CN103463046B - The application of Lycojaponicumin A in preparation treatment colorectal cancer medicine - Google Patents
The application of Lycojaponicumin A in preparation treatment colorectal cancer medicine Download PDFInfo
- Publication number
- CN103463046B CN103463046B CN201310436648.9A CN201310436648A CN103463046B CN 103463046 B CN103463046 B CN 103463046B CN 201310436648 A CN201310436648 A CN 201310436648A CN 103463046 B CN103463046 B CN 103463046B
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- CN
- China
- Prior art keywords
- lycojaponicumin
- colorectal cancer
- application
- preparation treatment
- medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 206010009944 Colon cancer Diseases 0.000 title claims abstract description 23
- 208000001333 Colorectal Neoplasms Diseases 0.000 title claims abstract description 23
- 239000003814 drug Substances 0.000 title claims abstract description 17
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- WGVQKABRYXBLGW-WUZBVLBZSA-N (1R,2S,5S,7S,10S,13S)-7-hydroxy-7-methyl-17-oxa-14-azapentacyclo[12.2.1.02,10.02,13.05,10]heptadecane-3,9-dione Chemical compound O=C([C@@]12CC3)C[C@@](C)(O)C[C@H]1CC(=O)[C@@]12[C@H]3N2CC[C@H]1O2 WGVQKABRYXBLGW-WUZBVLBZSA-N 0.000 title claims description 17
- 150000001875 compounds Chemical class 0.000 claims description 16
- 201000010989 colorectal carcinoma Diseases 0.000 abstract description 8
- 230000012010 growth Effects 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 4
- 230000002401 inhibitory effect Effects 0.000 abstract description 4
- 230000000118 anti-neoplastic effect Effects 0.000 abstract description 2
- 238000011161 development Methods 0.000 abstract description 2
- 238000011156 evaluation Methods 0.000 abstract description 2
- 229930185194 lycojaponicumin Natural products 0.000 abstract 4
- 229940079593 drug Drugs 0.000 description 4
- 239000002246 antineoplastic agent Substances 0.000 description 3
- 229940041181 antineoplastic drug Drugs 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000031700 light absorption Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 241001597008 Nomeidae Species 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 231100000206 health hazard Toxicity 0.000 description 1
- 150000002611 lead compounds Chemical class 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (1)
- The application of 1.LycojaponicuminA in preparation treatment colorectal cancer medicine, described compound L ycojaponicuminA structure as formula Ishown in:formula I.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310436648.9A CN103463046B (en) | 2013-09-23 | 2013-09-23 | The application of Lycojaponicumin A in preparation treatment colorectal cancer medicine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310436648.9A CN103463046B (en) | 2013-09-23 | 2013-09-23 | The application of Lycojaponicumin A in preparation treatment colorectal cancer medicine |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103463046A CN103463046A (en) | 2013-12-25 |
CN103463046B true CN103463046B (en) | 2015-11-25 |
Family
ID=49788244
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310436648.9A Expired - Fee Related CN103463046B (en) | 2013-09-23 | 2013-09-23 | The application of Lycojaponicumin A in preparation treatment colorectal cancer medicine |
Country Status (1)
Country | Link |
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CN (1) | CN103463046B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113368113B (en) * | 2020-03-10 | 2022-04-22 | 四川大学 | Anti-tumor application of benzothiadiazoloquinazolinone compound |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103059043A (en) * | 2011-10-24 | 2013-04-24 | 中国医学科学院药物研究所 | Clavatine A-C and preparation method as well as pharmaceutical composition and application thereof |
-
2013
- 2013-09-23 CN CN201310436648.9A patent/CN103463046B/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103059043A (en) * | 2011-10-24 | 2013-04-24 | 中国医学科学院药物研究所 | Clavatine A-C and preparation method as well as pharmaceutical composition and application thereof |
Non-Patent Citations (1)
Title |
---|
Lycojaponicumins AC, Three Alkaloids;xiao-jing wang;《organic letters》;20121231;第14卷(第10期);2614-2617 * |
Also Published As
Publication number | Publication date |
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CN103463046A (en) | 2013-12-25 |
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Legal Events
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SE01 | Entry into force of request for substantive examination | ||
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20151027 Address after: 266000 Shandong province Qingdao city Licang District Road No. 1020 Laoshan two unit 302 Applicant after: Li Shulan Address before: Metro Technology Building No. 69 Olympic Avenue in Jianye District of Nanjing city in Jiangsu province 210019 01 5 storey buildings Applicant before: Nanjing Guangkangxie Biomedical Technology Co., Ltd. |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C56 | Change in the name or address of the patentee | ||
CP02 | Change in the address of a patent holder |
Address after: 225327 Yongan village, Yongan Town, Taizhou District, Jiangsu, China, the 4 group Patentee after: Li Shulan Address before: 266000 Shandong province Qingdao city Licang District Road No. 1020 Laoshan two unit 302 Patentee before: Li Shulan |
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C41 | Transfer of patent application or patent right or utility model | ||
CB03 | Change of inventor or designer information |
Inventor after: Guan Sujun Inventor after: Li Wenjun Inventor before: Jiang Chunping Inventor before: Wang Zezheng |
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COR | Change of bibliographic data | ||
TR01 | Transfer of patent right |
Effective date of registration: 20170203 Address after: 261100 Weifang, Shandong, Hanting District, democratic Street, No. 201 Patentee after: Guan Sujun Address before: 225327 Yongan village, Yongan Town, Taizhou District, Jiangsu, China, the 4 group Patentee before: Li Shulan |
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CB03 | Change of inventor or designer information | ||
CB03 | Change of inventor or designer information |
Inventor after: Sun Juan Inventor after: Yuan Hua Inventor after: Zheng Mingxin Inventor before: Guan Sujun Inventor before: Li Wenjun |
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TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20171214 Address after: 262700 Shandong street health city of Weifang province Shouguang City, No. 45 Co-patentee after: Yuan Hua Patentee after: Sun Juan Address before: 261100 Weifang, Shandong, Hanting District, democratic Street, No. 201 Patentee before: Guan Sujun |
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CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20151125 Termination date: 20180923 |