CN103472125A - Hall effect based neural tissue imaging method and device - Google Patents
Hall effect based neural tissue imaging method and device Download PDFInfo
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- CN103472125A CN103472125A CN2013103516116A CN201310351611A CN103472125A CN 103472125 A CN103472125 A CN 103472125A CN 2013103516116 A CN2013103516116 A CN 2013103516116A CN 201310351611 A CN201310351611 A CN 201310351611A CN 103472125 A CN103472125 A CN 103472125A
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Abstract
Belonging to nondestructive testing technologies, the invention discloses a Hall effect based neural tissue imaging method and a device. The method comprises: placing a sample into a static magnetic field, letting the short pulse ultrasound emitted by a focused ultrasound transducer pass through an ultrasonic coupling medium and then irradiate on the sample, leaving the ions in the sample to generate a current through a Hall effect under the action of the static magnetic field and ultrasound, recording the current signal intensity by means of electrodes disposed on the sample surface, and then reestablishing a sample image by a maximum value projection algorithm. The device includes a water tank loaded with the ultrasonic coupling medium, the focused ultrasound transducer, magnets, electrodes, a filter, a signal amplifier, a signal acquisition card, a power amplifier, a function signal generator, a sample lifting platform, a three-dimensional electric scanning platform, a motor drive, a computer equipped with acquisition control software and motor control software, a connecting rod and a plastic film. The method and the device provided in the invention can realize nondestructive, high contrast and high resolution neural tissue imaging.
Description
Technical field
The invention belongs to Non-destructive Testing Technique, particularly a kind of nerve fiber formation method and device based on Hall effect.
Background technology
Neuroimaging general reference can be directly or indirectly to the function of nervous system (being mainly brain), structure, and pharmacological characteristics carries out the technology of imaging.Neuroimaging is medical science, Neuscience, and a newer field of psychology.According to the pattern of imaging, neuroimaging can be divided into structure imaging, is used for representing the structure of brain, thus auxiliary for example, diagnosis to some cerebral diseases (brain tumor or brain trauma).Functional imaging, be used for representing brain and carrying out the metabolic activity of certain task when (comprising sensation, motion, the functions such as cognition).Functional imaging is mainly used in Neuscience and psychological study, but just progressively becomes the new way of medical nerve section diagnosis recently.
The method of common neuroimaging has: (1) computer tomography imaging (CT), and it is mainly used to brain is carried out to fast imaging, observes tissue edema and ventricles of the brain expansion that wound causes; (2) diffuse optical imaging,
, it can be used for measuring brain tissue to outside stimulus or the metabolic alterations when carrying out certain function, but the method can't be observed the activity of deep-brain; (3) Magnetic resonance imaging (MRI), MRI can produce high definition structure or the function image of brain.The MRI structural images can be used for neurology department for brain tumor, the diagnosis of cranial vascular disease (such as apoplexy) etc.The ultimate principle of function Magnetic resonance imaging (Functional Magnetic Resonance Imaging, fMRI) is oxygenated haemoglobin and the difference of deoxyhemoglobin on magnetic property and the brain blood flow variation of following brain neurological motion; Magneticencephalogram (Magnetoencephalography, MEG), it can directly measure nervous activity; Manually-injected radioactivity metabolite is used in positron emission imaging (Position Emission Tomography, PET), detects the positron of generation when changing material and decay in brain, produces the Brain mapping picture.
Above several formation method all can not be seen nerve fiber intuitively by the mode of image, nerve fiber formation method based on Hall effect, under the double action of ultrasonic and static magnetic field, utilize the conductivity of nerve fiber and its hetero-organization different, can observe intuitively by image the structure of nerve fiber, and analyze its function.It is a kind of not damaged, high-contrast, high-resolution formation method.
Summary of the invention
The object of the invention is to provide a kind of nerve fiber imaging device based on Hall effect; This device is simple to operate, and positioning precision is high; Can realize the nerve fiber imaging of high resolving power, high-contrast simultaneously.
A kind of nerve fiber imaging device based on Hall effect, it is characterized in that: this device comprises one of water tank, focused transducer, magnet or logical galvanic coil that the ultrasonic coupling medium is housed, electrode, wave filter, signal amplifier, data acquisition card, power amplifier, function signal generator, sample lifting table, three-D electric scanning platform, drive motor, with computing machine and connecting link that gather to control software and Electric Machine Control software, the water tank bottom that the ultrasonic coupling medium is housed has plastic sheeting;
Described focused transducer, power amplifier, function generator and be electrically connected successively with gathering the computing machine of controlling software and Electric Machine Control software; Described three-D electric scanning platform, drive motor and above-mentionedly with gathering the computing machine of controlling software and Electric Machine Control software, be electrically connected successively; Electrode, wave filter, signal amplifier, data acquisition card and above-mentionedly with gathering the computing machine of controlling software and Electric Machine Control software, be electrically connected successively; Described focused transducer is connected by connecting link with the three-D electric scanning platform.
The method that described a kind of nerve fiber imaging device based on Hall effect carries out imaging is characterized in that step is as follows:
(1) focused transducer is immersed in the ultrasonic coupling medium in the water tank that the ultrasonic coupling medium is housed;
(2) sample is placed on to sample lifting table top, is placed in the static magnetic field that one of magnet or logical galvanic coil send;
(3) plastic sheeting of the water tank bottom of ultrasonic coupling medium is equipped with in the sample contact, with the ultrasonic coupling medium, with plastic sheeting, separates;
(4) pulse signal that function signal generator produces is after power amplifier amplifies, pass to focused transducer, focused transducer and then send pulse ultrasonic wave, gather the computing machine of controlling software and Electric Machine Control software and send and start the trigger pip gathered to having simultaneously;
(5) pulse ultrasonic wave that focused transducer sends, after the ultrasonic coupling medium, arrives sample, and the ion in sample, under the acting in conjunction of static magnetic field and impulse ultrasound, Hall effect occurs, and then generation current;
(6) electrode receives current signal, after wave filter, by signal amplifier, is amplified, then by data collecting card, gathered, then by data transmission and be stored into having in computing machine that gather to control software and Electric Machine Control software;
(7) after having carried out the primary current signals collecting, the 3-D scanning electric platforms drives focused transducer and moves to the next position, continues transponder pulse ultrasonic, the excitation current signal;
(8), after having gathered whole current signals, reconstruct the image of sample by the maximal value projection algorithm.
Action principle of the present invention is: sample is as in static magnetic field, the short pulse that focused transducer sends is ultrasonic after the ultrasonic coupling medium, be radiated on sample, ion in sample under static magnetic field and ultrasonic effect by the Hall effect generation current, by being placed on the electrode record current signal intensity of sample surfaces, the focus supersonic detector is after the three-D electric scanning platform drives scanning, ultrasonication is carried out in the positions different to sample, and the current signal of each position collected is rebuild the image of nerve fiber by the method for maximal value projection.
With existing neuroimaging method, compare, the present invention has following advantage:
1) the present invention carries out the nerve fiber imaging by ultrasound wave and static magnetic field acting in conjunction, is a kind of undamaged nerve fiber formation method;
2) the present invention uses focused transducer, and the ultrasound wave of emission focuses on neural position, can high resolving power, high-contrast nerve fiber is carried out to imaging;
3) the present invention uses three-D electric scanning platform drive focused transducer to carry out nerve stimulation, can realize quick nerve fiber imaging.
The accompanying drawing explanation
Fig. 1 is the schematic diagram of the described nerve fiber imaging based on Hall effect of embodiment 1, is wherein ultrasonic, and 2 is electric current, and 3 and 4 is nerve fiber, and 5 is static magnetic field.
Fig. 2 is the structural representation of the described a kind of nerve fiber imaging device based on Hall effect of embodiment 1, wherein 1 for magnet, 2 for focused transducer, 3 for electrode, 4 for wave filter, 5 for signal amplifier, 6 for data acquisition card, 7 for the computing machine with gather controlling software and Electric Machine Control software, 8 for drive motor, 9 for three-D electric scanning platform, 10 for connecting link, 11 for function signal generator, 12 for power amplifier, 13 for plastic sheeting, 14 for sample lifting table, 15 for the water tank of ultrasonic coupling medium is housed.
Embodiment
Below in conjunction with embodiment and accompanying drawing, the present invention is described in further detail
Embodiment 1: a kind of nerve fiber imaging device (structural representation as shown in Figure 1) based on Hall effect
This device comprise 1 for magnet, 2 for focused transducer, 3 for electrode, 4 for wave filter, 5 for signal amplifier, 6 for data acquisition card, 7 for the computing machine with gather controlling software and Electric Machine Control software, 8 for drive motor, 9 for three-D electric scanning platform, 10 for connecting link, 11 for function signal generator, 12 for power amplifier, 13 for plastic sheeting, 14 for sample lifting table, 15 for the water tank of ultrasonic coupling medium is housed.Described focused transducer 2, power amplifier 12 and function generator 11 and be electrically connected successively with computing machine 7 that gather to control software and Electric Machine Control software.Described focused transducer 2 is connected by connecting link 10 with three-D electric scanning platform 9.The signal that described function generator 11 sends passes to focused transducer 2 and produces ultrasound wave after power amplifier 3 amplifies, and to there being the computing machine 7 that gathers control software and Electric Machine Control software to send trigger pip, computing machine carries out data acquisition simultaneously.Sample is placed in described water tank 15 belows that the ultrasonic coupling medium is housed, and sample and ultrasonic coupling medium are separated by plastic sheeting 13.The ultrasound wave that described focused transducer 2 sends, after the ultrasonic coupling medium, arrives nerve fiber, under the effect of static magnetic field, and generation current signal in nerve fiber.Described focused transducer 2 is connected with 3-D scanning electric platforms 9 by connecting link 5, controls it by the computing machine 7 that collection control software and Electric Machine Control software are housed and moves.After ultrasonic irradiation is carried out in a certain position of nerve fiber, 3-D scanning electric platforms 9 drives focused transducer 2 and moves to the next position, proceed to irradiate, until carry out image reconstruction by the maximal value projection algorithm after the been scanned of all positions, for stability and the feasibility of verifying this experimental provision, we carry out imaging by the nerve fiber in vitro, and experimental result shows that this system can clearly reconstruct the image of nerve fiber.
Above-described embodiment is preferably embodiment of the present invention; but embodiments of the present invention are not restricted to the described embodiments; other any do not deviate from change, the modification done under Spirit Essence of the present invention and principle, substitutes, combination, simplify; all should be equivalent substitute mode, within being included in protection scope of the present invention.
Claims (2)
1. the nerve fiber imaging device based on Hall effect, it is characterized in that: this device comprises one of water tank, focused transducer, magnet or logical galvanic coil that the ultrasonic coupling medium is housed, electrode, wave filter, signal amplifier, data acquisition card, power amplifier, function signal generator, sample lifting table, three-D electric scanning platform, drive motor, with computing machine and connecting link that gather to control software and Electric Machine Control software, the water tank bottom that the ultrasonic coupling medium is housed has plastic sheeting;
Described focused transducer, power amplifier, function generator and be electrically connected successively with gathering the computing machine of controlling software and Electric Machine Control software; Described three-D electric scanning platform, drive motor and above-mentionedly with gathering the computing machine of controlling software and Electric Machine Control software, be electrically connected successively; Electrode, wave filter, signal amplifier, data acquisition card and above-mentionedly with gathering the computing machine of controlling software and Electric Machine Control software, be electrically connected successively; Described focused transducer is connected by connecting link with the three-D electric scanning platform.
2. application rights requires the method that 1 described a kind of nerve fiber imaging device based on Hall effect carries out imaging, it is characterized in that step is as follows:
(1) focused transducer is immersed in the ultrasonic coupling medium in the water tank that the ultrasonic coupling medium is housed;
(2) sample is placed on to sample lifting table top, is placed in the static magnetic field that one of magnet or logical galvanic coil send;
(3) plastic sheeting of the water tank bottom of ultrasonic coupling medium is equipped with in the sample contact, with the ultrasonic coupling medium, with plastic sheeting, separates;
(4) pulse signal that function signal generator produces is after power amplifier amplifies, pass to focused transducer, focused transducer and then send pulse ultrasonic wave, gather the computing machine of controlling software and Electric Machine Control software and send and start the trigger pip gathered to having simultaneously;
(5) pulse ultrasonic wave that focused transducer sends, after the ultrasonic coupling medium, arrives sample, and the ion in sample, under the acting in conjunction of static magnetic field and impulse ultrasound, Hall effect occurs, and then generation current;
(6) electrode receives current signal, after wave filter, by signal amplifier, is amplified, then by data collecting card, gathered, then by data transmission and be stored into having in computing machine that gather to control software and Electric Machine Control software;
(7) after having carried out the primary current signals collecting, the 3-D scanning electric platforms drives focused transducer and moves to the next position, continues transponder pulse ultrasonic, the excitation current signal;
(8), after having gathered whole current signals, reconstruct the image of sample by the maximal value projection algorithm.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104759039A (en) * | 2015-04-22 | 2015-07-08 | 燕山大学 | Transcranial Hall effect brain regulating and controlling device and method |
| CN104857640A (en) * | 2015-04-22 | 2015-08-26 | 燕山大学 | Closed-loop type transcranial ultrasonic brain stimulation apparatus |
| CN105251141A (en) * | 2015-10-10 | 2016-01-20 | 燕山大学 | Closed-loop transcranial magnetoacoustic stimulation device |
| CN105251125A (en) * | 2015-10-10 | 2016-01-20 | 燕山大学 | Integrated device of transcranial magnetoacoustic stimulation and electroencephalogram detection |
| CN107320860A (en) * | 2017-05-18 | 2017-11-07 | 北京宏强富瑞技术有限公司 | A kind for the treatment of head position detecting circuit |
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| WO2000019243A1 (en) * | 1998-09-30 | 2000-04-06 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Ultrasound probes implementing waveguide shielding and active compensation of noise |
| US6520911B1 (en) * | 1996-07-03 | 2003-02-18 | The United States Of America As Represented By The Department Of Health And Human Services | Ultrasound-hall effect imaging system and method |
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2013
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Patent Citations (2)
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| US6520911B1 (en) * | 1996-07-03 | 2003-02-18 | The United States Of America As Represented By The Department Of Health And Human Services | Ultrasound-hall effect imaging system and method |
| WO2000019243A1 (en) * | 1998-09-30 | 2000-04-06 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Ultrasound probes implementing waveguide shielding and active compensation of noise |
Non-Patent Citations (2)
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| HAN WEN: "Volumetric Hall Effect Tomography – A Feasibility Study", 《ULTRASON IMAGING》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104759039A (en) * | 2015-04-22 | 2015-07-08 | 燕山大学 | Transcranial Hall effect brain regulating and controlling device and method |
| CN104857640A (en) * | 2015-04-22 | 2015-08-26 | 燕山大学 | Closed-loop type transcranial ultrasonic brain stimulation apparatus |
| CN105251141A (en) * | 2015-10-10 | 2016-01-20 | 燕山大学 | Closed-loop transcranial magnetoacoustic stimulation device |
| CN105251125A (en) * | 2015-10-10 | 2016-01-20 | 燕山大学 | Integrated device of transcranial magnetoacoustic stimulation and electroencephalogram detection |
| CN107320860A (en) * | 2017-05-18 | 2017-11-07 | 北京宏强富瑞技术有限公司 | A kind for the treatment of head position detecting circuit |
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