CN103356939B

CN103356939B - Medicine for treatment of enuresis and its preparation method

Info

Publication number: CN103356939B
Application number: CN201310304483.XA
Authority: CN
Inventors: 肖中喜
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-07-18
Filing date: 2013-07-18
Publication date: 2014-12-03
Anticipated expiration: 2033-07-18
Also published as: CN103356939A

Abstract

Belonging to the technical field of traditional Chinese medicines, the invention particularly relates to a medicine for treatment of enuresis and its preparation method. The medicine is made from the following crude drugs by weight: 5-25 parts of ginseng, 5-25 parts of rhizoma polygonati, 10-30 parts of raspberries, 10-30 parts of Fructus alpiniae oxyphyllae, 10-30 parts of Semen Euryales, 5-25 parts of dark plums, 5-25 parts of cinnamon, and 10-30 parts of wolfberry fruits The medicine for treatment of enuresis provided in the invention has the characteristics of simple formula, low cost, homology of medicinal and food raw materials, convenient administration by children, good taste, definite efficacy, and an effective rate up to 99.4%.

Description

A kind of medicine for the treatment of the enuresis and preparation method thereof

Technical field

The invention belongs to technical field of Chinese medicines, particularly a kind of medicine for the treatment of the enuresis and preparation method thereof.

Background technology

The enuresis refers to that 3 years old above children's urinates urine in bed unawares in sleep, claims again " bed-wetting ".Performance clinically is mainly automatic micturition not in sleep, as fatigue on daytime, when weather is overcast and rainy, more easily occurs, and gently counts nocturnal enuresis once, and heavy every nocturnal enuresis one is to secondary, even more.The for a long time visible infant shallow complexion of enuresis, the hypophrenia, lassitude, dizzy Yao Acid, the not warm grade of extremity disease.Older child has coy or psychentonia.Mainly contain at present pharmacotherapy and physiotherapy for the enuresis.Physiotherapy is as massage.Pharmacotherapy has dividing of western medicine and treatment by Chinese herbs.

Western medicine uses the excited medication of central nervous system, as used meclofenoxane or use in conjunction Parasympatholytic and sympathomimetic drug, as atropine and ephedrine; Somebody applies vassopressin, as de-arginine vasopressin or more solidifying etc.Although some patients were is effective, recurrence large percentage, and vassopressin is applied to simple bed-wetting patient, because of comparatively difficulty of some indication master, still has certain danger.Treatment by Chinese herbs aspect, existing many composite Chinese medicine in the market, but also more or less there are many defects, and some prescriptions are too complicated, and some prices are too expensive, and patient's financial burden is excessive.

Summary of the invention

The object of this invention is to provide a kind of medicine for the treatment of the enuresis and preparation method thereof, pharmaceutical formulation is simple, and cost is lower, and determined curative effect.

For solving the problems of the technologies described above, the technical solution used in the present invention is as follows:

Treat a medicine for the enuresis, described medicine is made up of the crude drug of following weight portion: Radix Ginseng 5-25 part, Rhizoma Polygonati 5-25 part, Fructus Rubi 10-30 part, Fructus Alpiniae Oxyphyllae 10-30 part, Semen Euryales 10-30 part, Fructus Mume 5-25 part, Cortex Cinnamomi 5-25 part and Fructus Lycii 10-30 part.

Further, described raw material medicines in portions by weight is as follows: Radix Ginseng 5-15 part, Rhizoma Polygonati 5-15 part, Fructus Rubi 15-25 part, Fructus Alpiniae Oxyphyllae 15-25 part, Semen Euryales 15-25 part, Fructus Mume 5-15 part, Cortex Cinnamomi 5-15 part and Fructus Lycii 15-25 part.

Further, described raw material medicines in portions by weight is as follows: 20 parts of 10 parts of Radix Ginsengs, 10 parts of Rhizoma Polygonatis, 20 parts of Fructus Rubies, 20 parts of Fructus Alpiniae Oxyphyllae, 20 parts of Semen Euryaless, 10 parts of Fructus Mumes, 10 parts of Cortex Cinnamomis and Fructus Lycii.

Preferably, in described medicine, also comprise the adjuvant of following weight portion: white sugar 150-210 part, brown sugar 20-60 part, dextrin 2-30 part.

More preferred, the weight portion of described adjuvant is as follows: 180 parts of white sugar, 40 parts, brown sugar, 10 parts, dextrin.

In crude drug of the present invention, Radix Ginseng, strongly invigorating primordial QI, multiple arteries and veins is admittedly de-, and invigorating the spleen to benefit the lung, promotes the production of body fluid, and calms the nerves.Rhizoma Polygonati, boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.Fructus Rubi, kidney tonifying, controlling nocturnal emission with astringent drugs, reducing urination.Fructus Alpiniae Oxyphyllae, for impurity and shell gained are removed in Fructus Alpiniae Oxyphyllae, warming spleen and stopping diarrha, take the photograph saliva, warming the kidney, controlling nocturnal emission with astringent drugs reducing urination.Semen Euryales, supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, damp eliminating leukorrhagia stopping.Fructus Mume, astringes the lung, and astringing intestine to stop diarrhea promotes the production of body fluid, relieving colic caused by ascaris.Cortex Cinnamomi, mends fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.Fructus Lycii, nourishing the liver and kidney, replenishing vital essence to improve eyesight.All medicine compatibilities, have good therapeutic effect for the enuresis.

The present invention also provides a kind of preparation method of medicine of the described treatment enuresis, first crude drug is mixed and is extracted, and is then mixed with into acceptable dosage form on materia medica with adjuvant.

As being prepared into granule, capsule, pill, honey pill agent, tablet, decoction etc., adopt conventional method.

Preferably, when crude drug is extracted, be that its 4-10 ethanol doubly mixes and reflux 2-6h obtains extracting solution by crude drug and quality, afterwards that extracting solution is concentrated, to the 30-40% that volume is extracting solution, then fully mix with white sugar, brown sugar and dextrin after pulverizing.

White sugar, brown sugar and dextrin after pulverizing are crossed 80-100 mesh sieve.

Medicine of the present invention is preferably prepared into granule.

While preparing granule, by the concentrated solution and the adjuvant mixing granulation that obtain, then dry granulation agent.

Granule of the present invention, while taking, every day three times, each 4-8g.

Compared with prior art, tool has the following advantages in the present invention:

The pharmaceutical formulation that the present invention treats the enuresis is simple, and raw material is integration of edible and medicinal herbs, have no side effect, and granulation, children taking is convenient, features good taste; Cost is low, determined curative effect, and effective percentage is up to 99.4%.

Detailed description of the invention

With specific embodiment, technical scheme of the present invention is described below, but protection scope of the present invention is not limited to this:

Embodiment 1

Treat a medicine for the enuresis, made by crude drug and adjuvant:

Wherein, raw material medicines in portions by weight is composed as follows: 20 parts of 10 parts of Radix Ginsengs, 10 parts of Rhizoma Polygonatis, 20 parts of Fructus Rubies, 20 parts of Fructus Alpiniae Oxyphyllae, 20 parts of Semen Euryaless, 10 parts of Fructus Mumes, 10 parts of Cortex Cinnamomis and Fructus Lycii.

Adjuvant weight portion is composed as follows: 180 parts of white sugar, 40 parts, brown sugar, 10 parts, dextrin.

Preparation method is as follows:

First crude drug is mixed and extracted: be that its ethanol of 7 times mixes and reflux 4h obtains extracting solution by crude drug and quality, afterwards that extracting solution is concentrated, to volume be extracting solution 35%, then with pulverize after can cross 80 mesh sieves white sugar, brown sugar and dextrin fully mix.After mixing, granulate, afterwards the granule of dry the treatment enuresis.

While taking, every day three times, each 6g.

Embodiment 2

Treat a medicine for the enuresis, made by crude drug and adjuvant:

Wherein, raw material medicines in portions by weight is composed as follows: 10 parts of 5 parts of Radix Ginsengs, 5 parts of Rhizoma Polygonatis, 10 parts of Fructus Rubies, 10 parts of Fructus Alpiniae Oxyphyllae, 10 parts of Semen Euryaless, 5 parts of Fructus Mumes, 5 parts of Cortex Cinnamomis and Fructus Lycii.

Adjuvant weight portion is composed as follows: 150 parts of white sugar, 20 parts, brown sugar, 2 parts, dextrin.

Preparation method is as follows:

First crude drug is mixed and extracted: be that its ethanol of 4 times mixes and reflux 2h obtains extracting solution by crude drug and quality, afterwards that extracting solution is concentrated, to volume be extracting solution 30%, then with pulverize after can cross 80 mesh sieves white sugar, brown sugar and dextrin fully mix.After mixing, granulate, afterwards the granule of dry the treatment enuresis.

Instructions of taking is with embodiment 1.

Embodiment 3

Treat a medicine for the enuresis, made by crude drug and adjuvant:

Wherein, raw material medicines in portions by weight is composed as follows: 30 parts of 25 parts of Radix Ginsengs, 25 parts of Rhizoma Polygonatis, 30 parts of Fructus Rubies, 30 parts of Fructus Alpiniae Oxyphyllae, 30 parts of Semen Euryaless, 25 parts of Fructus Mumes, 25 parts of Cortex Cinnamomis and Fructus Lycii.

Adjuvant weight portion is composed as follows: 210 parts, and 60 parts, brown sugar, 30 parts, dextrin.

Preparation method is as follows:

First crude drug is mixed and extracted: be that its ethanol of 10 times mixes and reflux 6h obtains extracting solution by crude drug and quality, afterwards that extracting solution is concentrated, to volume be extracting solution 40%, then with pulverize after can cross 80 mesh sieves white sugar, brown sugar and dextrin fully mix.After mixing, granulate, afterwards the granule of dry the treatment enuresis.

Instructions of taking is with embodiment 1.

Embodiment 4

Treat a medicine for the enuresis, made by crude drug and adjuvant:

Wherein, raw material medicines in portions by weight is composed as follows: 15 parts of 5 parts of Radix Ginsengs, 5 parts of Rhizoma Polygonatis, 15 parts of Fructus Rubies, 15 parts of Fructus Alpiniae Oxyphyllae, 15 parts of Semen Euryaless, 5 parts of Fructus Mumes, 5 parts of Cortex Cinnamomis and Fructus Lycii.

Adjuvant weight portion is composed as follows: 160 parts of white sugar, 30 parts, brown sugar, 15 parts, dextrin.

Preparation method and instructions of taking are with embodiment 1.

Embodiment 5

Treat a medicine for the enuresis, made by crude drug and adjuvant:

Wherein, raw material medicines in portions by weight is composed as follows: 25 parts of 15 parts of Radix Ginsengs, 15 parts of Rhizoma Polygonatis, 25 parts of Fructus Rubies, 25 parts of Fructus Alpiniae Oxyphyllae, 25 parts of Semen Euryaless, 15 parts of Fructus Mumes, 15 parts of Cortex Cinnamomis and Fructus Lycii.

Adjuvant weight portion is composed as follows: 200 parts of white sugar, 50 parts, brown sugar, 25 parts, dextrin.

Preparation method and instructions of taking are with embodiment 1.

Effect data

1. diagnostic criteria

Must meet following three:

1) 5 years old or 5 years old above (or intelligent age is more than 4 years old) has not automatic micturition (in the daytime or night) repeatedly; 2) 5-6 year child, monthly has 2 bed-wettings at least, and more than 6 years old child monthly has 1 bed-wetting at least; 3) not because nervous system damage, epilepsy, physical disease or medicine cause.

2. criterion of therapeutical effect

Cure: transference cure, after drug administration without abnormal response, and without carrying out other treatment.

Effective: symptom obviously alleviates, number of times or frequency obviously reduce;

Invalid: symptom is without any change or have the trend of increasing the weight of.

3. case load according to this and effect

The routine enuresis patient of selection of clinical 158, takes the embodiment of the present invention 1 medicine, every day three times, each 6 _g, statistical result after three months: 130 examples are cured, effectively, 1 example is invalid for 27 examples.Total effective rate reaches 99.4%.

Other embodiment medicines are suitable with embodiment 1 effect of drugs.

Claims

1. treat the medicine of the enuresis for one kind, it is characterized in that, described medicine is made up of the crude drug of following weight portion: Radix Ginseng 5-25 part, Rhizoma Polygonati 5-25 part, Fructus Rubi 10-30 part, Fructus Alpiniae Oxyphyllae 10-30 part, Semen Euryales 10-30 part, Fructus Mume 5-25 part, Cortex Cinnamomi 5-25 part and Fructus Lycii 10-30 part.

2. the medicine of the treatment enuresis as claimed in claim 1, it is characterized in that, described raw material medicines in portions by weight is as follows: Radix Ginseng 5-15 part, Rhizoma Polygonati 5-15 part, Fructus Rubi 15-25 part, Fructus Alpiniae Oxyphyllae 15-25 part, Semen Euryales 15-25 part, Fructus Mume 5-15 part, Cortex Cinnamomi 5-15 part and Fructus Lycii 15-25 part.

3. the medicine of the treatment enuresis as claimed in claim 2, is characterized in that, described raw material medicines in portions by weight is as follows: 20 parts of 10 parts of Radix Ginsengs, 10 parts of Rhizoma Polygonatis, 20 parts of Fructus Rubies, 20 parts of Fructus Alpiniae Oxyphyllae, 20 parts of Semen Euryaless, 10 parts of Fructus Mumes, 10 parts of Cortex Cinnamomis and Fructus Lycii.

4. the medicine of the treatment enuresis as described in as arbitrary in claim 1-3, is characterized in that, also comprises the adjuvant of following weight portion: white sugar 150-210 part, brown sugar 20-60 part, dextrin 2-30 part in described medicine.

5. the medicine of the treatment enuresis as claimed in claim 4, is characterized in that, the weight portion of described adjuvant is as follows: 180 parts of white sugar, 40 parts, brown sugar, 10 parts, dextrin.

6. the preparation method of the medicine of the arbitrary described treatment enuresis of claim 1-5, is characterized in that, first crude drug is mixed and is extracted, and is then mixed with into acceptable dosage form on materia medica with adjuvant.

7. treat as claimed in claim 6 the preparation method of the medicine of the enuresis, it is characterized in that, be that its 4-10 ethanol doubly mixes and reflux 2-6h obtains extracting solution by crude drug and quality, afterwards that extracting solution is concentrated, to the 30-40% that volume is extracting solution, then fully mix with white sugar, brown sugar and dextrin after pulverizing.

8. the preparation method for the treatment of as claimed in claim 7 the medicine of the enuresis, is characterized in that, white sugar, brown sugar and dextrin after pulverizing are crossed 80-100 mesh sieve.

9. the preparation method for the treatment of as claimed in claim 7 the medicine of the enuresis, is characterized in that, concentrated solution and adjuvant mixing granulation, then dry granulation agent.