CN103333261B - 一种止血淀粉及其制备方法 - Google Patents
一种止血淀粉及其制备方法 Download PDFInfo
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- CN103333261B CN103333261B CN201310166694.1A CN201310166694A CN103333261B CN 103333261 B CN103333261 B CN 103333261B CN 201310166694 A CN201310166694 A CN 201310166694A CN 103333261 B CN103333261 B CN 103333261B
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- starch
- hemostatic
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- tissue
- modified starch
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- 229920002472 Starch Polymers 0.000 title claims abstract description 104
- 235000019698 starch Nutrition 0.000 title claims abstract description 104
- 239000008107 starch Substances 0.000 title claims abstract description 102
- 230000002439 hemostatic effect Effects 0.000 title claims abstract description 75
- 238000002360 preparation method Methods 0.000 title claims description 28
- 229920000881 Modified starch Polymers 0.000 claims abstract description 65
- 239000004368 Modified starch Substances 0.000 claims abstract description 63
- 235000019426 modified starch Nutrition 0.000 claims abstract description 63
- 230000000694 effects Effects 0.000 claims abstract description 35
- 239000008280 blood Substances 0.000 claims abstract description 12
- 210000004369 blood Anatomy 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims description 21
- 230000032050 esterification Effects 0.000 claims description 20
- 238000005886 esterification reaction Methods 0.000 claims description 20
- 239000000463 material Substances 0.000 claims description 20
- 208000027418 Wounds and injury Diseases 0.000 claims description 14
- 210000001519 tissue Anatomy 0.000 claims description 12
- 210000004185 liver Anatomy 0.000 claims description 7
- 210000000056 organ Anatomy 0.000 claims description 7
- 239000002994 raw material Substances 0.000 claims description 4
- 230000035876 healing Effects 0.000 claims description 3
- 230000001737 promoting effect Effects 0.000 claims description 3
- 241000271566 Aves Species 0.000 claims description 2
- 241000938605 Crocodylia Species 0.000 claims description 2
- 229920001353 Dextrin Polymers 0.000 claims description 2
- 239000004375 Dextrin Substances 0.000 claims description 2
- 241000124008 Mammalia Species 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 210000000988 bone and bone Anatomy 0.000 claims description 2
- 230000002490 cerebral effect Effects 0.000 claims description 2
- 239000002131 composite material Substances 0.000 claims description 2
- 238000004132 cross linking Methods 0.000 claims description 2
- 235000019425 dextrin Nutrition 0.000 claims description 2
- 238000006266 etherification reaction Methods 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 208000014674 injury Diseases 0.000 claims description 2
- 210000003734 kidney Anatomy 0.000 claims description 2
- 210000003205 muscle Anatomy 0.000 claims description 2
- 230000008520 organization Effects 0.000 claims description 2
- 210000004872 soft tissue Anatomy 0.000 claims description 2
- 238000000527 sonication Methods 0.000 claims description 2
- 210000000952 spleen Anatomy 0.000 claims description 2
- 238000009210 therapy by ultrasound Methods 0.000 claims description 2
- 230000008733 trauma Effects 0.000 claims description 2
- 238000011282 treatment Methods 0.000 claims description 2
- 238000002525 ultrasonication Methods 0.000 abstract description 2
- 238000002791 soaking Methods 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 56
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 33
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 32
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 16
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 16
- 239000003153 chemical reaction reagent Substances 0.000 description 16
- 239000002002 slurry Substances 0.000 description 16
- 239000002250 absorbent Substances 0.000 description 13
- 230000002745 absorbent Effects 0.000 description 11
- 238000010521 absorption reaction Methods 0.000 description 11
- 208000032843 Hemorrhage Diseases 0.000 description 10
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 7
- 230000008901 benefit Effects 0.000 description 6
- -1 hydroxypropyl Chemical group 0.000 description 6
- 125000002091 cationic group Chemical group 0.000 description 5
- 239000008187 granular material Substances 0.000 description 4
- 230000023597 hemostasis Effects 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 230000008961 swelling Effects 0.000 description 4
- 150000004676 glycans Chemical class 0.000 description 3
- 230000000025 haemostatic effect Effects 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000004925 denaturation Methods 0.000 description 2
- 230000036425 denaturation Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 229920002101 Chitin Polymers 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 229920000578 graft copolymer Polymers 0.000 description 1
- 238000009940 knitting Methods 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000036632 reaction speed Effects 0.000 description 1
- 239000004627 regenerated cellulose Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
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- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
Claims (11)
Priority Applications (1)
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CN201310166694.1A CN103333261B (zh) | 2013-05-08 | 2013-05-08 | 一种止血淀粉及其制备方法 |
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CN201310166694.1A CN103333261B (zh) | 2013-05-08 | 2013-05-08 | 一种止血淀粉及其制备方法 |
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CN103333261A CN103333261A (zh) | 2013-10-02 |
CN103333261B true CN103333261B (zh) | 2016-03-30 |
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Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103265641B (zh) * | 2013-05-08 | 2016-05-25 | 江苏德威兰医疗器械有限公司 | 一种止血淀粉及其制备方法 |
CN103265640B (zh) * | 2013-05-08 | 2016-03-30 | 江苏德威兰医疗器械有限公司 | 一种止血淀粉及其制备方法 |
CN103570838B (zh) * | 2013-10-17 | 2015-09-02 | 广州大学 | 一种复合改性高直链淀粉的制备方法 |
CN105770963A (zh) * | 2014-12-23 | 2016-07-20 | 重庆联佰博超医疗器械有限公司 | 一种多糖止血粉及其制备方法、应用 |
CN105107006B (zh) * | 2015-07-24 | 2018-02-16 | 成都仁天医疗器械有限公司 | 一种可降解淀粉基止血材料及其制备方法和应用 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101497670A (zh) * | 2008-01-29 | 2009-08-05 | 纪欣 | 生物相容性预糊化的变性淀粉及其制备方法 |
CN101785873A (zh) * | 2009-01-23 | 2010-07-28 | 纪欣 | 生物相容性止血及促进骨愈合材料及其制备方法 |
WO2011067403A1 (de) * | 2009-12-06 | 2011-06-09 | B. Braun Melsungen Ag | Stärkederivatmischungen |
CN103265640A (zh) * | 2013-05-08 | 2013-08-28 | 江苏德威兰医疗器械有限公司 | 一种止血淀粉及其制备方法 |
CN103265641A (zh) * | 2013-05-08 | 2013-08-28 | 江苏德威兰医疗器械有限公司 | 一种止血淀粉及其制备方法 |
-
2013
- 2013-05-08 CN CN201310166694.1A patent/CN103333261B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101497670A (zh) * | 2008-01-29 | 2009-08-05 | 纪欣 | 生物相容性预糊化的变性淀粉及其制备方法 |
CN101785873A (zh) * | 2009-01-23 | 2010-07-28 | 纪欣 | 生物相容性止血及促进骨愈合材料及其制备方法 |
WO2011067403A1 (de) * | 2009-12-06 | 2011-06-09 | B. Braun Melsungen Ag | Stärkederivatmischungen |
CN103265640A (zh) * | 2013-05-08 | 2013-08-28 | 江苏德威兰医疗器械有限公司 | 一种止血淀粉及其制备方法 |
CN103265641A (zh) * | 2013-05-08 | 2013-08-28 | 江苏德威兰医疗器械有限公司 | 一种止血淀粉及其制备方法 |
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Effective date of registration: 20160418 Address after: 225300 Jiangsu city of Taizhou province China pharmaceutical Road East, Xinyang City Road on the north side (G34 building) Patentee after: JIANGSU DEWEILAN MEDICAL INSTRUMENT Co.,Ltd. Patentee after: Zhou Xiao Address before: 225300 Jiangsu city of Taizhou province China pharmaceutical Road East, Xinyang City Road on the north side (G34 building) Patentee before: JIANGSU DEWEILAN MEDICAL INSTRUMENT Co.,Ltd. Patentee before: Liu Bozhi Patentee before: Zhou Xiao |
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Address after: 225300 the first floor to the fourth floor of workshop area on the east side of Tai Road and the north side of Xinyang Road (G34), China Medical Chengkou, Taizhou City, Jiangsu Province Patentee after: Jiangsu Deweilan medical equipment Limited by Share Ltd. Patentee after: Zhou Xiao Address before: 225300 Taizhou, Jiangsu, China, on the east side of Tai Chi Road, Xinyang Road, China (G34 building) Patentee before: JIANGSU DEWEILAN MEDICAL INSTRUMENT Co.,Ltd. Patentee before: Zhou Xiao |
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Denomination of invention: Hemostatic starch and its preparation method Effective date of registration: 20220623 Granted publication date: 20160330 Pledgee: Zhongguancun Technology Leasing Co.,Ltd. Pledgor: Jiangsu Deweilan medical equipment Limited by Share Ltd. Registration number: Y2022980008684 |
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