CN103341231A - Dosing device of visualization intracavity tissue and method of dosing device - Google Patents
Dosing device of visualization intracavity tissue and method of dosing device Download PDFInfo
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- CN103341231A CN103341231A CN201310300707XA CN201310300707A CN103341231A CN 103341231 A CN103341231 A CN 103341231A CN 201310300707X A CN201310300707X A CN 201310300707XA CN 201310300707 A CN201310300707 A CN 201310300707A CN 103341231 A CN103341231 A CN 103341231A
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Abstract
The invention relates to a dosing device of a visualization intracavity tissue. The dosing device comprises an injection pump, a balloon liquid filling tube, a monitoring air bag, a microneedle balloon, a microneedle, a camera, a display device, a balloon catheter and a guide wire guiding tube. A flowmeter is arranged at the outlet end of the injection pump. The balloon liquid filling tube is connected to one side of the outlet end of the injection pump, and the flowmeter and a liquid sucking connector are arranged at the inlet end of the injection pump. The monitoring air bag is electrically connected with the display device. The microneedle balloon is connected to the outlet end of the balloon liquid filling tube. The microneedle is arranged on the microneedle balloon. The camera is electrically connected with the display device. A dosing method comprises the steps of locating a lesion tissue, entering the lesion tissue, conveying medicine to the lesion tissue and separating the lesion tissue in sequence. The dosing device is simple and reasonable in structural design, simple in operation and low in cost. The dosing method is simple in process, the accurate locating on the lesion tissue can be achieved, and the whole dosing process is simple, easy to carry out and high in efficiency.
Description
Technical field
The present invention relates to field of medical technology, relate in particular to a kind of doser and method thereof of visual intraluminal tissue.
Background technology
Existing technology to the administration of intraluminal tissue top layer mainly contains following three kinds:
1, micropin medicine-feeding technology
Routine mainly is to use entry needle by percutaneous drug delivery, but this method has been brought misery to patient, simultaneously owing to wound greatly exists bigger infection risk, and can not realize the long-time continuous administration.Though the problem above percutaneous plaster has solved is owing to the obstruction of the human body natural cover for defense makes the bioavailability of medicament reduction.
The endoceliac some diseases of human body, such as the atherosclerosis in the lumen of vessels, hemangioma, the myocardial infarction of the chambers of the heart, gastral digestive tract ulcer, ulcerative colitis, Crohn ' s disease etc., the whole body administration is difficult to guarantee at the drug level of affected area, and the whole body side reaction is more, improve the affected area drug level by topical, can obtain reasonable therapeutic effect.Present endoceliac topical mainly is TAI(transcatheter arterial infusion) and interventional technique such as chamber mirror technology realize.The main intracavity topical mode of using has following several clinically at present: 1. by special foley's tube topical, as dual balloon catheter, permeate conduit, foley's tube with holes, way film foley's tube etc.; 2. by the intervention support topical, it mainly is to adopt certain methods that medicine is coated on the support, put into support after, medicine slowly discharges by methods such as simple diffusion or chemical actions has an effect; 3. ionization infiltration administration, it to the effect that according to the principle of ionization therapy, puts into diseased region with conduit as a motor, and forms certain electrical gradient, and the medicine that sacculus discharges permeates along certain electrical gradient to the chamber wall; 4. by the special carrier administration, take these special carriers to diseased region by intervention measures such as foley's tubes, make medicine and pathological changes tube wall specific bond, thereby strengthen tube wall to the picked-up of medicine or the Local Residence Time of prolong drug; 5. by the subsidiary catheter perfusion medicine of chamber mirror.But in the mode of above-mentioned topical, medicine all is to be confined to the mucosa of tube chamber or the intimal surface of blood vessel, still exists by the absorption problem than the depths focus.
At present, a kind of epidermis medication that can break through keratodermatitis---skin micropin medication has been arranged both at home and abroad.Number be in the patent of invention of US2007/7226439B2 in invention, the inventor has proposed the injection device that a kind of micropin adds the storage of elasticity medicine, and micropin improves skin to the permeability of transdermal drug by prick small hole at the horny layer of skin.Number be CN1562402A in invention, the inventor has proposed the metal micro-needle sequence in the method for epiderm skin administration and the manufacture method of micropin.At present the micropin technology has been applied to use in the treatment of some dermatosis, as Microneedle Therapy System in the skin wrinkle removal, the scar of dispelling, comedo, the application in the alopecia etc.; But this micropin can only be used in the percutaneous drug delivery field, namely can only external, can not in body cavity, realize effective administration, and the suitability is limited.
2, diagnosis and treatment visualization technique
At present, electronic gastroscope, intestinal mirror and branchofiberoscope have been widely used in the diagnosis of digestive tract and respiratory tract disease.Medical electronic endoscope abbreviates electronic gastroscope as, mainly is made up of three parts: scope, video processor and TV monitor.Also be equipped with some auxiliary device, as videocorder, photographing unit, suction pump and be used for importing used various treatment apparatus of the keyboard of various information and diagnoses and treatment etc.Lead the picture system and be made up of CCD and cable, its imaging mainly depends on the miniature image sensor of shank head end equipment.The image-forming principle of fujinon electronic video endoscope is the light that utilizes the light source of TV information center equipment to send, optical fibers in scope imports light into the acceptor intracavity, ccd image sensor receives the light that the mucosal surface reflection comes in the body cavity, convert this light to the signal of telecommunication, by lead signal is transported to the TV information center again, through the TV information center these signals of telecommunication processes are stored and handled again, be transferred at last in the TV monitor and demonstrate the colored mucosa image of being examined internal organs at screen.Produce the more famous company of video image dendoscope in the world by the Olympus (Olympas) etc. of the Ya Lun (WelchAllyn) of the U.S. and Japan.The intestinal mirror is similar to its principle with bronchoscope.Our eyes have been extended in the technical development of video image dendoscope, and let us is seen real focus.Yet adopting scope separately can only be to find focus, can not effectively solve problems such as focus administrations.
3, foley's tube technology
Conduit is the main tool of interventional therapy, and foley's tube is that conduit and inflatable sacculus are linked together, thereby can reach the blood vessel dilating wall, struts effects such as intervention support.Adopt sacculus can only play the effect of expanding tract separately, yet, can not use treatment meanss such as administration to the focus in the tract, function is single relatively, and is economical and practical inadequately.
Yet because three kinds of above-mentioned technical functionalitys are relatively single, the suitability is limited, and therapeutic effect is not good enough.Because therefore the situation that also above-mentioned three kinds of technology is not combined at present and utilize, is badly in need of complete function of design, method and the device thereof of the visual intraluminal tissue administration that therapeutic effect is good and economical and practical on the market.
Summary of the invention
The present invention be existingly give the technology therapeutic efficiency of intraluminal tissue top layer administration low in order to solve, poor effect and the treatment high problem of cost and propose a kind of visual intracavity lesion tissue positioned administration that not only can realize accurately and efficiently, the doser of the visual intraluminal tissue that therapeutic effect is good and economical and practical and method thereof.
The present invention is achieved by the following technical solutions:
The doser of above-mentioned visual intraluminal tissue, described doser comprise syringe pump, sacculus topping up pipe, monitoring air bag, micropin sacculus, micropin, photographic head, display device, foley's tube and seal wire guiding tube; The outbound port of described syringe pump is provided with current meter; Described sacculus topping up pipe is connected in a side of the described syringe pump port of export by described foley's tube, and its entrance point also is provided with effusion meter and drawing liquid joint; Described monitoring air bag is located on the described sacculus topping up pipe and with described display device and is electrically connected; Described micropin sacculus is connected in the port of export of described sacculus topping up pipe; Described micropin is located on the described micropin sacculus, and it communicates with the inner chamber of described micropin sacculus for porose microneedle configuration and endoporus; Described photographic head is positioned at described micropin sacculus one side and is electrically connected with described display device by described seal wire guiding tube.
The doser of described visual intraluminal tissue, wherein: described monitoring air bag and described sacculus topping up pipe are the integrative-structure of moulding by casting; Described monitoring air bag communicates with described sacculus topping up pipe inside and a side also is provided with pressure transducer; Described pressure transducer one end pierces into the inner chamber of described monitoring air bag, and the other end is electrically connected with described display device by described seal wire guiding tube.
The doser of described visual intraluminal tissue, wherein: the seal wire guiding tube that be used for to connect described photographic head is to be drawn by described display device, wears described sacculus topping up pipe and micropin sacculus more successively and stretches out to the right-hand member of described micropin sacculus; Described photographic head is connected in the end of that section seal wire guiding tube that stretches out to described micropin sacculus right-hand member.
The doser of described visual intraluminal tissue, wherein: described seal wire guiding tube and described sacculus topping up pipe and micropin sacculus wear the position that joins and all adopt moulding by casting.
A kind of medication of doser of visual intraluminal tissue, it is characterized in that, may further comprise the steps: (1) pathological tissues location: at first the related micropin one of micropin sacculus is slowly inserted the pathological tissues intracavity, and then by the demonstration on the display device micropin sacculus and micropin are accurately delivered to pathological tissues together; (2) enter pathological tissues: after above-mentioned steps (1) is finished, injecting liquid in the sacculus topping up pipe by syringe pump fills the micropin sacculus, then paste mutually towards pathological tissues and with the pathological tissues surface by the variation of the monitoring air bag monitoring pressure outside the pathological tissues chamber and with the micropin tip, strengthening syringe pump air pressure then makes the micropin tip insert the pathological tissues top layer, when pressure in the monitoring air bag reached a certain scope and stablizes, micropin had entered the pathological tissues top layer and has finished; (3) to the pathological tissues loading: after above-mentioned steps (2) is finished, open effusion meter, accelerate the injection speed of syringe pump, the medicine that makes doses is transported in the pathological tissues by the inner passage of micropin sacculus and micropin; (4) break away from pathological tissues: after above-mentioned steps (3) is finished, after namely reaching injection measurement, by the medicine in the drawing liquid joint extraction micropin sacculus, the micropin sacculus is diminished, micropin and pathological tissues surface are broken away from, under the guiding of seal wire guiding tube, sacculus topping up pipe is extracted out outside the pathological tissues chamber at last.
Beneficial effect:
The doser structural design of the visual intraluminal tissue of the present invention is simple, reasonable, and it is the doser that foley's tube technology, micropin technology and fujinon electronic video endoscope technology combine; Especially, combine to use by sacculus and micropin to make medicine can not only enter into the mucosa of tube chamber or the intimal surface of blood vessel comprehensively, and the drug absorption efficient than the depths focus is significantly improved; Can locate pathological tissues accurately and efficiently by being used of photographic head and display device, guarantee the safety of whole administration process; Moreover the design by current meter, effusion meter and monitoring air bag can effectively guarantee safety, the reliability that whole doser is operated in the administration process.Simultaneously, the seal wire guiding tube can play the effect that guiding micropin sacculus enters the pathological tissues intracavity.Whole doser is not only simple to operate, and can efficiently, accurately realize the administration of visual intracavity lesion tissue positioned, and therapeutic efficiency height, effective is economical and practical, is suitable for promoting and application.
The medication of the doser of the visual intraluminal tissue of the present invention, step is simple, can not only effectively realize the location accurately and efficiently to visual intracavity lesion tissue, and the safety of whole administration process, reliability are higher, and therapeutic effect is good.
Description of drawings
Fig. 1 is the structural representation of the doser of the visual intraluminal tissue of the present invention.
The specific embodiment
" left side " that relates among the present invention, " right side ", " on " and the noun of locality of " interior " description scheme all with accompanying drawing 1 in the structure of doser of visual intraluminal tissue towards consistent.
The doser of the visual intraluminal tissue of the present invention comprises syringe pump 1, sacculus topping up pipe 2, monitoring air bag 3, micropin sacculus 4, micropin 5, photographic head 6, display device 7, foley's tube 8 and seal wire guiding tube 9.
Syringe pump 1 is the high order end of whole doser, it is combined by the pump housing 11 and piston 12, the port of export of this syringe pump 1 also is provided with current meter 13, flow velocity when this current meter 13 detects syringe pump 1 injecting fluid in good time, excessive or too small whole administration process is brought influence to avoid syringe pump 1 flow velocity.
Sacculus topping up pipe 2 is connected in a side of syringe pump 1 port of export by foley's tube 8, the entrance point of this sacculus topping up pipe 2 also is provided with effusion meter 21 and drawing liquid joint 22, wherein, this effusion meter 21 specifically is connected on the foley's tube 8 of sacculus topping up pipe 2 one sides in the present embodiment; When monitoring air bag 3 internal pressures are stablized, namely micropin 5 begins to opening behind the top layer undertissue injectable drug, and this effusion meter 21 can be monitored injection volume.
Monitoring air bag 3 is located at sacculus topping up pipe 2 one sides and is the integrative-structure of moulding by casting with sacculus topping up pipe 2, the inner chamber of this monitoring air bag 3 communicates with sacculus topping up pipe 2 inside and also is provided with pressure transducer 31, wherein, this pressure transducer 31 is electrically connected with display device 7 by seal wire guiding tube 9, can be in good time pass to display device 7 and shows monitoring air bag 3 interior pressure signal.
Micropin sacculus 4 is positioned at the port of export of sacculus topping up pipe 2 and is connected as a single entity with sacculus topping up pipe 2; The length of this micropin sacculus 4 can be selected according to different tracts, and its suitableeest full diameter can become according to different tract diameters.
Micropin 5 is in array-like arrangement and is arranged on the micropin sacculus 4, and it communicates with the inner chamber of described micropin sacculus 4 for the porose microneedle configuration of metal and endoporus; The array size of this micropin 5 can be decided according to different pathological changes sizes.Wherein, this micropin 5 can be positioned at the side of micropin sacculus 4, also can be positioned at the tip of micropin sacculus 4, and this micropin 5 is positioned at the side of micropin sacculus 4 in the present embodiment; The tip diameter of micropin 5 is 10nm～10 μ m, and base diameter is 20-300 μ m, highly decides on the different tissues skin depth.
Photographic head 6 is positioned at the right-hand member of micropin sacculus 4, it is electrically connected with display device 7 by seal wire guiding tube 9, wherein, the seal wire guiding tube 9 that should be used for connection photographic head 6 is to be drawn by display device 7, and then wear sacculus topping up pipe 2 and micropin sacculus 4 successively and stretch out to the right-hand member of micropin sacculus 4, this photographic head 6 namely is located at the end of that section seal wire guiding tube 9 that stretches out to micropin sacculus 4 right-hand members; Wherein, seal wire guiding tube 9 all is moulding by casting with the position that capsule topping up pipe 2 and micropin sacculus 4 join.
The medication of the doser of the visual intraluminal tissue of the present invention may further comprise the steps:
1, pathological tissues location
At first micropin sacculus 4 related micropins 5 one are slowly inserted the pathological tissues intracavity, and then by the demonstration on the display device 7 micropin sacculus 4 and micropin 5 are accurately delivered to pathological tissues together;
2, enter pathological tissues
After treating that above-mentioned steps (1) is finished, thereby injecting medicine in the sacculus topping up pipe 2 by syringe pump 1 fills micropin sacculus 4, change by monitoring air bag 3 monitoring pressures outside the pathological tissues chamber this moment, micropin 5 tips are pasted mutually towards pathological tissues and with the pathological tissues surface, strengthening syringe pump 1 air pressure then makes micropin 5 tips insert the pathological tissues top layer, when pressure in the monitoring air bag 3 reached a certain scope (different tissue surface pressure limit differences) and stablizes, micropin 5 entered the pathological tissues top layer and finishes;
3, to the pathological tissues loading
After treating that above-mentioned steps (2) is finished, open effusion meter 21, accelerate the injection speed of syringe pump 1, the medicine that makes doses is transported in the pathological tissues by the inner passage of micropin sacculus 4 and micropin 5;
4, break away from pathological tissues
After treating that above-mentioned steps (3) is finished, after namely reaching injection measurement, the medicine by drawing liquid joint 22 is extracted out in the micropin sacculus 4 diminishes micropin sacculus 4, micropin 5 and pathological tissues surface are broken away from, under the guiding of seal wire guiding tube 9, sacculus topping up pipe 2 is extracted out outside the pathological tissues chambeies at last.
The apparatus structure simplicity of design of the visual intraluminal tissue administration of the present invention, reasonable, it is the doser that foley's tube, micropin technology and fujinon electronic video endoscope technology combine, not only simple to operate, and can realize the administration of visual intracavity lesion tissue positioned efficiently, accurately, therapeutic efficiency height, effective, economical and practical, be suitable for promoting and application.
The visual intraluminal tissue medication of the present invention is that step is simple in conjunction with the device of visual intraluminal tissue administration, can not only realize the accurate location to pathological tissues, and whole administration process simply, is easily gone and efficient is high.
Claims (5)
1. the doser of a visual intraluminal tissue is characterized in that: described doser comprises syringe pump, sacculus topping up pipe, monitoring air bag, micropin sacculus, micropin, photographic head, display device, foley's tube and seal wire guiding tube;
The outbound port of described syringe pump is provided with current meter;
Described sacculus topping up pipe is connected in a side of the described syringe pump port of export by described foley's tube, and its entrance point also is provided with effusion meter and drawing liquid joint;
Described monitoring air bag is located on the described sacculus topping up pipe and with described display device and is electrically connected;
Described micropin sacculus is connected in the port of export of described sacculus topping up pipe;
Described micropin is located on the described micropin sacculus, and it communicates with the inner chamber of described micropin sacculus for porose microneedle configuration and endoporus;
Described photographic head is positioned at described micropin sacculus one side and is electrically connected with described display device by described seal wire guiding tube.
2. the doser of visual intraluminal tissue as claimed in claim 1, it is characterized in that: described monitoring air bag and described sacculus topping up pipe are the integrative-structure of moulding by casting;
Described monitoring air bag communicates with described sacculus topping up pipe inside and a side also is provided with pressure transducer; Described pressure transducer one end pierces into the inner chamber of described monitoring air bag, and the other end is electrically connected with described display device by described seal wire guiding tube.
3. the doser of visual intraluminal tissue as claimed in claim 1, it is characterized in that: the seal wire guiding tube that be used for to connect described photographic head is to be drawn by described display device, wears described sacculus topping up pipe and micropin sacculus more successively and stretches out to the right-hand member of described micropin sacculus;
Described photographic head is connected in the end of that section seal wire guiding tube that stretches out to described micropin sacculus right-hand member.
4. the doser of visual intraluminal tissue as claimed in claim 3, it is characterized in that: described seal wire guiding tube and described sacculus topping up pipe and micropin sacculus wear the position that joins and all adopt moulding by casting.
5. as the medication of the doser of the arbitrary described visual intraluminal tissue of above-mentioned claim 1 to 4, it is characterized in that, may further comprise the steps:
(1) pathological tissues location: at first the related micropin one of micropin sacculus is slowly inserted the pathological tissues intracavity, and then by the demonstration on the display device micropin sacculus and micropin are accurately delivered to pathological tissues together;
(2) enter pathological tissues: after above-mentioned steps (1) is finished, injecting liquid in the sacculus topping up pipe by syringe pump fills the micropin sacculus, then paste mutually towards pathological tissues and with the pathological tissues surface by the variation of the monitoring air bag monitoring pressure outside the pathological tissues chamber and with the micropin tip, strengthening syringe pump air pressure then makes the micropin tip insert the pathological tissues top layer, when pressure in the monitoring air bag reached a certain scope and stablizes, micropin had entered the pathological tissues top layer and has finished;
(3) to the pathological tissues loading: after above-mentioned steps (2) is finished, open effusion meter, accelerate the injection speed of syringe pump, the medicine that makes doses is transported in the pathological tissues by the inner passage of micropin sacculus and micropin;
(4) break away from pathological tissues: after above-mentioned steps (3) is finished, after namely reaching injection measurement, by the medicine in the drawing liquid joint extraction micropin sacculus, the micropin sacculus is diminished, micropin and pathological tissues surface are broken away from, under the guiding of seal wire guiding tube, sacculus topping up pipe is extracted out outside the pathological tissues chamber at last.
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Cited By (7)
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| CN106386780A (en) * | 2016-12-09 | 2017-02-15 | 无锡丹卡科技有限公司 | Visual multi-functional anticorrosion injection and pumping device |
| CN106426729A (en) * | 2016-11-09 | 2017-02-22 | 江苏信息职业技术学院 | Semiconductor microneedle assembly based on gene therapy, manufacturing method and manufacturing mold |
| CN108742959A (en) * | 2018-04-21 | 2018-11-06 | 李皇德 | A kind of blood saccule, balloon-stent drug release device and its medicine release method |
| CN109009588A (en) * | 2018-07-27 | 2018-12-18 | 王才阳 | A kind of Cardiological intravascular stent system and application method |
| CN110811524A (en) * | 2019-11-08 | 2020-02-21 | 武汉佑康科技有限公司 | Visual thermotherapy device |
| CN113018660A (en) * | 2021-03-16 | 2021-06-25 | 中国科学技术大学 | Microneedle balloon for interventional drug delivery |
| CN114569868A (en) * | 2022-03-01 | 2022-06-03 | 中国人民解放军西部战区总医院 | Novel double-layer medicine balloon |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114569868A (en) * | 2022-03-01 | 2022-06-03 | 中国人民解放军西部战区总医院 | Novel double-layer medicine balloon |
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| CN103341231B (en) | 2016-04-06 |
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