CN103462860B - Compound preservative for cosmetics - Google Patents
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- CN103462860B CN103462860B CN201310461594.1A CN201310461594A CN103462860B CN 103462860 B CN103462860 B CN 103462860B CN 201310461594 A CN201310461594 A CN 201310461594A CN 103462860 B CN103462860 B CN 103462860B
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- 239000002537 cosmetic Substances 0.000 title claims abstract description 34
- 230000002335 preservative effect Effects 0.000 title abstract description 11
- 239000003755 preservative agent Substances 0.000 title abstract description 10
- 150000001875 compounds Chemical class 0.000 title abstract 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 32
- 239000002994 raw material Substances 0.000 claims abstract description 17
- 244000178870 Lavandula angustifolia Species 0.000 claims abstract description 10
- 235000010663 Lavandula angustifolia Nutrition 0.000 claims abstract description 10
- 239000007788 liquid Substances 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 241000628997 Flos Species 0.000 claims description 18
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- 238000002360 preparation method Methods 0.000 claims description 8
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- 238000000034 method Methods 0.000 abstract description 6
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- 238000001035 drying Methods 0.000 abstract description 2
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract description 2
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- AJBZENLMTKDAEK-UHFFFAOYSA-N 3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-4,9-diol Chemical compound CC12CCC(O)C(C)(C)C1CCC(C1(C)CC3O)(C)C2CCC1C1C3(C)CCC1C(=C)C AJBZENLMTKDAEK-UHFFFAOYSA-N 0.000 abstract 1
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- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 4
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- YKRGDOXKVOZESV-WRJNSLSBSA-N Paeoniflorin Chemical compound C([C@]12[C@H]3O[C@]4(O)C[C@](O3)([C@]1(C[C@@H]42)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C)OC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-WRJNSLSBSA-N 0.000 description 2
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- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 1
- 241000228245 Aspergillus niger Species 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
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- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
- 239000004378 Glycyrrhizin Substances 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- HIMJIPRMECETLJ-UHFFFAOYSA-N Wogonin Natural products COc1cc(O)c(O)c2C(=O)C=C(Oc12)c3ccccc3 HIMJIPRMECETLJ-UHFFFAOYSA-N 0.000 description 1
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- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
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- 239000004615 ingredient Substances 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- -1 lipid peroxide Chemical class 0.000 description 1
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- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
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- WNIFXKPDILJURQ-UHFFFAOYSA-N stearyl glycyrrhizinate Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=O)OCCCCCCCCCCCCCCCCCC)(C)CC5C4=CC(=O)C3C21C WNIFXKPDILJURQ-UHFFFAOYSA-N 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- DKVBOUDTNWVDEP-NJCHZNEYSA-N teicoplanin aglycone Chemical compound N([C@H](C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)OC=1C=C3C=C(C=1O)OC1=CC=C(C=C1Cl)C[C@H](C(=O)N1)NC([C@H](N)C=4C=C(O5)C(O)=CC=4)=O)C(=O)[C@@H]2NC(=O)[C@@H]3NC(=O)[C@@H]1C1=CC5=CC(O)=C1 DKVBOUDTNWVDEP-NJCHZNEYSA-N 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
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- XLTFNNCXVBYBSX-UHFFFAOYSA-N wogonin Chemical compound COC1=C(O)C=C(O)C(C(C=2)=O)=C1OC=2C1=CC=CC=C1 XLTFNNCXVBYBSX-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a compound preservative for cosmetics. The compound preservative for cosmetics comprises the following raw materials, by weight, 1-5 parts of lavender, 1-4 parts of calendula, 1-3 parts of radix scutellariae, 1-3 parts of paeoniae radix, 3-5 parts of rosemary, 1-3 parts of syzygium aromaticum and 3-5 parts of liquorice. The preparing method of the compound preservative comprises the steps that all raw materials of the amount of the formula are crushed and then are mixed, ethyl alcohol is added in the mixed raw materials which are extracted for one to three times under a water bath condition, extracting is conducted for 1-3 hours every time, extracting liquid of the one to three times is combined and filtered, filter liquid is decompressed, the ethyl alcohol is recycled, drying is conducted, and the compound preservative is obtained. According to the compound preservative for cosmetics, pure natural plants and Chinese herbal medicine with the preservative effect are selected and compounded to prepare the preservative, the compound preservative for cosmetics can effectively prevent microorganisms such as germs and fungus in the cosmetics from growing, the service life of the cosmetics is prolonged, the compound preservative is safe and nontoxic to human bodies, and the advantages of oxidation resistance, skin whitening, inflammation diminishing and the like are further achieved.
Description
Technical field
The invention belongs to cosmetics additive technical field, be specifically related to a kind of Compositional antiseptic agent for cosmetics.
Background technology
Some compositions in cosmetics, as organic components such as lipid, hydrocarbon, water soluble polymers, not only can provide the abundant nutritional labeling such as carbon source, nitrogenous source for growth of microorganism, its Oxidation can be again growth of microorganism and provides chemical energy.Once run into suitable environment, the microorganism in cosmetics will grow, breed, and makes it putrid and deteriorated.Microorganism makes cosmetics from deterioration main manifestations be the substrate of decomposing cosmetics, product is made to occur muddiness, precipitation and color change, the acid product that its metabolism generates changes the acid-base value of product, the gas generated then causes foaming, the outward appearance sending out the product that rises, affects and abnormal smells from the patient, in addition, microorganism also may produce toxin, causes user skin allergy, even causes skin infection.For preventing cosmetics secondary pollution mainly by adding antiseptic.Antiseptic essence is exactly kill and suppress the microorganism in cosmetics, the long-time protective agent maintaining cosmetics quality.Antiseptic is by acting on multiple target spots such as the cell membrane of microorganism, cell wall and enzyme, and destroy the division of cell, bacteria growing inhibiting and breeding, reach antiseptical object.
Because the microbe species causing cosmetics putrid and deteriorated is various, and the suitable pH value of single antiseptic, minimal inhibitory concentration and scope of restraining fungi have certain restriction, and therefore, single antiseptic may reach separately anticorrosion hardly, the object of sterilizing.Therefore, in order to more effectively prevent cosmetics putrid and deteriorated and secondary pollution before the deadline, Compositional antiseptic agent is applied in cosmetics more and more widely.
Summary of the invention
The technical problem to be solved in the present invention is to provide one effectively can suppress the microbial growth such as antibacterial, fungus in cosmetics, extends cosmetics useful life, nontoxic to human-body safety, also has the Compositional antiseptic agent of the advantages such as antioxidation, whitening and antiinflammatory.
Technical scheme provided by the invention is a kind of Compositional antiseptic agent for cosmetics, and it is made up of the raw material of following weight portion: lavandula angustifolia 1 ~ 5 part, Flos Inulae 1 ~ 4 part, Radix Scutellariae 1 ~ 3 part, Peony Root 1 ~ 3 part, Herba Rosmarini Officinalis 3 ~ 5 parts, Flos Caryophylli 1 ~ 3 part, 3 ~ 5 parts, Radix Glycyrrhizae;
As preferably, the weight portion of above-mentioned raw materials is: lavandula angustifolia 3 parts, Flos Inulae 2.5 parts, Radix Scutellariae 2 parts, Peony Root 2 parts, Herba Rosmarini Officinalis 4 parts, Flos Caryophylli 2.5 parts, 4 parts, Radix Glycyrrhizae.
The preparation method of this Compositional antiseptic agent is: mix after each raw material pulverizing of formula ratio, add ethanol, extracts 1 ~ 3 time, extract 1 ~ 3h, merge extractive liquid, at every turn under water bath condition, filters, by decompression filtrate recycling ethanol, dry, to obtain final product.
According to the specific embodiment of the invention, in its preparation process, bath temperature is 60 ~ 75 DEG C.
According to a particular embodiment of the invention, in its preparation process, the volumetric concentration of ethanol is 60 ~ 75%, and its consumption is 10 ~ 12 times of each raw material gross weight.
The addition of antiseptic of the present invention in cosmetics is 0.5 ~ 1.5%, and its PH scope of application is 2 ~ 10.
The present invention's screening has the pure natural plant of antiseptic and inhibiting bacteria function effect and Chinese herbal medicine is raw material, wherein, Radix Scutellariae is heat clearing and damp drying medicine, containing Radix Scutellariae glycosides, Radix Scutellariae aglycon, Wogonin, Chinese Radix Scutellariae glycosides, the new plain isoreactivity composition of Radix Scutellariae, through modern pharmacological research, these active component have wider antimicrobial spectrum, to staphylococcus aureus, various skin fungus has inhibitory action, also has antioxidation simultaneously, significantly can suppress the generation of lipid peroxide.Peony Root is containing peoniflorin, benzoic acid isoreactivity composition, and peoniflorin has blood vessel dilating, comparatively broad-spectrum antiseptic and antiinflammation, and benzoic acid has antibacterial, antioxidative effect.Peony Root is good antiseptic, and can also have certain therapeutical effect to mottle by blood circulation promoting and blood stasis dispelling, has white-skinned face function.Radix Glycyrrhizae taste traditional tonic medicine, containing glycyrrhizin, enoxolone and several amino acids isoreactivity composition in Radix Glycyrrhizae, these active component give the effects such as Radix Glycyrrhizae antiinflammatory, sterilization, antiallergic, have certain antibacterial action to staphylococcus aureus.And lavandula angustifolia, Flos Inulae, Herba Rosmarini Officinalis, Flos Caryophylli is pure natural plant, containing phenols and tannin isoreactivity composition in these plants, has broad-spectrum antibacterial effect.Above-mentioned raw materials is composite, extract its effective ingredient and make the microbial growth such as antibacterial, fungus that antiseptic can effectively suppress in cosmetics, effectively can extend the useful life of cosmetics, nontoxic to human-body safety, also there is the advantages such as antioxidation, whitening and antiinflammatory.
Detailed description of the invention
The present invention is further elaborated for following specific embodiment, but not as a limitation of the invention.
Embodiment 1
Preparation for the Compositional antiseptic agent of cosmetics: after lavandula angustifolia 1kg, Flos Inulae 1kg, Radix Scutellariae 1kg, Peony Root 1kg, Herba Rosmarini Officinalis 3kg, Flos Caryophylli 1kg and Radix Glycyrrhizae 3kg being pulverized, mixing is placed in container, add the ethanol that volumetric concentration is 60%, its addition is 10 times of raw material gross weight, 1h is extracted under 605 DEG C of water bath condition, by extracting liquid filtering, decompression filtrate recycling ethanol, dry, to obtain final product.
Embodiment 2
Preparation for the Compositional antiseptic agent of cosmetics: after lavandula angustifolia 5kg, Flos Inulae 4kg, Radix Scutellariae 3kg, Peony Root 3kg, Herba Rosmarini Officinalis 5kg, Flos Caryophylli 3kg and Radix Glycyrrhizae 5kg being pulverized, mixing is placed in container, add the ethanol that volumetric concentration is 75%, its addition is 12 times of raw material gross weight, extract 3 times under 75 DEG C of water bath condition, extract 3h, merge extractive liquid, at every turn, filter, by decompression filtrate recycling ethanol, dry, to obtain final product.
Embodiment 3
Preparation for the Compositional antiseptic agent of cosmetics: after lavandula angustifolia 3kg, Flos Inulae 2.5kg, Radix Scutellariae 2kg, Peony Root 2kg, Herba Rosmarini Officinalis 4kg, Flos Caryophylli 2.5kg and Radix Glycyrrhizae 4kg being pulverized, mixing is placed in container, add the ethanol that volumetric concentration is 70%, its addition is 11 times of raw material gross weight, extract 2 times under 70 DEG C of water bath condition, extract 2.5h, merge extractive liquid, at every turn, filter, by decompression filtrate recycling ethanol, dry, to obtain final product.
Embodiment 4
Preparation for the Compositional antiseptic agent of cosmetics: after lavandula angustifolia 1kg, Flos Inulae 4kg, Radix Scutellariae 1kg, Peony Root 3kg, Herba Rosmarini Officinalis 3kg, Flos Caryophylli 3kg and Radix Glycyrrhizae 3kg being pulverized, mixing is placed in container, add the ethanol that volumetric concentration is 60 ~ 75%, its addition is 10 ~ 12 times of raw material gross weight, extract 1 ~ 3 time under 60 ~ 75 DEG C of water bath condition, extract 1 ~ 3h, merge extractive liquid, at every turn, filter, by decompression filtrate recycling ethanol, dry, to obtain final product.
Applicant adopts paper disk method to measure the bacteriostatic activity of antiseptic of the present invention, and concrete process of the test is as follows:
1, test method
Escherichia coli (8099), staphylococcus aureus (ATCC6538) are inoculated cultured solution of broth respectively, at 37 DEG C, cultivates 24h; Candida albicans (ATCC10231) inoculation is husky protects weak fluid medium, at 25 DEG C, cultivate 5d; Aspergillus niger (ATCC16404) inoculates Cha Shi fluid medium, at 25 DEG C, cultivate 6d.With normal saline, four kinds of bacterial culturess being diluted to concentration is respectively 10
6the bacteria suspension of CFU/ml.
Respectively above-mentioned four kinds of bacteria suspensions are coated on aseptic cotton carrier and make lawn on nutrient agar panel, then cut-off footpath is the sterilizing filter paper dick of 3cm, after evenly picking the antiseptic that embodiment 1 ~ 4 makes respectively, then be attached to respectively on flat board that four kinds of different bacteria suspensions make.Antibacterial culturing 24h, fungal culture 5d, observed result.
2, evaluation methodology:
Paper disk method bacteriostatic diameter >=10mm is that effectively bacteriostatic diameter < 10mm is invalid.
3, result of the test is in table 1
Table 1 paper disk method antiseptic fungistatic effect
As seen from the above table, the antiseptic that embodiment 1 ~ 4 is obtained all has obvious inhibitory action to four kinds of antibacterials, with preservative effectiveness the best that embodiment 3 is obtained.
Claims (4)
1. for the Compositional antiseptic agent of cosmetics, it is characterized in that: it is made up of the raw material of following weight portion: lavandula angustifolia 1 ~ 5 part, Flos Inulae 1 ~ 4 part, Radix Scutellariae 1 ~ 3 part, Peony Root 1 ~ 3 part, Herba Rosmarini Officinalis 3 ~ 5 parts, Flos Caryophylli 1 ~ 3 part, 3 ~ 5 parts, Radix Glycyrrhizae;
Its preparation method is: mix after each raw material pulverizing of formula ratio, add ethanol, extracts 1 ~ 3 time, extract 1 ~ 3h, merge extractive liquid, at every turn under water bath condition, filters, by decompression filtrate recycling ethanol, dry, to obtain final product.
2. the Compositional antiseptic agent for cosmetics according to claim 1, is characterized in that: the weight portion of each raw material is: lavandula angustifolia 3 parts, Flos Inulae 2.5 parts, Radix Scutellariae 2 parts, Peony Root 2 parts, Herba Rosmarini Officinalis 4 parts, Flos Caryophylli 2.5 parts, 4 parts, Radix Glycyrrhizae.
3. the Compositional antiseptic agent for cosmetics according to claim 1 and 2, is characterized in that: bath temperature is 60 ~ 75 DEG C.
4. the Compositional antiseptic agent for cosmetics according to claim 1 and 2, is characterized in that: the volumetric concentration of ethanol is 60 ~ 75%, and its consumption is 10 ~ 12 times of each raw material gross weight.
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| CN201310461594.1A CN103462860B (en) | 2013-09-30 | 2013-09-30 | Compound preservative for cosmetics |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310461594.1A CN103462860B (en) | 2013-09-30 | 2013-09-30 | Compound preservative for cosmetics |
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| CN103462860B true CN103462860B (en) | 2015-07-08 |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103830153B (en) * | 2014-03-27 | 2015-11-18 | 广东伊茗药业有限公司 | A kind of moisture-keeping cosmetics and preparation method thereof |
| CN104840401A (en) * | 2015-05-26 | 2015-08-19 | 胡红慧 | Plant preservative for skincare product |
| CN110075034B (en) * | 2019-06-04 | 2022-02-22 | 上海美浮特生物科技有限公司 | Pure plant preservative composition, preparation method thereof and application thereof in facial mask |
| CN112057378A (en) * | 2020-08-25 | 2020-12-11 | 中北大学 | Botanical cosmetic preservative and preparation method thereof |
| CN114344226B (en) * | 2022-02-25 | 2023-03-17 | 河南科技大学 | Traditional Chinese medicine preservative, preparation method and application |
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2013
- 2013-09-30 CN CN201310461594.1A patent/CN103462860B/en active Active
Non-Patent Citations (2)
| Title |
|---|
| 丁香、甘草与迷迭香的抑菌作用及其在酱油中的应用研究;吴周和 等;《中国酿造》;20031231(第4期);第18-21页 * |
| 化妆品防腐剂的研究现状及今后发展趋势探讨;朱昱燕 等;《2006年中国化妆品学术研讨会论文集》;20060501;第297-300页 * |
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