CN103445978A - 磷酸氢钙型牙膏 - Google Patents
磷酸氢钙型牙膏 Download PDFInfo
- Publication number
- CN103445978A CN103445978A CN2013103521877A CN201310352187A CN103445978A CN 103445978 A CN103445978 A CN 103445978A CN 2013103521877 A CN2013103521877 A CN 2013103521877A CN 201310352187 A CN201310352187 A CN 201310352187A CN 103445978 A CN103445978 A CN 103445978A
- Authority
- CN
- China
- Prior art keywords
- hydrogen phosphate
- calcium hydrogen
- extract
- water
- toothpaste
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 title claims abstract description 37
- 235000019700 dicalcium phosphate Nutrition 0.000 title claims abstract description 37
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 35
- 239000000606 toothpaste Substances 0.000 title claims abstract description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 53
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 37
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 13
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 12
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229920000609 methyl cellulose Polymers 0.000 claims abstract description 12
- 239000001923 methylcellulose Substances 0.000 claims abstract description 12
- 239000000811 xylitol Substances 0.000 claims abstract description 12
- 229960002675 xylitol Drugs 0.000 claims abstract description 12
- 235000010447 xylitol Nutrition 0.000 claims abstract description 12
- 239000000284 extract Substances 0.000 claims description 68
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 21
- 241000628997 Flos Species 0.000 claims description 21
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 21
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 19
- 229940079593 drug Drugs 0.000 claims description 16
- 239000003814 drug Substances 0.000 claims description 16
- 229930192961 schisandrol Natural products 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 12
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 11
- NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 claims description 11
- 229940092705 beclomethasone Drugs 0.000 claims description 11
- 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 11
- 208000007117 Oral Ulcer Diseases 0.000 abstract description 8
- 208000002399 aphthous stomatitis Diseases 0.000 abstract description 8
- 208000024891 symptom Diseases 0.000 abstract description 6
- 210000000214 mouth Anatomy 0.000 abstract description 3
- 241000894006 Bacteria Species 0.000 abstract description 2
- 206010042674 Swelling Diseases 0.000 abstract 1
- HQYLVDYBSIUTBB-UHFFFAOYSA-L disodium;3-[2-(2-carboxylatoethoxy)ethyl-[2-(dodecanoylamino)ethyl]amino]propanoate Chemical compound [Na+].[Na+].CCCCCCCCCCCC(=O)NCCN(CCC([O-])=O)CCOCCC([O-])=O HQYLVDYBSIUTBB-UHFFFAOYSA-L 0.000 abstract 1
- 235000010981 methylcellulose Nutrition 0.000 abstract 1
- 230000008961 swelling Effects 0.000 abstract 1
- 239000008367 deionised water Substances 0.000 description 16
- 229910021641 deionized water Inorganic materials 0.000 description 16
- 229960000935 dehydrated alcohol Drugs 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 238000001556 precipitation Methods 0.000 description 8
- 239000006228 supernatant Substances 0.000 description 8
- 206010018286 Gingival pain Diseases 0.000 description 7
- 206010018291 Gingival swelling Diseases 0.000 description 7
- 208000024283 Gingival haemorrhages Diseases 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 206010018276 Gingival bleeding Diseases 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 208000025865 Ulcer Diseases 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 231100000397 ulcer Toxicity 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 2
- 239000000084 colloidal system Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 230000000680 avirulence Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000000622 irritating effect Effects 0.000 description 1
- 239000011344 liquid material Substances 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Description
实施例1 | 实施例2 | 实施例3 | 实施例4 | 实施例5 | |
无变化 | 0 | 1 | 2 | 1 | 1 |
变化不显著 | 1 | 5 | 5 | 3 | 4 |
有变化 | 8 | 5 | 6 | 8 | 6 |
变化非常显著 | 11 | 9 | 7 | 8 | 9 |
有效率 | 95% | 70% | 65% | 80% | 75% |
显效率 | 55% | 45% | 35% | 40% | 45% |
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310352187.7A CN103445978B (zh) | 2013-08-13 | 2013-08-13 | 磷酸氢钙型牙膏 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310352187.7A CN103445978B (zh) | 2013-08-13 | 2013-08-13 | 磷酸氢钙型牙膏 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103445978A true CN103445978A (zh) | 2013-12-18 |
CN103445978B CN103445978B (zh) | 2015-10-21 |
Family
ID=49729103
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310352187.7A Active CN103445978B (zh) | 2013-08-13 | 2013-08-13 | 磷酸氢钙型牙膏 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN103445978B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105997720A (zh) * | 2016-07-09 | 2016-10-12 | 青岛大学 | 一种美白牙膏 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103040640A (zh) * | 2012-12-31 | 2013-04-17 | 龙启知 | 抗菌牙膏 |
-
2013
- 2013-08-13 CN CN201310352187.7A patent/CN103445978B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103040640A (zh) * | 2012-12-31 | 2013-04-17 | 龙启知 | 抗菌牙膏 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105997720A (zh) * | 2016-07-09 | 2016-10-12 | 青岛大学 | 一种美白牙膏 |
CN105997720B (zh) * | 2016-07-09 | 2019-01-29 | 青岛大学 | 一种美白牙膏 |
Also Published As
Publication number | Publication date |
---|---|
CN103445978B (zh) | 2015-10-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C41 | Transfer of patent application or patent right or utility model | ||
CB03 | Change of inventor or designer information |
Inventor after: Hong Fang Inventor after: Li Zhouxin Inventor after: Lan Yijun Inventor before: Song Fanhua |
|
COR | Change of bibliographic data | ||
TR01 | Transfer of patent right |
Effective date of registration: 20160108 Address after: 363000 Lantian Economic Development Zone, Fujian, Zhangzhou Patentee after: Frog Prince (China) Daily Chemicals Co.,Ltd. Address before: 201107 Shanghai city Minhang District Minhang Road 88 Lane No. 1-30 building twenty-second room T159 Patentee before: SHANGHAI FANGMU FINE CHEMICAL Co.,Ltd. |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20181127 Address after: 363005 Lantian Economic Development Zone, Zhangzhou City, Fujian Province Patentee after: FROG PRINCE (FUJIAN) BABY CARE PRODUCTS Co.,Ltd. Address before: 363000 Lantian Economic Development Zone, Zhangzhou City, Fujian Province Patentee before: Frog Prince (China) Daily Chemicals Co.,Ltd. |
|
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20131218 Assignee: Fujian Herun Supply Chain Management Co.,Ltd. Assignor: FROG PRINCE (FUJIAN) BABY CARE PRODUCTS Co.,Ltd. Contract record no.: X2023980050751 Denomination of invention: Calcium hydrogen phosphate toothpaste Granted publication date: 20151021 License type: Common License Record date: 20240124 |
|
EE01 | Entry into force of recordation of patent licensing contract |