CN103431401A - Antioxidant health care food and application thereof - Google Patents
Antioxidant health care food and application thereof Download PDFInfo
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- CN103431401A CN103431401A CN2013104203176A CN201310420317A CN103431401A CN 103431401 A CN103431401 A CN 103431401A CN 2013104203176 A CN2013104203176 A CN 2013104203176A CN 201310420317 A CN201310420317 A CN 201310420317A CN 103431401 A CN103431401 A CN 103431401A
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Abstract
The invention discloses an antioxidant health care food. The health care food is prepared from the following raw materials in parts by weight: 5-8 parts of hematococcus pluvialis powder and 1-3 parts of grape seed extract. According to the invention, the two antioxidant substances, namely the hematococcus pluvialis powder and the grape seed extract, are combined in the previous proportions to develop the synergistic effect of the hematococcus pluvialis powder and the grape seed extract, and then the antioxidant effect is excellent; in addition, a plurality of effects of the two substances can be developed at the same time. The invention also provides an application of the health care food in preparation of antioxidant and anti-aging products.
Description
Technical field
The present invention relates to the technical field of health food, specifically a kind of antioxidant functional food.
Background technology
The National Health Foods industry was risen the eighties in last century, in the short more than ten years, developed the industry that becomes a uniqueness rapidly, and particularly within 1998, health products trade has entered a unprecedented high-speed developing period so far.According to statistics, external health products at home the sales volume on market often with the speed more than 12%, increasing every year.
Health food mainly comprises dietary supplement ingredient (vitamin, mineral calcium magnesium and trace element, various health products); The functional beverage that contains physiological activator and food; The natural colouring matter of plant extract and antioxidant; The garden stuff processing product; Biosynthetic function compound sugar and polypeptide etc.
Oxidation is the biggest threat of skin aging, and diet is unhealthy, Exposure to Sunlight, pressure, environmental pollution etc. can allow the skin free radical spread unchecked, thereby produces the oxidative phenomenas such as complexion dimness, lack of water, is all " arch-criminal " of health generation oxidation.Under normal circumstances, the free radical in human body is among the dynamic equilibrium in continuous generation and removing.Too much or removed slowly, it,, by attacking life macromolecule material and various cell, can cause the various damages of body in molecular level, cellular level and histoorgan level to free-radical generating, and the senescence process of acceleration body also brings out various diseases.Human body, when inevitably producing free radical, is also producing the polyphenoils of resisting free radical naturally, with the oxidation of offsetting the radical pair human body cell, attacks.Studies have shown that, the antioxidant system of human body be one can be comparable with immune system, have and improve and the system of complicated function, the oxidation resistant ability of body is stronger, just more healthy, life is also longer.The antioxidation of body, can keep the balance of generation and the elimination of free radical, to prevent disease and anti-ageing wait for a long time significant.
The health food of the anti-oxidation function that does not still adopt grape seed extract and haematococcus pluvialis powder prescription to prepare at present.
Summary of the invention
The object of the present invention is to provide a kind of antioxidant functional food, can strengthen antioxidation, have that anti-inflammatory is anti-infective, fatigue-relieving simultaneously concurrently, strengthen the effects such as immunity.
For achieving the above object, the invention discloses a kind of antioxidant functional food, made by following weight portion raw material proportioning: 5~8 parts of haematococcus pluvialis powders, 1~3 part of grape seed extract.
Preferably, by following weight portion raw material proportioning, made: 7 parts of haematococcus pluvialis powders, 2 parts of grape seed extracts.
Wherein, described haematococcus pluvialis powder is the aubergine powder obtained after broken wall and spray-drying by haematococcus pluvialis cell, content astaxanthin in described haematococcus pluvialis powder >=1%.
Described Proanthocyanidin from Grape-seed Extracts >=80%.
Haematococcus pluvialis powder in the present invention and grape seed extract all can obtain by directly buying commercially available product.
The preparation method of health food of the present invention can be: get haematococcus pluvialis powder, the grape seed extract of described weight portion, sieve respectively, mix, granulate, drying, add or do not add auxiliary material to be prepared into any one formulation on pharmacy according to common process.
Described formulation is granule or capsule (hard shell capsules, soft capsule) or tablet (ordinary tablet, dispersing tablet, oral disnitegration tablet, lozenge, chewable tablets, effervescent tablet) or oral liquid etc.
Described auxiliary material is: as diluent commonly used in the solid pharmaceutical preparations such as tablet, capsule, granule, disintegrant, excipient, adhesive, lubricant, filler etc.; Surfactant commonly used, diluent, anticorrisive agent, stabilizing agent, flavouring, thickener, glidant etc. in the oral liquids such as syrup, oral liquid.Specifically refer to starch, lactose, dextrin, Icing Sugar, microcrystalline cellulose, sweet mellow wine, xylitol, polyethylene glycol, calcium sulfate, calcium monohydrogen phosphate, calcium carbonate, modified starch, sorbierite, polyvinyl pyrrolidone, heavy magnesium carbonate, sodium carboxymethylcellulose, HPMC, methylcellulose, ethyl cellulose, carboxyrnethyl starch sodium, hydroxypropyl cellulose, PVP K30, white bole, pregelatinized starch, dolomol, talcum powder, superfine silica gel powder, stevioside glycosides, betaine, aspartame, glycyrrhizin, saccharin sodium, citric acid, sodium acid carbonate, sodium carbonate, potassium sorbate, sorbic acid etc.
The present invention also further provides the application of above-mentioned health food in anti-oxidant, the anti-aging product of preparation.
Grape seed extract is the new and effective natural material that can not synthesize in a kind of human body extracted from grape pip.It is anti-oxidant, the strongest material of removing free radical ability that current occurring in nature is found, its antioxidation activity is 50 times, ascorbic 20 times of vitamin E, it can effectively remove unnecessary free radical in human body, has the superpower effect that delays senility and strengthen immunity.The application of Grape Seed Extract Procyanidin is very extensive, for example: zoopery and clinical research are found, Grape Seed Extract Procyanidin can reduce cholesterol and low-density lipoprotein white level effectively, antithrombotic, contribute to prevent the generation of cardiovascular and cerebrovascular disease, and some tumour cell is had to cytotoxicity, play antineoplastic action.Its disease-prevention health effect basis is exactly its ability of removing free radical, in addition, it also has bioavilability preferably, is easy to be combined with collagen, stabilizing cell membrane and antienzyme activity, these abilities and oxidation resistance are collaborative makes it be expected to become a kind of health products that have much DEVELOPMENT PROSPECT.
Haematococcus pluvialis is the monoplast green alga of one way of life in fresh water, and Determination of Astaxanthin in Haematococcus Pluvialis content, up to 1.5%~3.0%, therefore is counted as " concentrate " of natural astaxanthin.The haematococcus pluvialis extract is as a kind of novel living resources, it has the raising body immunity, delay skin aging, safeguard the functions such as different physiological roles such as eyes and central nervous system health, particularly anti-oxidation function is superpower, is described as " super antioxidant ", and to the absolute nonhazardous effect of human body, for cosmetics, health food and feed, have broad application prospects at present.
In animal and plant, exist many polyphenoils to participate in forming the antioxidant in body, because polyphenoils is numerous, single antioxidant can not represent that to the antioxidant status effect they act synergistically in vivo mutually.The present invention is combined two kinds of polyphenoils of haematococcus pluvialis powder and grape seed extract by certain proportioning; act synergistically; antioxidant effect is good; and can bring into play the multiple efficacies of two kinds of materials simultaneously; as anti-infective as protective effect, ultraviolet radiation preventing, inhibition tumour, the anti-inflammatory of eye and central nervous system, relieving sports fatigue, strengthen the human body energy metabolism, strengthen immunity, angiocardiopathy preventing etc.
The specific embodiment
In order to make purpose of the present invention, technical scheme and advantage clearer, below in conjunction with embodiment, the present invention is further elaborated.
The raw material sources that embodiment adopts: grape seed extract (procyanidin content >=80%), directly by market, to be buied, haematococcus pluvialis powder (content astaxanthin >=1%), directly buied by market.
Embodiment 1
Prepare following weight portion raw material: 5 parts of haematococcus pluvialis powders, 3 parts of grape seed extracts.The preparation method is as follows: take haematococcus pluvialis powder and the grape seed extract after sieving by formula rate, blend is even, granulates and dries, and incapsulates in shell and obtains capsule; Perhaps use automatic rotation Zhanang machine, the pressing moulding, obtain soft capsule; The auxiliary material of preparation is auxiliary material commonly used, and the heavily about 0.6g(of every capsules is haematococcus pluvialis powder 0.125g wherein, grape seed extract 0.075g).Consumption is: take twice every day, and each two, the haematococcus pluvialis powder 0.5g of every daily ingestion, grape seed extract 0.3g.
Perhaps above-mentioned raw materials is joined to extrusion modling in the tablet forming machine, obtain tablet.The auxiliary material of preparation is auxiliary material commonly used, and every tablet is 0.5 gram (wherein haematococcus pluvialis powder 0.17g, grape seed extract 0.1g) heavily approximately.Consumption is: take each a slice, the haematococcus pluvialis powder 0.5g of every daily ingestion, grape seed extract 0.3g every day three times.
Perhaps by said ratio, directly by conventional method, be prepared into oral formulations.
Embodiment 2
Prepare following weight portion raw material: 7 parts of haematococcus pluvialis powders, 2 parts of grape seed extracts.The preparation method is with embodiment 1.
The heavily about 0.6g(of every capsules is haematococcus pluvialis powder 0.175g wherein, grape seed extract 0.05g).Consumption is: take twice every day, and each two, the haematococcus pluvialis powder 0.7g of every daily ingestion, grape seed extract 0.2g.
Every tablet is 0.5 gram (wherein haematococcus pluvialis powder 0.23g, grape seed extract 0.07g) heavily approximately.Consumption is: take each a slice, the haematococcus pluvialis powder 0.7g of every daily ingestion, grape seed extract 0.2g every day three times.
Embodiment 3
Prepare following weight portion raw material: 8 parts of haematococcus pluvialis powders, 1 part of grape seed extract.The preparation method is with embodiment 1.
Every capsules is 0.6 gram (wherein haematococcus pluvialis powder 0.2g, grape seed extract 0.025g) heavily approximately.Consumption is: take twice every day, and each two, the haematococcus pluvialis powder 0.8g of every daily ingestion, grape seed extract 0.1g.
Every tablet is 0.5 gram (wherein haematococcus pluvialis powder 0.27g, grape seed extract 0.04g) heavily approximately.Consumption is: take each a slice, the haematococcus pluvialis powder 0.8g of every daily ingestion, grape seed extract 0.1g every day three times.
The oxidation resistance experiment
1. material: a clean level ICR mouse inbred lines, male and female half and half, weight (19 ± 2) g, provided by the western pul in Shanghai-Bi Kai company.The D-galactolipin is Sigma company product; SOD, MDA, GSH-Px detection kit are built up company purchased from Nanjing.
2. the experiment group is set: 70 mouse are divided into to 7 groups at random by body weight, are respectively the blank group, the aging model group, experiment A group (soft capsule of embodiment 1), experiment B group (soft capsule of embodiment 2), experiment C group (soft capsule of embodiment 3), control group A, control group B.Except the blank group, all the other respectively organize every day to mouse peritoneal injection of d-galactose 120mg/kg, continuous 8 weeks; Blank group and aging model group every day are at the mouse peritoneal injecting normal saline.Simultaneously, experiment A organizes every day to the soft capsule in four embodiment 1 of mouse stomach; Experiment B organizes every day to the soft capsule in four embodiment 2 of mouse stomach; Experiment C organizes every day to the soft capsule in four embodiment 3 of mouse stomach.Control group A every day is to mouse stomach haematococcus pluvialis powder 0.9g, and control group B every day is to mouse stomach grape seed extract 0.9g.As shown in table 1:
Table 1:
3. it is 20 ℃ of left and right that room temperature is set.Connect 8 weeks, after the last administration, measure heart tissue's homogenate SOD vigor and the MDA content of mouse by the detection kit explanation, GSH-Px vigor in brain tissue homogenate.
4. result of the test: experimental data adopts statistics software to carry out variance analysis.
4.1 aging model group mouse core tissue homogenate SOD vigor, the GSH-Px of brain tissue homogenate vigor are lower than blank group (P<0.05), heart MDA content significantly increases (P<0.05) than the blank group, illustrates that the method for successful Application D-galactolipin lumbar injection is set up the aging model mouse.
4.2 experiment A, B, C group mouse core tissue homogenate SOD vigor, brain tissue homogenate's GSH-Px vigor significantly improve (P<0.05), heart MDA content significantly reduces (P<0.05).Control group A, control group B mouse core tissue homogenate SOD vigor, the GSH-Px of brain tissue homogenate vigor improve (P<0.1), and heart MDA content reduces (P<0.1).
4.3 experiment A, B, C group are with respect to control group A, control group B, its vigor degree that improves body SOD, GSH-Px antioxidase is higher.
In this experiment, after the subacute aging mouse model of setting up by the injection of D-galactolipin, after using antioxidant functional food of the present invention, improved mouse body SOD, the vigor of GSH-Px antioxidase, thereby the elimination of free radical in the promotion body, alleviating lipid peroxidation occurs, the protection biomembrane, played oxidation resistant effect, the minimizing of free radical simultaneously can also delay senility by the mechanism of inhibited apoptosis, from experimental result 4.3, also can find out, the oxidation resistance of the antioxidant functional food of the present invention's formula is better than haematococcus pluvialis powder and the grape seed extract of single formula Isodose, illustrate that formula that haematococcus pluvialis powder and grape seed extract combine through this proportioning brought into play the synergy of the two, there is the more effect of high-quality.
Other formulation except the glue capsule in the embodiment of the present invention 1,2,3 has also been carried out above similar anti-oxidant test, and result is identical with the above results.
This health food can be applicable in anti-oxidant, the anti-aging product of preparation; antioxidant effect is good; and can bring into play the multiple efficacies of two kinds of materials simultaneously: as anti-infective as protective effect, ultraviolet radiation preventing, inhibition tumour, the anti-inflammatory of eye and central nervous system, relieving sports fatigue strengthens the human body energy metabolism, strengthens immunity, angiocardiopathy preventing etc.
The above; be only the present invention's specific embodiment preferably, but protection scope of the present invention is not limited to this, anyly is familiar with in technical scope that those skilled in the art disclose in the present invention; the variation that can expect easily or replacement, within all should being encompassed in protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain of claim.
Claims (6)
1. an antioxidant functional food, is characterized in that, by following weight portion raw material proportioning, made: 5~8 parts of haematococcus pluvialis powders, 1~3 part of grape seed extract.
2. antioxidant functional food as claimed in claim 1, is characterized in that, by following weight portion raw material proportioning, made: 7 parts of haematococcus pluvialis powders, 2 parts of grape seed extracts.
3. antioxidant functional food as claimed in claim 1 or 2, is characterized in that, described haematococcus pluvialis powder is the aubergine powder obtained after broken wall and spray-drying by haematococcus pluvialis cell, content astaxanthin in described haematococcus pluvialis powder >=1%.
4. antioxidant functional food as claimed in claim 1 or 2, is characterized in that, described Proanthocyanidin from Grape-seed Extracts >=80%.
5. antioxidant functional food as claimed in claim 1 or 2, is characterized in that, this health food is prepared to capsule or tablet or oral liquid, and wherein capsule refers to hard shell capsules, soft capsule; Tablet refers to ordinary tablet, dispersing tablet, oral disnitegration tablet, lozenge, chewable tablets, effervescent tablet.
6. the described health food of claim 1 or 2 has the application in anti-oxidant, anti-aging product in preparation.
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