CN103463139A - Preparation method of extracting anti-inflammation, detumescent and itching-relieving paste for skins from micro-algae meal - Google Patents
Preparation method of extracting anti-inflammation, detumescent and itching-relieving paste for skins from micro-algae meal Download PDFInfo
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Abstract
The invention specifically provides a preparation method of extracting an anti-inflammation, detumescent and itching-relieving paste for skins from micro-algae meal. Specifically, the method comprises the following steps of taking the micro-algae meal produced by a process for producing docosahexoenoic acid from microalgae as a raw material, firstly smashing the micro-algae meal into powder, then adding ethanol, stirring uniformly with stirring, cooling, centrifuging, taking a liquid supernatant, indirectly heating the liquid supernatant, vacuumizing, and concentrating to a sticky state, thus obtaining the skin anti-inflammation, detumescent and itching-relieving paste extracted from the micro-algae meal. A produced skin externally-applied paste has the functions of resisting bacteria, relieving itching, eliminating inflammation and detumescing, and is suitable for locally treating neurodermatitis, contact dermatitis, chronic eczema, insect bite dermatitis and itch dermatoses. The production process is non-toxic, harmless and pollution-free, changes algal meal scrap wastes into medicine products, greatly increases utilization rate of the wastes, is an excellent, stable and reliable production method for the externally-applied skin anti-inflammation, detumescent and itching-relieving paste, efficiently uses the wastes, and has significant social and economic benefits.
Description
Technical field
The invention belongs to the biological medicine technology field, the present invention has more specifically related to a kind of preparation method and application thereof of skin anti-inflammation detumescence itching-relieving cream of microalgae dregs of rice extraction.
Background technology
Skin pruritus, redness, inflammation are common dermatosiss, are also one of a kind of frequently-occurring diseases, have a strong impact on people's health, usually are divided into neurodermatitis, contact dermatitis, chronic eczema, insect bite dermatitis and itching skin disease etc.The patient feels pruritus, pain, numbness, scorching hot etc. and be unable to bear scratching or rubbing usually, can cause skin scar, and severe patient can cause skin carcinoma.Therefore, the antipruritic nontoxic medicine had no side effect of a kind of skin anti-inflammation detumescence of specially good effect is that many patients are urgently required, and microalgae dregs of rice extract just has this good function.Microalgae is for extracting the DHA(docosahexenoic acid as schizochytrium limacinum algae (Schizochytrium sp.), my Ken Shi kettle algae (Ulkenia amoeboida), Kou Shi Crypthecodinium cohnii (Crypthecodinium cohnii) etc.) after, not only contain micro residue DHA, phospholipid in its residue Seaweed meal, and contain a certain amount of protein, polypeptide, oligopeptide, aminoacid and polysaccharide etc., raw material is used in the medicine extraction that is a kind of food source, has been proved its nontoxic having no side effect.Wherein DHA is docosahexenoic acid, is commonly called as NAOHUANGJIN, is a kind of to the very important polyunsaturated fatty acid of human body, belongs to the important member in Omega-3 unsaturated fatty acid family.Extracting pharmaceutical material from oil expression leftover bits and pieces Seaweed meal, is that refuse is become to the dotey, is the resource reutilization of a brilliance, important medical usage is not only arranged, but also environment is played to beyond thought protective effect.Treat dermopathic application with microalgae dregs of rice extract, there is no so far bibliographical information.Therefore, preparation method and the application tool thereof of developing the anti-inflammation detumescence itching-relieving cream that a kind of microalgae dregs of rice extract are of great significance.
Summary of the invention
The present invention seeks to for the problems referred to above, a kind of preparation method that can effectively treat the skin anti-inflammation detumescence itching-relieving cream extracted by the microalgae dregs of rice of neurodermatitis, contact dermatitis, chronic eczema, insect bite dermatitis, itching skin disease and pruritus vulvae is provided.This preparation method is simple to operate, not high to equipment requirements, and prepared product is nontoxic to have no side effect, improve the utilization rate of microalgae raw material, environmental protection, its product of preparing is applied to treat the dermatosis aspect, antiinflammatory, detumescence, antipruritic effect are remarkable, and application prospect is boundless.
for realizing this purpose, the present invention adopts following technical scheme:
A kind of preparation method of being extracted skin anti-inflammation detumescence itching-relieving cream by the microalgae dregs of rice, the microalgae dregs of rice that the microalgae of take is produced docosahexenoic acid (DHA) are raw material, first the microalgae dregs of rice are ground into to powder, then add ethanol, the limit edged stirs, cooling rear centrifuging and taking supernatant, this supernatant of indirect, evacuation is concentrated into sticky shape, the skin anti-inflammation detumescence itching-relieving cream must this microalgae dregs of rice extracted.
Described microalgae include but not limited to natural or the fermentation the thalline microalgae, as the schizochytrium limacinum algae (
schizochytriumsp.), my Ken Shi kettle algae (
ulkenia amoeboida), the Kou Shi Crypthecodinium cohnii (
crypthecodinium cohnii) etc.
A kind of preparation method of being extracted skin anti-inflammation detumescence itching-relieving cream by the microalgae dregs of rice, its concrete preparation process is as follows:
1) the microalgae dregs of rice are crushed to powder without graininess;
2) add while stirring warm ethanol, until by microalgae dregs of rice powder dissolution;
3), after being cooled to room temperature, centrifugal supernatant and the precipitation of separating, get supernatant;
4) this supernatant of indirect, evacuation, desolvation is sloughed fishy smell;
5) be concentrated into sticky shape, obtain the skin anti-inflammation detumescence itching-relieving cream that these microalgae dregs of rice extract.
The ethanol that described ethanol is mass concentration 95%, its add quality be microalgae dregs of rice powder 3-6 doubly, the temperature of described ethanol is 30-45 ℃, the time that described limit edged stirs is 0.5 to 2 hour.Described centrifugal for revolution is limited in 4500-8000 rpm, the time is controlled at 10-20 min.Described indirect includes but not limited to water-bath, the equipment of similar functions, and described temperature is 45-50 ℃, and described evacuation vacuum is in the 0.09-0.1MPa scope, and the time is controlled at 1-2 hour.Described supernatant process heats the sticky shape material of evacuation acquisition but is not limited to pasty masses, both obtains the skin anti-inflammation detumescence itching-relieving cream that the microalgae dregs of rice extract.
The skin anti-inflammation detumescence itching-relieving cream extracted by the microalgae dregs of rice of the present invention, contain polypeptide and oligopeptide, polysaccharide, each seed amino acid and micro-DHA that abundant phospholipid comprises lecithin, multiple proteins, nervous system regulation is arranged, promotes cell proliferation, application international advanced technology equipment Q-TOF carries out the component molecules quality determination, the quality of its main molecules is: 859.4295Da, 860.4247Da, 861.4265Da, 881.3959Da, 897.3695Da, 655.3727Da, 629.3989Da, 572.3506Da, 457.2188Da; 845.4148 Da, 846.4137Da, 847.4132Da, 867.3830Da, 883.3513Da, 641.3594Da, 558.3416 Da, 450.2122Da; 768.3970Da, 769.4003Da, 806.3417Da, 640.3295Da, 431.2219Da, 411.7028Da, 385.7471 Da, 384.7480Da; 359.2596Da, 377.2340Da, 431.2219Da, 445.1986Da, 447.2154Da, 463.1877Da, 465.2006Da, 493.1587Da, 521.2416 Da, 558.2595 Da, 605.3124 Da, 658.3226 Da, 674.3123 Da; 314.0943Da, 336.0898 Da, 364.2172 Da, 393.2314Da.It not only can kill the antibacterial of skin surface, can also eliminate the inflammatory reaction caused by neutrophilic granulocyte, the skin surface cell is had to repair simultaneously.Therefore, described skin anti-inflammation detumescence itching-relieving cream is for the preparation of topical therapeutic medicine or the sterilizing article for the treatment of neurodermatitis, contact dermatitis, chronic eczema, insect bite dermatitis, itching skin disease and pruritus vulvae.
The main component of described skin anti-inflammation detumescence itching-relieving cream is that to take lecithin, DHA be substrate, and include any of above-mentioned molecular weight or surpass the inclusion of the skin anti-inflammation detumescence itching-relieving cream that the microalgae dregs of rice that a kind of material forms extract, also there is the antipruritic effect of anti-inflammation detumescence, be applicable to topical therapeutic or the sterilizing article of neurodermatitis, contact dermatitis, chronic eczema, insect bite dermatitis and itching skin disease and pruritus vulvae.
remarkable advantage of the present invention is:the involved in the present invention skin anti-inflammation detumescence itching-relieving cream extracted by the microalgae dregs of rice, there is curative effect fast, effective, efficacy stability, easy to use, the raw material microalgae dregs of rice are from the microalgae mushroom, the microalgae mushroom belongs to the raw-food material source of the food nutrition supplement DHA that the pressure of state approval adds, in this production process also without the use of any poisonous and hazardous chemical reagent, therefore, nontoxic the having no side effect of microalgae dregs of rice skin anti-inflammatory anti-itch cream that the inventive method is prepared, environmental protection, the skin disease ointment that is better than selling on existing market, improved the utilization rate of microalgae raw material, drug effect is remarkable, there is significant society and economic benefit.
The accompanying drawing explanation
Fig. 1 is situation before and after the skin anti-inflammation detumescence itching-relieving cream that after mosquito bite, dermatitis patients is used the microalgae dregs of rice of the present invention to extract voluntarily.
Fig. 2 is that the Q-TOF level Four bar flight time tandem mass spectrometer of the main component of the skin anti-inflammation detumescence itching-relieving cream extracted by the microalgae dregs of rice of the present invention is analyzed collection of illustrative plates, wherein abscissa means mass-to-charge ratio (m/z) value of ion, vertical coordinate means the intensity of ion flow, usually mean with relative intensity, the strongest ion flow intensity is decided to be to 100%.
the specific embodiment
Below in conjunction with embodiment, further set forth the present invention.These implementation examples only are not used in and limit the scope of the invention for the present invention is described.
One, following all related all preparation methoies by microalgae dregs of rice skin anti-inflammation detumescence itching-relieving cream of embodiment of enumerating, all there is the method the present invention relates to and be not limited to cited method, following examples are preferred embodiment of the present invention, all equalizations of doing according to the present patent application the scope of the claims change and modify, and all should belong to covering scope of the present invention.
Take schizochytrium limacinum algae DHA(docosahexenoic acid) oily leftover bits and pieces Seaweed meal 1 kg, be ground into powder without graininess; The ethanol that the concentration that adds warm 30 ℃ of 3 L is 95%, limit edged 0.5 h that stirs, until by the Seaweed meal powder dissolution; After being cooled to room temperature, centrifugal revolution is 4500 rpm, and centrifugal 10min separates supernatant and precipitation, gets supernatant; Supernatant is steamed in 45 ℃ of water-baths, and vacuum is under 0.09 MPa condition, evacuation 1 h, and desolvation is sloughed fishy smell; Be concentrated into sticky colloid, both skin anti-inflammation detumescence itching-relieving cream of the present invention.
embodiment 2
Take my Ken Shi kettle algae DHA(docosahexenoic acid) oily leftover bits and pieces Seaweed meal 1 kg, be ground into powder without graininess; The ethanol that the concentration that adds warm 40 ℃ of 4 L is 95%, limit edged 1 h that stirs, until by the Seaweed meal powder dissolution; After being cooled to room temperature, centrifugal revolution is 5000 rpm, and centrifugal 20 min separate supernatant and precipitation, get supernatant; Supernatant is steamed in 46 ℃ of water-baths, and vacuum is under 0.095 MPa condition, evacuation 1 h, and desolvation is sloughed fishy smell; Be concentrated into sticky cream matter, both skin anti-inflammation detumescence itching-relieving cream of the present invention.
embodiment 3
Take Kou Shi Crypthecodinium cohnii DHA(docosahexenoic acid) oily leftover bits and pieces Seaweed meal 1 kg, be ground into powder without graininess; The ethanol that the concentration that adds warm 50 ℃ of 5 L is 95%, limit edged 1.5 h that stir, until by the Seaweed meal powder dissolution; After being cooled to room temperature, centrifugal revolution is 6000 rpm, and centrifugal 15 min separate supernatant and precipitation, get supernatant; Supernatant is steamed in 47 ℃ of water-baths, and vacuum is under 0.095 MPa condition, evacuation 1 h, and desolvation is sloughed fishy smell; Be concentrated into viscous fluid, both skin anti-inflammation detumescence itching-relieving cream of the present invention.
Take schizochytrium limacinum algae DHA(docosahexenoic acid) oily leftover bits and pieces Seaweed meal 1 kg, be ground into powder without graininess; The ethanol that the concentration that adds warm 50 ℃ of 6 L is 95%, limit edged 1.5 h that stir, until by the Seaweed meal powder dissolution; After being cooled to room temperature, centrifugal revolution is 7000 rpm, and centrifugal 20 min separate supernatant and precipitation, get supernatant; Utilize 48 ℃ of indirect supernatant of heater, vacuum is under 0.1 MPa condition, evacuation 1.5 h, and desolvation is sloughed fishy smell; Be concentrated into sticky colloid, both skin anti-inflammation detumescence itching-relieving cream of the present invention.
embodiment 5
Take my Ken Shi kettle algae DHA(docosahexenoic acid) oily leftover bits and pieces Seaweed meal 1 kg, be ground into powder without graininess; The ethanol that the concentration that adds warm 50 ℃ of 6 L is 95%, limit edged 2 h that stir, until by the Seaweed meal powder dissolution; After being cooled to room temperature, centrifugal revolution is 8000 rpm, and centrifugal 20min separates supernatant and precipitation, gets supernatant; Utilize 50 ℃ of indirect supernatant of heater, vacuum is under 0.1 MPa condition, evacuation 2h, and desolvation is sloughed fishy smell; Be concentrated into sticky cream matter, both skin anti-inflammation detumescence itching-relieving cream of the present invention.
embodiment 6
The skin anti-inflammation detumescence itching-relieving cream extracted by the microalgae dregs of rice of the present invention, application international advanced technology equipment Q-TOF level Four bar flight time tandem mass spectrometer carries out the component molecules quality determination, in mass spectrum, abscissa means mass-to-charge ratio (m/z) value of ion, from left to right the value of mass-to-charge ratio increases, for with unicharged ion, the numerical value that abscissa means is the quality of ion; Vertical coordinate means the intensity of ion flow, usually with relative intensity, means, the strongest ion flow intensity is decided to be to 100%, and the intensity of other ion flow means with its percent.As shown in Figure 2, the quality of its main molecules is: 859.4295Da, 860.4247Da, 861.4265Da, 881.3959Da, 897.3695Da, 655.3727Da, 629.3989Da, 572.3506Da, 457.2188Da; 845.4148 Da, 846.4137Da, 847.4132Da, 867.3830Da, 883.3513Da, 641.3594Da, 558.3416 Da, 450.2122Da; 768.3970Da, 769.4003Da, 806.3417Da, 640.3295Da, 431.2219Da, 411.7028Da, 385.7471 Da, 384.7480Da; 359.2596Da, 377.2340Da, 431.2219Da, 445.1986Da, 447.2154Da, 463.1877Da, 465.2006Da, 493.1587Da, 521.2416 Da, 558.2595 Da, 605.3124 Da, 658.3226 Da, 674.3123 Da; 314.0943Da, 336.0898 Da, 364.2172 Da, 393.2314Da, contain polypeptide and oligopeptide, polysaccharide, each seed amino acid and micro-DHA that abundant phospholipid comprises lecithin, multiple proteins, nervous system regulation is arranged, promotes cell proliferation.
Two, following all related all microalgae dregs of rice anti-inflammation detumescence itching-relieving creams of embodiment of enumerating, all have the pharmic function the present invention relates to and be not limited to cited function.
Clinical case 2, Gulou District Miss Lin of Fuzhou City, 25 years old age, unknown cause instep redness, blister, very to itch hard to bearly, diagnosis is pimple dermatitis, use the doctor to reopen after a cessation of business and sell ointment, without significant curative effect, use the skin anti-inflammation detumescence itching-relieving cream extracted by the microalgae dregs of rice of the present invention instead, after coating, antipruritic immediately, recovery from illness in 3 days.
embodiment 9
Clinical case 3, Fuzhou City's Taijiang District Mr. Chen, at 45 years old age, be that waist belt contact skin causes skin of lumbar region redness, blister, touches and itch, and smears the skin anti-inflammation detumescence itching-relieving cream that the microalgae dregs of rice of the present invention extract, after coating, contact has not itched, the red and swollen disappearance after 2 hours, and bubble tightens, broken skin place incrustation, recovery from illness in 3 days.
embodiment 10
embodiment 11
Clinical case 5, Gulou District Mrs Jiang of Fuzhou City, 35 years old age, the neck cervical region goes out flat pimple, and play is itched hard to bear, and the scratching skin is broken, diagnosis is neurodermatitis, use the doctor to reopen after a cessation of business and sell ointment, without significant curative effect, use the skin anti-inflammation detumescence itching-relieving cream extracted by the microalgae dregs of rice of the present invention instead, after coating, itch and disappear at once, redness dies down, recovery from illness afterwards in 3 days.
embodiment 12
The human body skin irritation test: select the adult of skin health, former regiones brachii medialis territory is tested position, and a side is trial zone, and opposite side is check plot, gets four layers of hospital gauze and is cut into 1 cm
2, the skin anti-inflammation detumescence itching-relieving cream of coating the present embodiment 1 is 0.05 g approximately, is attached to forearm inboard and cover polyacrylic film, with medical proof fabric, fix, and the edible maror of the suitable user of duration of test, irritable food, the experiment position does not get wet.Within 24 hours, open observation, the experiment position is all aobvious negative, without erythema, pimple, edema or other allergic phenomenas, occurs, test occurs without erythema, pimple, edema or other allergic phenomenas continuously, test continuous week age, prove the skin nonirritant, and nontoxic having no side effect.
Same, embodiment 2,3,4 and 5 has also been done to corresponding human body skin irritation test, the effect of result of the test and embodiment 1 is without significant difference, therefore do not repeat at this.
Claims (10)
1. a preparation method of being extracted skin anti-inflammation detumescence itching-relieving cream by the microalgae dregs of rice, it is characterized in that: the microalgae dregs of rice that the microalgae of take is produced docosahexenoic acid DHA are raw material, first Seaweed meal is ground into to powder, then add ethanol, the limit edged stirs, cooling rear centrifuging and taking supernatant, this supernatant of indirect, evacuation is concentrated into sticky shape, the skin anti-inflammation detumescence itching-relieving cream must this microalgae dregs of rice extracted.
2. the preparation method of being extracted skin anti-inflammation detumescence itching-relieving cream by the microalgae dregs of rice according to claim 1, it is characterized in that: described microalgae comprises thalline microalgae natural or fermentation.
3. the preparation method of being extracted skin anti-inflammation detumescence itching-relieving cream by the microalgae dregs of rice according to claim 1, its feature exists: its concrete preparation process is as follows:
1) the microalgae dregs of rice are crushed to powder without graininess;
2) add while stirring warm ethanol, until by microalgae dregs of rice powder dissolution;
3), after being cooled to room temperature, centrifugal supernatant and the precipitation of separating, get supernatant;
4) this supernatant of indirect, evacuation, desolvation is sloughed fishy smell;
5) be concentrated into sticky shape, obtain the skin anti-inflammation detumescence itching-relieving cream that these microalgae dregs of rice extract.
4. according to the described preparation method of being extracted skin anti-inflammation detumescence itching-relieving cream by the microalgae dregs of rice of claim 1 or 3, it is characterized in that: the ethanol that described ethanol is mass concentration 95%, its add quality be microalgae dregs of rice powder 3-6 doubly, the temperature of described ethanol is 30-45 ℃, the time that described limit edged stirs is 0.5 to 2 hour, described centrifugal revolution is 4500-8000 rpm, and the time is 10-20 min.
5. according to the described preparation method of being extracted skin anti-inflammation detumescence itching-relieving cream by the microalgae dregs of rice of claim 1 or 3, it is characterized in that: described indirect includes but not limited to water-bath, described temperature is 45-50 ℃, described evacuation vacuum is in the 0.09-0.1MPa scope, and the time is controlled at 1-2 hour.
6. according to the described preparation method of being extracted skin anti-inflammation detumescence itching-relieving cream by the microalgae dregs of rice of claim 1 or 3, it is characterized in that: the sticky shape material that described supernatant obtains through the heating evacuation is not limited to pasty masses, has both obtained the skin anti-inflammation detumescence itching-relieving cream that the microalgae dregs of rice extract.
7. the skin anti-inflammation detumescence itching-relieving cream that method is extracted as claimed in claim 1, it is characterized in that: composition comprises lecithin, protein, polypeptide, oligopeptide, aminoacid, DHA, polysaccharide, the molecular mass of the main component that it comprises is distributed as: 859.4295Da, 860.4247Da, 861.4265Da, 881.3959Da, 897.3695Da, 655.3727Da, 629.3989Da, 572.3506Da, 457.2188Da; 845.4148 Da, 846.4137Da, 847.4132Da, 867.3830Da, 883.3513Da, 641.3594Da, 558.3416 Da, 450.2122Da; 768.3970Da, 769.4003Da, 806.3417Da, 640.3295Da, 431.2219Da, 411.7028Da, 385.7471 Da, 384.7480Da; 359.2596Da, 377.2340Da, 431.2219Da, 445.1986Da, 447.2154Da, 463.1877Da, 465.2006Da, 493.1587Da, 521.2416 Da, 558.2595 Da, 605.3124 Da, 658.3226 Da, 674.3123 Da; 314.0943Da, 336.0898 Da, 364.2172 Da, 393.2314Da.
8. the application of the skin anti-inflammation detumescence itching-relieving cream that method is extracted as claimed in claim 1 is characterized in that: described skin anti-inflammation detumescence itching-relieving cream is for the preparation of medicine or the sterilizing article for the treatment of neurodermatitis, contact dermatitis, chronic eczema, insect bite dermatitis, itching skin disease or pruritus vulvae.
9. the application of skin anti-inflammation detumescence itching-relieving cream according to claim 8, it is characterized in that: the main component of described skin anti-inflammation detumescence itching-relieving cream is that to take lecithin, DHA be substrate, and includes any of the described molecular weight of claim 7 or surpass the inclusion of the skin anti-inflammation detumescence itching-relieving cream that the microalgae dregs of rice that a kind of material forms extract.
10. the application of skin anti-inflammation detumescence itching-relieving cream according to claim 9, it is characterized in that: the inclusion of described skin anti-inflammation detumescence itching-relieving cream has effect claimed in claim 9, is applicable to topical therapeutic or the sterilizing article of neurodermatitis, contact dermatitis, chronic eczema, insect bite dermatitis and itching skin disease and pruritus vulvae.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104940143A (en) * | 2015-05-20 | 2015-09-30 | 青岛博恩高科生物技术有限公司 | Alliin micro-pills and preparation method thereof |
| CN106755229A (en) * | 2016-11-24 | 2017-05-31 | 福州大学 | A kind of preparation method of schizochytrium limacinum algae cake protein Peptides |
| CN107550769A (en) * | 2017-09-14 | 2018-01-09 | 王雷 | A kind of preparation method of marine alga ferment facial mask |
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| CN102295983A (en) * | 2011-07-21 | 2011-12-28 | 上海辰浩生物技术有限公司 | Production method for comprehensive utilization of microalgae |
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| CN102295983A (en) * | 2011-07-21 | 2011-12-28 | 上海辰浩生物技术有限公司 | Production method for comprehensive utilization of microalgae |
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| 刘利晓等: "日粮中添加亚麻油和微藻粉粕对鸡肉中脂肪酸组成的影响研究", 《营养饲料》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104940143A (en) * | 2015-05-20 | 2015-09-30 | 青岛博恩高科生物技术有限公司 | Alliin micro-pills and preparation method thereof |
| CN106755229A (en) * | 2016-11-24 | 2017-05-31 | 福州大学 | A kind of preparation method of schizochytrium limacinum algae cake protein Peptides |
| CN107550769A (en) * | 2017-09-14 | 2018-01-09 | 王雷 | A kind of preparation method of marine alga ferment facial mask |
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Effective date of registration: 20170630 Address after: 350109, A501, room 5, building 10, Haixi garden, Innovation Zone, Fuzhou hi tech Zone, Fujian Patentee after: Fujian blue Hao Biological Technology Co., Ltd. Address before: 350002, No. 607, No. 8, No. 118 West 2nd Ring Road, Taijiang District, Fujian, Fuzhou Patentee before: Li Hao |