CN103446247A - High-seepage-force compound essential oil for preventing skins from being aged - Google Patents

High-seepage-force compound essential oil for preventing skins from being aged Download PDF

Info

Publication number
CN103446247A
CN103446247A CN2013104189060A CN201310418906A CN103446247A CN 103446247 A CN103446247 A CN 103446247A CN 2013104189060 A CN2013104189060 A CN 2013104189060A CN 201310418906 A CN201310418906 A CN 201310418906A CN 103446247 A CN103446247 A CN 103446247A
Authority
CN
China
Prior art keywords
essential oil
oil
seepage
skin
tea tree
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN2013104189060A
Other languages
Chinese (zh)
Other versions
CN103446247B (en
Inventor
李俊
李江平
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HUBEI LISHIZHEN BIO-TECH Co Ltd
Original Assignee
HUBEI LISHIZHEN BIO-TECH Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HUBEI LISHIZHEN BIO-TECH Co Ltd filed Critical HUBEI LISHIZHEN BIO-TECH Co Ltd
Priority to CN201310418906.0A priority Critical patent/CN103446247B/en
Publication of CN103446247A publication Critical patent/CN103446247A/en
Application granted granted Critical
Publication of CN103446247B publication Critical patent/CN103446247B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Landscapes

  • Medicines Containing Plant Substances (AREA)
  • Cosmetics (AREA)

Abstract

The invention provides high-seepage-force compound essential oil for preventing skins from being aged. The essential oil is prepared by taking purple perilla essential oil as bottom oil and adding folium artemisiae argyi essential oil, tea tree essential oil and pine needle essential oil; the volume percentage of each component is as follows: 1.89%-7.14% of the folium artemisiae argyi essential oil, 0.94%-3.64% of the tea tree essential oil, 0.94%-3.64% of the pine needle essential oil and 86.20%-96.15% of the purple perilla essential oil; the folium artemisiae argyi essential oil is Chinese mugwort essential oil. The high-seepage-force compound essential oil is prepared by taking the purple perilla essential oil as a main functional component and adding the folium artemisiae argyi essential oil, the tea tree essential oil and the pine needle essential oil of natural aromatic plants; the high-seepage-force compound essential oil can be used for adjusting the releasing of chemical substances of a human body, and regulating, controlling and balancing a skin system, so as to have the effects of enhancing the seepage force, increasing blood circulation, activating cells, dehumidifying and sterilizing, disinfecting and easing pains, relaxing the muscles and activating collaterals, resisting oxidization, and preventing the skins from being aged.

Description

A kind of high penetration compound essential Oil that prevents skin aging
Technical field
The present invention relates to the medicines and health protection technical field, relate in particular to the fragrant plant compound essential Oil that a kind of penetration is strong, prevent skin aging.
Background technology
The aging rate of female skin is faster than the male.With age growth, the loss of moisture in human body, cause supporting skin elasticated net fracture, skin histology atrophy, subside, follow the string, when the elasticity of skin corium and water conservation degree reduce, skin will manifest the aging phenomenons such as drying, coarse, lax, wrinkle, corse sweat pore, dimness, mottle.
Quintessence oil comes from the parts such as the flower, leaf, root, skin, stem, branch, fruit, seed of fragrant plant, the oily mater with characteristic perfume of taking the methods such as distillation, squeezing, extraction, absorption to make.They are mixture of chemical compound lot.Mainly contain terpene hydrocarbons, arene, alcohols, aldehydes, ketone, ethers, esters and phenols etc.
In existing market, the kind of quintessence oil is a lot, a feast for the eyes, but the quintessence oil of anti aging effect is but very rare.Quintessence oil need to act on inside of human body just can bring into play its effect, and the part quintessence oil penetration in existing market is inadequate, therefore greatly reduces the performance of its effect.
Summary of the invention
The purpose of this invention is to provide a kind of penetration strong, increase blood circulation, activating cell, dehumidifying sterilization, sterilization analgesia, tendons relaxing and meridians dredging, hole oxidation, prevent skin aging plant compound essential Oil.
The objective of the invention is to be achieved through the following technical solutions:
A kind of high penetration compound essential Oil that prevents skin aging, using Fructus Perillae quintessence oil as end oil in this quintessence oil, be equipped with P-Cymene, tea tree ethereal oil and Essential Oil From Pine Needles stirring and form, and the shared percent by volume of each component is: P-Cymene 1.89%~7.14%; Tea tree ethereal oil 0.94%~3.64%; Essential Oil From Pine Needles 0.94%~3.64%; Fructus Perillae quintessence oil 86.20%~96.15%.
Described P-Cymene is the Chinese mugwort quintessence oil.Described perilla oil is the Folium Perillae seed oil.
The present invention be take Fructus Perillae quintessence oil as main effect composition, adopts P-Cymene, tea tree ethereal oil and the Essential Oil From Pine Needles of natural aromatic plant formulated, the release of balance the body chemical substance, regulation and control and balance integumentary system.
The quintessence oil of natural aromatic plant is mostly from the vapor distillation such as fruit, flower, leaf, root or seed of plant
Method or cold-press method extract, and main component is micromolecular compound, comprises terpenoid, alcohols, phenolic compound.The quintessence oil molecular action mainly contains in the mode of human body: nasal cavity sucks and skin massaging absorbs.Suction is to make quintessence oil enter the fastest method of human body, by nasal cavity, the volatile oil molecule is sucked, make the quintessence oil molecule pass to the nasal epithelium formed by olfactory receptor cell on nasal cavity top from the throat rear portion by nasal meatus, remake the olfactory region of using brain, inspire the release of chemical substance, then send instruction via the brain nervus centralis, remove regulation and control and balance integumentary system, thus activating cell, tendons relaxing and meridians dredging.
Massage is a kind of application mode of the most comfortable of combining with the sense of touch therapy in quintessence oil application.Because the structure of quintessence oil molecule is less, skin permeation very easily, massage can help the quintessence oil molecule to penetrate in body, accelerate to absorb, make body and mind loose, simultaneously the active blood of energy, promote lymph circulation, and the gratification that increases happiness and takeed good care of in contact skin, be conducive to physical and mental health.
In formula of the present invention, Folium Perillae, English name Clary Sage, Latin is called Salvia Sclarea, and the Labiatae Salvia officinalis L. belongs to, original producton location France.Folium Perillae has another name called red Soviet Union, Fructus Perillae, also is common perilla, is the medicine food dual purpose plant of the first batch of approval of country, has the effects such as expectorant, lung moistening, pain relieving, removing toxic substances.The Salvia Sclare L. Herb is containing quintessence oil 0.10~0.15%, and the spica oil-containing is the highest, can reach 0.18% left and right.The quintessence oil main component is linalyl acetate and linalool, accounts for respectively 60%, more than 20%.The Salvia Sclare L. quintessence oil is considered to the mitigation of parasympathetic nervous system and sedation, to tired, anxiety is effective.Perilla oil reaches 56.14-64.82% containing а-linolenic acid, а-linolenic acid is the fatty acid of needed by human, it is converted into vital activity factor D HA and the EPA(plant NAOHUANGJIN of metabolism necessity in human body),, containing cholesterol, human body is not had to more significant health care and medical efficacy.Perilla oil has following effect: effect for reducing blood fat, improve memory, defying age, anticancer, antiallergic, blood fat-reducing blood pressure-decreasing, hepatoprotective, nourishing the brain and improving intelligence, vision protection.
Chinese mugwort is a kind of Compositae herbaceos perennial, in all parts of the country all over giving birth to, and take Hubei Qi Zhou product person as good.Lunar calendar May, be Ai Shengchang the most vigorous, also be that oil content is the highest the time, therefore the Folium Artemisiae Argyi person that generally gathers can not miss this best time.
Li Shizhen (1518-1593 A.D.) also has penetrating the discussion to the effect of Folium Artemisiae Argyi: " the living micro-hardship of Folium Artemisiae Argyi is too hot, and ripe micro-suffering is too bitter.Give birth to warm ripe heat, pure sun also.Can get the sun kidney-yang, can return the exhausted Yuanyang of hanging down.Clothes walk three the moon, and cut one by one cold-damp, turn awful atmosphere for merging.Saturating all warps of moxibustion, and control hundred kinds of pathogenic factor, playing the artificially safe of severe and lingering illness, its merit is also large.”
The purposes of Chinese mugwort Folium Artemisiae Argyi in medical treatment is a lot, too numerous to enumerate.The Folium Artemisiae Argyi decoction, have good effect to gynaecopathia such as dysfunctional uterine hemorrhage, dysmenorrhea, menoxenias; Decoct the soup washout and can treat the diseases such as skin eczema pruritus; Folium Artemisiae Argyi is mashed into floss, makes moxa roll or Chinese mugwort cake, can be for traditional Chinese medical science moxibustion therapy.
The attending effectiveness of Chinese mugwort quintessence oil, the blood of regulating the flow of vital energy, the warming the meridian arteries and veins, dispelling cold and dampness, pain relieving, antibiotic, antiinflammatory, the excitation digestive gland, relieving cough and reducing sputum, short circulation, QI invigorating, promote immunity.
The English of Camellia sinensis is called tea tree/ti-tree, and Chinese Melaleuca Alternifolia by name or Australia Camellia sinensis, belong to Myrtaceae, and its abnormal smells from the patient is fresh, pure and fresh, and some is pungent and pungent, and color is very light, viscosity as water quality.
The topmost chemical composition of tea tree ethereal oil is ethylene, dipentene, limonene, cineol, Oleum sesami brain, anisoxide.Tea tree ethereal oil can be used as soap, facial cream, milky lotion, deodorizer, disinfectant and air freshener.Tea tree ethereal oil abnormal smells from the patient delicate fragrance uniqueness is strong, it has the antimicrobial acivity, biocidal efficacies, antibacterial activity, nonirritant of All Pure Nature, good skin osmosis and unique advantages such as armaticity, and it can be treated and cuts scratch, very fast with rear wound healing, hemostasis power is superpower, acne and sore, comedo, mosquito bite, trick tinea etc., also effective in cure to seasick carsick symptom, can be with fixed attention.
Single tea tree ethereal oil purposes in fact is unlimited, if but also have other quintessence oil on hand, can make its performance concertedness.
Folium Pini brims with the forest breath, and its fragrance is like large boundless imposing manner, can make the emotion of solidifying and the agitation of heart clear off, and makes dispirited soul take on an entirely new look.Folium Pini has purification function to skin, but and activating cell, strengthen blood circulation, make Cellular respiration, strengthen oxygen unimpeded interchange in vivo, remove body odour.Folium Pini separately can alleviate respiratory system defect and treatment flu.
Essential Oil From Pine Needles has following effect: antiinflammatory, antibiotic, remove nasal obstruction, deodorization, diuresis, sterilize, reduce phlegm, regain one's strength, make skin warm, inspire antiperspirant, excitation, benefit body etc.
Essential Oil From Pine Needles also has great skin curative effect, valuable for the skin blocked, but and eczema, chronic eczema also mat pinaster quintessence oil improve.The Essential Oil From Pine Needles wound of cutting that can also heal, and pacify the skin of irriate.
In the present invention, above-mentioned four kinds of quintessence oils are carried out to organic combination, between various quintessence oils, complement each other, not only make it there is extremely strong penetration, and can increase blood circulation, activating cell, dehumidifying sterilization, sterilization analgesia, tendons relaxing and meridians dredging, hole oxidation, prevent skin aging.
The specific embodiment
Below by specific embodiment, technical scheme of the present invention is further described.But following examples do not form limitation of the invention.
The using method of compound essential Oil of the present invention mainly contains three large modes:
1. champignon is used.By compound essential Oil of the present invention, according to every 10 cubic metres, use 2, the employing heat source type
Scent diffusion equipment expands fragrant.
2. spraying is used.By compound essential Oil of the present invention, add 4~8 according to every 10 milliliters of pure water or distilled water, fully shake up the diffusion of spraying.
3. massage is used.By compound essential Oil of the present invention, add 4~8 according to substrate such as every 10 milliliters of base oils or emulsions, fully mix, carry out skin massaging, take the breast neck massaging as good.
embodiment 1
What in the present embodiment, provide a kind ofly prevents that the high penetration compound essential Oil of skin aging from adopting following proportioning: Fructus Perillae quintessence oil 100mL, Chinese mugwort quintessence oil 4 mL, tea tree ethereal oil 2 mL, Essential Oil From Pine Needles 2 mL.
Using method: in the space of 50 cubic metres, 10 compound essential Oil of the present invention are carried out to perfume (or spice) with the heat source type scent diffusion equipment
Smoke and expand perfume.
embodiment 2
What in the present embodiment, provide a kind ofly prevents that the high penetration compound essential Oil of skin aging from adopting following proportioning: Fructus Perillae quintessence oil 50mL, Chinese mugwort quintessence oil 3 mL, tea tree ethereal oil 1.5mL, Essential Oil From Pine Needles 2 mL.
Using method: by compound essential Oil of the present invention, according to every 10 milliliters of pure water or distilled water, add 4~8
Drip, fully shake up, in the front 10 centimetres of diffusions of spraying of face, deeply breathe.
embodiment 3
What in the present embodiment, provide a kind ofly prevents that the high penetration compound essential Oil of skin aging from adopting following proportioning: Fructus Perillae quintessence oil 75mL, Chinese mugwort quintessence oil 2 mL, tea tree ethereal oil 1mL, Essential Oil From Pine Needles 1mL.
Using method: by compound essential Oil of the present invention, in 20 milliliters of Jojoba oil, add 10, fully mix,
Carry out breast skin of neck massage 5~10 minutes.
The compound essential Oil of above embodiment prevents that the effect of skin aging, high penetration from studies have shown that by following:
Get the female Kunming mouse of SPF level, 20 of 3 monthly ages, 80 of 12 monthly ages.The mice at 80 12 monthly ages is divided into to 4 groups at random: be respectively Normal group, A group, B group and C group, 20 every group.Another using the female Kunming mouse at 20 3 monthly ages as young group of contrast, its weight is 25-27g.Mice is by the group sub-cage rearing.Under identical natural conditions, routine is raised food drinking-water, and adaptability starts to be tested after raising.Slough mao 2cm * 4cm on skin that asks of mouse back two omoplates before experiment with shaver, the A-C group is coated with outward with the compound essential Oil prepared in embodiment 1-3 respectively, and Normal group and young matched group are coated with outward with deionized water, preservative film protection 2h.Smear every day once, smear 0.5g at every turn, smear continuously 50 days.After having tested, mice is put to death, measure HYP, SOD, MDA and the LF value at its experiment skin place.
the mensuration of the preparation of 10% skin homogenate and SOD, MDA, LF:
Get the rear about 0.5g of skin histology piece of back depilation, through pre-cooling 0.9% sodium chloride solution rinsing, remove subcutaneous fat and other connective tissues, filter paper is wiped away dry, weighed quality, piece of tissue shreds in the rear homogenate tube of falling people, pre-cooling 0.9% sodium chloride solution that adds 9 times of quality of this piece of tissue, make 10% tissue homogenate (carrying out in frozen water) with interior cut tissue refiner, and then multigelation is 3 times, make it fully broken, cellular content is free in liquid phase fully.In skin homogenate, the index parameters such as SOD activity, MDA content, skin LF, all build up bio-engineering corporation's test kit description method with reference to Nanjing and measured.
The measurement result of mouse skin SOD, MDA, LF shows: the younger matched group of Normal group SOD activity significantly descends, and the content of MDA, LF significantly increases.
Compound essential Oil prepared by the embodiment 1-3 natural aging mice skin SOD activity that all can obviously raise, obviously descend the content of its MDA, LF.This experimental result confirms that compound essential Oil of the present invention has significant function of anti-skin aging.
the mensuration of HYP and collagen protein:
By the mouse back skin depilatory and after removing connective tissue, acetone: ether: (V/V) defat in 1: 1,80 ℃ of oven dry, precision takes 50mg, adds 6mol/L hydrochloric acid solution 2mL and mixes, in 80 ℃ of baking oven hydrolysis 36h; Get hydrolyzed solution 0.4mL and regulate its pH value between 6-7 with the sodium hydroxide solution of 6mol/L, add water and be settled to 10.0mL; Get hydrolyzed solution 0.2mL and enter test tube, add successively buffer 1mL, ammonia amine T lmL, perchloric acid 1mL, developer 1mL, mix, 60 ℃ of water-bath 15min, 550nm wavelength 1cm optical path colorimetric, the standard curve pipe is prepared in blank zeroing simultaneously.In sample, the mass fraction of collagen protein be take in collagen protein the HYP mass fraction and is calculated as 13%.
The measurement result demonstration of mouse skin HYP and collagen content, in the mouse skin of A-C group, the content compared with normal matched group of HYP is significantly improved, and difference has utmost point significance.This illustrates that compound essential Oil of the present invention can promote the synthetic of skin collagen, makes skin be tending towards rejuvenation.

Claims (3)

1. a high penetration compound essential Oil that prevents skin aging, it is characterized in that: using Fructus Perillae quintessence oil in this quintessence oil as end oil, be equipped with P-Cymene, tea tree ethereal oil and Essential Oil From Pine Needles stirring and form, the shared percent by volume of each component is: P-Cymene 1.89%~7.14%; Tea tree ethereal oil 0.94%~3.64%; Essential Oil From Pine Needles 0.94%~3.64%; Fructus Perillae quintessence oil 86.20%~96.15%.
2. the high penetration compound essential Oil that prevents skin aging according to claim 1, it is characterized in that: described P-Cymene is the Chinese mugwort quintessence oil.
3. the high penetration compound essential Oil that prevents skin aging according to claim 1, it is characterized in that: described perilla oil is the Folium Perillae seed oil.
CN201310418906.0A 2013-09-13 2013-09-13 High-seepage-force compound essential oil for preventing skins from being aged Expired - Fee Related CN103446247B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201310418906.0A CN103446247B (en) 2013-09-13 2013-09-13 High-seepage-force compound essential oil for preventing skins from being aged

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201310418906.0A CN103446247B (en) 2013-09-13 2013-09-13 High-seepage-force compound essential oil for preventing skins from being aged

Publications (2)

Publication Number Publication Date
CN103446247A true CN103446247A (en) 2013-12-18
CN103446247B CN103446247B (en) 2015-04-22

Family

ID=49729360

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201310418906.0A Expired - Fee Related CN103446247B (en) 2013-09-13 2013-09-13 High-seepage-force compound essential oil for preventing skins from being aged

Country Status (1)

Country Link
CN (1) CN103446247B (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104830571A (en) * 2015-04-30 2015-08-12 蕲春时珍本草科技有限公司 Artemisia argyi essential oil soap
CN105496858A (en) * 2015-12-20 2016-04-20 青岛海特新蓝生物科技有限公司 Essential oil for facilitating wound healing
CN105535261A (en) * 2015-12-30 2016-05-04 暨南大学 Folium artemisiae argyi health-care essential oil and preparation method thereof
CN106259495A (en) * 2015-05-20 2017-01-04 周海腾 A kind of quintessence oil of driving away mosquito
CN106420991A (en) * 2016-12-19 2017-02-22 福建万亿店中店电子商务有限责任公司 Skin care massage oil containing tea tree essential oil
CN109260059A (en) * 2018-11-15 2019-01-25 广东轻工职业技术学院 A kind of essential oil composition with anti-acne and skin repair and application
CN110200857A (en) * 2019-07-08 2019-09-06 江苏康地源生态农场有限公司 It is a kind of with anti-oxidant, delaying skin aging effect compound wormwood essential oil
CN114504523A (en) * 2022-01-05 2022-05-17 郑重远 A compound liquid containing Perilla seed oil and oleum Rosae Rugosae for caring skin

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
吴桂花: "艾叶挥发油和多糖提取工艺及生物活性研究", 《中国优秀硕士学位论文全文数据库》 *
李梓: "拉雅松和细叶云南松挥发性成分的提取及生物活性研究", 《中国优秀硕士学位论文全文数据库》 *
王丽梅等: "紫苏油对衰老模型大鼠的抗衰老作用研究", 《食品科技》 *
邵兴锋等: "茶树精油的生物活性及其在对虾保鲜中的应用", 《江苏农业学报》 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104830571A (en) * 2015-04-30 2015-08-12 蕲春时珍本草科技有限公司 Artemisia argyi essential oil soap
CN106259495A (en) * 2015-05-20 2017-01-04 周海腾 A kind of quintessence oil of driving away mosquito
CN105496858A (en) * 2015-12-20 2016-04-20 青岛海特新蓝生物科技有限公司 Essential oil for facilitating wound healing
CN105535261A (en) * 2015-12-30 2016-05-04 暨南大学 Folium artemisiae argyi health-care essential oil and preparation method thereof
CN106420991A (en) * 2016-12-19 2017-02-22 福建万亿店中店电子商务有限责任公司 Skin care massage oil containing tea tree essential oil
CN109260059A (en) * 2018-11-15 2019-01-25 广东轻工职业技术学院 A kind of essential oil composition with anti-acne and skin repair and application
CN109260059B (en) * 2018-11-15 2021-09-10 广州市衡拓贸易有限公司 Essential oil composition with acne removing and skin repairing effects and application thereof
CN110200857A (en) * 2019-07-08 2019-09-06 江苏康地源生态农场有限公司 It is a kind of with anti-oxidant, delaying skin aging effect compound wormwood essential oil
CN114504523A (en) * 2022-01-05 2022-05-17 郑重远 A compound liquid containing Perilla seed oil and oleum Rosae Rugosae for caring skin

Also Published As

Publication number Publication date
CN103446247B (en) 2015-04-22

Similar Documents

Publication Publication Date Title
CN103446247B (en) High-seepage-force compound essential oil for preventing skins from being aged
Davis Aromatherapy An AZ: The most comprehensive guide to aromatherapy ever published
Rose The aromatherapy book: applications and inhalations
CN104042523A (en) Natural plant therapeutic massage essential oil
CN103007104A (en) Compound Chinese mugwort essential oil
CN103830440A (en) Health care essential oil with sedative effect
CN110339331A (en) A kind of plant is releived essential oil
Hedaoo et al. A review on aromatherapy
CN105030016A (en) Chinaberry bark carpet with air purifying function
KR20210066267A (en) Aroma oil serum composition comprising frankincense oil
CN104924819A (en) Stationary storing barrel in combination of active mineral substances and mosquito repelling extracts
CN102266545B (en) Compound essential oil with functions of relaxing tendons and activating collaterals and preparation method thereof
Stiles The essential oils complete reference guide: Over 250 recipes for natural wholesome aromatherapy
CN104857181A (en) Essential oil capable of slimming and shaping body
Valnet Essential Oils and Aromatherapy
Halligudi et al. The science and art of aromatherapy: a brief review
CN106729070A (en) A kind of external application energy gauging for mitigating arthralgia and preparation method thereof
CN105435275A (en) Combined formula of lemon blended fragrant essential oil
KR100505486B1 (en) Fiber with biological material and its manufacturing method
CN107441340A (en) A kind of hand and foot from chapping cream of the antipruritic nourishes rough skin of swelling and pain relieving and preparation method thereof
CN106880698A (en) A kind of plants essential oil and preparation method for treating child's property vaginitis
Curtis et al. Essential Oils: All-natural remedies and recipes for your mind, body and home
Curtis et al. Neal's Yard Remedies Essential Oils: Restore* Rebalance* Revitalize* Feel the Benefits* Enhance Natural Beauty* Create Blends
CN107982101B (en) Natural repair factor capable of effectively repairing and regenerating, preparation method and application thereof
Tourles Stephanie Tourles's Essential Oils: A Beginner's Guide: Learn Safe, Effective Ways to Use 25 Popular Oils; Make 100 Aromatherapy Blends to Enhance Health; Soothe Common Ailments and Promote Well-Being

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20150422

Termination date: 20210913