CN103494723B - Stem cell skin care composition and manufacturing method and application thereof - Google Patents
Stem cell skin care composition and manufacturing method and application thereof Download PDFInfo
- Publication number
- CN103494723B CN103494723B CN201310261542.XA CN201310261542A CN103494723B CN 103494723 B CN103494723 B CN 103494723B CN 201310261542 A CN201310261542 A CN 201310261542A CN 103494723 B CN103494723 B CN 103494723B
- Authority
- CN
- China
- Prior art keywords
- stem cell
- add
- cell
- parts
- stir
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 210000000130 stem cell Anatomy 0.000 title claims abstract description 58
- 239000000203 mixture Substances 0.000 title claims abstract description 25
- 238000004519 manufacturing process Methods 0.000 title claims description 8
- 210000004027 cell Anatomy 0.000 claims abstract description 49
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 21
- 229920001908 Hydrogenated starch hydrolysate Polymers 0.000 claims abstract description 11
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims abstract description 10
- 150000001413 amino acids Chemical class 0.000 claims abstract description 10
- 239000003906 humectant Substances 0.000 claims abstract description 10
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims abstract description 9
- 108010009736 Protein Hydrolysates Proteins 0.000 claims abstract description 8
- 229930182478 glucoside Natural products 0.000 claims abstract description 8
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 8
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 7
- 229960005070 ascorbic acid Drugs 0.000 claims abstract description 7
- 235000010323 ascorbic acid Nutrition 0.000 claims abstract description 7
- 239000011668 ascorbic acid Substances 0.000 claims abstract description 7
- -1 ascorbic acid glucoside Chemical class 0.000 claims abstract description 7
- 239000000679 carrageenan Substances 0.000 claims abstract description 7
- 229920001525 carrageenan Polymers 0.000 claims abstract description 7
- 229940113118 carrageenan Drugs 0.000 claims abstract description 7
- 235000010418 carrageenan Nutrition 0.000 claims abstract description 7
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims abstract description 7
- 238000003756 stirring Methods 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 235000021452 apple slice Nutrition 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 10
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 9
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 9
- 229940069521 aloe extract Drugs 0.000 claims description 9
- 238000001816 cooling Methods 0.000 claims description 9
- 229920002307 Dextran Polymers 0.000 claims description 7
- 239000007864 aqueous solution Substances 0.000 claims description 7
- 230000002421 anti-septic effect Effects 0.000 claims description 6
- 210000003491 skin Anatomy 0.000 abstract description 39
- 230000032683 aging Effects 0.000 abstract description 13
- 239000013589 supplement Substances 0.000 abstract description 7
- 210000004927 skin cell Anatomy 0.000 abstract description 5
- 230000007547 defect Effects 0.000 abstract description 4
- 230000004060 metabolic process Effects 0.000 abstract description 4
- 230000010076 replication Effects 0.000 abstract description 4
- 241001116389 Aloe Species 0.000 abstract description 2
- 235000011399 aloe vera Nutrition 0.000 abstract description 2
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 abstract 1
- 229920001503 Glucan Polymers 0.000 abstract 1
- 208000031888 Mycoses Diseases 0.000 abstract 1
- 229920002385 Sodium hyaluronate Polymers 0.000 abstract 1
- 230000030833 cell death Effects 0.000 abstract 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 229920000223 polyglycerol Polymers 0.000 abstract 1
- 230000036559 skin health Effects 0.000 abstract 1
- 229940010747 sodium hyaluronate Drugs 0.000 abstract 1
- 230000007423 decrease Effects 0.000 description 7
- 210000002514 epidermal stem cell Anatomy 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 230000001172 regenerating effect Effects 0.000 description 5
- 230000004069 differentiation Effects 0.000 description 4
- 230000001771 impaired effect Effects 0.000 description 4
- 230000033001 locomotion Effects 0.000 description 4
- 238000012423 maintenance Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 239000002537 cosmetic Substances 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 238000005984 hydrogenation reaction Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 230000008929 regeneration Effects 0.000 description 3
- 238000011069 regeneration method Methods 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 241000220225 Malus Species 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 230000004768 organ dysfunction Effects 0.000 description 2
- 231100000915 pathological change Toxicity 0.000 description 2
- 230000036285 pathological change Effects 0.000 description 2
- 230000004962 physiological condition Effects 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 230000000284 resting effect Effects 0.000 description 2
- 210000001082 somatic cell Anatomy 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 230000017423 tissue regeneration Effects 0.000 description 2
- 230000001228 trophic effect Effects 0.000 description 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- DBTMGCOVALSLOR-UHFFFAOYSA-N 32-alpha-galactosyl-3-alpha-galactosyl-galactose Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(OC2C(C(CO)OC(O)C2O)O)OC(CO)C1O DBTMGCOVALSLOR-UHFFFAOYSA-N 0.000 description 1
- 244000101643 Aloe ferox Species 0.000 description 1
- 235000015858 Aloe ferox Nutrition 0.000 description 1
- AFHJQYHRLPMKHU-XXWVOBANSA-N Aloin Natural products O=C1c2c(O)cc(CO)cc2[C@H]([C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O2)c2c1c(O)ccc2 AFHJQYHRLPMKHU-XXWVOBANSA-N 0.000 description 1
- 241000255789 Bombyx mori Species 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- RXVWSYJTUUKTEA-UHFFFAOYSA-N D-maltotriose Natural products OC1C(O)C(OC(C(O)CO)C(O)C(O)C=O)OC(CO)C1OC1C(O)C(O)C(O)C(CO)O1 RXVWSYJTUUKTEA-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 241000581835 Monodora junodii Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- AFHJQYHRLPMKHU-OSYMLPPYSA-N aloin A Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1[C@@H]1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 AFHJQYHRLPMKHU-OSYMLPPYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- AFHJQYHRLPMKHU-UHFFFAOYSA-N isobarbaloin Natural products OC1C(O)C(O)C(CO)OC1C1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 AFHJQYHRLPMKHU-UHFFFAOYSA-N 0.000 description 1
- FYGDTMLNYKFZSV-UHFFFAOYSA-N mannotriose Natural products OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(OC2C(OC(O)C(O)C2O)CO)C(O)C1O FYGDTMLNYKFZSV-UHFFFAOYSA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000004215 skin function Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- FYGDTMLNYKFZSV-BYLHFPJWSA-N β-1,4-galactotrioside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@H](CO)O[C@@H](O[C@@H]2[C@@H](O[C@@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-BYLHFPJWSA-N 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
The invention discloses a stem cell skin care composition which comprises the following components by weight: 3-5 parts of polyglycerol, 2-5 parts of hydrogenated starch hydrolysate, 2-3 parts of an amino acid humectants, 0.5-1 part of stem cells, 0.1-0.5 part of sodium hyaluronate, 5-10 parts of aloe extracts, 3-10 parts of mycose, 8-10 parts of glucan, 2-4 parts of ascorbic acid glucoside, 0.05-0.2 part of sodium hydroxide, 0.1-0.2 part of disodium ethylene diamine tetraacetate, and 0.5-1 part of carrageenan. The invention also discloses an application of the stem cell skin care composition. The beneficial effects of the stem cell skin care composition are that: the composition can effectively supply and supplement stem cells with self-differentiation and replication capabilities, thus enhances the metabolism of skin cells themselves, makes up the defect that common face mask has insufficient newborn vital cell supplement after pathological cell death, which leads to rapid aging of people, and plays a true role in delaying aging and conserving skin health.
Description
Technical field
The present invention relates to a kind of skin care item, especially a kind of stem cell skin care compositions with reparation pathological changes and deferring senility and preparation method thereof and application.
Background technology
Along with the development of social economy's level, people more and more advocate beautiful pursuit, so various cosmetics and skincare product arises at the historic moment.Wherein mask series products is a series products very popular in these cosmetics and skincare products.But existing mask class cosmetics are generally only to have moisturizing or whitening function; Or be mainly the normal physiological function of simply strengthening and safeguard sick cell.But after sick cell decline, the regenerative cell with vitality supplements deficiency, cause people old and feeble fast, defying age ability wretched insufficiency.
Summary of the invention
The object of the invention is the deficiency existing for the above existing mask series products, provide a kind of by strengthening and supplementary human body has the stem cell of differentiation of self and replication capacity, provide and produce and there is vigorous vitality regenerative cell, substitute endlessly aging and sick cell, thereby reach reparation pathological changes, the object stem cell skin care compositions of slow down aging.
Another object of the present invention is to provide a kind of manufacture method of stem cell skin care compositions.
The 3rd object of the present invention is to provide a kind of application of stem cell skin care compositions.
To achieve these goals, the technical solution adopted in the present invention is: stem cell skin care compositions, by the component that comprises following parts by weight, made:
The manufacture method of stem cell skin care compositions, it step comprising is as follows:
(1) first disodiumedetate is added in water and stirred, be incubated half an hour after being heated to 80-90 degree Celsius simultaneously;
(2) in (1) step water, add successively polyglycereol, hydrogenated starch hydrolysate, amino acid humectant, carrageenan and hyaluronate sodium, be stirred to completely after dissolving and start cooling;
(3) after temperature drops to 45-55 degree Celsius, add Aloe extract, trehalose and dextran, stir;
(4) add stem cell after cooling the temperature to 35-45 degree Celsius, stir.
(5) finally add with sodium hydroxide and regulate the ascorbic acid glucoside aqueous solution that pH value is 7-8, stir.
In above-mentioned formula, polyglycereol, hydrogenated starch hydrolysate, amino acid humectant, hyaluronate sodium all have moisture-keeping functions, can effectively pin the moisture in skin, keep skin beauty water tender and there is elasticity, above-mentioned four kinds of wetting agents are more conventional on the market raw material, it,, by the compounded combination of above-mentioned content proportioning, moistening effect is significantly strengthened, and cost of material is very low.Aloe extract wherein, trehalose, the conditioner that dextran is good to skin, it is effectively nursed one's health skin, the nutrient that supplementary skin is lost.Stem cell (stem cells, SC) is the pluripotent cell that a class has the of self-replication capacity (self-renewing), and it can be divided into several functions cell.The present invention preferably uses safer plant stem cell, particularly dried apple slices cell.Described stem cell is used in conjunction with together with above-mentioned each component, when smearing or spreading on skin, by the synergism with various compositions, can effectively strengthen the metabolism of skin cell self, made up common mask after sick cell decline, the regenerative cell with vitality supplements not enough, to cause the quick aging of people defect, has played real slow down aging, the object of maintenance skin.
Above-mentioned composition of the present invention can be made various types of skin care item such as cream frost, water preparation and mask as required.
A stem cell skin protection mask, by the component that comprises following parts by weight, made:
Described polyglycereol is ten polyglycereol preferably.
Described antiseptic can be the euxyl PE 9010 that German Shu Mei company produces.
Described stem cell is plant stem cell, wide material sources, and safety.
Described stem cell preferably apple stem cell.Dried apple slices cell can be repaired damaged cell: in people's vital movement process, the air and the bad food (pigment that pollute, antiseptic) absorption, causes the imbalance of human body internal and external environment, accumulates a large amount of free radicals and corrodes cell membrane, make cell impaired, inflammatory reaction occurs, cause organ dysfunction to decline, dried apple slices cell detects impaired cell after entering human body, for these cells inject trophic factors (specific aim protein), reach the object of repairing damaged cell; Dried apple slices cell can activate rest cell: dried apple slices cell enters the motion of the epidermal stem cells of being sunk into sleep by drive after human body, reach the object of activation, the epidermal stem cells of human body 90%-95% is all in resting state, and 1 epidermal stem cells can divide 4,000,000 active somatic cells of generation; Dried apple slices cell can promote cell regeneration: stem cell remains static under physiological conditions, only after receiving mobilization signal, just start its self renewal and differentiation mechanism, upgrade aging death cell and damaged tissue repair, and the dried apple slices cell best mobilization signal that is body cell.
Described hydrogenated starch hydrolysate (Hydrogenatedstarchhydroly sates) is by a series of multi-sugar alcohol mixture that obtain after Starch Hydrolysis, hydrogenation, wherein except single, double poly-multi-sugar alcohol, also containing a large amount of hydrogenation oligosaccharide and hydrogenation polysaccharide, is generally sorbitol, maltose alcohol, maltotriose and other more senior sugar alcohol mixtures.Described hydrogenated starch hydrolysate can be Fructus Hordei Germinatus oligose base glucosides, the MG-60 that preferred Japanese Lin Yuan company produces.
Barbaloin content in described Aloe extract (butt meter) >=28.0%(Ku Suola Aloe) and >=18.0 Aloe ferox Millers.Inferior raw material is the conventional raw material in market.The Aloe extract that can select Chuan Sheng bio tech ltd, Shaanxi to produce.
The trehalose that the trehalose that uses can select Japanese Lin Yuan chemical company to produce.
Amino acid humectant can be selected the raw amino acid humectant NMF-50 of Shandong markon's good fortune pharmaceutical Co. Ltd.
Described water is deionized water.
A manufacture method for stem cell skin protection mask, it step comprising is as follows:
(1) in water, add disodiumedetate (EDTA-2Na) to stir, be incubated half an hour after being heated to 80-90 degree Celsius simultaneously;
(2) add successively polyglycereol, hydrogenated starch hydrolysate, amino acid humectant, carrageenan and hyaluronate sodium, with the rotating speed of 20-50rpm, be stirred to after dissolving completely and start cooling;
(3) after temperature drops to 45-55 degree Celsius, add antiseptic, Aloe extract, trehalose and dextran, stir.
(4) after temperature is down to 35-45 degree Celsius, add stem cell, with the rotating speed of 20-50rpm, stir.
(5) finally add with sodium hydroxide and regulate the ascorbic acid glucoside aqueous solution that pH value is 7-8, the rotating speed of 10-20rpm stirs.
Because the mankind's aging and stem cell have close relationship, the minimizing of stem cell population, directly causes human body cell liveness to decline, and regeneration capacity is low, and defence capability declines, and finally moves towards old and feeble.The repair ability that Switzerland green apple stem cell is powerful, maintenance skin corium and epidermal area near the eyes, can strengthen skin function, improves fine wrinkle, allows skin near the eyes obviously become younger.
Compared with prior art, the invention has the beneficial effects as follows: can effectively provide and supplement the stem cell with differentiation of self and replication capacity, thereby strengthened the metabolism of skin cell self, made up common mask after sick cell decline, the regenerative cell with vitality supplements not enough, cause people's defect of aging fast, played real slow down aging, the object of maintenance skin.
The specific embodiment
Below in conjunction with specific embodiment, mask of the present invention is described in detail.
Embodiment 1
Stem cell skin care compositions, by the component that comprises following parts by weight, made:
Embodiment 2
Stem cell skin care compositions, by the component that comprises following parts by weight, made:
Embodiment 3
Stem cell skin care compositions, by the component that comprises following parts by weight, made:
Embodiment 4
Stem cell skin care compositions, by the component that comprises following parts by weight, made:
Described stem cell is plant stem cell, wide material sources, and safety.Described stem cell preferably apple stem cell.Dried apple slices cell can be repaired damaged cell: in people's vital movement process, the air and the bad food (pigment that pollute, antiseptic) absorption, the imbalance that causes human body internal and external environment, accumulate a large amount of free radicals and corrode cell membrane, make cell impaired, inflammatory reaction occurs, cause organ dysfunction to decline.Dried apple slices cell detects impaired cell after entering human body, for these cells inject trophic factors (specific aim protein), reaches the object of repairing damaged cell; Dried apple slices cell can activate rest cell: dried apple slices cell enters the motion of the epidermal stem cells of being sunk into sleep by drive after human body, reaches the object of activation.The epidermal stem cells of human body 90%-95% is all in resting state, and 1 epidermal stem cells can divide 4,000,000 active somatic cells of generation; Dried apple slices cell can promote cell regeneration: stem cell remains static under physiological conditions, only after receiving mobilization signal, just start its self renewal and differentiation mechanism, upgrade aging death cell and damaged tissue repair, and the dried apple slices cell best mobilization signal that is body cell.The dried apple slices cell (PhytoCellTec Alp Rose) that described stem cell selects Switzerland woods hundred happy (Mibelle Biochemistry) to produce.
The manufacture method of above-mentioned stem cell skin care compositions, it step comprising is as follows:
(1) first disodiumedetate is added after being heated to 85 degrees Celsius when stirring in water and be incubated half an hour;
(2) in (1) step water, add successively polyglycereol, hydrogenated starch hydrolysate, amino acid humectant, carrageenan and hyaluronate sodium, be stirred to completely after dissolving and start cooling;
(3) after temperature drops to 50 degrees Celsius, add Aloe extract, trehalose and dextran, stir;
(4) add stem cell after cooling the temperature to 40 degrees Celsius, stir.
(5) finally add with sodium hydroxide and regulate the ascorbic acid glucoside aqueous solution of pH value between 7-8, stir.Water in described aqueous solution can be remainder water in above-mentioned formula, can be also with extra water, but wherein a small amount of water is little to this recipe-imposed.
Above-mentioned technical process can effectively keep the activity of various active component, makes the skin care item effect of its formation reach optimum efficiency.
Above-mentioned composition of the present invention can be made various types of skin care item such as cream frost, water preparation and mask as required.
Embodiment 5
A stem cell skin protection mask, by the component that comprises following parts by weight, made:
Embodiment 6
A stem cell skin protection mask, by the component that comprises following parts by weight, made:
Embodiment 7
A stem cell skin protection mask, by the component that comprises following parts by weight, made:
Embodiment 8
A stem cell skin protection mask, by the component that comprises following parts by weight, made:
A manufacture method for stem cell skin protection mask, it step comprising is as follows:
(1) be incubated half an hour be heated to 85 degrees Celsius when adding disodiumedetate (EDTA-2Na) to stir in water after;
(2) add successively polyglycereol, hydrogenated starch hydrolysate, amino acid humectant, carrageenan and hyaluronate sodium, with the rotating speed of 30rpm, be stirred to after dissolving completely and start cooling;
(3) after temperature drops to 50 degrees Celsius, add antiseptic, Aloe extract, trehalose and dextran, stir.
(4) after temperature is down to 40 degrees Celsius, add stem cell, with the rotating speed of 30rpm, stir.
(5) finally add the ascorbic acid glucoside aqueous solution that regulates pH value with sodium hydroxide, the rotating speed of 15rpm stirs;
(6) on the paste mixture coating (5) step being obtained and carrier (preferably silkworm silk carrier).
The present invention is through the clinical use of thousands of examples, be summarized as follows: skin is not had to ill effect, can effectively improve skin condition, make its activity recovery and elasticity, there are two moisturizing effects, can effectively improve Skin Cell differentiation of self and replication capacity, thereby strengthened the metabolism of skin cell self, made up common mask after sick cell decline, the regenerative cell with vitality supplements not enough, cause people's defect of aging fast, played real slow down aging, the object of maintenance skin.
More than describe preferred embodiment of the present invention in detail, should be appreciated that the ordinary skill of this area just can design according to the present invention be made many modifications and variations without creative work.Therefore, all technical staff in the art according to the present invention design on prior art basis by logical analysis, reasoning or according to the available technical scheme of limited experiment, all should be among the determined protection domain by these claims.
Claims (5)
1. stem cell skin care compositions, is characterized in that, by the component that comprises following parts by weight, is made:
Described stem cell is dried apple slices cell.
2. the manufacture method of stem cell skin care compositions according to claim 1, is characterized in that, it step comprising is as follows:
(1) first disodiumedetate is added in water and stirred, be incubated half an hour after being heated to 80-90 degree Celsius simultaneously;
(2) in (1) step water, add successively polyglycereol, hydrogenated starch hydrolysate, amino acid humectant, carrageenan and hyaluronate sodium, be stirred to completely after dissolving and start cooling;
(3) after temperature drops to 45-55 degree Celsius, add Aloe extract, trehalose and dextran, stir;
(4) add stem cell after cooling the temperature to 35-45 degree Celsius, stir;
(5) finally add with sodium hydroxide and regulate the ascorbic acid glucoside aqueous solution that pH value is 7-8, stir.
3. a stem cell skin protection mask, is characterized in that, by the component that comprises following parts by weight, is made:
Described stem cell is dried apple slices cell.
4. a kind of stem cell skin protection mask according to claim 3, is characterized in that, by the component that comprises following parts by weight, is made:
5. the manufacture method of a kind of stem cell skin protection mask according to claim 3, is characterized in that, it step comprising is as follows:
(1) in water, add disodiumedetate to stir, be incubated half an hour after being heated to 80-90 degree Celsius simultaneously;
(2) add successively polyglycereol, hydrogenated starch hydrolysate, amino acid humectant, carrageenan and hyaluronate sodium, with the rotating speed of 20-50rpm, be stirred to after dissolving completely and start cooling;
(3) after temperature drops to 45-55 degree Celsius, add antiseptic, Aloe extract, trehalose and dextran, stir;
(4) after temperature is down to 35-45 degree Celsius, add stem cell, with the rotating speed of 20-50rpm, stir;
(5) finally add with sodium hydroxide and regulate the ascorbic acid glucoside aqueous solution that pH value is 7-8, the rotating speed of 10-20rpm stirs.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310261542.XA CN103494723B (en) | 2013-06-26 | 2013-06-26 | Stem cell skin care composition and manufacturing method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310261542.XA CN103494723B (en) | 2013-06-26 | 2013-06-26 | Stem cell skin care composition and manufacturing method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103494723A CN103494723A (en) | 2014-01-08 |
| CN103494723B true CN103494723B (en) | 2014-11-12 |
Family
ID=49860053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310261542.XA Active CN103494723B (en) | 2013-06-26 | 2013-06-26 | Stem cell skin care composition and manufacturing method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103494723B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104042516B (en) * | 2014-06-26 | 2016-10-12 | 广州市络捷生物科技有限公司 | One has white-skinned face function herbal composite and its preparation method and application |
| CN104666179A (en) * | 2015-02-06 | 2015-06-03 | 广州九美仟惠生物科技有限公司 | Facial mask capable of relieving and repairing weak skin and enhancing skin activity and preparation method of facial mask |
| CN105168025B (en) * | 2015-09-06 | 2018-06-01 | 薇碧生物科技（上海）有限公司 | Nanoparticle transdermal agent and preparation method thereof |
| CN106983713B (en) * | 2017-03-31 | 2020-06-26 | 杭州哈佛赛尔干细胞技术有限公司 | Stem cell skin care composition and preparation method and using method thereof |
| CN107929220A (en) * | 2017-12-01 | 2018-04-20 | 广州市韵丽生物科技有限公司 | It is a kind of that there is stem cell skin care compound for repairing anti-aging function and preparation method thereof |
| CN107823010A (en) * | 2017-12-13 | 2018-03-23 | 杭州荣泽生物科技有限公司 | stem cell facial mask and its stem cell facial mask liquid |
| CN109876012B (en) * | 2019-03-21 | 2022-01-11 | 北京隆祺生物科技有限公司 | Medicinal composition and application thereof in promoting skin wound healing |
| CN112451469A (en) * | 2020-12-11 | 2021-03-09 | 广州市拉凯尔干细胞研究所 | Stem cell double-layer skin care essence and preparation method thereof |
| CN114632024A (en) * | 2022-03-11 | 2022-06-17 | 毕杰辉 | Refreshing and moisturizing composition containing hydrogenated starch hydrolysate |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101742629B1 (en) * | 2010-11-30 | 2017-06-01 | (주)아모레퍼시픽 | Cosmetic composition for promoting the stemness of adipose-derived stem cell containing apple stem cell extracts |
| MX356540B (en) * | 2011-05-10 | 2018-06-01 | Mary Kay Inc | Cosmetic compositions. |
| CN102670444B (en) * | 2012-05-23 | 2013-09-11 | 成都鹏翔生物科技有限公司 | Skin base solution and preparation method thereof |
-
2013
- 2013-06-26 CN CN201310261542.XA patent/CN103494723B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN103494723A (en) | 2014-01-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103494723B (en) | Stem cell skin care composition and manufacturing method and application thereof | |
| CN104814900B (en) | A kind of lightening compositions and preparation method thereof | |
| CN102704319B (en) | The manufacture method of face paper and beauty and skin care paper film and facial mask | |
| CN105726457A (en) | Oligopeptide mask essence | |
| CN106420482A (en) | Skin energy activating sparkling essence | |
| CN108125892A (en) | A kind of marine organism moisture-retention anti-aging cosmetics composition | |
| CN108078831A (en) | A kind of multi-functional skin Essence and preparation method thereof | |
| CN107496310A (en) | A kind of facial treatment essence liquid and preparation method thereof | |
| CN110251453A (en) | It is a kind of for smoothing wrinkle, whitening and the stem cell secretion factor skin care item and preparation method thereof for desalinating acne print | |
| CN104473841A (en) | Traditional Chinese medicine mask containing dendrobe | |
| CN110974773A (en) | Skin care product for anti-allergic repair and preparation method thereof | |
| CN110101633A (en) | A kind of promotion cytothesis and improve endocrine Chinese medicinal herb essence stoste | |
| CN113786371A (en) | Composition for preparing blueberry seaweed mask, mask and preparation method | |
| CN109044926A (en) | A kind of skin whitening, moisturizing skin care item formula and preparation method thereof | |
| CN102349655A (en) | Collagen polyphenol granules | |
| CN107648585A (en) | A kind of anti-ageing anti-wrinkle Essence containing white fungus, aurantiamarin and soluble protein | |
| CN111557862A (en) | Medical recombinant human collagen and preparation method thereof | |
| CN108653143A (en) | A kind of facial treatment essence liquid | |
| CN108783138A (en) | A kind of women face-nourishing health-care beverage and preparation method thereof | |
| CN112972291A (en) | Non-animal-derived whitening anti-aging cosmetic and preparation method thereof | |
| CN101972223B (en) | Plant cell agerasia essence | |
| CN104546590A (en) | Moisturizing facial mask and preparation method thereof | |
| CN109453085A (en) | A kind of composition and preparation method thereof that can go black eye and oedema | |
| CN112263530A (en) | Multi-effect cleansing foam | |
| CN111481462A (en) | Application of alisol in delaying skin aging, improving skin youth state and preparing beauty and skin care product |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20140108 Assignee: Guangzhou excellent Biotechnology Co., Ltd. Assignor: Ma Yuxian Contract record no.: 2015440000863 Denomination of invention: Stem cell skin care compositions and preparation method thereof and application Granted publication date: 20141112 License type: Common License Record date: 20151218 |
|
| LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20160128 Address after: 313100, Huzhou, Zhejiang Province, Changxing County painting Creek industrial function area, No. 179-1, Pheasant Road Patentee after: Zhejiang Yitong Agel Ecommerce Ltd Address before: Guangzhou City, Guangdong province 510315 Gang Lu Haizhuqu District pomegranate Southern Medical University No. 13 the four teaching building on the two floor. Patentee before: Ma Yuxian |
|
| C56 | Change in the name or address of the patentee | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 313100, Huzhou, Zhejiang Province, Changxing County painting Creek industrial function area, No. 179-1, Pheasant Road Patentee after: Zhejiang Yitong electronic commerce Limited by Share Ltd Address before: 313100, Huzhou, Zhejiang Province, Changxing County painting Creek industrial function area, No. 179-1, Pheasant Road Patentee before: Zhejiang Yitong Agel Ecommerce Ltd |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20181204 Address after: 150050 Tonghe Street, Harbin City, Heilongjiang Province, No. 34-1, Building 2, Building 3, Unit 1, Building 2 Patentee after: Ma Yuxian Address before: 313100 No. 179-1 Pheasant Island Avenue, Paixi Industrial Functional Zone, Changxing County, Huzhou City, Zhejiang Province Patentee before: Zhejiang Yitong electronic commerce Limited by Share Ltd |
|
| TR01 | Transfer of patent right |