CN103480032B - A kind of argentiferous plural gel dressing and preparation method thereof - Google Patents
A kind of argentiferous plural gel dressing and preparation method thereof Download PDFInfo
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- CN103480032B CN103480032B CN201310439351.8A CN201310439351A CN103480032B CN 103480032 B CN103480032 B CN 103480032B CN 201310439351 A CN201310439351 A CN 201310439351A CN 103480032 B CN103480032 B CN 103480032B
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Abstract
The invention discloses a kind of argentiferous plural gel dressing and preparation method thereof, described argentiferous plural gel dressing, comprises shitosan, Nano Silver, glycerine and Geniposide. Taking natural macromolecular material as raw material, utilize nontoxic crosslinking technological, taking Geniposide as crosslinking agent, produce plural gel village material, Nano Silver is loaded on gel diaphragm and is made, can quick-acting haemostatic powder, analgesia; There is good biocompatibility, can be absorbed by the body, from dissolubility debridement, adhesion wound, " secondary injury " while having avoided to greatest extent more change dressings; For wound healing provides a positive moist environment, possess certain sepage absorbability, effectively promote organization healing; Reduce and stop scar forming, press down scar successful. The present invention has hemostasis, alleviating pain, impel slough to come off, isolate many effects such as pathogen, the protection surface of a wound, and be convenient to observe wound, make simple, cost is low.
Description
Technical field
The present invention relates to medicine equipment and preparing technical field thereof, relate in particular to a kind of argentiferous plural gel dressing and system thereofPreparation Method.
Background technology
Skin is the vitals of human body, and it plays and control body temperature, protects from infection and the work of body fluid loss, immunity and sensingWith. Due to reasons such as wound, scratch, exanthemv and burns, may cause the injury on a large scale of skin. The damage of skin is easyCause bacterium to infect, body fluid runs off and causes various complication. Conventionally adopt wound dressing to protect wound, prevent woundInfection and dehydration, maintain in wound be conducive to treatment wet environment, improve result for the treatment of, promote wound healing.
Normal gauze dressing gauze is processed by cotton, burlap conventionally, and absorbability is good, simple for production, cost is low, but nothingMethod keeps the surface of a wound moistening, and wound healing is slow, easily comes off, and surface of a wound granulation tissue is easily grown in the naked eyes of dressing, the workload of changing dressingsDamage greatly and easily cambium.
Although nonwoven absorbability increases, there are other shortcomings of gauze; Although plastic foil anti-adhesive gauze energyEnough prevent dressing fibre shedding, adhesion wound, but without absorbability, be difficult to fix.
The dressing of foam class is made up of polyurethane and polyoxyethylene glycol porous foam, and internal layer is hydrophily materialMaterial and skin are hydrophobic material, aim at and absorb sepage design, therefore there is stronger absorption function, keep moist environment, accelerate woundRecovery is closed, but inviscid, is not easy to fixingly and opaque, is not easy to observe wound situation.
The 3 D stereo that aerogel dressing is made up of gelatin, polysaccharide, many dielectric complexes compound and methacrylic resinNetted water imbibition polymer. Can there is aquation repeatedly while contact with tissue in this dressing, the moisture content in tissue is absorbed depositedIn material, along with the increase of water absorption, swelling is until reach balance gradually in dressing, and water imbibition is strong, high insulating effect, translucent being beneficial toObserve wound, but inviscid, be not easy to fixing and not strong to the buffer action of bacterium.
Summary of the invention
The object of this invention is to provide a kind of moist environment that both can maintain the surface of a wound, possess again certain sepage and absorb energyPower, viscosity is good, be convenient to fixing but adhesion wound, transparent, be convenient to observe wound situation, and has good antibacterial bacteriostatic and shortThe argentiferous plural gel dressing of healing function.
Another object of the present invention is to provide a kind of preparation method of described argentiferous plural gel dressing.
For realizing the technical scheme that object of the present invention adopts be: a kind of argentiferous plural gel dressing, comprises following weightThe constituent of amount part: shitosan 25000-35000 part, Nano Silver 100-300 part, glycerine 50-150 part, Geniposide 30-75Part, deionized water 5000-25000 part.
A preparation method for described argentiferous plural gel dressing, comprises the following steps:
A) by the weighed each raw material of described formulation ratio;
B) shitosan of described weight portion is scattered in the deionized water of described weight portion, after stirring, described in addingThe Nano Silver of weight portion and glycerine, make mixed liquor;
C) get described mixed liquor, add the Geniposide of described weight portion to be cross-linked, 35-40 DEG C of reaction 12-36hh.
The present invention is made up of natural macromolecular material shitosan and Nano Silver, taking natural macromolecular material as raw material, utilizesNontoxic crosslinking technological, taking Geniposide as crosslinking agent, produces plural gel village material, and Nano Silver is loaded on gel diaphragm and is made,Product is hydrogel state, and viscosity is good, be convenient to fixing but adhesion wound, transparent, be convenient to observe wound situation, can be surface of a wound dimensionHold a moistening environment, meet wound " wet union " theory, be conducive to wound healing, bactericidal nano-silver performance is splendid and anti-Bacterium spectrum is wide, can provide advantage for the surface of a wound, ensures wound healing; Shitosan moisturizing, refrigerant and comfortable, has accelerationHemostatic function, analgesia, can promote the formation of blood coagulation and thrombus, accelerates the secretion of III collagen, can be absorbed by the body, self-dissolvingProperty debridement, adhesion wound, thus promote the formation of granulation tissue and epithelial tissue, promote wound healing, reduce and stop scarTrace forms, and presses down scar successful, and has certain bacteria resistance function; Nano Silver mainly carries out bactericidal, prevent that bacterium from infecting function,And there is certain promotion wound healing function; Two kinds of compositions are combined together, and play Synergistic, the cumulative effect of function,Make product there is good sterilization, antibacterial and agglutinant dual-use function simultaneously. The present invention is by adopting Geniposide as crosslinkedAgent, abandoned conventional crosslinking agent glutaraldehyde and selected natural biological crosslinking agent Geniposide, thereby further reduce gel mouldCytotoxicity, improve the mechanical property of gel mould and slow down the degraded of gel mould; And by process optimization, be prepared into and have necessarily" half-dried " gel diaphragm of mechanical strength, both can maintain the moist environment of the surface of a wound, possesses again certain sepage absorbability, greatlyGround has improved the performance of effective promotion organization healing.
Argentiferous plural gel dressing of the present invention has the softness close with human body skin, and when moistening, one also can protectHold certain form and intensity; Can keep the moist environment of the surface of a wound, have the ability of good absorption wound exudate, and have certainGas permeability; Dressing is nontoxic, the reaction that human body is not harmful to and stimulation, and can stop bacterium to enter the surface of a wound to preventCause superinfection, avoid wound contact particle and poisonous pollutant; Have and have the effect such as hemostasis, pain relieving, can promote granulationGrowth and skin regeneration, healing acceleration, reduces scar; Excellent storage stability, has good degradability, and discarded object is to ringBorder does not produce pollution.
Argentiferous plural gel dressing of the present invention, flap coverage can antibacterial, antibacterial, anti-inflammatory anti-itch, effectively prevents germInfect; Can quick-acting haemostatic powder, analgesia; There is good biocompatibility, can be absorbed by the body, from dissolubility debridement, adhesion wound," secondary injury " while having avoided to greatest extent more change dressings; For wound healing provides a positive moist environment, possess oneFixed sepage absorbability, effectively promotes organization healing; Reduce and stop scar forming, press down scar successful. The present invention hasHemostasis, alleviating pain, impel slough to come off, isolate pathogen, many effects such as the protection surface of a wound etc., and be convenient to observe woundMouthful, make simple, cost is low, has good popularization and using value.
Detailed description of the invention
Argentiferous plural gel dressing of the present invention, comprises the constituent of following weight fraction: shitosan 25000-35000Part, Nano Silver 100-300 part, glycerine 50-150 part, Geniposide 30-75 part, deionized water 5000-25000 part.
Its preparation method, comprises the following steps:
A) by the weighed each raw material of described formulation ratio;
B) shitosan of described weight portion is scattered in the deionized water of described weight portion, after stirring, described in addingThe Nano Silver of weight portion and glycerine, make mixed liquor;
C) get described mixed liquor, add the Geniposide of described weight portion to be cross-linked, 35-40 DEG C is reacted 12-36h and get final product.
The present invention has the softness close with human body skin, and when moistening, one also can keep certain form and strongDegree; Can keep the moist environment of the surface of a wound, have the ability of good absorption wound exudate, and have certain gas permeability; Dressing withoutPoison, the reaction that human body is not harmful to and stimulation, and can stop bacterium to enter the surface of a wound in case major structure becomes superinfection, keep awayExempt from wound contact particle and poisonous pollutant; Have and have the effect such as hemostasis, pain relieving, can promote granulation growth and skin regeneration,Healing acceleration, reduces scar; Excellent storage stability, has good degradability, and discarded object does not produce pollution to environment. CoverThe lid surface of a wound can antibacterial, antibacterial, anti-inflammatory anti-itch, effectively prevents courses of infection; Can quick-acting haemostatic powder, analgesia; There is good biologyCompatibility, can be absorbed by the body, from dissolubility debridement, and adhesion wound, " the secondary wound while having avoided to greatest extent more change dressingsEvil "; For wound healing provides a positive moist environment, possess certain sepage absorbability, effectively promote organization healing;Reduce and stop scar forming, press down scar successful.
Below in conjunction with specific embodiment, the present invention will be further described.
Embodiment mono-
A kind of argentiferous plural gel dressing, comprises the constituent of following weight fraction: 25000 parts of shitosans, Nano Silver 100Part, 50 parts of glycerine, 30 parts of Geniposides, 5000 parts of deionized waters.
Its preparation method, comprises the following steps:
A) by the weighed each raw material of described formulation ratio;
B) shitosan of described weight portion is scattered in the deionized water of described weight portion, after stirring, described in addingThe Nano Silver of weight portion and glycerine, make mixed liquor;
C) get described mixed liquor, add the Geniposide of described weight portion to be cross-linked, 35 DEG C are reacted 12h and get final product.
Embodiment bis-
A kind of argentiferous plural gel dressing, comprises the constituent of following weight fraction: 28000 parts of shitosans, Nano Silver 180Part, 80 parts of glycerine, 45 parts of Geniposides, 15000 parts of deionized waters.
Its preparation method, comprises the following steps:
A) by the weighed each raw material of described formulation ratio;
B) shitosan of described weight portion is scattered in the deionized water of described weight portion, after stirring, described in addingThe Nano Silver of weight portion and glycerine, make mixed liquor;
C) get described mixed liquor, add the Geniposide of described weight portion to be cross-linked, 37 DEG C are reacted 18h and get final product.
Embodiment tri-
A kind of argentiferous plural gel dressing, comprises the constituent of following weight fraction: 32000 parts of shitosans, Nano Silver 250Part, 130 parts of glycerine, 65 parts of Geniposides, 20000 parts of deionized waters.
Its preparation method, comprises the following steps:
A) by the weighed each raw material of described formulation ratio;
B) shitosan of described weight portion is scattered in the deionized water of described weight portion, after stirring, described in addingThe Nano Silver of weight portion and glycerine, make mixed liquor;
C) get described mixed liquor, add the Geniposide of described weight portion to be cross-linked, 39 DEG C are reacted 30h and get final product.
Embodiment tetra-
A kind of argentiferous plural gel dressing, comprises the constituent of following weight fraction: 35000 parts of shitosans, Nano Silver100-300 part, 150 parts of glycerine, 75 parts of Geniposides, 25000 parts of deionized waters.
Its preparation method, comprises the following steps:
A) by the weighed each raw material of described formulation ratio;
B) shitosan of described weight portion is scattered in the deionized water of described weight portion, after stirring, described in addingThe Nano Silver of weight portion and glycerine, make mixed liquor;
C) get described mixed liquor, add the Geniposide of described weight portion to be cross-linked, 40 DEG C are reacted 36h and get final product.
Model case 1
Yin, man, 20 years old, ride motor tumble injury, large area scratch outside knee and forearm, scratches and grabs because of incrustation sufferings, causesIncrustation is come off hemorrhage, because worrying scar, use product argentiferous plural gel dressing of the present invention, after 7 days, wound is healed completelyClose, continue to use 10 days, scar completely without, recover normal skin, and without recurrence.
Model case 2
Shut out certain, man, 30 years old, shank II degree was scalded, and wound is because dealing with improperly, and the raw sore of suppurating, is used product argentiferous of the present inventionPlural gel dressing, after 3 days, fester disappears, and after 7 days, affected part area obviously dwindles, rear continuous application wound healing in 10 days, 30 daysRear scar disappears, and without sharp trace, rear continuous use 15 days, returns to one's perfect health, and it is normal that skin recovers, and the later stage pays a return visit without recurrence.
Model case 3
Cold certain, female, 55 years old, paralysis bed in traffic accident, the raw bedsore of stern, distributes stench, seek medical advice and have no resolution in many places, rear use thisBright product argentiferous plural gel dressing is treated, use continuously after 15 days, stench disappear, ambient color subtract fade red, 30 daysRear sore face obviously reduces, and cambium is ripe gradually, sore face healing after 70 days, and skin is ruddy, after 90 days, returns to one's perfect health, and skin is extensiveMultiple normal, the later stage pays a return visit without recurrence.
Claims (2)
1. an argentiferous plural gel dressing, is characterized in that: it comprises the constituent of following weight portion: shitosan 25000-35000 parts, Nano Silver 100-300 part, glycerine 50-150 part, Geniposide 30-75 part, deionized water 5000-25000 part.
2. a preparation method for argentiferous plural gel dressing as claimed in claim 1, is characterized in that: it comprises following stepRapid:
A) press the weighed each raw material of formulation ratio;
B) shitosan of described weight portion is scattered in the deionized water of described weight portion, after stirring, adds described weightNano Silver and the glycerine of part, make mixed liquor;
C) get described mixed liquor, add the Geniposide of described weight portion to be cross-linked, 35-40 DEG C is reacted 12-36h and get final product.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105214130A (en) * | 2015-07-20 | 2016-01-06 | 四川大学 | A kind of collagen-based wound dressing and preparation method thereof |
| CN106729941A (en) * | 2017-03-07 | 2017-05-31 | 南京林业大学 | A kind of preparation method of chitosan-based sponge dressing |
| CN109276747A (en) * | 2018-10-15 | 2019-01-29 | 苏州汇涵医用科技发展有限公司 | The preparation method of yellowing-resistant silver dressings |
| CN111035801B (en) * | 2020-01-14 | 2022-01-14 | 青岛科技大学 | Silver nanocluster based chitosan hydrogel dressing and preparation method and application thereof |
| CN113633627B (en) * | 2020-04-24 | 2023-06-16 | 华中科技大学 | Transparent photo-thermal antibacterial hydrogel patch, preparation and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101278896A (en) * | 2008-05-23 | 2008-10-08 | 山东赛克赛斯药业科技有限公司 | Chitosan nano silver gel agent and uses thereof |
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| CN102100923B (en) * | 2011-01-21 | 2013-08-14 | 陕西师范大学 | Preparation method of micron Ag2O2 doped chitosan hydrogel antibacterial auxiliary material |
| CN102847193B (en) * | 2012-07-04 | 2015-04-29 | 杭州科洛生物技术有限公司 | Chitosan fluid dressing film |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101278896A (en) * | 2008-05-23 | 2008-10-08 | 山东赛克赛斯药业科技有限公司 | Chitosan nano silver gel agent and uses thereof |
Non-Patent Citations (1)
| Title |
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| 京尼平对壳聚糖及明胶的交联反应;姚芳脸 等;《天津大学学报》;20071231;第40卷(第12期);第1485-1489页 * |
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Address after: Three 473000 Nanyang Road, Henan Province Li River eco industrial park Wei Patentee after: Henan Huibo Medical Co., Ltd. Address before: Three 473000 Nanyang Road, Henan Province Li River eco industrial park Wei Patentee before: Nanyang Hui Bo Bioisystech Co., Ltd |
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Address after: 473000 Nanyang City, Henan Province, the new energy economic and Technological Development Zone, the middle of the road in the middle of the road, ten Patentee after: Henan Huibo Medical Co., Ltd. Address before: Three 473000 Nanyang Road, Henan Province Li River eco industrial park Wei Patentee before: Henan Huibo Medical Co., Ltd. |