CN103372047A - Eucommia bark buccal tablets and preparation method thereof - Google Patents
Eucommia bark buccal tablets and preparation method thereof Download PDFInfo
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- CN103372047A CN103372047A CN2012101104583A CN201210110458A CN103372047A CN 103372047 A CN103372047 A CN 103372047A CN 2012101104583 A CN2012101104583 A CN 2012101104583A CN 201210110458 A CN201210110458 A CN 201210110458A CN 103372047 A CN103372047 A CN 103372047A
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- eucommia bark
- cortex eucommiae
- eucommiae
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Abstract
The invention discloses eucommia bark buccal tablets and a preparation method thereof. The eucommia bark buccal tablets are characterized by comprising the following components in percentage by weight: 70-97 percent of ultramicro folium cortex eucommiae powder, 1-20 percent of a flavoring agent, 1-10 percent of an adhesive and 0.1-1 percent of a lubricating agent, wherein the grain size of the ultramicro folium cortex eucommiae powder is not more than 100 micrometers. The eucommia bark buccal tablets are prepared by the steps of: carrying out enzyme deactivation on folium cortex eucommiae, crushing, ultramicro-grinding, blending, preparing soft materials, sieving, pelleting, drying and tabletting. Therefore, the raw materials are more easily available, the growth of eucommia bark plants can not be seriously damaged, the cost is lowered and treatment methods are different. According to the eucommia bark buccal tablets and the preparation method thereof, the folium cortex eucommiae is subjected to ultramicro grinding, so that an eucommia bark extract can be prevented from being easily humidified, the eucommia bark buccal tablets are conveniently absorbed and digested by a human body, the health care function of the eucommia bark is improved, and the quality and curative effect of the eucommia bark products are also improved.
Description
Technical field
The present invention relates to Cortex Eucommiae buccal tablet and relative manufacturing process technical field.
Background technology
The Cortex Eucommiae (Eucommia ulmoides oliv) is the medicine source plant resource of China's preciousness.All elaborate in the books such as famous in ancient medical book Shennong's Herbal, Compendium of Material Medica and current authoritative medical book " Traditional Chinese Medicine voluminous dictionary ", say its can liver-kidney tonifying, clothes can make light of one's life by commiting suicide anti-oldly, can control soreness of the waist and knees, impotence due to deficiency of the kidney.Modern medicine further studies show that the Cortex Eucommiae, the Cortex Eucommiae is rich in chlorogenic acid, flavone etc. more than 40 plants active ingredient, have 16 kinds of comprehensive effects such as the metabolism of promotion, enhancing immunity, slow down aging, adjusting blood pressure, inhibition tumor, particularly clear up human vas, treatment hypertension, hyperlipidemia, hyperglycemia, curative effect is unusually remarkable, is described as top quality natural depressor by medical circle.
For a long time eucommia resource utilization is all take Cortex Eucommiae as raw material, and the long-term utilization of Cortex Eucommiae causes the scarcity of eucommia resource, the destruction of environment.In recent years, Folium Eucommiae has become the focus of Cortex Eucommiae research, many famous medical mechanisms have all made long-term and careful pharmacological research and clinical treatment both at home and abroad, show Folium Eucommiae except containing the effective ingredient the same with skin, the Eucommia Tea made from bright Folium Eucommiae and the effective ingredient of extraction have equal health-care effect.Be open " method for preparing high-purity chlorogenic acid and total flavones from Folium Eucommiae " (publication number: CN1974527A) of Chinese invention patent application of 200610123973.X such as application number.
Superfine grinding refers to object is crushed to micron order, because granule develops to miniaturization, causes the material table area to increase considerably.Therefore, superfine powder has unique physics and chemistry character, and such as good dissolubility, dispersibility, adsorptivity, chemism etc., its application is very extensive.Superfine powder is easy to use, nutrition digestion absorbs easily, dietary fiber can be fully utilized.
National inventing patent discloses " a kind of eucommia bark tablet and preparation method thereof " 200410017639.7, it is comprised of adjuvants such as the extract of the Chinese medicines such as the Cortex Eucommiae, Semen Ziziphi Spinosae, Caulis Polygoni Multiflori, Radix Puerariae, Concha Ostreae, Semen Cassiae, Rhizoma Chuanxiong and lactose, micropowder silica gel, carboxymethylstach sodium, the steps such as preparation method comprises pre-treatment, it is concentrated to extract, spray drying, pelletizing press sheet, film coating.
For improving Cortex Eucommiae product quality and curative effect, the present invention adopts Folium Eucommiae, is broken into superfine powder through micropowder, and the tablettings such as interpolation adjuvant are processed into Cortex Eucommiae buccal tablet, and difference is that 1. raw material is different, and the present invention adopts single Folium Eucommiae; 2. processing method is different, and the present invention is with the Folium Eucommiae micronizing.Can avoid the easy moisture absorption problem of Cortex Eucommiae extract, improve simultaneously the health care of the Cortex Eucommiae.3. the selected Folium Eucommiae of buccal tablet is primary raw material, do not contain artificial color and antiseptic, be equipped with sugar-free raw material " Sorbitol ", refining forming, can be used as the sweeting agent of glycosuria disease, hepatopathy, cholecystitis, obesity patient's food, in the metabolic process of human body, do not stimulate the secretion of insulin, the equal edible of diabetics.
Summary of the invention
Primary technical problem to be solved by this invention provides the Cortex Eucommiae buccal tablet that a kind of source is more abundant rationally, absorb easily, improve health-care effect.
Another technical problem to be solved by this invention provides a kind of preparation method of relevant Cortex Eucommiae buccal tablet.
The present invention solves the technical scheme that above-mentioned primary technical problem adopts: a kind of Cortex Eucommiae buccal tablet, it is characterized in that comprising ultra micro Folium Eucommiae powder body 70～97%, sweeting agent 1～20%, bonding agent 1～10%, lubricant 0.1～1%, and adopt mass percent; Ultra micro Folium Eucommiae powder body particle diameter≤below the 100 μ m.
Preferably, sweeting agent adopts in Sorbitol or xylitol, glucose, aspartame, the sucrose one or more.
Preferably, bonding agent adopts beta-schardinger dextrin-or starch.
Preferably, lubricant adopts magnesium stearate or calcium stearate.
The present invention solves the technical scheme that above-mentioned another technical problem adopts: a kind of preparation method of above-mentioned Cortex Eucommiae buccal tablet is characterized in that step is followed successively by:
1. pulverize: dried Folium Eucommiae is pulverized, and obtaining granularity is 60-80 purpose dry powder;
2. micronizing: above-mentioned Eucommia Leaf Powder further is crushed to particle diameter≤below the 100 μ m, form ultra micro Folium Eucommiae powder body;
3. prepare burden: in ultra micro Folium Eucommiae powder body, add sweeting agent, bonding agent, lubricant adjuvant, in proportion mixing by above-mentioned prescription;
4. make soft material: add wetting agent and adjust humidity of materials, make water content reach 60-70 (wt) %;
5. the granulation of sieving: the soft material that will make is screened into granule;
6. dry: refer to wet grain is put into baking oven, oven dry makes moisture in 5 (wt) %;
7. granulate: refer to that the grain that drying is good sieves again, make material become size evenly, without the adhesion caking, be easy to the granule of tabletting;
8. tabletting: refer to the material behind the granulate is pressed into sheet with tablet machine.
Preferably, Folium Eucommiae completes before pulverizing.
Compared with prior art, the invention has the advantages that, adopt Folium Eucommiae, be broken into superfine powder through micropowder, the tablettings such as interpolation adjuvant are processed into Cortex Eucommiae buccal tablet, and raw material sources are abundanter like this, can the heavy damage plant growing, reduced cost, processing method is different, and the present invention is with the Folium Eucommiae micronizing, can avoid the easy moisture absorption problem of Cortex Eucommiae extract, be convenient to absorption of human body digestion, improved the health care of the Cortex Eucommiae, also improve Cortex Eucommiae product quality and curative effect.
The specific embodiment
Below in conjunction with examples of implementation the specific embodiment of the present invention is described further.
The proportioning of Cortex Eucommiae buccal tablet is: buccal tablet proportioning (in weight portion): ultra micro Folium Eucommiae powder body 70～97%, sweeting agent 1～20%, bonding agent 1～10%, lubricant 0.1～1%.
Examples of implementation 1
Buccal tablet proportioning (in weight portion): ultra micro Folium Eucommiae powder body 70%, sweeting agent (xylitol) 20%, bonding agent (beta-schardinger dextrin-) 9%, lubricant (magnesium stearate) 1%.
Examples of implementation 2
Buccal tablet proportioning (in weight portion): ultra micro Folium Eucommiae powder body 80%, sweeting agent (Sorbitol) 18.9%, bonding agent (starch) 1%, lubricant (calcium stearate) 0.1%.
Examples of implementation 3
Buccal tablet proportioning (in weight portion): ultra micro Folium Eucommiae powder body 80%, sweeting agent (Sorbitol) 10%, bonding agent (beta-schardinger dextrin-) 9.5%, lubricant (magnesium stearate) 0.5%.
The preparation flow of Cortex Eucommiae buccal tablet:
Folium Eucommiae → complete → pulverize → micronizing → ultra micro Folium Eucommiae powder body → soft the material of preparing burden → make → granulation → drying of sieving → tabletting → packing.
Concrete preparation method:
1. pulverize: dried Folium Eucommiae is pulverized, and obtaining granularity is 60～80 purpose dry powder;
2. micronizing: Cortex Eucommiae powder further is crushed to particle diameter≤below the 100 μ m, form ultra micro Folium Eucommiae powder body;
3. prepare burden: in order to make product good mouthfeel is arranged, in ultrafine powder, add the adjuvants such as bonding agent, sweeting agent, lubricant by above-mentioned prescription, in proportion mixing;
4. make soft material: add wetting agent and adjust humidity of materials, make water content reach 60～70wt%;
5. the granulation of sieving: the soft material that will make is screened into granule 16～18 orders size;
6. dry: refer to wet grain is put into baking oven, oven dry makes moisture about 3wt%;
7. granulate: refer to that the grain that drying is good sieves again, make material become size evenly, without the adhesion caking, be easy to the granule of tabletting;
8. tabletting: refer to the material behind the granulate is pressed into sheet with tablet machine;
9. pack: the packing of product.
Product quality indicator;
1. organoleptic indicator
(1) color and luster: be brown;
(2) outward appearance: the tablet profile is neat, smooth surface;
(3) mouthfeel: have the peculiar fragrance of tea containing leaves of Eucommia ulmoides;
2. physical and chemical index: moisture≤5.0%;
3. microbiological indicator: total number of bacteria≤1000/g; Coliform≤30/100g; Pathogenic bacterium must not detect.
4. shelf life of products: under the room temperature, 12 months shelf-lifves.
The advantage of this product is:
1. this product is tablet, is not easy the moisture absorption; This products taste of while, the sensory properties such as color and luster, fragrance are stable, the easy preservation of product.
2. Cortex Eucommiae buccal tablet effective ingredient (chlorogenic acid 〉=0.3mg/g, total flavones 〉=20mg/g).
3. the selected Folium Eucommiae of this buccal tablet is primary raw material, does not contain artificial color and antiseptic, is equipped with that sugar-free raw material " Sorbitol " is refining to be formed.The equal edible of diabetics.
Claims (6)
1. a Cortex Eucommiae buccal tablet is characterized in that comprising ultra micro Folium Eucommiae powder body 70～97%, sweeting agent 1～20%, bonding agent 1～10%, lubricant 0.1～1%, adopts mass percent; Ultra micro Folium Eucommiae powder body particle diameter≤below the 100 μ m.
2. Cortex Eucommiae buccal tablet according to claim 1 is characterized in that: sweeting agent adopts in Sorbitol or xylitol, glucose, aspartame, the sucrose one or more.
3. Cortex Eucommiae buccal tablet according to claim 1 is characterized in that: bonding agent employing beta-schardinger dextrin-or starch.
4. Cortex Eucommiae buccal tablet according to claim 1 is characterized in that: lubricant employing magnesium stearate or calcium stearate.
5. the preparation method of claim 1 Cortex Eucommiae buccal tablet is characterized in that step is followed successively by:
1) pulverize: dried Folium Eucommiae is pulverized, and obtaining granularity is 60-80 purpose dry powder;
2) micronizing: above-mentioned Eucommia Leaf Powder further is crushed to particle diameter≤below the 100 μ m, forms ultra micro Folium Eucommiae powder body;
3) batching: in ultra micro Folium Eucommiae powder body, add sweeting agent, bonding agent, lubricant adjuvant, in proportion mixing by above-mentioned prescription;
4) make soft material: add wetting agent and adjust humidity of materials, make water content reach 60-70 (wt) %;
5) granulation of sieving: the soft material that will make is screened into granule;
6) drying: refer to wet grain is put into baking oven, oven dry makes moisture in 5 (wt) %;
7) granulate: refer to that the grain that drying is good sieves again, make material become size evenly, without the adhesion caking, be easy to the granule of tabletting;
8) tabletting: refer to the material behind the granulate is pressed into sheet with tablet machine.
6. preparation method according to claim 5, it is characterized in that: Folium Eucommiae completes before pulverizing.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012101104583A CN103372047A (en) | 2012-04-13 | 2012-04-13 | Eucommia bark buccal tablets and preparation method thereof |
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| CN2012101104583A CN103372047A (en) | 2012-04-13 | 2012-04-13 | Eucommia bark buccal tablets and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105639652A (en) * | 2016-03-14 | 2016-06-08 | 河南科技学院 | Eucommia ulmoides and blueberry composite chewable tablets and preparation method thereof |
| CN107801999A (en) * | 2017-12-14 | 2018-03-16 | 东北林业大学 | A kind of folium cortex eucommiae buccal tablet with vasorelaxation action |
| CN109010425A (en) * | 2018-10-15 | 2018-12-18 | 安徽世茂中药股份有限公司 | A kind of processing method of the lamiophlomis rotata prepared slices of Chinese crude drugs |
| CN109349642A (en) * | 2018-12-26 | 2019-02-19 | 陕西天承生物科技股份有限公司 | A kind of folium cortex eucommiae compound buccal lozenge and preparation method thereof improved the immunity of the human body |
| CN109730305A (en) * | 2018-12-26 | 2019-05-10 | 陕西学前师范学院 | A kind of folium cortex eucommiae appetizing compound buccal lozenge and preparation method thereof |
| CN110074341A (en) * | 2019-04-26 | 2019-08-02 | 普正药业集团股份有限公司 | A kind of Gallus domesticlus brisson Orally taken product and preparation method thereof |
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| CN101816424A (en) * | 2010-05-11 | 2010-09-01 | 张家界岩泊渡食品厂 | Nutritive eucommia bark vermicelli and powder slices |
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| CN101816424A (en) * | 2010-05-11 | 2010-09-01 | 张家界岩泊渡食品厂 | Nutritive eucommia bark vermicelli and powder slices |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105639652A (en) * | 2016-03-14 | 2016-06-08 | 河南科技学院 | Eucommia ulmoides and blueberry composite chewable tablets and preparation method thereof |
| CN105639652B (en) * | 2016-03-14 | 2019-04-02 | 河南科技学院 | Cortex Eucommiae blueberry composite chewable tablet and preparation method thereof |
| CN107801999A (en) * | 2017-12-14 | 2018-03-16 | 东北林业大学 | A kind of folium cortex eucommiae buccal tablet with vasorelaxation action |
| CN109010425A (en) * | 2018-10-15 | 2018-12-18 | 安徽世茂中药股份有限公司 | A kind of processing method of the lamiophlomis rotata prepared slices of Chinese crude drugs |
| CN109349642A (en) * | 2018-12-26 | 2019-02-19 | 陕西天承生物科技股份有限公司 | A kind of folium cortex eucommiae compound buccal lozenge and preparation method thereof improved the immunity of the human body |
| CN109730305A (en) * | 2018-12-26 | 2019-05-10 | 陕西学前师范学院 | A kind of folium cortex eucommiae appetizing compound buccal lozenge and preparation method thereof |
| CN110074341A (en) * | 2019-04-26 | 2019-08-02 | 普正药业集团股份有限公司 | A kind of Gallus domesticlus brisson Orally taken product and preparation method thereof |
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Application publication date: 20131030 |