CN103417769A - Preparation method of gynecological preoperative bowl-cleansing oral granules - Google Patents
Preparation method of gynecological preoperative bowl-cleansing oral granules Download PDFInfo
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- CN103417769A CN103417769A CN2013103587889A CN201310358788A CN103417769A CN 103417769 A CN103417769 A CN 103417769A CN 2013103587889 A CN2013103587889 A CN 2013103587889A CN 201310358788 A CN201310358788 A CN 201310358788A CN 103417769 A CN103417769 A CN 103417769A
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Abstract
The invention discloses a preparation method of gynecological preoperative bowl-cleansing oral granules and solves the problems in gynecological preoperative treatment. The preparation method is characterized in that the granules are made with, by weight, 10-30 parts of horseweed herb, 6-12 parts of cinnamon seeds, 3-10 parts of Chinese mosla, 6-12 parts of Chinese starjasmine stem, 3-10 parts of loofah sponge, 6-12 parts of Barbary wolfberry fruit, 6-12 parts of Dipsacus root, 6-12 parts of grassleaf sweelflag rhizome, 6-12 parts of sunflower flower, 1-5 parts of Turbo cornutus solander, 3-10 parts of ox horn bone, and 10-25 parts of magnesium sulfate. The preparation method includes: 1, extracting essential oil for use from the rough powders of the Dipsacus root, cinnamon seeds and loofah sponge; 2, crushing the Turbo cornutus solander and ox horn bone into fine powder for use; 3, adding water to decoct the horseweed herb, Chinese mosla, Chinese starjasmine stem, Barbary wolfberry fruit, sunflower flower and grassleaf sweelflag rhizome for two times, filtering, combining filtrate, condensing the filtrate, adding ethanol to allow for sedimentation, taking supernate, recovering the ethanol, and condensing to obtain thick paste; 4, adding the essential oil obtained in the step 1, the fine powder obtained in the step 2 and magnesium sulfate into the thick paste obtained in the step 3, mixing well to obtain granules, and drying the granules. Clinical experiments show that the granules have good effect of gynecological preoperative bowel cleansing and is worthy of clinical application and popularization.
Description
Technical field
The present invention relates to drug world, be specifically related to the preparation method of the preoperative oral bowel relieving granule of a kind of gynecological.
Background technology
Intestinal is prepared to comprise before gynecilogical operation stimulates enterokinesia, softening and remove feces, gets rid of the enteral pneumatosis, prevents that the patient from can not control defecation and increase opportunities for contamination because anaesthetizing rear Sphincter ani chalasia; Reduce the enteral pneumatosis full and have feces and affect operation technique simultaneously.Clinical practice confirms, by Oral Rhubarb, Natrii Sulfas, Radix Glycyrrhizae mixing water decocting liquid intestinal tract cleaning, can also alleviate hands postoperative abdominal distention discomfort.Traditional method is that the art proxima luce (prox. luc) advances without the slag liquid food, preoperative late oral purgative (as: mannitol), and art is used 0.2% suds cleansing enema once morning again.There is following defect in this kind of intestinal stand-by mode: 1. mannitol is a kind of hyperosmotic dehydration agent, and intestinal stimulates strong, and patient's emotion, sleep state are had a significant effect; 2. the last coloclysis time of Traditional Method is art 6am in morning, and 8am enters operating room, during do not have time enough thoroughly emptying by intestinal, in art, easily pollute; 3. can not produce beneficial effect to post-operative recovery.
At present, also there is report to use Chinese medicine preparation to carry out preoperative bowel relieving, as oral above-mentioned Radix Et Rhizoma Rhei, Natrii Sulfas, Radix Glycyrrhizae mixing water decocting liquid, but medicine great majority used are all the purgatives medicine things such as Radix Et Rhizoma Rhei, take rear zest strong, patient's emotion, sleep state are had a significant effect, and Semen Platycladi etc. the cathartic medicine is wayward rushes down the lower time.So lack now a kind of preoperative bowel relieving that is applicable to, rush down effectively lower and can not affect sleep again, can produce the medicine of beneficial effect for post-operative recovery.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides the preoperative oral intestinal canal of gynecological that a kind of curative effect is affirmed and side effect is little to prepare medicine.
The technical scheme that the present invention solves its technical problem is: the preoperative oral intestinal canal of a kind of gynecological is prepared medicine, it is characterized in that being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts of Horseweed Herbs, 6 ~ 12 parts of Fructus cinnamomi immaturus, 3 ~ 10 parts of Herba Moslae Chinensis, 6 ~ 12 parts of Caulis Trachelospermis, 3 ~ 10 parts of Retinervus Luffae Fructuss, 6 ~ 12 parts of Fructus Lycii, 6 ~ 12 parts of Radix Dipsaci, 6 ~ 12 parts of Rhizoma Acori Graminei, 6 ~ 12 parts of Flos Helianthis, 1 ~ 5 part of Turbo cornutus Solander, 3 ~ 10 parts, the Cornu Bovis seu Bubali cheek, 10 ~ 25 parts, magnesium sulfate.
Chinese medicine of the present invention is that the raw material by following optimum weight part proportioning is prepared from: 20 parts of Horseweed Herbs, 10 parts of Fructus cinnamomi immaturus, 6 parts of Herba Moslae Chinensis, 10 parts of Caulis Trachelospermis, 6 parts of Retinervus Luffae Fructuss, 10 parts of Fructus Lycii, 10 parts of Radix Dipsaci, 10 parts of Rhizoma Acori Graminei, 10 parts of Flos Helianthis, 2 parts of Turbo cornutus Solander, 6 parts, the Cornu Bovis seu Bubali cheek, 20 parts, magnesium sulfate.
Chinese medicine of the present invention can be prepared from by following method:
(1) Radix Dipsaci, Fructus cinnamomi immaturus, Retinervus Luffae Fructus coarse powder are extracted to volatile oil with vapor distillation respectively, and mixing for standby use after collecting;
(2) Turbo cornutus Solander, the Cornu Bovis seu Bubali cheek were pulverized to 150 mesh sieves, and became fine powder standby;
(3) Horseweed Herb, Herba Moslae Chinensis, Caulis Trachelospermi, Fructus Lycii, Flos Helianthi, Rhizoma Acori Graminei are decocted with water 2 times, filter, merging filtrate, it is 1.20(50 ℃ that filtrate is concentrated into relative density), adding ethanol, to make containing alcohol amount be 60%, and the standing precipitation that makes, get supernatant, reclaim ethanol and be concentrated into relative density 1.25, obtaining thick paste;
(4) volatile oil of step 1 gained, the fine powder of step 2 gained, magnesium sulfate are added to the thick paste of step 3 gained, stir, granulation, drying, obtain.
In prioritization scheme, described simmer down to concentrating under reduced pressure.
Wherein said: Horseweed Herb, for Compositae Herba Erigerontis aceris platymiscium Horseweed Herb Erigeron canadensis L., be used as medicine with herb or bright leaf.Property mildly bitter flavor, suffering, cool.But the merit clearing away heat-damp and promoting diuresis, dissipating blood stasis for subsidence of swelling.
Fructus cinnamomi immaturus is the tender fruit of the children of canella Cortex Cinnamomi.Gas fragrance, distinguish the flavor of micro-sweet.Nature and flavor Wen Xingan, return the stomach warp.But merit warming spleen and stomach for dispelling cold.
Herba Moslae Chinensis is the herb of labiate Mosla chinensis Maxim. Bulbophyllum reptans Lindl..Nature and flavor are arduous, temperature.Merit can be driven away summer heat, and invigorates blood circulation, regulate the flow of vital energy, and removing dampness.
Caulis Trachelospermi is the dry zone leaf rattan of apocynaceae plant trachelospermum jasminoide Trachelospermum jasminoides (Lindl.) Lem..Hardship, be slightly cold.GUIXIN, liver, kidney channel.But the merit dispelling wind and removing obstruction in the collateral, the removing heat from blood detumescence.
Retinervus Luffae Fructus is the vascular bundle of the dry mature fruit of cucurbitaceous plant Fructus Luffae Luffa cylindrica (L.) Roem..Sweet, flat.Return lung, stomach, Liver Channel.But the merit dredging collateral, invigorate blood circulation, and dispels the wind.
The fruit that Fructus Lycii is Solanaceae Lycium Fructus Lycii Polygonatum kingianum Coll.et Hemsl., but the merit spermatogenesis is mended marrow, enriching yin and nourishing kidney, benefiting vital QI for tranquillizing.
Radix Dipsaci is the dry root of Dipsacaceae herbaceos perennial Radix Dipsaci Himalayan Teasel Root.The bitter in the mouth suffering; Slightly warm in nature.Return liver, kidney channel.But merit invigorating the liver and kidney; Bone and muscle strengthening; Blood circulation regulating; Continuous folding wound; Only metrorrhagia.
The dry rhizome that Rhizoma Acori Graminei is Rhizoma Acori Graminei Citrus reticulata Blanco, but merit removing dampness appetizing, the eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.
Flos Helianthi is the flower of feverfew Helianthi Helianthus annuus L..Distinguish the flavor of micro-sweet; Property is put down.Merit can be dispeled the wind; Suppressing the hyperactive liver; Dampness removing.
Turbo cornutus Solander is the operculum of covering of Mollusca Turbinidae Turbo cornulus Turbo cornutus Solander.Salty in the mouth; Property is put down.Return kidney channel.But merit clearing away damp-heat; Remove phlegm-fire; Separate sore.Distinguish the flavor of micro-sweet; Property is put down.Merit can be dispeled the wind; Suppressing the hyperactive liver; Dampness removing.
The Cornu Bovis seu Bubali cheek, be Artiodactyla Bovidae cattle Bos taurus domesticus Gmelin, with the inner hard bone heart of Cornu Bovis seu Bubali, is used as medicine.The nature and flavor hardship, temperature.Merit can be stopped blooding.
Composition principle: gynecilogical operation is preoperative will carry out intestinal processing, namely bowel relieving.Traditional method is that the art proxima luce (prox. luc) advances without the slag liquid food, preoperative late oral purgative (as: mannitol or Chinese medicine cathartic prescription), and art morning, 0.2% suds (or normal saline) cleansing enema was once again.There is following defect in this kind of intestinal stand-by mode: 1. mannitol or Chinese medicine cathartic prescription, and intestinal stimulates strong, and patient's emotion, sleep state are had a significant effect; 2. the last coloclysis time of Traditional Method is art 6am in morning, and 8am enters operating room, during do not have time enough thoroughly emptying by intestinal, in art, easily pollute; 3. can not produce beneficial effect to post-operative recovery.We be take magnesium sulfate as cathartic, coordinate the medicine of fugitive stable enterokinesia, and suitable reduction intestinal contents reaction sensitivity that intestinal is stimulated, lax intestinal smooth.Like this, the magnesium sulfate that enters on the one hand intestinal is difficult for absorbing at intestinal, forms hyperosmotic state, completes the catharsis effect; The lax intestinal smooth of the medicine of fugitive stable enterokinesia, alleviate awareness of defecation on the other hand, to guarantee Sleeping.Simultaneously, other pharmaceutical components in we complete and invigorate blood circulation, eliminate the phlegm, the effect of eliminating stagnation, dredging collateral, promote the gynecilogical operation post-operative recovery.
Compared with prior art, the present invention has following characteristics.
1, Horseweed Herb and Fructus cinnamomi immaturus coordinate for monarch drug, the inventor studies discovery: the mixing water decocting liquid of Horseweed Herb and Fructus cinnamomi immaturus is wriggled without obvious inhibitory action to the isolated mouse ileum, but, during the excitatory state at gastrointestinal smooth muscle under magnesium sulfate stimulates, remarkable relexation is arranged.Its mechanism of action may be relevant to the smooth muscle relaxation of Horseweed Herb total flavones water soluble part, but this kind of effect coordinates with Fructus cinnamomi immaturus and can only come into force for the intestinal wall smooth muscle under excited state.Under this dosage, the pharmacological action time of Horseweed Herb is about 8 ~ 10 hours, namely takes medicine night, can alleviate the awareness of defecation under the magnesium sulfate stimulation, and guarantee suitable sleep, after art drug effect in morning is lost, can complete the effect of cleaning intestinal.
2, Herba Moslae Chinensis dehumidifying regulating QI to relieve pain, Caulis Trachelospermi dredging collateral reducing swelling and alleviating pain, alleviate the discomfort that postoperative pelvic cavity excitation causes.
3, Fructus Lycii enriching yin and nourishing kidney, the Radix Dipsaci nourishing the liver and kidney, Rhizoma Acori Graminei removing dampness appetizing, the postoperative function of intestinal canal that is conducive to recovers, and shortens fasting time, is conducive to early recovery.
4, the Retinervus Luffae Fructus motionless blood of invigorating blood circulation, and the strong muscle effect of dredging collateral is arranged.
5, inventor's experimentation shows: low dose of Turbo cornutus Solander can be stablized intestinal mucosa effectively.
6, Flos Helianthi is using corrigent, and this medicine can obviously strengthen small intestinal and shrink, and lasting medicine, utilizes low dose of Flos Helianthi to prevent the Horseweed Herb overaction.
7, add the low dose of Cornu Bovis seu Bubali cheek in the loose dredging collateral medicine of one row, play assistant and make use, reduce side effect.
8, medicine material consumption of the present invention is groped in a large number to sum up through the inventor and is drawn, each raw material consumption is for all to have curative effect preferably in the following weight parts scope.
9, adopt the granule dosage form, easy to use.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, the crude drug weight proportion: 20 parts of Horseweed Herbs, 10 parts of Fructus cinnamomi immaturus, 6 parts of Herba Moslae Chinensis, 10 parts of Caulis Trachelospermis, 6 parts of Retinervus Luffae Fructuss, 10 parts of Fructus Lycii, 10 parts of Radix Dipsaci, 10 parts of Rhizoma Acori Graminei, 10 parts of Flos Helianthis, 2 parts of Turbo cornutus Solander, 6 parts, the Cornu Bovis seu Bubali cheek, 20 parts, magnesium sulfate.
The preparation method of embodiment 1 is: Horseweed Herb, Fructus cinnamomi immaturus, Herba Moslae Chinensis, Caulis Trachelospermi, Retinervus Luffae Fructus, Fructus Lycii, Radix Dipsaci, Rhizoma Acori Graminei, Flos Helianthi, Turbo cornutus Solander, the Cornu Bovis seu Bubali cheek, magnesium sulfate mixing and water adding are decocted, get filtrate after 30 minutes, medicinal residues add water continuation decoction and get filtrate after 20 minutes, and twice filtrate is merged into decoction.
Embodiment 2, the crude drug weight proportion: 10 parts of Horseweed Herbs, 6 parts of Fructus cinnamomi immaturus, 3 parts of Herba Moslae Chinensis, 6 parts of Caulis Trachelospermis, 3 parts of Retinervus Luffae Fructuss, 6 parts of Fructus Lycii, 6 parts of Radix Dipsaci, 6 parts of Rhizoma Acori Graminei, 6 parts of Flos Helianthis, 1 part of Turbo cornutus Solander, 3 parts, the Cornu Bovis seu Bubali cheek, 10 parts, magnesium sulfate.
Embodiment 3, the crude drug weight proportion: 20 parts of Horseweed Herbs, 10 parts of Fructus cinnamomi immaturus, 6 parts of Herba Moslae Chinensis, 10 parts of Caulis Trachelospermis, 6 parts of Retinervus Luffae Fructuss, 10 parts of Fructus Lycii, 10 parts of Radix Dipsaci, 10 parts of Rhizoma Acori Graminei, 10 parts of Flos Helianthis, 2 parts of Turbo cornutus Solander, 6 parts, the Cornu Bovis seu Bubali cheek, 20 parts, magnesium sulfate.
Embodiment 4, the crude drug weight proportion: 30 parts of Horseweed Herbs, 12 parts of Fructus cinnamomi immaturus, 10 parts of Herba Moslae Chinensis, 12 parts of Caulis Trachelospermis, 10 parts of Retinervus Luffae Fructuss, 12 parts of Fructus Lycii, 12 parts of Radix Dipsaci, 12 parts of Rhizoma Acori Graminei, 12 parts of Flos Helianthis, 5 parts of Turbo cornutus Solander, 10 parts, the Cornu Bovis seu Bubali cheek, 25 parts, magnesium sulfate.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) Radix Dipsaci, Fructus cinnamomi immaturus, Retinervus Luffae Fructus coarse powder are extracted to volatile oil with vapor distillation respectively, and mixing for standby use after collecting;
(2) Turbo cornutus Solander, the Cornu Bovis seu Bubali cheek were pulverized to 150 mesh sieves, and became fine powder standby;
(3) Horseweed Herb, Herba Moslae Chinensis, Caulis Trachelospermi, Fructus Lycii, Flos Helianthi, Rhizoma Acori Graminei are decocted with water 2 times, filter, merging filtrate, it is 1.20(50 ℃ that filtrate is concentrated into relative density), adding ethanol, to make containing alcohol amount be 60%, and the standing precipitation that makes, get supernatant, reclaim ethanol and be concentrated into relative density 1.25, obtaining thick paste;
(4) volatile oil of step 1 gained, the fine powder of step 2 gained, magnesium sulfate are added to the thick paste of step 3 gained, stir, granulation, drying, obtain.
In prioritization scheme, described simmer down to concentrating under reduced pressure.
Described magnesium sulfate can be the magnesium sulfate powder, can be also Adlerika.
Effective combination of said medicine, coordinate mutually, effectively reaches the purpose of the preoperative cleaning intestinal of gynecilogical operation, and do not affect Sleeping, is beneficial to post-operative recovery.The above results is the clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case is selected: the gynecological that accept for medical treatment year March in March, 2012 ~ 2013 chooses date for operation and needs cleansing enema patient 78 examples.
1.1.2 grouping: be divided at random matched group 26 examples, decoction group 26 examples, groups of grains 26 examples.
1.2 method.
1.2.1 administering mode: all case art proxima luce (prox. luc)s advance without the slag liquid food, and matched group is taked conventional method of clyster: preoperative late oral mannitol, art morning, the normal saline cleansing enema was once again.The decoction group adopts embodiment 1 gained decoction oral at preoperative late 8 o'clock, and art normal saline in morning cleansing enema once.Groups of grains adopts embodiment 3 gained particulate orals at preoperative late 8 o'clock, and art normal saline in morning cleansing enema once.
1.2.2 observation index: after the bowel relieving operation, observe patient's defecation frequency, record intestinal tract cleaning and pneumatosis situation in art, and micturition time after operation in patients and untoward reaction are passed judgment on.
1.2.3 intestine cleaning effect evaluation criterion: effectively be intestinal in operation in patients and keep complete relaxed state, and visual area exposes fully; Invalidly be intestinal high level expansion in operation in patients, and visual area is capped.
2 results.
2.1 intestinal tract cleaning situation and transfusion definition situation in art: the effective percentage of matched group, decoction group, groups of grains bowel relieving is 100%.
2.2 three groups of operation in patients between eve defecation, art defecation in morning situation, the postoperative aerofluxus situation of insomnia situation see the following form:
| Group | Number of cases | Defecation at night (inferior) | Art defecation in morning (inferior) | Insomnia (example) | Postoperative aerofluxus (h) |
| Matched group | 26 | 2.62±032 | 2.11±0.11 | 18 | 37.83±7.14 |
| The decoction group | 26 | 0.95±0.23 | 5.53±0.55 | 6 | 23.36±5.62 |
| Groups of grains | 26 | 0.91±0.43 | 4.63±0.23 | 7 | 25.33±8.42 |
Result shows: apply decoction of the present invention or granule dosage form preoperative night and orally can reduce the defecation frequency at night, increase art defecation in morning, reduce the generation of insomnia, reach as early as possible postoperative aerofluxus, and compare (P<0.05) with matched group.
2.3 before three groups of operation in patients, bowel relieving nursing satisfaction relatively: the matched group patient is 88.46% to preoperative bowel relieving nursing satisfaction, and the satisfaction of decoction group, groups of grains bowel relieving is 100%.
3. conclusion.
The demonstration of this result of study, the preoperative oral decoction of the present invention or granule intestine cleaning effect are obvious, can effectively reduce the defecation frequency at night, increase art defecation in morning, reduce the generation of insomnia, reach as early as possible postoperative aerofluxus, increase the satisfaction of patient to nursery work.
Claims (2)
1. the preparation method of the preoperative oral bowel relieving granule of gynecological, it is characterized in that, crude drug comprises: Horseweed Herb, Fructus cinnamomi immaturus, Herba Moslae Chinensis, Caulis Trachelospermi, Retinervus Luffae Fructus, Fructus Lycii, Radix Dipsaci, Rhizoma Acori Graminei, Flos Helianthi, Turbo cornutus Solander, the Cornu Bovis seu Bubali cheek, magnesium sulfate are comprised of following steps:
(1) Radix Dipsaci, Fructus cinnamomi immaturus, Retinervus Luffae Fructus coarse powder are extracted to volatile oil with vapor distillation respectively, and mixing for standby use after collecting;
(2) Turbo cornutus Solander, the Cornu Bovis seu Bubali cheek were pulverized to 150 mesh sieves, and became fine powder standby;
(3) Horseweed Herb, Herba Moslae Chinensis, Caulis Trachelospermi, Fructus Lycii, Flos Helianthi, Rhizoma Acori Graminei are decocted with water 2 times, filter, merging filtrate, it is 1.20(50 ℃ that filtrate is concentrated into relative density), adding ethanol, to make containing alcohol amount be 60%, and the standing precipitation that makes, get supernatant, reclaim ethanol and be concentrated into relative density 1.25, obtaining thick paste;
(4) volatile oil of step 1 gained, the fine powder of step 2 gained, magnesium sulfate are added to the thick paste of step 3 gained, stir, granulation, drying, obtain.
2. the preparation method of the preoperative oral bowel relieving granule of a kind of gynecological according to claim 1, is characterized in that: the simmer down to concentrating under reduced pressure described in described step (3).
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107349250A (en) * | 2017-07-11 | 2017-11-17 | 赖李元 | A kind of enteron aisle scrubs solid orally ingestible and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107349250A (en) * | 2017-07-11 | 2017-11-17 | 赖李元 | A kind of enteron aisle scrubs solid orally ingestible and preparation method thereof |
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