CN103432165B - Controlled-release multifunctional veterinary iron supplementing injection and production process thereof - Google Patents
Controlled-release multifunctional veterinary iron supplementing injection and production process thereof Download PDFInfo
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- CN103432165B CN103432165B CN201310377873.XA CN201310377873A CN103432165B CN 103432165 B CN103432165 B CN 103432165B CN 201310377873 A CN201310377873 A CN 201310377873A CN 103432165 B CN103432165 B CN 103432165B
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Abstract
The invention discloses a controlled-release multifunctional veterinary iron supplementing injection and a production process thereof. The controlled-release multifunctional veterinary iron supplementing injection comprises iron-dextrin, vitamin A, crystalline-state vitamin D3, vitamin E, an emulsifier Cremaphor and a food-grade antioxidant. The production method of the controlled-release multifunctional veterinary iron supplementing injection comprises the following steps of fully mixing the vitamin A with the vitamin D3 and the vitamin E at first, adding the emulsifier Cremaphor to the mixture after mixing, stirring the mixture in an emulsifying stirrer at the stirring temperature of 50 DEG C and the rotating speed of 45 r/min to obtain a homogeneous transparent solution, and then adding the iron-dextrin to the vitamin mixed solution for emulsification. The controlled-release multifunctional veterinary iron supplementing injection is simple in production process, has an obvious controlled release effect and a stable pesticide effect, and has no untoward effects such as allergy and stress.
Description
technical field:
The present invention relates to a kind of animal health-care product, particularly a kind of slow release multifunctional iron supplement injection for animals and production technology thereof.
background technology:
At present, for the deficiency disease of preventing animal iron deficiency anemia and fatsoluble vitamin, majority is all single DexFerrum, do not add various vitamin, and minority with the addition of the product of vitamin, in production technology or the simple elementary step, coating technique lacks, slow release effect is not obvious, also some product often occur in the process used stress, irritated, poisoning, invalid etc. problem.
summary of the invention:
The object of the invention is, in order to overcome above deficiency, to provide a kind of efficacy stability, without anaphylaxis, the slow release multifunctional of untoward reaction iron supplement injection for animals and production technology thereof stress be waited.
Object of the present invention is achieved through the following technical solutions: comprise the iron dextran of 10% concentration, density be MIU/g retinol1 .7, crystalline state vitamin D3, vitamin E, emulsifying agent Cremaphor EL(synthetic castor oil) and food grade antioxidants BHT(bis-six ditertbutylparacresol), described iron dextran: vitamin A: crystalline state vitamin D3: vitamin E: emulsifying agent Cremaphor EL(synthetic castor oil): food grade antioxidants BHT(bis-six ditertbutylparacresol) mass ratio correspond to respectively: 94-94.5%; 0.4-0.6%; 0.001-0.003%; 0.8-1.2%; 3.5-4.5%; 0.09-0.12%.
Its optimum proportioning is: iron dextran: vitamin A: crystalline state vitamin D3: vitamin E: emulsifying agent Cremaphor(synthetic castor oil): food grade antioxidants BHT(bis-six ditertbutylparacresol) mass ratio correspond to respectively: 94.3095%:0.588%:0.0025%:1.0000%:4.000%:0.1000%.
A production technology for slow release multifunctional iron supplement injection for animals, comprises the following steps:
1) put into a reaction pot after vitamin A, vitamin D3, vitamin E being heated to 50 DEG C in water bath with thermostatic control fully to mix, rotating speed is 45 revs/min, is stirred as transparent and homogeneous solution.
2) emulsifying agent Cremaphor EL(synthetic castor oil is added after mixing), food grade antioxidants BHT(bis-six ditertbutylparacresol), more fully mix, until be transparent and homogeneous solution.
3) after first iron dextran being put into emulsifying agitator, add above-mentioned vitamin mixture and carry out emulsifying, emulsifying rate is 2500 revs/min, and temperature is room temperature, and emulsifying mixing time is 5 minutes, until mixed liquor is homogeneous, obtains product.
4) product is sent to canning line by transmission pump.
The present invention compared with prior art has the following advantages:
Processing technology is simple, and slow release effect is obvious, efficacy stability, without irritated, stress wait untoward reaction.
detailed description of the invention:
in order to deepen the understanding of the present invention, below in conjunction with embodiment, the invention will be further described, and this embodiment only for explaining the present invention, does not form limiting the scope of the present invention.
A kind of detailed description of the invention of a kind of slow release multifunctional of the present invention iron supplement for animals injection, comprise the following steps: comprise iron dextran, concentration is the vitamin A of 1.7MIU/g, crystalline state vitamin D3, vitamin E, emulsifying agent Cremaphor EL(synthetic castor oil) and food grade antioxidants, described iron dextran: vitamin A (1.7MIU/g): crystalline state vitamin D3: vitamin E: emulsifying agent Cremaphor EL(synthetic castor oil): food grade antioxidants BHT(bis-six ditertbutylparacresol) mass ratio correspond to respectively: 94-94.5%, 0.4-0.6%, 0.001-0.003%, 0.8-1.2%, 3.5-4.5%, 0.09-0.12%, its optimum proportioning is described iron dextran: vitamin A: crystalline state vitamin D3: vitamin E: emulsifying agent Cremaphor EL(synthetic castor oil): food grade antioxidants BHT(bis-six ditertbutylparacresol) mass ratio correspond to respectively: 94.3095%:0.588%:0.0025%:1.0000%:4.000%:0.1000%.
A production technology for slow release multifunctional iron supplement injection for animals, comprises the following steps:
1) put into a reaction pot after vitamin A, vitamin D3, vitamin E being heated to 50 DEG C in water bath with thermostatic control fully to mix, rotating speed is 45 revs/min, is stirred as transparent and homogeneous solution.
2) add emulsifying agent Cremaphor EL(synthetic castor oil after mixing), food grade antioxidants BHT(bis-six ditertbutylparacresol), more fully to mix, until be transparent and homogeneous solution.
3) after first iron dextran being put into emulsifying agitator, add above-mentioned vitamin mixture and carry out emulsifying, emulsifying rate is 2500 revs/min, and temperature is room temperature, and emulsifying mixing time is 5 minutes, until mixed liquor is homogeneous, obtains product.
4) product is sent to canning line by transmission pump.
Embodiment one: put into a reaction pot after 0.588 gram of vitamin A, 0.0025 gram of vitamin D3 and 1.0 grams of vitamin Es are heated to 50 DEG C in water bath with thermostatic control and fully mix, rotating speed is 45 revs/min, is stirred as transparent and homogeneous solution.
2) 4.0 grams of emulsifying agent Cremaphor EL(synthetic castor oils are added after mixing), 0.1 gram of food grade antioxidants BHT(bis-six ditertbutylparacresol), more fully mix, until be transparent and homogeneous solution.
3) after first 94.3095 grams of iron dextran being put into emulsifying agitator, add above-mentioned vitamin mixture and carry out emulsifying, emulsifying rate is 2500 revs/min, and temperature is room temperature, and emulsifying mixing time is 5 minutes, until mixed liquor is homogeneous, obtains product.
4) product is sent to canning line by transmission pump.
Embodiment two: put into a reaction pot after 0.45 gram of vitamin A, 0.002 gram of vitamin D3 and 0.8 gram of vitamin E are heated to 50 DEG C in water bath with thermostatic control and fully mix, rotating speed is 45 revs/min, is stirred as transparent and homogeneous solution.
2) 3.7 grams of emulsifying agent Cremaphor EL(synthetic castor oils are added after mixing), 1.048 grams of food grade antioxidants BHT(bis-six ditertbutylparacresols), more fully mix, until be transparent and homogeneous solution.
3) after first 94 grams of iron dextran being put into emulsifying agitator, add above-mentioned vitamin mixture and carry out emulsifying, emulsifying rate is 2500 revs/min, and temperature is room temperature, and emulsifying mixing time is 5 minutes, until mixed liquor is homogeneous, obtains product.
4) product is sent to canning line by transmission pump.
Embodiment three:
Put into a reaction pot after 0.5 gram of vitamin A, 0.003 gram of vitamin D3 and 0.85 gram of vitamin E are heated to 50 DEG C in water bath with thermostatic control fully to mix, rotating speed is 45 revs/min, is stirred as transparent and homogeneous solution.
2) 4.047 grams of emulsifying agent Cremaphor EL(synthetic castor oils are added after mixing), 0.1 gram of food grade antioxidants BHT(bis-six ditertbutylparacresol), more fully mix, until be transparent and homogeneous solution.
3) after first 94.5 grams of iron dextran being put into emulsifying agitator, add above-mentioned vitamin mixture and carry out emulsifying, emulsifying rate is 2500 revs/min, and temperature is room temperature, and emulsifying mixing time is 5 minutes, until mixed liquor is homogeneous, obtains product.
4) product is sent to canning line by transmission pump.
The present invention has guarantee good product quality, and slow release effect is obvious, efficacy stability, without irritated, stress wait untoward reaction, and once, relative cost is low in an animal injection in all one's life.
Claims (3)
1. a slow release iron supplement injection for animals; it is characterized in that: comprise the iron dextran of 10% concentration, vitamin A, crystalline state vitamin D3, vitamin E, emulsifying agent synthetic castor oil and food grade antioxidants that density is 1.7MIU/g two six ditertbutylparacresol, described iron dextran: vitamin A: crystalline state vitamin D3: vitamin E: emulsifying agent synthetic castor oil: the mass ratio of food grade antioxidants two six ditertbutylparacresol corresponds to respectively: 94-94.5%; 0.4-0.6%; 0.001-0.003%; 0.8-1.2%; 3.5-4.5%; 0.09-0.12%.
2. a kind of slow release iron supplement injection for animals according to claim 1, is characterized in that: described iron dextran: vitamin A: crystalline state vitamin D3: vitamin E: emulsifying agent synthetic castor oil: the mass ratio of food grade antioxidants corresponds to respectively: 94.3095%:0.588%:0.0025%:1.0000%:4.000%:0.1000%.
3. the production method of a kind of slow release according to claim 1 iron supplement injection for animals, comprises the following steps:
1) vitamin A, crystalline state vitamin D3, vitamin E are put into a reaction pot be heated to 50 DEG C in water bath with thermostatic control after fully to mix, rotating speed is 45 revs/min, is stirred as transparent and homogeneous solution;
2) add emulsifying agent synthetic castor oil, food grade antioxidants two six ditertbutylparacresol after mixing, more fully mix, until be transparent and homogeneous solution;
3) after first iron dextran being put into emulsifying agitator, add above-mentioned vitamin mixture and carry out emulsifying, emulsifying rate is 2500 revs/min, and temperature is room temperature, and emulsifying mixing time is 5 minutes, until mixed liquor is homogeneous, obtains product;
4) product is sent to canning line by transmission pump.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106361849A (en) * | 2016-08-31 | 2017-02-01 | 天津市中升挑战生物科技有限公司 | Oral liquid capable of supplementing iron for beasts and preparing method thereof |
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| CN106236709B (en) * | 2016-08-26 | 2020-05-01 | 天津市中升挑战生物科技有限公司 | Glucoheptosylvine nano-emulsion and preparation method thereof |
| CN107519198A (en) * | 2017-07-21 | 2017-12-29 | 南通市第人民医院 | A kind of iron dextran injection and preparation method thereof |
| CN108497172A (en) * | 2018-02-27 | 2018-09-07 | 湖南加农正和生物技术有限公司 | A kind of ferro element and vitamin enrichment supplementing preparation and its production method |
| CN108498556A (en) * | 2018-05-25 | 2018-09-07 | 四川伴农动保生物技术有限公司 | A kind of qi-blood tonifying iron dextran injection and preparation method for animals |
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| WO2007108712A1 (en) * | 2006-03-17 | 2007-09-27 | Tatyana Vyacheslavovna Popkova | Kit and method for treating or preventing anemia caused by iron deficiency |
| CN102440952A (en) * | 2010-10-15 | 2012-05-09 | 天津瑞普生物技术股份有限公司 | Iron-dextrin long-acting injection and preparation method thereof |
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| CN106361849A (en) * | 2016-08-31 | 2017-02-01 | 天津市中升挑战生物科技有限公司 | Oral liquid capable of supplementing iron for beasts and preparing method thereof |
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