phlegm yellow thick, middle wind-phlegm fan, demented frightened carbuncle; Sanguis Draxonis sweet in the mouth, one-tenth, property is put down.Effect: promoting blood circulation to remove blood stasis, hemostasis, pain relieving, granulation promoting.The ingenious prescription of 16 taste Chinese herbal medicine, the mutual coordinative role of medicine, plays the specially good effect for the treatment of primary trigeminal neuralgia altogether.
The each raw material of the present invention also can the embodiment that mixes of ratio (percentage by weight) listed by according to the form below realize.Its processing technique is identical with embodiment 1.
Below in conjunction with my institute, the clinical preliminary test that namely central hospital of In Shandong Weihai Wendeng City carries out is done further the present invention, is described in detail:
Case selection: according to " neurological " the 6th edition diagnostic criteria of Jia Jianping chief editor, is diagnosed as " trigeminal neuralgia " patient 63 example, wherein man 24 example, female 39 example, between 42 ~ 63 years old age, and the course of disease 6 months to 3 years.
Therapeutic Method: every day potion divide 2 times oral, each (medicine) being taken before meal 125 ~ 135m1.Take two months, then be interrupted 3 weeks: the first week every day potion of taking medicine and take 4 days, stop 3 days; Second week potion every day takes 3 days, stops 4 days; 3rd week every day, potion took 2 days, stopped 5 days, with consolidate curative effect.
The standard of curative effect evaluation: " the disease of tcm Standardization of diagnosis and curative effect " issued with reference to State Administration of Traditional Chinese Medicine formulates healing, effective, effective, invalid curative effect judging standard:
Cure: patient's repeated relapsing trigeminal neuralgia Clinical symptom and sign disappears, then without outbreak;
Effective: patient's repeated relapsing trigeminal neuralgia Clinical symptom and sign disappears substantially, occasionally have outbreak, the persistent period is short, and attack degree is light;
Effective: patient episode's property trigeminal neuralgia catabasis comparatively take medicine before obviously extend, duration of seizure comparatively before shorten, and degree alleviates;
Invalid: to contrast after taking medicine Yu before taking medicine, outbreak and persistent period, the state of an illness was unchanged without change.
Therapeutic effect: use decoction of the present invention to treat 63 examples altogether, according to curative effect judgment criteria, cures 28 examples, effective 27 examples, effective 2 examples, and invalid 6 examples, total effective rate is about 90.5%.
Claims (1)
1. treat the Chinese medicine composition of primary trigeminal neuralgia for one kind, it is characterized in that: raw material composition is by weight percentage, Fructus Xanthii 7 ~ 11%, Fructus Forsythiae 6 ~ 9%, Radix Bupleuri 5 ~ 7%, Cortex Magnoliae Officinalis 5 ~ 8%, Pheretima 6 ~ 9%, Radix Angelicae Sinensis 10 ~ 13%, Herba Ephedrae 5 ~ 8%, Radix Gentianae 4 ~ 7%, Fructus Viticis 4 ~ 7%, Herba Asari 4 ~ 8%, Herba Schizonepetae 3 ~ 6%, Fructus Toosendan 5 ~ 9%, Fructus Trichosanthis 2 ~ 6%, Vascular aurantii 3 ~ 6%, Arisaema Cum Bile 3 ~ 6%, Sanguis Draxonis 1 ~ 3%, by medicinal for above-mentioned raw materials water soaking, filtrate of removing slag after decocting to obtain.
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| CN102228567A (en) * | 2011-06-21 | 2011-11-02 | 霍庆如 | Medicine for treating trigeminal neuralgia |
| CN102309617A (en) * | 2010-06-30 | 2012-01-11 | 兰圣国 | Traditional Chinese medicine decoction for treating prosopalgia |
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| CN102309617A (en) * | 2010-06-30 | 2012-01-11 | 兰圣国 | Traditional Chinese medicine decoction for treating prosopalgia |
| CN102228567A (en) * | 2011-06-21 | 2011-11-02 | 霍庆如 | Medicine for treating trigeminal neuralgia |
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