CN103458823B - Unit for oral cavity care - Google Patents
Unit for oral cavity care Download PDFInfo
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- CN103458823B CN103458823B CN201280017399.3A CN201280017399A CN103458823B CN 103458823 B CN103458823 B CN 103458823B CN 201280017399 A CN201280017399 A CN 201280017399A CN 103458823 B CN103458823 B CN 103458823B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C19/00—Dental auxiliary appliances
- A61C19/06—Implements for therapeutic treatment
- A61C19/063—Medicament applicators for teeth or gums, e.g. treatment with fluorides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C19/00—Dental auxiliary appliances
- A61C19/06—Implements for therapeutic treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C15/00—Devices for cleaning between the teeth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- Epidemiology (AREA)
- Dentistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract
A kind of unit for oral cavity care that can give full play to pharmacy effect is provided.There is in oral cavity preparation and preparation in described oral cavity coated in the unit for oral cavity care of intraoral spreading implement (1), in described oral cavity, preparation contains cationic antibacterial as its effective ingredient, described spreading implement (1) has following composition: holding body (4), the upper electric conductivity coated body (2) arranged of described holding body (4), power supply, be connected with described power cathode and in described holding body (4), expose the negative terminal (5) of formation, the positive terminal (3) separated with described negative terminal (5) while being connected with the positive pole and described coated body (2) of described power supply.
Description
Technical field
The present invention relates to a kind of unit for oral cavity care.
CLAIM OF PRIORITY based on No. 2011-086318, the patent application Patent that the application proposed in Japan by April 8th, 2011, quotes its content at this.
Background technology
In periodontal disease prevention, sterilization or the biomembranous removal of periodontal pathogenic bacteria are very important, but are difficult to common toothbrush the biomembrane removing between cog portion or tooth neck formation.
In addition, in the prevention of periodontal disease with in improving, preparation in the oral cavity of the effective ingredient containing sterilization etc. is coated between cog portion or tooth cervical region etc. and is considered to effective to kill the pathogenic bacteria becoming the cause of disease.Usually, the cationic germicide of quaternary ammonium salt etc. is used as antibacterial.
All the time, for by the clean of between cog portion with for the purpose of the medicament coating between cog portion, multiple interdental brush scheme is proposed.
Have while proposing to receive medicinal liquid class in the cavity being configured as handle by deformable elastomeric material, the interdental cleaning tool (such as, patent documentation 1) wearing the aperture be connected with space outerpace in described cavity near bottom is installed at toothbrush.According to the invention of patent documentation 1, seek, while cleaning between cog portion with toothbrush, the medicinal liquid in handle cavity to be coated between cog portion.
In addition, the little toothbrush in the between cog portion (such as, patent documentation 2) proposing to use hollow line is had.According to the invention of patent documentation 2, seek composition by loading dentifrice in advance in hollow line effectively to remove the tartar between cog portion.
Or, have and propose to mediate inorganic powder in resin filament, the interdental brush (such as, patent documentation 3) of adsorption of effective component on the inorganic powder that this resin filament surface is exposed.According to the invention of patent documentation 3, seek, while clean between cog portion, the effective ingredient be adsorbed on resin filament to be coated patient part.
In addition, as the utensil in order to effectively remove tartar, there are proposition ion toothbrush (such as, patent documentation 4), ion interdental brush (such as, patent documentation 5).In saliva containing positively charged calcium ion, this calcium ion crosslinking tooth as negative charge and the tartar as negative charge.The invention of patent documentation 4,5 imports anion in oral cavity, in and the electric charge of calcium ion in tartar, to weaken the adsorptivity of tartar, remove tartar by friction.
Prior art document
Patent documentation
Patent documentation 1: Japanese Utility Model opens clear 63-194633 publication
Patent documentation 2: Japanese Patent Laid-Open 5-192355 publication
Patent documentation 3: Japanese Patent Laid-Open 2003-61746 publication
Patent documentation 4: Japanese Patent Laid-Open 2001-190336 publication
Patent documentation 5: Japanese Patent Laid-Open 10-243820 publication
Summary of the invention
But the invention of patent documentation 1 ~ 3, is difficult to discharge medicament from interdental brush.
The invention of patent documentation 4 ~ 5, although the removal facilitating tartar, still unsatisfactory in the prevention of periodontal disease and improvement.
And also there are the following problems: even if only at the medicament of patient part coating cationic antibacterial etc., pharmacy effect also cannot give full play to.
At this, the object of this invention is to provide the unit for oral cavity care that can give full play to pharmacy effect.
It is generally acknowledged that the killing effect of cationic antibacterial to pathogenic bacteria is high, even if but cationic antibacterial is coated in oral cavity, be also difficult to obtain sufficient effect.
The present inventor is through constantly making great efforts the result of research, obtain following knowledge: because intraoral biomembrane is anionic property, even if therefore only at diseased region coating cationic antibacterial, cationic antibacterial can not act on antibacterial under effective state.
The present inventor is based on above-mentioned knowledge, and the result of further investigation further, finding by importing positive charge in oral cavity, cationic antibacterial high-effective penetrating can be made to enter biomembrane, effectively play a role, thus complete the present invention.
Namely, unit for oral cavity care of the present invention, it is characterized in that, there is in oral cavity preparation and preparation in described oral cavity coated in the unit for oral cavity care of intraoral spreading implement, in described oral cavity, preparation contains cationic antibacterial as its effective ingredient, described spreading implement has: holding body, the electric conductivity coated body that described holding body is arranged, power supply, be connected with described power cathode and in described holding body, expose the negative terminal of formation, the positive terminal separated with described negative terminal while being connected with the positive pole and described coated body of described power supply.
Described coated body is preferably made up of electroconductive polymer, the preferred quaternary ammonium salt of described effective ingredient.
Described unit for oral cavity care, the specific insulation of coated body described in it is 1 × 10
2below Ω cm.
Described unit for oral cavity care, it is characterized in that, described effective ingredient is selected from the biguanides antibacterial of the quaternary ammonium salt of cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, stearalkonium chloride, lauryl trimethyl ammonium chloride, myristyl trimonium ammonium chloride, CTAB, stearyl trimethyl ammonium chloride etc., Chlorhexidine hydrochloride, chlorhexidine gluconate, hydrochloric acid Win-21904 or gluconic acid Win-21904 etc.
Described unit for oral cavity care, is characterized in that, described effective ingredient is quaternary ammonium salt.
Described unit for oral cavity care, the content of the cationic antibacterial in its oral cavity in preparation, relative to preparation in oral cavity 100 quality %, at below more than 0.001 quality % 0.2 quality %.
Described unit for oral cavity care, the conductive material that electroconductive polymer described in it contains is selected from the metal-oxide or carbon of the metal, titanium oxide, zinc oxide etc. of gold, silver etc.
Described unit for oral cavity care, the shape of coated body described in it is the taper shape along the top orientation reduced to coated body.
Described unit for oral cavity care, it is formed with the recessed bar that more than 2 circumferencial directions extend on the side of described coated body.
Described unit for oral cavity care, it is formed with the recessed bar of spiral extension on the side of described coated body.
Described unit for oral cavity care, it is formed from the bottom of coated body to the recessed bar that top orientation extends on the side of described coated body.
Described unit for oral cavity care, coated body described in it is the bearing of trend of positive terminal is longitudinal rectangle tabular.
Described unit for oral cavity care, coated body described in it forms the bristle be made up of more than 2 filaments with electric conductivity in support sector, described bristle along from the bottom of coated body to top orientation reduced.
Described unit for oral cavity care, its electric conductivity filament forming described bristle is selected from following: the filament be spun to by electroconductive polymer, be core and the filament constructed with the core sheath that the macromolecule not containing conductive material covers, be island with electroconductive polymer and with the filament of the macromolecule the not containing conductive material sea island structure that is sea, the macromolecule spinning that will not contain conductive material and the filament of its Surface coating conductive material with electroconductive polymer.
Described unit for oral cavity care, is characterized in that, the thickness of described electric conductivity filament is at Φ more than 0.05 below 0.3mm.
Described unit for oral cavity care, coated body described in it is formed with the bristle be made up of more than 2 filaments with electric conductivity in support sector, and described bristle is identical to top orientation diameter from the bottom of coated body.
According to unit for oral cavity care of the present invention, the effect of medicament can be given full play to.
Accompanying drawing explanation
Fig. 1 is the plane graph of the spreading implement about one embodiment of the present invention.
Fig. 2 is the sectional view of the spreading implement about one embodiment of the present invention.
Fig. 3 A is the plane graph of the coated body about one embodiment of the present invention.
Fig. 3 B is the plane graph of the coated body about one embodiment of the present invention.
Fig. 3 C is the plane graph of the coated body about one embodiment of the present invention.
Fig. 3 D is the plane graph of the coated body about one embodiment of the present invention.
Fig. 3 E is the plane graph of the coated body about one embodiment of the present invention.
Fig. 3 F is the plane graph of the coated body about one embodiment of the present invention.
Fig. 4 is the ideograph representing model bactericidal assay experimental system.
Symbol description
1: spreading implement
2:100,110,120,13,140,150 coated bodies
3: positive terminal
4: holding body
5: negative terminal
6: battery
Detailed description of the invention
Unit for oral cavity care of the present invention has: preparation and preparation in this oral cavity is coated intraoral spreading implement in the oral cavity containing cationic antibacterial.
In addition, " in oral cavity nurse " is the behavior of health in the treatment of clean, gingival massage, periodontal disease or dental caries, improvement or prevention etc., maintenance oral cavity in the oral cavity in.
(in oral cavity preparation)
In oral cavity of the present invention, preparation contains cationic antibacterial.
The dosage form of preparation in oral cavity, there is no specific restriction, such as, can adopt the dosage form same with preparation in existing oral cavity of the liquid such as aqueous solution or aqueous dispersions, colloidal sol shape, gel, granular etc.
< cationic antibacterial >
As cationic antibacterial, the composition of preparation in oral cavity is used to as long as existing, just there is no specific restriction, such as, the biguanides antibacterial of the quaternary ammonium salt of cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, stearalkonium chloride, lauryl trimethyl ammonium chloride, myristyl trimonium ammonium chloride, CTAB, stearyl trimethyl ammonium chloride etc., Chlorhexidine hydrochloride, chlorhexidine gluconate, hydrochloric acid Win-21904, gluconic acid Win-21904 etc. can be enumerated.In cationic antibacterial, the quaternary ammonium salt of preferred sterilizing power excellence, more preferably cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, further preferred cetylpyridinium chloride.These cationic antibacterial, one kind or two or morely separately can carry out appropriately combined use.
The content of the cationic antibacterial in oral cavity in preparation, can consider that the kind of cationic antibacterial decides, preferably below more than 0.001 quality % 0.2 quality %, more preferably below more than 0.01 quality % 0.1 quality %.
Any composition > of <
In oral cavity of the present invention in preparation, in the scope not affecting effect of the present invention, the medicament (any medicament) beyond cationic antibacterial, grinding agent, adhesion agent, binding agent, the surfactant (arbitrary surfaces activating agent) of decationize antibacterial, sweeting agent, pigment, spice, pH adjusting agent, buffer agent etc. can be allocated into.
[any medicament]
As any medicament, tranexamic acid can be enumerated, ε-caproic acid, β-glycyrrhizic acid, the antiinflammatory of glycyrrhizic acid dipotassium etc., ascorbic acid, the antioxidant of the ascorbic acid derivates of magnesium L-ascorbyl-2-phosphate etc. etc., sodium fluoride, potassium fluoride, stannous fluoride, strontium fluoride, the fluoride of sodium monofluorophosphate etc., ortho-phosphoric potassium salt, the water-soluble phosphoric acid compound of sodium salt etc., allantoin aluminium chlorhydroxide, chamenol, sodium chloride, DL-tocopherol acetas, beta-cholestanol, α-bisabolol, triclosan, isopropyl methyl phenol, azulenes, enoxolone, enoxolone, sodium copper chlorophyllin, chlorophyll, the sequestering phosphate cpd of glycerophosphate etc., the copper compound of copper gluconate etc., aluctyl., strontium chloride, potassium nitrate, berberine, hydroxamic acid or derivatives thereof, zeolite, vinyl methyl ether, copolymer-maleic anhydride, polyvinylpyrrolidone, epicholestanol, trichloro-symmetrical diphenyl urea, zinc citrate, the soft extract of Radix Angelicae Sinensis, Cortex Phellodendri extract, chamomile, Flos Caryophylli, Herba Rosmarini Officinalis, Radix Scutellariae, the plant extract etc. of Flos Carthami etc.These any medicament, one kind or two or morely separately can carry out appropriately combined use.
In addition, in the scope not affecting effect of the present invention, in oral cavity, in compositions, the addition of any medicament can be set to effective dose.
As grinding agent, such as, dicalcium phosphate dihydrate, anhydrous dicalcium phosphate, calcium pyrophosphate, aluminium hydroxide, aluminium oxide, crystal type Zirconium orthosilicate., polymethyl methacrylate, insoluble calcium metaphosphate, precipitated calcium carbonate, ground calcium carbonate, magnesium carbonate, tricresyl phosphate magnesium, zeolite, Zirconium orthosilicate., tricalcium phosphate, hydroxyapatite, fluor-apatite, calcium deficiency apatite, tricalcium phosphate, tetracalcium phosphate, OCP, synthetic resin grinding agent, precipitated silica, silica gel, aluminosilicate, zirconium silicate etc. can be enumerated.In oral cavity, in preparation, the content of grinding agent such as can be set as below more than 5 quality % 50 quality %.
As adhesion agent, at least one in the sugar alcohol of the Polyethylene Glycol of glycerol, Sorbitol, propylene glycol, mean molecule quantity 200 ~ 6000, ethylene glycol, reduction starch sugar compound etc., polyhydric alcohol can be used.In oral cavity, in preparation, the content of adhesion agent such as can be set as below more than 10 quality % 40 quality %.
As binding agent, the organic binder bond of sodium alginate, propylene glycol alginate, sodium carboxymethyl cellulose, polyvinyl alcohol, hydroxyethyl-cellulose, sodium polyacrylate, xanthan gum, carbopol, guar gum, gelatin, microcrystalline Cellulose etc. can be enumerated; Or, the inorganic binder of montorillonite clay, Kaolin, bentonite etc.In oral cavity, the content of preparation such as can be set as below more than 0.5 quality % 3 quality %.
As arbitrary surfaces activating agent, known anionic surfactant, nonionic surfactant, amphoteric surfactant can be added.Such as; as anionic surfactant, the acyl sarcosinates of the alkyl sulfate of sodium lauryl sulfate etc., sodium lauroyl sarcosine, myristyl sodium sarcosinate etc., laureth sulfate, N-lauroyl taurate, α olefin sulfonate etc. can be enumerated.As nonionic surfactant, the carbon number that include, for example alkyl is the alkyl polyglucoside of 8 ~ 16, the fatty acid-based carbon number of sucrose list or dilaurate etc. is the sucrose fatty acid ester of 12 ~ 18, milk sugar fats acid esters, lactose fatty acid ester, maltitol fatty acid ester, the polyol fatty acid ester of glycerol monostearate etc., Tween-20, the polyoxyethylene sorbitan carboxylic ester of polyoxyethylene sorbitan monostearate etc., the alkanoyl ethanolamine of lauroyl diethanolamine etc., polyoxyethylene polyoxypropylene propylene glycol, lauric acid ten polyglycerin ester etc.As amphoteric surfactant, include, for example alkyl dimethyl oxyneurine, fatty acid propyl amides betanin, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazole quinoline betanin etc.
These arbitrary surfaces activating agents, one kind or two or morely separately can carry out appropriately combined use.In oral cavity, in preparation, the content of arbitrary surfaces activating agent such as can be set as below more than 0.1 quality % 3 quality %.
As sweeting agent, saccharin sodium, aspartame, stevioside, Stevia rebaudiana (Bertoni) Hemsl extract, p-met hoxycinnamic aldehyde, neohesperidin dihydrochalcone (ネ オ ヘ ス ペ リ ヅ Le ヅ ヒ De ロ カ Le コ Application), perillartine etc. can be enumerated.
(spreading implement)
About the spreading implement in one embodiment of the present invention, be described with reference to the following drawings.
Spreading implement 1 shown in Fig. 1 ~ 2 has coated body 2, holding body 4, positive terminal 3, negative terminal 5, is so-called ion interdental brush.
As shown in Figure 2, in holding body 4, there is battery 6, be provided with the negative conductive portion 50 being connected to battery 6 negative pole 62, the positive conductive portion 30 being connected to battery 6 positive pole 64.
Negative conductive portion 50 is connected with the negative terminal 5 holding body 4 being exposed setting.
Positive conductive portion 30 is connected with the wire outstanding from holding body 4 top and positive terminal 3, positive terminal 3 is provided with the coated body 2 covered on positive terminal 3 top 32.
Holding body 4 is tubular articles with the end.From holding body 4 rear end to the length L on top, be not particularly limited, such as, can be set as more than 5cm below 20cm.The rear end of holding body 4 refers to one end of side, negative conductive portion 50, and top refers to one end of side, positive conductive portion 30.The maximum thickness R of holding body 4 is not particularly limited, such as, can be set as more than 1.6cm below 5cm.The material of holding body 4, if the material of insulating properties, is just not particularly limited, and include, for example the polyolefin of polypropylene, polyethylene etc.; The polyester of polyethylene terephthalate etc.; The resin etc. of polystyrene etc.
Coated body 2 is contact gingival surfaces or inserts between cog portion, preparation in oral cavity is coated the component of the oral cavity organization such as tooth or gingiva.
If the material of coated body 2 has electric conductivity, be just not particularly limited, preferred volume resistivity is 1 × 10
2below Ω cm, more preferably at 60 below Ω cm.Exceed described higher limit 1 × 10
2during Ω cm, the position according to coated body 2 likely occurs by magnitude of current heterogeneity.
The hardness of coated body 2 is not particularly limited, but stimulates the physical property of tooth or gingiva to relax, and preferably soft material, more preferably hardness (measured value with durometer A) is less than more than 15 80.
As such material, the electroconductive polymer of the electric conductivity polyester of conductive material of can enumerating and make the electric conductivity silicon containing conductive material in the silicone rubber of methyl silicone rubber, vinyl methyl silicone rubber, phenyl-methyl silicone rubber or these mixture etc., make the conductive polyolefine containing conductive material in the polyolefin of polyethylene, polypropylene or these mixture etc., make the Electrical Conductive Polyamide containing conductive material in polyamide, make to contain in the polyester of polyethylene terephthalate etc. etc.
As the conductive material that electroconductive polymer contains, such as, the metal-oxide or carbon etc. of the metal of gold, silver etc., titanium oxide, zinc oxide etc. can be enumerated, use and stability in oral cavity from the viewpoint of coated body 2, preferred carbon.These conductive materials, one kind or two or morely separately can carry out appropriately combined use.
Although the content of the conductive material of electroconductive polymer is more, specific insulation declines more, has hardening trend.Therefore, the content of the conductive material in electroconductive polymer, can consider that the kind of high molecular kind or conductive material decides.
The shape of coated body 2 can consider that coating object decides, such as, can be set as the approximate circle taper reduced along the orient diameter to coated body 2 top.By being set as by coated body 2 in approximate circle taper, be easy to preparation in oral cavity to coat the narrow and small position of demarcation line etc. of between cog portion, tooth and gingiva.
In addition, as other form, the coated body 100 can enumerated as shown in Figure 3A is such, is set as approximate circle taper, its side is formed with the recessed bar 102 that more than 2 circumferencial directions extend.Coated body 100 can be possessed in oral cavity while preparation in recessed bar 102, coats coating object.The material of coated body 100 is identical with the material of coated body 2.
In addition, such as, the coated body 110 can enumerated as shown in Figure 3 B is such, is set as approximate circle taper, its side is formed with the recessed bar 112 of spiral extension.Coated body 110 can be possessed in oral cavity while preparation in recessed bar 112, coats coating object.The material of coated body 110 is identical with the material of coated body 2.
Or the coated body 120 can enumerated as shown in Figure 3 C is such, is set as approximate circle taper, its side is formed with the recessed bar 122 extended to the direction on coated body 120 top from coated body 120 bottom.Coated body 120 can be possessed in oral cavity while preparation in recessed bar 122, coats coating object.The material of coated body 120 is identical with the material of coated body 2.
Further, as other form, the coated body 130 that also can be as shown in Figure 3 D is such, and the plan view being longitudinal direction with the bearing of trend of positive terminal 3 is in approximate rectangular tabular.Coated body 130, owing to being tabular, is therefore suitable for preparation in broad coating oral cavity, region.The material of coated body 130 is identical with the material of coated body 2.
In addition, such as, the coated body 140 can enumerated as shown in FIGURE 3 E is such, and support sector 142 is formed the bristle 144 be made up of more than 2 filaments (electric conductivity filament) with electric conductivity.Bristle 144 is set as the shape reduced along the orient diameter from bottom to top.The material of support sector 142 is identical with the material of coated body 2.
Form the electric conductivity filament of bristle 144, can be listed below: the filament that electroconductive polymer is spun to, be core with electroconductive polymer and the filament constructed with the core sheath that the macromolecule not containing conductive material covers, be island with electroconductive polymer and with the filament of the macromolecule the not containing conductive material sea island structure that is sea, the macromolecule spinning that will not contain conductive material and the filament etc. of its Surface coating conductive material.Such electric conductivity filament one kind or two or morely separately can carry out appropriately combined use.
The specific insulation of electric conductivity filament is preferably 1 × 10
2below Ω cm, more preferably at 60 below Ω cm.
The thickness of electric conductivity filament is not particularly limited, and such as, is above below the 0.3mm of Φ 0.05mm.
In addition, such as, the coated body 150 can enumerated as illustrated in Figure 3 F is such, and support sector 152 is formed the bristle 154 be made up of electric conductivity filament.This bristle 154 is set as that the orient diameter from bottom to top is roughly the same.
The electric conductivity filament forming bristle 154 is identical with the electric conductivity filament forming bristle 144.
In addition, as other form, also the tinsel having electric conductivity or do not have the filament apparatus of electric conductivity conductive can be carried out twisted as coated body.But, from the viewpoint of mitigation, between cog portion is stimulated, the coated body being carried out by the positive terminal of tinsel etc. covering preferably is set.
As long as the material of positive terminal 3 has the just passable of electric conductivity, such as, the metal of gold, silver etc. can be enumerated, the metal-oxide of silicon oxide, zinc oxide etc. or carbon etc.
The material in positive conductive portion 30 is identical with positive terminal 3.
The material of negative terminal 5 is identical with positive terminal 3, and the material in negative conductive portion 50 is identical with positive terminal 3.
(in oral cavity care method)
Below, for periodontal disease biological film sterilizing, be described using care method in the oral cavity of spreading implement 1.
First, make preparation in oral cavity be attached to coated body 2, hands contact negative terminal 5, holds holding body 4.By coated body 2 insert port intracavity, such as between cog portion.When coated body 2 is inserted between cog portion, by preparation, saliva or intraoral moisture moistening in oral cavity, oral cavity organization and coated body 2 are energized.Therefore, electric current with in the hands of the negative pole 62 of battery 6, negative conductive portion 50, negative terminal 5, user, health, oral cavity, coated body 2, positive terminal 3, positive conductive portion 30, positive pole 64 order circulation.Now, produce the convection current of positive charge to oral cavity organization from coated body 2, the cationic antibacterial of the positive charge of being ostracised by this convection current infiltrates through biomembrane.Its result, cationic antibacterial acts on the pathogenic bacteria in biomembrane, kills these pathogenic bacterias.And owing to there being the current flowing of 1 ~ 100 μ A in human body, therefore electric current promotes the blood circulation of gingiva, activation gingiva tissue.
As mentioned above, according to the present embodiment, owing to there is preparation in the oral cavity containing cationic antibacterial and arranging the spreading implement of coated body at positive terminal, make cationic antibacterial to high-effective penetrating in biomembrane, the effect of cationic antibacterial can be given full play to.
And, because the electroconductive polymer of coated body by soft material is formed, therefore, it is possible to relax, the physical property of tooth or gingiva is stimulated.
(other embodiment)
The present invention is not limited to above-mentioned embodiment.
In above-mentioned embodiment, spreading implement is set as ion interdental brush, as long as but spreading implement arranges coated body on positive terminal, such as, also can be following ion toothbrush: there is the head extending in holding body and arrange, described holding body arranges negative terminal, the electric conductivity filament that described head is implanted positive terminal and covered by this positive terminal.Filament for this ion toothbrush is preferably towards the diminishing shape of top end diameter, i.e. so-called taper hair.Taper hair, owing to being easy to bending, being therefore not easy to cause pain to diseased region, and can entering between fine gap, and cationic antibacterial can be made to infiltrate through in biomembrane.
In above-mentioned embodiment, be formed with recessed bar, but the present invention is not limited to this in the coated body side of Fig. 3 A ~ C, the side of coated body also replaceable recessed bar is formed with raised line.
In above-mentioned embodiment, be illustrated for the ion interdental brush that coated body extends at holding body length direction, but the present invention is not limited thereto, such as, spreading implement may also be coated body be connected to crisscross with holding body length direction on ion interdental brush.
Embodiment
Below, describe the present invention in detail with embodiment, but the present invention is not limited to the following stated.
The modulation of preparation in (Production Example 1) oral cavity
In pH7.0 phosphate buffer normal saline (PBS solution), dissolve cetylpyridinium chloride (CPC), modulate the CPC solution of 0.1 quality %, as preparation in oral cavity.
(embodiment 1)
Use electric conductivity silicon (conductive material: carbon, specific insulation 20 Ω cm) be configured as bottom diameter 3mm, the conical coated body of length 10mm (hardness (measured value with durometer A)=50), make the spreading implement identical with Fig. 1 spreading implement 1.In this spreading implement, employ the polypropylene molded body as holding body, the tinsel of the Φ 0.25mmSUS304 as positive terminal, the flat board as the titanium oxide of negative terminal respectively.The battery of 9V is employed in power supply.
Use the spreading implement obtained, by method evaluation bactericidal effect as follows and use sense, its result is as shown in table 1.
(evaluation methodology)
< bactericidal effect >
According to the model bactericidal assay employing experimental system 200 shown in Fig. 4, evaluate bactericidal effect.
Experimental system 200 have arrange in outer container 230, outer container 230 inner pressurd vessel 220, spreading implement 1, electric conductivity negative pole extension body 52.
Outer container 230 and inner pressurd vessel 220 are installed by shown in Fig. 4.PBS solution 232 is stored in outer container 230, in inner pressurd vessel 220, formation model biomembrane 224 on the film filter 221 that inner bottom surface is arranged, preparation 222 in storage oral cavity.Model organism film 224 is method (the Japanese oral hygiene proceedings 54 (4) 437 according to gloomy Shima etc., 2004), formed by four kinds of Mixed culture of Actinomycesviscosus (A.viscosus), veillonella parvula (V.parvula), Fusobacterium nucleatum (F.nucleatum), porphyromonas gingivalis (P.gingivalis).The coated body 2 of spreading implement 1 is immersed in oral cavity in preparation 222, negative pole extension body 52 is connected to negative terminal 5.The top of length fast body 52 is connected to the negative plate 54 being arranged in PBS solution 232.After being energized 10 minutes with the DC current of 9V, the viable count of rating model biomembrane 224.
< viable count measures >
At the end of experiment, the biomembrane on film filter is sampled, by this sampling with after ultrasound wave dispersion, agar plate is cultivated, bacterial population alive (CFU/ plate) is tried to achieve to the clump count counting of porphyromonas gingivalis on agar plate, represents (CFU:colonyformingunit writes a Chinese character in simplified form) with common logarithm logCFU.
< use sense >
According to following evaluation criterion, 10 people experimenters have non-stimulated evaluation to during coated body insertion between cog portion and from during between cog portion pull-out coated body to gingiva.Evaluate point average with 10 people is " A " more than 2.5 points, more than 2 points and less than 2.5 points be " B ", less than 2 points be " C ", evaluate.
[evaluation criterion]
3 points: almost experience less than the stimulation to gingiva.
2 points: experience the stimulation to gingiva a little.
1 point: strongly experience the stimulation to gingiva.
(embodiment 2)
Except the hardness of coated body being set as, except 80, obtaining spreading implement similarly to Example 1, evaluate the use sense of the spreading implement obtained.Evaluation result is as shown in table 1.In addition, only in order to confirm the difference of the use sense caused due to coated body hardness in the present embodiment, the evaluation of bactericidal effect is not thus carried out.
(embodiment 3)
Except the hardness of coated body being set as, except 90, obtaining spreading implement similarly to Example 1, evaluate the use sense of the spreading implement obtained.Evaluation result is as shown in table 1.In addition, only in order to confirm the difference of the use sense caused due to coated body hardness in the present embodiment, the evaluation of bactericidal effect is not thus carried out.
(comparative example 1)
Replace preparation 222 in the oral cavity in inner pressurd vessel 220 and use PBS solution, under no power, coated body 2 was immersed in PBS solution after 10 minutes, measures biomembranous viable count, its result is as shown in table 1.And evaluate use sense, its result is as shown in table 1.
(comparative example 2)
Use in oral cavity except preparation except replacing PBS, measure biomembranous viable count in the same manner as comparative example 1, its result is as shown in table 1.And evaluate use sense, its result is as shown in table 1.
(comparative example 3)
Use except PBS solution except replacing preparation 222 in the oral cavity in inner pressurd vessel 220, be energized process 10 minutes similarly to Example 1.Measure biomembranous viable count after energising process, its result is as shown in table 1.And evaluate use sense, its result is as shown in table 1.
(comparative example 4)
Except replacing preparation 222 in the oral cavity in inner pressurd vessel 220, beyond isopropyl methyl phenol (IPMP) aqueous solution using 0.1 quality %, be energized process 10 minutes similarly to Example 1.
Measure biomembranous viable count after energising process, its result is as shown in table 1.And evaluate use sense, its result is as shown in table 1.
(comparative example 5)
By insulating properties tinsel (the Φ 0.25mm that surface covers with polyethylene, SUS system) carry out twisted, between this tinsel, clamp 300 nylon filaments (Φ 0.05mm), be made the diameter 3mm of bottom, the diameter 2mm of top ends, the coated body of length 10mm.Evaluate the bactericidal effect to this coated body and use sense similarly to Example 1, its result is as shown in table 1.
[table 1]
As shown in table 1, be suitable for embodiments of the invention 1, its logCFU is 3.2, and use sense is " A ".On the other hand, there is not the comparative example 1,2,5 of positive charge convection current from coated body and replace cationic antibacterial and use the comparative example 3,4, its logCFU of PBS solution or IPMP aqueous solution more than 7, effective bactericidal effect can not be had by accreditation.
As can be seen from these results, by using unit for oral cavity care, its spreading implement having preparation in the oral cavity containing cationic antibacterial and positive terminal is connected to coated body, can infiltrate through cationic antibacterial in biomembrane effectively.
Industrial utilizes probability
Unit for oral cavity care of the present invention, by have in the oral cavity containing cationic antibacterial preparation and preparation in this oral cavity is coated intraoral spreading implement, can provide the unit for oral cavity care giving full play to pharmacy effect.
Claims (10)
1. a unit for oral cavity care, it to have in oral cavity preparation and preparation in described oral cavity is coated the unit for oral cavity care of intraoral spreading implement, it is characterized in that,
In described oral cavity, preparation contains cationic antibacterial as its effective ingredient,
Described spreading implement has: holding body; The electric conductivity coated body that described holding body is arranged; Power supply; Be connected with described power cathode and in described holding body, expose the negative terminal of formation; With the positive terminal separated with described negative terminal while being connected with the positive pole and described coated body of described power supply,
The shape of described coated body is the taper shape along the top orientation reduced to coated body, and the side of described coated body is formed with recessed bar or raised line.
2. unit for oral cavity care according to claim 1, is characterized in that, described coated body is made up of electroconductive polymer.
3. unit for oral cavity care according to claim 2, the specific insulation of described coated body is 1 × 10
2below Ω cm.
4. unit for oral cavity care according to claim 1, it is characterized in that, described effective ingredient is selected from the biguanides antibacterial of the quaternary ammonium salt, Chlorhexidine hydrochloride, chlorhexidine gluconate, hydrochloric acid Win-21904, gluconic acid Win-21904 etc. of cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, stearalkonium chloride, lauryl trimethyl ammonium chloride, myristyl trimonium ammonium chloride, CTAB, stearyl trimethyl ammonium chloride etc.
5. unit for oral cavity care according to claim 4, is characterized in that, described effective ingredient is quaternary ammonium salt.
6. unit for oral cavity care according to claim 1, the content of the cationic antibacterial in oral cavity in preparation is at below more than 0.001 quality % 0.2 quality %.
7. unit for oral cavity care according to claim 2, the conductive material that described electroconductive polymer contains is selected from the metal-oxide or carbon of the metal of gold, silver, titanium oxide, zinc oxide.
8. unit for oral cavity care according to claim 1, the side of described coated body is formed more than 2 the recessed bars along the circumferential direction extended.
9. unit for oral cavity care according to claim 1, the side of described coated body is formed the recessed bar of spiral extension.
10. unit for oral cavity care according to claim 1, the side of described coated body is formed from the bottom of coated body to the recessed bar that top orientation extends.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011086318A JP5926891B2 (en) | 2011-04-08 | 2011-04-08 | Oral care unit |
| JP2011-086318 | 2011-04-08 | ||
| PCT/JP2012/059027 WO2012137751A1 (en) | 2011-04-08 | 2012-04-03 | Unit for oral cavity care |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103458823A CN103458823A (en) | 2013-12-18 |
| CN103458823B true CN103458823B (en) | 2016-01-13 |
Family
ID=46969149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280017399.3A Active CN103458823B (en) | 2011-04-08 | 2012-04-03 | Unit for oral cavity care |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP5926891B2 (en) |
| KR (1) | KR20140008362A (en) |
| CN (1) | CN103458823B (en) |
| WO (1) | WO2012137751A1 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102015206900B4 (en) * | 2015-04-16 | 2023-07-27 | Adidas Ag | sports shoe |
| JP6860503B2 (en) * | 2015-05-05 | 2021-04-14 | コスモ ハラランビディス， | Device for electrical stimulation of periodontal complex and surrounding tissue |
| US11103696B2 (en) | 2015-05-05 | 2021-08-31 | Cosmo Haralambidis | Device for electrical stimulation of peridontal complex and surrounding tissue |
| MX2018000271A (en) * | 2015-07-07 | 2018-04-11 | Colgate Palmolive Co | Oral care implement and monofilament bristle for use with the same. |
| AU2020292453B2 (en) * | 2019-06-14 | 2023-03-16 | The Procter & Gamble Company | Kit for applying emulsion compositions |
| BR112021024257A2 (en) * | 2019-06-14 | 2022-01-11 | Procter & Gamble | Device for application of emulsion compositions |
| JP7446099B2 (en) | 2019-12-06 | 2024-03-08 | エア・ウォーター株式会社 | Composition for treating infection in root canals and dentinal tubules of teeth |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN200953930Y (en) * | 2006-08-16 | 2007-10-03 | 诗丽雅化妆品（泉州）有限公司 | Toothbrush |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0342805Y2 (en) * | 1987-05-30 | 1991-09-09 | ||
| JP3110556B2 (en) * | 1992-05-21 | 2000-11-20 | ライオン株式会社 | Interdental brush and manufacturing method thereof |
| JPH10243820A (en) * | 1997-03-04 | 1998-09-14 | Hiroshi Fukuba | Ion interdental brush |
| JPH11137577A (en) * | 1997-11-07 | 1999-05-25 | Lion Corp | Interdental cleaner |
| JPH11188050A (en) * | 1997-12-26 | 1999-07-13 | Lion Corp | Cleaner for interproximal space |
| JP2002101955A (en) * | 2000-09-29 | 2002-04-09 | Rapisu Kk | Interdental brush |
| JP2002186634A (en) * | 2000-12-22 | 2002-07-02 | Mind Up:Kk | Electric interdental brush |
| JP3493359B1 (en) * | 2003-03-20 | 2004-02-03 | 宣美 辛島 | Iontophoretic therapy device |
| JP2007167527A (en) * | 2005-12-26 | 2007-07-05 | Lion Corp | Artificial teeth cleaner |
| DE102006027756A1 (en) * | 2006-06-16 | 2007-12-20 | Braun Gmbh | Toothbrush and toothbrush head and toothbrush bristles for this |
| JP2009050607A (en) * | 2007-08-29 | 2009-03-12 | Pentel Corp | Toothbrush |
| JP2010124904A (en) * | 2008-11-25 | 2010-06-10 | Panasonic Electric Works Co Ltd | Oral cavity care instrument |
-
2011
- 2011-04-08 JP JP2011086318A patent/JP5926891B2/en not_active Expired - Fee Related
-
2012
- 2012-04-03 CN CN201280017399.3A patent/CN103458823B/en active Active
- 2012-04-03 KR KR1020137022895A patent/KR20140008362A/en not_active Application Discontinuation
- 2012-04-03 WO PCT/JP2012/059027 patent/WO2012137751A1/en active Application Filing
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN200953930Y (en) * | 2006-08-16 | 2007-10-03 | 诗丽雅化妆品（泉州）有限公司 | Toothbrush |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012137751A1 (en) | 2012-10-11 |
| JP2012217616A (en) | 2012-11-12 |
| CN103458823A (en) | 2013-12-18 |
| KR20140008362A (en) | 2014-01-21 |
| JP5926891B2 (en) | 2016-05-25 |
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