CN103385864A - Method for manufacturing medicinal hollow hard capsule from fish-skin glue and fish scale glue - Google Patents
Method for manufacturing medicinal hollow hard capsule from fish-skin glue and fish scale glue Download PDFInfo
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- CN103385864A CN103385864A CN2012101387830A CN201210138783A CN103385864A CN 103385864 A CN103385864 A CN 103385864A CN 2012101387830 A CN2012101387830 A CN 2012101387830A CN 201210138783 A CN201210138783 A CN 201210138783A CN 103385864 A CN103385864 A CN 103385864A
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Abstract
The invention discloses a method for manufacturing a medicinal hollow hard capsule from fish-skin glue and fish scale glue. The method is as below: placing powder or granular fish-skin glue and/ or fish scale glue in a stainless steel container; adding distilled water, stirring uniformly to make the fish-skin glue and/ or fish scale glue absorb water and expand; heating the container with stirring to melt the glue into a glue solution; adding (or not) a pigment into the glue solution; pumping out bubbles in the glue solution under negative pressure; and finally carrying out glue soaking, drying and cutting to obtain the medicinal hollow capsule. The prepared medicinal hollow capsule does not contain residual harmful elements, and has appearance brightness and charge performance as good as those of a gelatin capsule, and can be used to substitute the hollow capsule manufacture mode using gelatins of livestock, such as pig, cattle and sheep. The medicinal hollow capsule is safe and innocuous to human body; and the method opens up a novel approach for medicament package material, and has characteristics of simple manufacture and low cost.
Description
Technical field
The present invention relates to a kind of manufacture method of medicinal gastric solubility empty hard capsule, particularly relate to a kind of fish glue from skin and fish glue from scale of using and use the method for Gelatin production empty hard capsule as primary raw material to replace tradition.
Background technology
For a long time, it is that raw material is made that medicinal empty hard capsule all adopts gelatin, and the raw material of manufacturing gelatin, the overwhelming majority is the skin limit of purchase Leather Factory and the leftover bits and pieces after the finished leather of tanning, and, though these raw materials are reprocessed processing through gelatin factory, is difficult to thoroughly remove harmful element residual in gelatin product (such as chromium), so that harmful element is brought in capsule, after fill becomes medicament capsule,, for patient, after just dosing a patient with, this has brought great potential safety hazard again.Simultaneously, this is also that the current bovine spongiform encephalopathy that occurs in the world, swine fever cause the whole mankind gelatin food to be existed the reason of guarding the heart afterwards, in fact more difficult what bear is that some Yi Silan religion, the helpless canon of will running counter to of Hindoo believers go to take the medicament of with the capsule of Corii Sus domestica, Corii Bovis seu Bubali manufacturing, being filled, and its heart is contradiction abrim.
Summary of the invention
The object of the invention is to overcome the deficiency of prior art, a kind of method of making medicinal empty hard capsule with fish glue from skin, fish glue from scale is provided, the skin or the squama that are the employing Fish are that the albumin glue that raw material is made comes for the manufacture of medicinal hollow capsule with the gelatin made from livestock products skins such as pig, cattle, sheep that replaces current generally use, there do not is residual harmful element, its apparent brightness of the Capsules of making and powder charge performance all compare favourably with gelatine capsule, are a kind of medicinal empty hard capsules harmless to human security.
The technical solution adopted for the present invention to solve the technical problems is: a kind of method of making medicinal empty hard capsule with fish glue from skin, fish glue from scale comprises the steps:
A. impregnation: powdery or granular fish glue from skin and/or fish glue from scale are placed in rustless steel container, add the distilled water of 5～8 times by the gross weight of glue, stir and make fish glue from skin and/or the abundant imbibition of fish glue from scale;
B. colloidal sol: the fish glue from skin after expansion is completed and/or fish glue from scale are placed in water-bath together with container and heat, and warming while stirring is controlled temperature and is no more than 90 ℃, until fish glue from skin and/or fish glue from scale dissolve into glue fully;
C. de-bubble: glue is moved to sealed container, and temperature remains on 60 ℃～75 ℃, the bubble extract glue under negative pressure condition in;
D. be stained with glue: glue is moved to and is stained with in the glue groove, the mould of making in order to hundreds of rustless steels, be arranged on the stainless template of monoblock, mould, towards the glue face, is stretched in the glue of 45 ℃～55 ℃, after every mould all is stained with glue equably reposefully, template is pulled away glue Sui slowly be about to mould and turn over upwards,, with a gentle wind springing up between 10 ℃～20 ℃, make the glue rapid condensation on mould and fix;
E. oven dry: the template that will be stained with glue is sent drying room to, dries at 35 ℃～40 ℃ temperature;
F. cut: on template, the capsule protegulum of drying is transferred to, and with guillotine, the capsule protegulum is cut into respectively the length of different size, then two capsule protegulum fits are finished product with one is long and the other is short.
Also comprise between described step b and step c:
B1. toning: add the food coloring of required color and luster to glue, and stir and form glue with certain color, wherein the consumption of food coloring be no more than with ten thousand of glue total amount/.
The abundant imbibition of described fish glue from skin and/or fish glue from scale refers to that fish glue from skin and/or fish glue from scale soaked 0.5～1.5 hour in distilled water.
The particle diameter of described granular fish glue from skin and/or fish glue from scale is greater than the aperture in 40 mesh sieve holes.
The particle diameter of described powdery fish glue from skin and/or fish glue from scale is less than or equal to the aperture in 40 mesh sieve holes.
a kind of fish glue from skin of using of the present invention, fish glue from scale is made the method for medicinal empty hard capsule, be that to take the skins of Fish or squama be the albumin glue made of raw material with replace current generally use with pig, cattle, the gelatin that the livestock products skins such as sheep are made is for the manufacture of medicinal hollow capsule, fish glue from skin and fish glue from scale are skin and the fish scales under a large amount of Fish Stripping of fish products processing factory processing, carry out the new albumin glue source of deep processing comprehensive utilization, after fresh fish body Stripping gets, boil again plastic through pre-treatment, technical process is without adding any harmful substance, product quality reaches GB6783--94 food additive gelatin standard and GB235-98 pharmagel standard.Fish glue from skin and fish glue from scale product have two kinds of forms usually, i.e. powdery and granular, and the glue of two kinds of shapes all can use, and the particle diameter of colloid is granular greater than the aperture in 40 mesh sieve holes; The particle diameter of colloid be less than or equal to 40 mesh sieve holes aperture for powdery.
the invention has the beneficial effects as follows, be raw material owing to having adopted powdery or granular fish glue from skin and/or fish glue from scale, pass through impregnation, colloidal sol, mix colours or do not mix colours, de-bubble, be stained with glue, oven dry and the operation such as cut after make medicinal hollow capsule, there do not is residual harmful element, its apparent brightness of the Capsules of making and powder charge performance all compare favourably with gelatine capsule, be used for replacing pig, cattle, the livestock products gelatin such as sheep are made the mode of Capsules, harmless to human security, hew out again simultaneously the new way of a drug packages material, have and make simply, the characteristics that cost is low.
The specific embodiment
Below in conjunction with embodiment, the present invention is described in further detail; But a kind of method with fish glue from skin, the medicinal empty hard capsule of fish glue from scale manufacturing of the present invention is not limited to embodiment.
Embodiment one, and a kind of method of making medicinal empty hard capsule with fish glue from skin, fish glue from scale of the present invention, comprise the steps:
A. impregnation: powdery or granular fish glue from skin and fish glue from scale are placed in rustless steel container, add the distilled water of 6 times by two brood lac gross weights, stir and make fish glue from skin and the abundant imbibition of fish glue from scale;
B. colloidal sol: the fish glue from skin after expansion is completed and fish glue from scale are placed in water-bath together with container and heat, and warming while stirring is controlled temperature and is no more than 90 ℃, until fish glue from skin dissolves into glue fully with fish glue from scale;
C. de-bubble: glue is moved to sealed container, and temperature remains on 60 ℃～75 ℃, the bubble extract glue under negative pressure condition in;
D. be stained with glue: glue is moved to and is stained with in the glue groove, the mould of making in order to hundreds of rustless steels, be arranged on the stainless template of monoblock, mould, towards the glue face, is stretched in the glue of 50 ℃, after every mould all is stained with glue equably reposefully, template is pulled away glue Sui slowly be about to mould and turn over upwards,, with a gentle wind springing up between 10 ℃～20 ℃, make the glue rapid condensation on mould and fix;
E. oven dry: the template that will be stained with glue is sent drying room to, dries at 38 ℃ of temperature;
F. cut: on template, the capsule protegulum of drying is transferred to, and with guillotine, the capsule protegulum is cut into respectively the length of different size, then two capsule protegulum fits are finished product with one is long and the other is short.
Wherein,
The abundant imbibition of described fish glue from skin and fish glue from scale refers to that fish glue from skin and fish glue from scale soaked 0.5～1.5 hour in distilled water;
The particle diameter of described granular fish glue from skin and fish glue from scale is greater than the aperture in 40 mesh sieve holes;
The particle diameter of described powdery fish glue from skin and fish glue from scale is less than or equal to the aperture in 40 mesh sieve holes.
a kind of fish glue from skin of using of the present invention, fish glue from scale is made the method for medicinal empty hard capsule, be that to take the skins of Fish or squama be the albumin glue made of raw material with replace current generally use with pig, cattle, the gelatin that the livestock products skins such as sheep are made is for the manufacture of medicinal hollow capsule, fish glue from skin and fish glue from scale are skin and the fish scales under a large amount of Fish Stripping of fish products processing factory processing, carry out the new albumin glue source of deep processing comprehensive utilization, after fresh fish body Stripping gets, boil again plastic through pre-treatment, technical process is without adding any harmful substance, product quality reaches GB6783--94 food additive gelatin standard and GB235-98 pharmagel standard.Fish glue from skin and fish glue from scale product have two kinds of forms usually, i.e. powdery and granular, and the glue of two kinds of shapes all can use, and the particle diameter of colloid is granular greater than the aperture in 40 mesh sieve holes; The particle diameter of colloid be less than or equal to 40 mesh sieve holes aperture for powdery.
The present embodiment is to adopt fish glue from skin and the prepared medicinal empty hard capsule of fish glue from scale, and this medicinal empty hard capsule is colourless capsule.
Embodiment two, and a kind of method of making medicinal empty hard capsule with fish glue from skin, fish glue from scale of the present invention, be with the difference of embodiment one, also comprises between described step b and step c:
B1. toning: add the food coloring of required color and luster to glue, and stir and form glue with certain color, wherein the consumption of food coloring be no more than with ten thousand of glue total amount/.
The present embodiment is to adopt fish glue from skin and the prepared medicinal empty hard capsule of fish glue from scale, and this medicinal empty hard capsule is the colored capsule with certain color.
Embodiment three, and a kind of method of making medicinal empty hard capsule with fish glue from skin, fish glue from scale of the present invention, comprise the steps:
A. impregnation: powdery or granular fish glue from skin are placed in rustless steel container, add the distilled water of 5 times by the gross weight of fish glue from skin, stir and make the abundant imbibition of fish glue from skin;
B. colloidal sol: the fish glue from skin after expansion is completed is placed in water-bath together with container and heats, and warming while stirring is controlled temperature and is no more than 90 ℃, until fish glue from skin dissolves into glue fully;
B1. toning: add the food coloring of required color and luster to glue, and stir and form glue with certain color, wherein the consumption of food coloring be no more than with ten thousand of glue total amount/;
C. de-bubble: glue is moved to sealed container, and temperature remains on 60 ℃～75 ℃, the bubble extract glue under negative pressure condition in;
D. be stained with glue: glue is moved to and is stained with in the glue groove, the mould of making in order to hundreds of rustless steels, be arranged on the stainless template of monoblock, mould, towards the glue face, is stretched in the glue of 55 ℃, after every mould all is stained with glue equably reposefully, template is pulled away glue Sui slowly be about to mould and turn over upwards,, with a gentle wind springing up between 10 ℃～20 ℃, make the glue rapid condensation on mould and fix;
E. oven dry: the template that will be stained with glue is sent drying room to, dries at 40 ℃ of temperature;
F. cut: on template, the capsule protegulum of drying is transferred to, and with guillotine, the capsule protegulum is cut into respectively the length of different size, then two capsule protegulum fits are finished product with one is long and the other is short.
Wherein,
The abundant imbibition of described fish glue from skin refers to that fish glue from skin soaked 0.5～1.5 hour in distilled water;
The particle diameter of described granular fish glue from skin is greater than the aperture in 40 mesh sieve holes;
The particle diameter of described powdery fish glue from skin is less than or equal to the aperture in 40 mesh sieve holes.
The present embodiment is to adopt the prepared medicinal empty hard capsule of fish glue from skin, and this medicinal empty hard capsule is the colored capsule with certain color.
Embodiment four, and a kind of method of making medicinal empty hard capsule with fish glue from skin, fish glue from scale of the present invention, comprise the steps:
A. impregnation: powdery or granular fish glue from scale are placed in rustless steel container, add the distilled water of 8 times by the gross weight of fish glue from scale, stir and make the abundant imbibition of fish glue from scale;
B. colloidal sol: the fish glue from scale after expansion is completed is placed in water-bath together with container and heats, and warming while stirring is controlled temperature and is no more than 90 ℃, until fish glue from scale dissolves into glue fully;
B1. toning: add the food coloring of required color and luster to glue, and stir and form glue with certain color, wherein the consumption of food coloring be no more than with ten thousand of glue total amount/;
C. de-bubble: glue is moved to sealed container, and temperature remains on 60 ℃～75 ℃, the bubble extract glue under negative pressure condition in;
D. be stained with glue: glue is moved to and is stained with in the glue groove, the mould of making in order to hundreds of rustless steels, be arranged on the stainless template of monoblock, mould, towards the glue face, is stretched in the glue of 45 ℃, after every mould all is stained with glue equably reposefully, template is pulled away glue Sui slowly be about to mould and turn over upwards,, with a gentle wind springing up between 10 ℃～20 ℃, make the glue rapid condensation on mould and fix;
E. oven dry: the template that will be stained with glue is sent drying room to, dries at 35 ℃ of temperature;
F. cut: on template, the capsule protegulum of drying is transferred to, and with guillotine, the capsule protegulum is cut into respectively the length of different size, then two capsule protegulum fits are finished product with one is long and the other is short.
Wherein,
The abundant imbibition of described fish glue from scale refers to that fish glue from scale soaked 0.5～1.5 hour in distilled water;
The particle diameter of described granular fish glue from scale is greater than the aperture in 40 mesh sieve holes;
The particle diameter of described powdery fish glue from scale is less than or equal to the aperture in 40 mesh sieve holes.
The present embodiment is to adopt the prepared medicinal empty hard capsule of fish glue from scale, and this medicinal empty hard capsule is the colored capsule with certain color.
Above-described embodiment only is used for further illustrating a kind of method of making medicinal empty hard capsule with fish glue from skin, fish glue from scale of the present invention; but the present invention is not limited to embodiment; every foundation technical spirit of the present invention, to any simple modification, equivalent variations and modification that above embodiment does, all falls in the protection domain of technical solution of the present invention.
Claims (5)
1. a method of making medicinal empty hard capsule with fish glue from skin, fish glue from scale, is characterized in that: comprise the steps:
A. impregnation: powdery or granular fish glue from skin and/or fish glue from scale are placed in rustless steel container, add the distilled water of 5～8 times by the gross weight of glue, stir and make fish glue from skin and/or the abundant imbibition of fish glue from scale;
B. colloidal sol: the fish glue from skin after expansion is completed and/or fish glue from scale are placed in water-bath together with container and heat, and warming while stirring is controlled temperature and is no more than 90 ℃, until fish glue from skin and/or fish glue from scale dissolve into glue fully;
C. de-bubble: glue is moved to sealed container, and temperature remains on 60 ℃～75 ℃, the bubble extract glue under negative pressure condition in;
D. be stained with glue: glue is moved to and is stained with in the glue groove, the mould of making in order to hundreds of rustless steels, be arranged on the stainless template of monoblock, mould, towards the glue face, is stretched in the glue of 45 ℃～55 ℃, after every mould all is stained with glue equably reposefully, template is pulled away glue Sui slowly be about to mould and turn over upwards,, with a gentle wind springing up between 10 ℃～20 ℃, make the glue rapid condensation on mould and fix;
E. oven dry: the template that will be stained with glue is sent drying room to, dries at 35 ℃～40 ℃ temperature;
F. cut: on template, the capsule protegulum of drying is transferred to, and with guillotine, the capsule protegulum is cut into respectively the length of different size, then two capsule protegulum fits are finished product with one is long and the other is short.
2. use fish glue from skin according to claim 1, fish glue from scale are made the method for medicinal empty hard capsule, it is characterized in that: also comprise between described step b and step c:
B1. toning: add the food coloring of required color and luster to glue, and stir and form glue with certain color, wherein the consumption of food coloring be no more than with ten thousand of glue total amount/.
3. use fish glue from skin according to claim 1 and 2, fish glue from scale are made the method for medicinal empty hard capsule, and it is characterized in that: the abundant imbibition of described fish glue from skin and/or fish glue from scale refers to that fish glue from skin and/or fish glue from scale soaked 0.5～1.5 hour in distilled water.
4. use fish glue from skin according to claim 1 and 2, fish glue from scale are made the method for medicinal empty hard capsule, and it is characterized in that: the particle diameter of described granular fish glue from skin and/or fish glue from scale is greater than the aperture in 40 mesh sieve holes.
5. use fish glue from skin according to claim 1 and 2, fish glue from scale are made the method for medicinal empty hard capsule, and it is characterized in that: the particle diameter of described powdery fish glue from skin and/or fish glue from scale is less than or equal to the aperture in 40 mesh sieve holes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101387830A CN103385864A (en) | 2012-05-07 | 2012-05-07 | Method for manufacturing medicinal hollow hard capsule from fish-skin glue and fish scale glue |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101387830A CN103385864A (en) | 2012-05-07 | 2012-05-07 | Method for manufacturing medicinal hollow hard capsule from fish-skin glue and fish scale glue |
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| CN2012101387830A Pending CN103385864A (en) | 2012-05-07 | 2012-05-07 | Method for manufacturing medicinal hollow hard capsule from fish-skin glue and fish scale glue |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5322068A (en) * | 1976-08-03 | 1978-03-01 | Yatarou Takahashi | Soil conditioner |
| CN1191721A (en) * | 1997-02-25 | 1998-09-02 | 陈志强 | Collagen capsule for medicine and its making method |
| US20010024678A1 (en) * | 1997-12-26 | 2001-09-27 | Robert Scott | Gelatin compositions |
| WO2002094959A1 (en) * | 2001-05-21 | 2002-11-28 | Croda International Plc | Improved alkaline process for preparing type b fish gelatin |
| CA2447566A1 (en) * | 2003-10-31 | 2005-04-30 | Georges Takerkart | Geletins with improved gliding power, to processes for their preparation and their applications |
| CN1985809A (en) * | 2005-12-20 | 2007-06-27 | 黄族和 | Preparing process of botanical hollow enteric hard capsule |
-
2012
- 2012-05-07 CN CN2012101387830A patent/CN103385864A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5322068A (en) * | 1976-08-03 | 1978-03-01 | Yatarou Takahashi | Soil conditioner |
| CN1191721A (en) * | 1997-02-25 | 1998-09-02 | 陈志强 | Collagen capsule for medicine and its making method |
| US20010024678A1 (en) * | 1997-12-26 | 2001-09-27 | Robert Scott | Gelatin compositions |
| WO2002094959A1 (en) * | 2001-05-21 | 2002-11-28 | Croda International Plc | Improved alkaline process for preparing type b fish gelatin |
| CA2447566A1 (en) * | 2003-10-31 | 2005-04-30 | Georges Takerkart | Geletins with improved gliding power, to processes for their preparation and their applications |
| CN1985809A (en) * | 2005-12-20 | 2007-06-27 | 黄族和 | Preparing process of botanical hollow enteric hard capsule |
Non-Patent Citations (1)
| Title |
|---|
| 南京药学院药剂学教研组: "《药剂学》", 31 May 1985, article "硬胶囊剂", pages: 769 * |
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Application publication date: 20131113 |