CN103386334A - Refrigerating method for micro-fluidic chip - Google Patents
Refrigerating method for micro-fluidic chip Download PDFInfo
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- CN103386334A CN103386334A CN2013103416298A CN201310341629A CN103386334A CN 103386334 A CN103386334 A CN 103386334A CN 2013103416298 A CN2013103416298 A CN 2013103416298A CN 201310341629 A CN201310341629 A CN 201310341629A CN 103386334 A CN103386334 A CN 103386334A
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- fluidic chip
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Abstract
The invention provides a refrigerating method for a micro-fluidic chip. The refrigerating method is used for realizing local or overall refrigeration of the chip by integrating a chemical reagent capable of generating endothermic reaction in the micro-fluidic chip. The working principle of the micro-fluidic chip is as follows: water is injected into the chip to perform endothermic reaction with the chemical reagent to obtain a self-cooling effect, and according to a position design of the endothermic reaction, the local or overall refrigeration of the chip can be realized. By using the refrigerating method provided by the invention, an electronic refrigerating device is not needed, and the refrigerating method is easy and convenient to operate and is especially suitable for a portable micro total analysis system.
Description
Technical field
The present invention relates to a kind of method for temperature manipulation of micro-fluidic chip, particularly relate to a kind of refrigerating method of micro-fluidic chip.
Background technology
In recent years, the micro-fluidic chip technology had obtained in fields such as biology, chemistry, medical science study widely and apply.Due in the application process of micro-fluidic chip, often reaction and the detection of many chemistry, biology, all need to carry out under lower temperature conditions.Therefore, cooling is controlled in the application of micro-fluidic chip and is extremely important.At present, the refrigeration of micro-fluidic chip is mainly to rely on the electronic device such as additional semiconductor cooler or refrigerating fan and realize.But above-mentioned refrigerating method has the following disadvantages: or need complicated peripheral hardware, otherwise preparation technology is loaded down with trivial details and expensive.These weak points have all affected the popularization of micro-fluidic chip, particularly at some, instrument and equipment are required the micro-total analysis application of portability.By contrast, if can adopt from cooling mode, and it is integrated on micro-fluidic chip, thereby realizes the temperature of micro-fluidic chip is controlled, have very important practical significance.
Summary of the invention
For achieving the above object, the invention provides a kind of refrigerating method of micro-fluidic chip, it is characterized in that the method is to realize chip part or integrally cooling by the integrated chemical reagent that the endothermic reaction can occur in micro-fluidic chip.
The invention provides a kind of refrigerating method of micro-fluidic chip, it is characterized in that, described micro-fluidic chip material is the combination of wherein a kind of of dimethyl silicone polymer, glass, polyethylene, polytetrafluoroethylene (PTFE), polyvinyl chloride, metal or two kinds.
The invention provides a kind of refrigerating method of micro-fluidic chip, it is characterized in that, described chemical reagent is NH
4Cl, NH
4NO
3, KNO
3, NaNO
3, Na
2CO
3, KCl, (NH
4)
2SO
4, NH
4The solid crystals of the compounds such as CNS, powder or hydrate, can be a kind of in above-mentioned substance, can be also two or more mixture arbitrarily wherein.
The invention provides a kind of refrigerating method of micro-fluidic chip, it is characterized in that, the operation principle of described micro-fluidic chip is to injected water in chip, water and the chemical reagent generation endothermic reaction and obtain from cooling-down effect,, according to the Position Design of the endothermic reaction, can realize part or integrally cooling to chip.Above-mentioned water, can be to be placed in chip exterior, adopts pump valve equipment to inject chip during use; Can be also that sealing is integrated in chip internal, during use, it be discharged.
For realizing except direct use pure water, can also using solution mixture, the crystallization water etc. from cooling function, for convenience and the refrigeration that guarantees chip-stored, preferred crystal salt compound with the crystallization water, sal glauberi for example.
Use refrigerating method provided by the invention, need not to use the electronic cooling device, easy and simple to handle, be specially adapted to portable micro-total analysis system.
Description of drawings
Fig. 1. the refrigerating method schematic diagram of a kind of micro-fluidic chip provided by the invention.Wherein, A is from the cooling type micro-fluidic chip; B is chemical reagent; C is water; D is isolating valve; E is mixing and the product of two kinds of materials.
Specific embodiments
The following examples are further described the present invention in connection with Figure of description.
Embodiment is a kind of from the cooling type micro-fluidic chip
A kind of from the cooling type micro-fluidic chip, be prepared from by polymethyl methacrylate.As shown in Figure 1, A is micro-fluidic chip, and B is NH
4NO
3C is pure water; D is adjustable isolating valve; E is mixing and the product of two kinds of materials.Before refrigeration, rely on isolating valve D to separate between chemical reagent B and water C, can not contact each other; This moment, temperature and the room temperature of micro-fluidic chip A were equal to.During refrigeration, open isolating valve D, and chemical reagent B and water C are fully mixed, form mixture E, simultaneously due to the strong endothermic reaction occurring, thereby make the temperature of micro-fluidic chip A descend at short notice, thereby realize the refrigerating function of chip.
Use micro-fluidic chip refrigerating method provided by the invention, need not to use outside refrigeration plant, easy and simple to handle, be specially adapted to portable micro-total analysis system.
Claims (7)
1. the refrigerating method of a micro-fluidic chip, is characterized in that the method is to realize chip part or integrally cooling by the integrated chemical reagent that the endothermic reaction can occur in micro-fluidic chip.
2. according to the refrigerating method of a kind of micro-fluidic chip claimed in claim 1, it is characterized in that, described micro-fluidic chip material is the combination of wherein a kind of of dimethyl silicone polymer, glass, polyethylene, polytetrafluoroethylene (PTFE), polyvinyl chloride, metal or two kinds.
3., according to the refrigerating method of a kind of micro-fluidic chip claimed in claim 1, it is characterized in that, described chemical reagent is NH
4Cl, NH
4NO
3, KNO
3, NaNO
3, Na
2CO
3, KCl, (NH
4)
2SO
4, NH
4The solid crystals of the compounds such as CNS or powder, can be a kind of in above-mentioned substance, can be also two or more mixture arbitrarily wherein.
4. according to the refrigerating method of a kind of micro-fluidic chip claimed in claim 1, it is characterized in that, the operation principle of described micro-fluidic chip is to injected water in chip, water and the chemical reagent generation endothermic reaction and obtain from cooling-down effect,, according to the Position Design of the endothermic reaction, can realize part or integrally cooling to chip.
5., according to the refrigerating method of claim 1 and 4 described a kind of micro-fluidic chips, it is characterized in that, described water, can be to be placed in chip exterior, adopts pump valve equipment to inject chip during use; Can be also that sealing is integrated in chip internal, during use, it be discharged.
6., according to the refrigerating method of claim 1 and 4 described a kind of micro-fluidic chips, it is characterized in that, described water, can be pure water, solution mixture, the crystallization water etc., preferred crystal salt compound with the crystallization water.
7., according to the refrigerating method of a kind of micro-fluidic chip claimed in claim 1, it is characterized in that, use refrigerating method provided by the invention, need not to use the electronic cooling device, easy and simple to handle, be specially adapted to portable micro-total analysis system.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013103416298A CN103386334A (en) | 2013-08-07 | 2013-08-07 | Refrigerating method for micro-fluidic chip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013103416298A CN103386334A (en) | 2013-08-07 | 2013-08-07 | Refrigerating method for micro-fluidic chip |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103386334A true CN103386334A (en) | 2013-11-13 |
Family
ID=49530861
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2013103416298A Pending CN103386334A (en) | 2013-08-07 | 2013-08-07 | Refrigerating method for micro-fluidic chip |
Country Status (1)
| Country | Link |
|---|---|
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1907555A (en) * | 2006-07-17 | 2007-02-07 | 南京工业大学 | Composite heat exchange type micro reactor |
| CN101384349A (en) * | 2005-12-22 | 2009-03-11 | 国际壳牌研究有限公司 | Microchannel apparatus for removal of combustible , volatile contaminants |
| CN102295586A (en) * | 2010-06-23 | 2011-12-28 | 中国科学院大连化学物理研究所 | Method for synthesizing petroleum sulfonate in micro reactors |
| CN102645117A (en) * | 2012-05-02 | 2012-08-22 | 西安交通大学 | Microchannel cooler |
-
2013
- 2013-08-07 CN CN2013103416298A patent/CN103386334A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101384349A (en) * | 2005-12-22 | 2009-03-11 | 国际壳牌研究有限公司 | Microchannel apparatus for removal of combustible , volatile contaminants |
| CN1907555A (en) * | 2006-07-17 | 2007-02-07 | 南京工业大学 | Composite heat exchange type micro reactor |
| CN102295586A (en) * | 2010-06-23 | 2011-12-28 | 中国科学院大连化学物理研究所 | Method for synthesizing petroleum sulfonate in micro reactors |
| CN102645117A (en) * | 2012-05-02 | 2012-08-22 | 西安交通大学 | Microchannel cooler |
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| DD01 | Delivery of document by public notice |
Addressee: Suzhou YoungChip Chip Technology Co., Ltd. Document name: Notification of Passing Preliminary Examination of the Application for Invention |
|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| DD01 | Delivery of document by public notice |
Addressee: Ye Jiaming Document name: Notification of Publication and of Entering the Substantive Examination Stage of the Application for Invention |
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| DD01 | Delivery of document by public notice |
Addressee: Suzhou YoungChip Chip Technology Co., Ltd. Document name: the First Notification of an Office Action |
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| DD01 | Delivery of document by public notice |
Addressee: Suzhou YoungChip Chip Technology Co., Ltd. Document name: Notification that Application Deemed to be Withdrawn |
|
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20131113 |