CN103494640A - Laser system for surgical department - Google Patents
Laser system for surgical department Download PDFInfo
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- CN103494640A CN103494640A CN201310478676.7A CN201310478676A CN103494640A CN 103494640 A CN103494640 A CN 103494640A CN 201310478676 A CN201310478676 A CN 201310478676A CN 103494640 A CN103494640 A CN 103494640A
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Abstract
The invention discloses a laser system for the surgical department. The laser system comprises a laser device system, a measuring device, a control device, a deflection device and a focusing optical device. The laser device system comprises a laser wavelength conversion device composed of a near-infrared pulse laser device and a nonlinear crystal, the input end of the laser wavelength conversion device receives near-infrared pulse laser sent by the near-infrared pulse laser device and converts the wavelength of the near-infrared pulse laser, and the laser wavelength conversion device outputs infrared pulse laser and quintuple frequency ultraviolet pulse laser obtained through wavelength conversion. The measuring device comprises an optical coherence tomography system, one or more measurers and a coupler. The laser system for the surgical department is high in integration degree, good in stability, safe and reliable and effectively improves the safety of the surgical operation.
Description
Technical field
The invention belongs to medical ultrashort pulse laser field, relate in particular to a kind of surgery laser system.
Background technology
In recent years, along with the development of laser technique, and, due to its peculiar advantage had, laser instrument is applied in the medical science surgical operation more and more.For example: current common laser cornea operations; The dermatosis such as laser therapy verruca plana; Laser scalpel etc.Because of its safety and effectiveness, the application of laser instrument in surgical operation obtained the confirmation of science and approval widely.
The laser cutting method generally adopted at present is after first being cut open with a kind of mechanical blades incision ，Gai position, a position to be treated, then is cut by the interior tissue that the ArF excimer laser is treated therapentic part.But the penetrance of Ultra-Violet Laser in some endotheliums, matrix organization is very little, is only suitable for surface cut, and type is huge, and energy stability is poor, easily is subject to the image of environment temperature and humidity.In addition, due to its design and operation, mechanical blades easily produces the complication disease after treatment, and the precision of laser surgery is affected.
In recent years, in order to overcome the defect of Ultra-Violet Laser, scientific and technical personnel have released near-infrared femtosecond laser parallel micromachining technology and have replaced mechanical blades, utilize the penetrability of near-infrared laser, focus on the degree of depth certain in the tissue to be treated line scanning of going forward side by side under computer control, laser energy makes tissue to be treated produce photo-cleavage, has reached the effect that therapentic part is cut for the treatment of.This laser micro-machining technology is more accurate, and post-operative complication still less, has obtained the consistent favorable comment of industry.
But, because current femtosecond laser equipment is still huge, and belong to respectively two autonomous devices with the excimer laser of carrying out surface cut, uncorrelated mutually.Therefore, when needs are treated, prepare two laser instrument in therapeutic room, this way is not only loaded down with trivial details but also easily increase the raising of human error rate, has directly affected medical safety.
In addition, in the laser surgery process, also very important for the accurate location at position to be treated, all the more so during especially for relatively meticulous cerebral surgery operation and ophthalmologic operation, do not allow to exist a bit deviation.For obtain tested position accurately and repeatably image and measurement, need be Range Imaging device fixed range and in position repeatably by the imaging of tested position.Therefore, importantly determine operating distance suitable between tested position and image device (also referred to as the Z distance).Can cause image inaccurate and that not too can repeat from the position displacement of this fixed range, or the error on even measuring.
All there is defect in various degree in three major ways of the above-mentioned error of minimizing at present commonly used (reference imaging method, method and the peak signal method measured based on bundle triangulation).The reference imaging method is highly subjective and is difficult to carry out for size and the profile at different positions to be treated.Making in this way can not be with high accuracy and the required fixed position of repeatable acquisition.Method based on triangulation can make patient not feel well, and is disagreeableness, and the added complexity of this method is higher.Due to the quality of the image that exists impact to obtain and other factors (as surround lighting) of signal, the peak signal method neither be very reliable.
In sum, be directed to the surgical laser system at meticulous position in prior art, exist complicated operation, integrated level is low, locates the defects such as inaccurate, and the existence of these defects directly affects medical safety.What therefore urgent need can address the above problem is safe and reliable, is simple and easy to the medical surgical laser system of use.
Summary of the invention
In order to address the above problem, the invention provides a kind of laser system that can be used for multiple surgery (as: department of cerebral surgery, department of dermatologry, ophthalmology and dentistry etc.) medical surgery.This surgery combines the advantage of ultraviolet light and ultrashort pulse by laser system, can realize treating with a laser instrument cutting, the cutting of therapentic part.And, by accurately location and focusing, significantly improve the Stability and veracity of operation.
According to an aspect of the present invention, provide a kind of surgery laser system, described laser system comprises:
Optical Maser System, for exporting the required laser pulse of surgical operation, described laser pulse is near infrared pulsed laser and five frequency multiplication ultraviolet pulse lasers;
Measuring device, measure in real time for the feature for the treatment of therapentic part;
Control device, receive the measurement result of described measuring device, and control described arrangement for deflecting according to described measurement result;
Arrangement for deflecting, for changing on described position to be treated and/or the position of the focus in described position to be treated;
Focus optics, for described femto-second laser pulse being focused on to the selected part at position to be treated, produce at least one focus; Two-dimentional diffraction structure or hologram three-dimensional diffraction structure that described focus produces for described position to be treated apply described laser pulse on described position to be treated after;
Described Optical Maser System comprises: near infrared pulsed laser device and the optical maser wavelength conversion equipment be comprised of nonlinear crystal; The input of described optical maser wavelength conversion equipment is for receiving the near infrared pulsed laser that described near infrared pulsed laser device sends, and described near infrared pulsed laser is carried out to the wavelength conversion, the five frequency multiplication ultraviolet pulse lasers of the outfan of described optical maser wavelength conversion equipment for exporting pulsed infrared laser and obtaining through the wavelength conversion;
Described measuring device comprises: the optical coherence tomography system, scanned for treating therapentic part; One or more measuring devices; And bonder, described bonder is connected to described optical coherence tomography system and described one or more measuring device, and combined beam is provided.
According to a specific embodiment of the present invention, the wavelength of described near infrared pulsed laser is 850nm～1080nm, and the wavelength of described five frequency multiplication ultraviolet pulse lasers is 165nm～210nm.
According to another specific embodiment of the present invention, the scope of the numerical aperture of described focus optics is 0.1～0.2.
According to another specific embodiment of the present invention, the diameter of the focus in described position to be treated is 0.5 μ m～2.5 μ m.
According to another specific embodiment of the present invention, described optical coherence tomography system comprises time domain optical coherence tomography system, the domain optical coherence tomographic system based on spectrometer and the domain optical coherence tomographic system based on Sweep Source.
According to another specific embodiment of the present invention, described measuring device is the topography imager that includes the placido cone.
According to another specific embodiment of the present invention, described bonder at least comprises a beam splitter, and described beam splitter is for combining the information that described measuring device obtains.
According to another specific embodiment of the present invention, in described optical maser wavelength conversion equipment, comprise frequency doubling device and mixer device.
According to another specific embodiment of the present invention, the Nd:YAG pulse laser that the near infrared pulsed laser device is semiconductor laser pumping or Nd:YLF pulse laser.
According to another specific embodiment of the present invention, described laser system also comprises display device, and described display device is connected with described measuring device, and shows in real time the measurement result of described measuring device.
Surgery laser system provided by the invention, adopt frequency multiplication/mixing nonlinear crystal to realize exporting near infrared pulsed laser and five frequency multiplication ultraviolet pulse lasers with a laser instrument, and the laser that is combined with two kinds of different frequencies is treated therapentic part and performed the operation.Reduce equipment cost, simplified procedure operation.And adopt the OCT scanning system to treat therapentic part to carry out the real time scan monitoring, obtain measurement data more accurately, and use these data to be controlled laser instrument, reach optimized surgical effect, effectively improved accuracy and the safety of operation.Focus optics in the present invention can be in the situation that be no more than " the removal threshold value " of material, the angle that laser pulse is focused (being the numerical aperture of focus optics) is larger, the energy of the pulse in the isopulse persistent period is lower, and then it is more accurate to treat the processing of therapentic part.
The accompanying drawing explanation
By reading the detailed description that non-limiting example is done of doing with reference to the following drawings, it is more obvious that other features, objects and advantages of the present invention will become:
Fig. 1 is the structural representation by a kind of specific embodiment of laser system according to a kind of surgery provided by the invention.
In accompanying drawing, same or analogous Reference numeral represents same or analogous parts.
The specific embodiment
Disclosing hereinafter provides many different embodiment or example to be used for realizing different structure of the present invention.Of the present invention open in order to simplify, hereinafter parts and the setting of specific examples are described.In addition, the present invention can be in different examples repeat reference numerals and/or letter.This repetition is in order to simplify and purpose clearly, itself do not indicate the relation between discussed various embodiment and/or setting.It should be noted that illustrated parts are not necessarily drawn in proportion in the accompanying drawings.The present invention has omitted description to known assemblies and treatment technology and technique to avoid unnecessarily limiting the present invention.
With reference to figure 1, Fig. 1 is the structural representation by a kind of specific embodiment of laser system according to a kind of surgery provided by the invention.Surgery laser system provided by the invention comprises: Optical Maser System 1, test set 2, control device 3, arrangement for deflecting 4 and focus optics 5.The laser chalk that Optical Maser System 1 sends enters arrangement for deflecting 2 and control device 3.Control device 2 receives the laser that sends of Optical Maser System 1, can record the information such as its intensity, frequency, wavelength, and laser is continued to be sent to measuring device 2.Measuring device 2 sends laser as position 6 to be treated, and accepts the light through position to be treated 6 reflections, and feeds back to control device 3 after this light is processed.Control device 3 receives measuring device 2 feedacks, and the laser that the Optical Maser System 1 arrangement for deflecting 4 received according to this information sends carries out deflection control.Laser process focus optics 5 through arrangement for deflecting 4 modulation, focus on position 6 to be treated, treats therapentic part and treated.
Optical Maser System 1 is comprised of laser instrument 11 and optical maser wavelength conversion equipment 12.Described near infrared pulsed laser device 11 is preferably semiconductor pumped Nd:YAG pulse laser or Nd:YLF pulse laser.The near infrared pulsed laser that laser instrument 11 sends enters into optical maser wavelength conversion equipment 12, carries out the optical maser wavelength dress and changes, to produce the five frequency multiplication ultraviolet pulse lasers for surgical operation therapy.
Preferably, optical maser wavelength conversion equipment 12 comprises frequency doubling device and mixer device.Frequency doubling device and mixer device carry out frequency multiplication operation or mixing operation to laser pulse respectively.Preferably, frequency multiplication operation and mixing operation complete by nonlinear crystal.According to different needs, nonlinear crystal can be for carrying out frequency multiplication or mixing to optical maser wavelength.Preferably, described nonlinear crystal includes but not limited to: three Lithium biborates (LBO), barium metaborate (BBO), potassium dihydrogen phosphate (KDP), six cesium lithium borates (CLBO), potassium dideuterium phosphate (DKDP), potassium titanium oxide phosphate (KTP) or lithium iodate (LiIO3) etc.
The wavelength of the near-infrared laser pulse that laser instrument 11 sends is 850nm～1080nm, for example: 850nm, 950nm or 1080nm.The wavelength of the pulse laser that generally, the Nd:YAG laser instrument sends is 1064nm; And the wavelength of the laser that the Nd:YLF pulse laser sends is 1053nm.The wavelength of the near-infrared laser pulse that laser instrument 11 is sent converts five frequency multiplication ultraviolet pulse lasers to, optional, can directly use frequency-doubling crystal to carry out five frequency multiplication operations; Optionally, can also carry out twice frequency multiplication near infrared pulsed laser and obtain laser of quadruple output, the near infrared pulsed laser before the laser of quadruple obtained and frequency multiplication is carried out mixing again, obtains five frequency multiplication ultraviolet pulse lasers; Optionally, can also carry out successively frequency multiplication and frequency tripling to the near infrared pulsed laser of laser instrument 11 outputs, then obtained double-frequency laser and frequency tripled laser be carried out to mixing, obtain five frequency multiplication ultraviolet pulse laser outputs.The wavelength of described five frequency multiplication ultraviolet pulse lasers is 165nm～210nm, for example: 165nm, 185nm or 210nm.Its pulse frequency is between 1Hz to 1GHz, and pulse width is between 10fs to 100ns.
Five frequency multiplication ultraviolet pulse lasers after optical maser wavelength conversion equipment 12 is processed and undressed near infrared pulsed laser are simultaneously from Optical Maser System output, and the laser of 4 pairs of Optical Maser Systems of control device 3 and arrangement for deflecting, 1 output is received and it is carried out to subsequent operation.
Control device 3 receives the laser that Optical Maser System 1 sends, and its inner transmitting device can be by Laser Transmission to measuring device 2, and laser measuring device for measuring 2 receives described laser, and uses its information for the treatment of therapentic part 6 to be surveyed.Control device 2 is two-way communication with Optical Maser System 1, it can receive the laser that Optical Maser System 1 sends, also can be according to the measurement result of measuring device 2, Optical Maser System 1 is controlled to the pulse strength of the laser sent to arrangement for deflecting 4 such as control Optical Maser System 1, pulsewidth, time etc.
Means of optical coherence tomography is generally used for imaging and measures biological tissue, so it for example is highly suitable for, in meticulous surgical operation: cerebral surgery operation, eye surgery etc.Optionally, described optical coherence tomography system 21 includes but not limited to time domain optical coherence tomography system, the domain optical coherence tomographic system based on spectrometer and the domain optical coherence tomographic system based on Sweep Source.Optical coherence tomography system 21 can be applied together to be provided in independent one-tenth shadow system unavailable other valuable information with associated, registration and improve and measure and analysis with other camera chains.For example, can be by the accurate operating distance of determining between tested tissue and imaging system in conjunction with optical coherence tomography system 21.As everyone knows, means of optical coherence tomography can produce high-definition picture, and this high-resolution can be used for the range measurement of clock like precision.Therefore, optical coherence tomography system 21 and measuring device 22 combine and can obtain the exact position at position 6 to be treated, in order to treat, therapentic part 6 is located accurately and accurate treatment.Optionally, measuring device 22 includes but not limited to: wavefront system, biostatistics's measuring system, laser surgery system, topographic surveying system etc.
Optionally, optical coherence tomography system 21 can be used various scan patterns, for example: zigzag scanning, discontinuously line by line scan, line by line scan continuously, helical scanning and/or circular scan.In addition, scanning speed can scanning between or scan period be conditioned.Scanning can further repeat once or several times.Optionally, scanning speed for example, between 80 microseconds to 120 micron per second: 80 microseconds, 100 microseconds or 120 microseconds.
Take measuring device 22 as the topography imager that includes placido cone be example.The laser that optical coherence tomography system 21 is sent with together with laser in combination that the topography imager sends by bonder 23 (beam splitter in described bonder 23).Optionally, can between bonder 23 and position to be treated 6, place an optical system (as the placido cone), in order to obtain better OCT information (as the degree of depth or the image-forming information at position 6 to be treated).The light path of measuring device 22 can obtain the image of the placido cone be projected on position to be treated.In this embodiment, the information at position 6 to be treated can be used from the clearly defined distance of the information of optical coherence tomography system 21 and use the information calculating from the placido cone of topographic surveying system.The interference signal that optical coherence tomography system 21 obtains can calculate the distance of position 6 to be treated with respect to reference position.Preferably, can analyze the interference signal that optical coherence tomography system 21 obtains with blood processor 25, and the information such as reference position at the position to be treated 6 that calculates are fed back to control device 3.
Optionally, described laser system also comprises display device, and described display device is connected with described measuring device, for showing the real-time pattern at position 6 to be treated.Control device 3 get that measuring device 2 sends for example, about the various information with therapentic part 6 (, with the position of therapentic part 6, angle, with the distance of Optical Maser System 1 etc.), and control arrangement for deflecting 4 according to above-mentioned information.
Arrangement for deflecting 4 generally includes two revolving mirrors that rotation axis is perpendicular to one another, and can make to come from by means of rotatablely moving of revolving mirror the laser beam lateral deflection of Optical Maser System 1.That is to say, can change two-dimensionally the position of the focus of laser pulse on position 6 to be treated by means of arrangement for deflecting 4 and focus optics 5, make focus can be placed in the arbitrfary point in position 6 to be treated.Optionally, the scope of the numerical aperture of described focus optics is 0.1～0.2, for example: 0.1,0.15 or 0.2.
Focus optics 5 also can comprise actuation element, and this actuation element can change bifocal size and/or the position of focus 5 on z direction (perpendicular to the direction of position to be treated 6 front surfaces).Therefore, can dimensionally change by arrangement for deflecting 4 and focus optics 5 co-operatings the position of the focus that laser beam forms on therapentic part 6.Preferably, the diameter of the focus in described position 6 to be treated is 0.5 μ m～2.5 μ m, for example: 0.5 μ m, 1.5 μ m or 2.5 μ m.
Control device 3 receives the laser pulse of Optical Maser System 1, and the information such as the frequency of this laser pulse, time are analyzed in order to the deflection of arrangement for deflecting 4 is synchronizeed with the laser pulse that Optical Maser System 1 sends, to avoid arrangement for deflecting 4 to move when not receiving laser pulse, lose the deflection of laser pulse is controlled.
Surgery provided by the invention is high by the laser system integrated level, and good stability is safe and reliable, has effectively improved operating safety.
Although describe in detail about example embodiment and advantage thereof, be to be understood that and can carry out various variations, substitutions and modifications to these embodiment in the situation that do not break away from the protection domain that spirit of the present invention and claims limit.For other examples, when those of ordinary skill in the art should easily understand within keeping protection domain of the present invention, the order of processing step can change.
In addition, range of application of the present invention is not limited to technique, mechanism, manufacture, material composition, means, method and the step of the specific embodiment of describing in description.From disclosure of the present invention, as those of ordinary skill in the art, will easily understand, for the technique, mechanism, manufacture, material composition, means, method or the step that have existed or be about to develop at present later, wherein they carry out identical function or the identical result of acquisition cardinal principle of corresponding embodiment cardinal principle of describing with the present invention, according to the present invention, can be applied them.Therefore, claims of the present invention are intended to these technique, mechanism, manufacture, material composition, means, method or step are included in its protection domain.
Claims (10)
1. a surgery laser system, described laser system comprises:
Optical Maser System, for exporting the required laser pulse of surgical operation, described laser pulse is near infrared pulsed laser and five frequency multiplication ultraviolet pulse lasers;
Measuring device, measure in real time for the feature for the treatment of therapentic part;
Control device, receive the measurement result of described measuring device, and control arrangement for deflecting according to described measurement result;
Arrangement for deflecting, for changing on described position to be treated and/or the position of the focus in described position to be treated;
Focus optics, for described femto-second laser pulse being focused on to the selected part at position to be treated, produce at least one focus; Described focus is apply described laser pulse on described position to be treated after, the two-dimentional diffraction structure that described position to be treated produces or hologram three-dimensional diffraction structure;
It is characterized in that,
Described Optical Maser System comprises: near infrared pulsed laser device and the optical maser wavelength conversion equipment be comprised of nonlinear crystal; The input of described optical maser wavelength conversion equipment is for receiving the near infrared pulsed laser that described near infrared pulsed laser device sends, and described near infrared pulsed laser is carried out to the wavelength conversion, the five frequency multiplication ultraviolet pulse lasers of the outfan of described optical maser wavelength conversion equipment for exporting pulsed infrared laser and obtaining through the wavelength conversion;
Described measuring device comprises: the optical coherence tomography system, scanned for treating therapentic part; One or more measuring devices; And bonder, described bonder is connected to described optical coherence tomography system and described one or more measuring device, and combined beam is provided.
2. laser system according to claim 1, is characterized in that, the wavelength of described near infrared pulsed laser is 850nm～1080nm, and the wavelength of described five frequency multiplication ultraviolet pulse lasers is 165nm～210nm.
3. laser system according to claim 1, is characterized in that, the scope of the numerical aperture of described focus optics is 0.1～0.2.
4. laser system according to claim 1, is characterized in that, the diameter of the focus in described position to be treated is 0.5 μ m～2.5 μ m.
5. laser system according to claim 1, it is characterized in that, described optical coherence tomography system comprises time domain optical coherence tomography system, the domain optical coherence tomographic system based on spectrometer and the domain optical coherence tomographic system based on Sweep Source.
6. laser system according to claim 1, is characterized in that, described measuring device is the topography imager that includes the placido cone.
7. laser system according to claim 1, is characterized in that, described bonder at least comprises a beam splitter, and described beam splitter is for combining the information that described measuring device obtains.
8. laser system according to claim 1, is characterized in that, in described optical maser wavelength conversion equipment, comprises frequency doubling device and mixer device.
9. laser system according to claim 1, is characterized in that, the Nd:YAG pulse laser that the near infrared pulsed laser device is semiconductor laser pumping or Nd:YLF pulse laser.
10. laser system according to claim 1, is characterized in that, described laser system also comprises display device, and described display device is connected with described measuring device, and show in real time the measurement result of described measuring device.
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| CN201310478676.7A CN103494640A (en) | 2013-10-15 | 2013-10-15 | Laser system for surgical department |
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| CN201310478676.7A CN103494640A (en) | 2013-10-15 | 2013-10-15 | Laser system for surgical department |
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