CN103439438B - Electric spraying two-stage gas-assisted focusing device - Google Patents
Electric spraying two-stage gas-assisted focusing device Download PDFInfo
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- CN103439438B CN103439438B CN201310386376.6A CN201310386376A CN103439438B CN 103439438 B CN103439438 B CN 103439438B CN 201310386376 A CN201310386376 A CN 201310386376A CN 103439438 B CN103439438 B CN 103439438B
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Abstract
The invention belongs to the technical field of electric spraying mass spectrometry, and relates to the field of gas-assisted focusing devices for electrically spraying sample ions. The electric spraying two-stage gas-assisted focusing device mainly comprises a first-stage device and a second-stage device, wherein the first-stage device comprises a first-stage air inlet, a first-stage slit, a first-stage curved surface and a first-stage air outlet; and the second-stage device comprises a second-stage air inlet, a second-stage slit, a second-stage curved surface, a second-stage air outlet and an air leaking cavity. The electric spraying two-stage gas-assisted focusing device is characterized in that second-stage airflow is discharged from the air leaking cavity without passing through the first-stage device, therefore electric spraying ions can be successfully conveyed; and the electric spraying two-stage gas-assisted focusing device can be made of any material which is easily machined, and is simple in manufacture process, low in cost, flexible in size and easy to realize.
Description
Technical field
The present invention relates to electrospray ionization mass spectrum research field, the gas especially for electrospray sample ion assists aggregation apparatus field.
Background technology
In recent years, a large amount of research work has been carried out in the sensitivity and resolution of people always with regard to improving electrospray ionization mass spectrum (ESI-MS) further, wherein gordian technique how to improve electron spray ion transport efficiency, namely electrospray ionization mass spectrum ion gun is ionized the ion produced and be more effectively transported to Mass Spectrometer Method ingate, thus improve electrospray ionization mass spectrum sensitivity and resolution.There is various gas servicing unit at present for improving ion transport efficiency, but generally all only have one-level gas to assist aggregation apparatus, improve limited to electron spray ion transport efficiency.
Summary of the invention
It is simple and be easy to the two-stage gas servicing unit processed that the present invention proposes a kind of structure, is conducive to improving ion transport efficiency further.
The technical solution used in the present invention is:
Electron spray two-stage gas assists aggregation apparatus to reach the ultimate principle of effect and Venturi effect based on hydromechanical Koln.Venturi effect refers to that hydrodynamic pressure can reduce when the narrow zone of fluid by pipeline; Koln reaches effect and refers to the attached wall phenomenon of jet, i.e. the phenomenon that flows along curved surface of jet.In first order device, gas enters one-level slit (4) by one-level air intake opening (3), and produce Koln at one-level curved surface (5) place and reach wall attachment effect, air-flow changes direction, and the wall finally along one-level gas outlet (6) blows out; In the device of the second level, gas enters secondary slit (8) by secondary inlet mouth (7), and produce Koln at secondary curved surface (9) place and reach wall attachment effect, air-flow changes direction, is finally discharged along secondary gas outlet (10) by disappointing chamber (11).Electron spray two-stage gas assists aggregation apparatus to pass through to change the direction of motion of air-flow body, reaches auxiliary effect of assembling ion.
2, method for making
Consider actual processing, as shown in Figure of description 2, design one-level air intake opening, one-level curved surface, one-level gas outlet are on part (12), and secondary inlet mouth is on part (18), secondary curved surface, secondary gas outlet, on part (16), lose heart chamber on part (14).The gasket seal (13,17) that one-level slit, secondary slit width are processed into by corresponding thickness sheet material limits, and adopts the red copper of certain thickness in actual production.
Electron spray two-stage gas assists aggregation apparatus method for making step as follows:
1) machining makes part (12), part (14), part (16), part (18), gasket seal (13,17), sleeve (15);
2) outsourcing precision plug beats bolt, nut;
3) parts (12), gasket seal (13) successively, part (14), sleeve (15), part (16), gasket seal (17), part (18).
This electron spray two-stage gas assists the beneficial effect of aggregation apparatus to be further increase the transport efficiency of electrospray ionization mass spectrum ion, and structure is simple, cost is low, size is flexible, stable performance.
Accompanying drawing explanation
Fig. 1 electron spray two-stage gas assists the complete section figure of aggregation apparatus.
Fig. 2 electron spray two-stage gas assists the assembling explosive view of aggregation apparatus.
Fig. 3 electron spray two-stage gas assists the fundamental diagram of aggregation apparatus.
In figure: 1. first order device, 2. second level device, 3. one-level air intake opening, 4. one-level slit, 5. one-level curved surface, 6. one-level gas outlet, 7. secondary inlet mouth, 8. secondary slit, 9. secondary curved surface, 10. secondary gas outlet, 11 disappointing chambeies, 12. parts one, 13. gasket seals, 14. part two, 15. sleeves, 16. parts three, 17. gasket seals, 18. part four, 19. bolts hole, G1. primary air stream, G2. secondary air flow, G3. goes out air-flow, N4. electron spray nozzle needle, O5. Mass Spectrometer Method ingate.
Embodiment
The embodiment of patent of the present invention is described in detail below in conjunction with technical scheme and accompanying drawing.
After electron spray charged drop is formed, in the transport process of Mass Spectrometer Method ingate, there is the losses of ions of 99% by electron spray nozzle needle at present, thus affecting mass spectrometric detection limit and sensitivity.Therefore improve ion transport efficiency and have very important effect to the mass spectrometric detection limit of raising and sensitivity.The electron spray two-stage gas that the present invention designs and produces assists aggregation apparatus, by changing the direction of motion of air-flow body, reaching auxiliary effect of assembling ion, and verifying through experimental data.
As shown in Figure 3, aggregation apparatus is assisted to be fixed between electron spray nozzle needle N4 and Mass Spectrometer Method ingate O5 electron spray two-stage gas, spacing adjusts to correct position, and passes through the position of adjustable Work-table adjusting device, makes electron spray nozzle needle, this device, Mass Spectrometer Method ingate central coaxial.According to actual needs, electron spray nozzle needle gos deep into this device certain position, is no more than 30mm.
The nitrogen of certain pressure enters this device respectively by gas regulator through one-level air intake opening 3, secondary inlet mouth 7, then adjusts the pressure fitted that best I and II air intake opening sought by gas regulator.
Electron spray two-stage gas assists aggregation apparatus sectional view as shown in Figure 1.As shown in Figure 2, gasket seal 13,17 is red copper to actual parts assembling explosive view, and all the other are stainless steel, and within roughness Ra 3.2, the securing member for stationary installation one, device two can play bolt, nut realization by precision plug.
Electron spray two-stage gas assists the principle of work of aggregation apparatus as shown in Figure 3, and primary air stream G1 enters from one-level air intake opening 3, through one-level slit 4, produces wall attachment effect, then discharged by one-level gas outlet 6 wall at one-level curved surface 5 place; Secondary air flow G2 enters from secondary inlet mouth 7, through secondary slit 8, produces wall attachment effect, then discharged by disappointing chamber through secondary gas outlet 10 at secondary curved surface 9 place.G1 and G2 air-flow drives out air-flow G3, changes the G3 air-flow after direction and speed and the electron spray ion current that electron spray nozzle needle N4 sprays is played to the effect accelerated and assemble.
Claims (7)
1. electron spray two-stage gas assists aggregation apparatus, comprise first order device (1) and second level device (2), it is characterized in that: first order device (1) comprises one-level air intake opening (3), one-level slit (4), one-level curved surface (5) and one-level gas outlet (6), gas enters one-level slit (4) by one-level air intake opening (3), produce Koln at one-level curved surface (5) place and reach wall attachment effect, air-flow changes direction, and the wall finally along one-level gas outlet (6) blows out; Second level device (2) comprises secondary inlet mouth (7), secondary slit (8), secondary curved surface (9), secondary gas outlet (10) and disappointing chamber (11), gas enters secondary slit (8) by secondary inlet mouth (7), produce Koln at secondary curved surface (9) place and reach wall attachment effect, air-flow changes direction, and along the wall of secondary gas outlet (10), discharged by disappointing chamber (11); One-level slit and secondary slit width adjustable, the sheet material gasket seal (13,17) being 20 ~ 100 μm by thickness is formed.
2. electron spray two-stage gas according to claim 1 assists aggregation apparatus, it is characterized in that: I and II gas outlet wall configuration includes but not limited to Cylinder Surface or conical camber, Surface Rough rugosity should be less than Ra3.2, reaches wall attachment effect to improve air-flow Koln.
3. electron spray two-stage gas according to claim 1 and 2 assists aggregation apparatus, it is characterized in that, sleeve (15) limits the distance of first order device and second level device, limits the width in chamber (11) of losing heart simultaneously.
4. electron spray two-stage gas according to claim 1 and 2 assists aggregation apparatus, it is characterized in that: sealed attachment between each part in first order device, second level device, and conjunction plane roughness should be less than Ra3.2 to guarantee sealed attachment; Play bolt by precision plug between first order device and second level device, fastening nuts connects.
5. electron spray two-stage gas according to claim 3 assists aggregation apparatus, it is characterized in that: sealed attachment between each part in first order device, second level device, and conjunction plane roughness should be less than Ra3.2 to guarantee sealed attachment; Play bolt by precision plug between first order device and second level device, fastening nuts connects.
6. the electron spray two-stage gas according to claim 1,2 or 5 assists aggregation apparatus, it is characterized in that: also comprise one-level air intake opening and coordinate with the admission pressure of secondary inlet mouth, and one-level inlet charge pressure is more than or equal to the admission pressure of secondary inlet mouth; Electron spray nozzle needle gos deep into electron spray two-stage gas and assists aggregation apparatus to be no more than 30mm.
7. electron spray two-stage gas according to claim 3 assists aggregation apparatus, it is characterized in that: also comprise one-level air intake opening and coordinate with the admission pressure of secondary inlet mouth, and one-level inlet charge pressure is more than or equal to the admission pressure of secondary inlet mouth; Electron spray nozzle needle gos deep into electron spray two-stage gas and assists aggregation apparatus to be no more than 30mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310386376.6A CN103439438B (en) | 2013-08-29 | 2013-08-29 | Electric spraying two-stage gas-assisted focusing device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310386376.6A CN103439438B (en) | 2013-08-29 | 2013-08-29 | Electric spraying two-stage gas-assisted focusing device |
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| Publication Number | Publication Date |
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| CN103439438A CN103439438A (en) | 2013-12-11 |
| CN103439438B true CN103439438B (en) | 2015-03-11 |
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Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7405397B2 (en) * | 2002-03-28 | 2008-07-29 | Mds Sciex Inc. | Laser desorption ion source with ion guide coupling for ion mass spectroscopy |
| WO2004057638A2 (en) * | 2002-12-18 | 2004-07-08 | Brigham Young University | Method and apparatus for aerodynamic ion focusing |
| GB2455351B (en) * | 2007-12-07 | 2012-04-11 | Microsaic Systems Plc | Air amplifier |
| CN102142352B (en) * | 2011-02-12 | 2013-05-08 | 浙江好创生物技术有限公司 | Electro-spray ion generator |
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