CN103316174A - Traditional Chinese medicinal composition for treating acute cholecystitis and preparation method thereof - Google Patents

Traditional Chinese medicinal composition for treating acute cholecystitis and preparation method thereof Download PDF

Info

Publication number
CN103316174A
CN103316174A CN2013102884619A CN201310288461A CN103316174A CN 103316174 A CN103316174 A CN 103316174A CN 2013102884619 A CN2013102884619 A CN 2013102884619A CN 201310288461 A CN201310288461 A CN 201310288461A CN 103316174 A CN103316174 A CN 103316174A
Authority
CN
China
Prior art keywords
parts
rhizoma
radix
herba
chinese medicine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN2013102884619A
Other languages
Chinese (zh)
Other versions
CN103316174B (en
Inventor
朱克兰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Liu Yongjuan
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201310288461.9A priority Critical patent/CN103316174B/en
Publication of CN103316174A publication Critical patent/CN103316174A/en
Application granted granted Critical
Publication of CN103316174B publication Critical patent/CN103316174B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Landscapes

  • Medicines Containing Plant Substances (AREA)

Abstract

The invention relates to a traditional Chinese medicinal composition for treating acute cholecystitis and a preparation method thereof. The traditional Chinese medicinal composition is prepared from the following medicinal raw materials in parts by weight: 12-24 parts of pteris multifida poir, 12-24 parts of oriental wormwood, 12-24 parts of honeysuckle, 12-24 parts of rheum officinale, 9-15 parts of moutan bark, 9-15 parts of lysimachia christinae hance, 9-15 parts of root of common peony, 5-13 parts of root of Chinese thorowax, 5-13 parts of astragalus membranaceus, 5-13 parts of coptis chinensis, 5-13 parts of polygonum cuspidatum, 5-13 parts of dandelion, 5-13 parts of fructus forsythiae, 5-13 parts of pericarpium citri reticulatae viride, 3-7 parts of immature bitter orange, 3-7 parts of cassia twig, 3-7 parts of mangnolia officinalis, 3-7 parts of rhizoma corydalis, 3-7 parts of endothelium corneum gigeriae galli, 3-7 parts of ginger processed pinellia and 3-7 parts of liquorice. The medicinal composition has the advantages of remarkable treating efficacy, quick acting, low recurrence possibility, and simple and convenient preparation method.

Description

A kind of Chinese medicine composition for the treatment of acute cholecystitis and preparation method thereof
Technical field
The present invention relates to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine composition for the treatment of acute cholecystitis and preparation method thereof.
Background technology
Acute cholecystitis is the acute suppurative inflammation of gallbladder, is one of clinical common acute abdomen; The common cause that causes primary disease comprises: calculus cause at the cystic duct incarceration block, intracapsular bile of gallbladder smoulders, concentrated cholate infringement mucous membrane of gallbladder causes inflammation, antibacterial infects, chemical stimulation etc.
The symptom of acute cholecystitis mainly contain upper right abdomen painful, feel sick, vomiting and heating etc.; Its time that continues of its stomachache that causes is often longer, does to breathe and change gallbladder variant position pain is increased the weight of, and right upper quadrant of the abdomen has tenderness, and tension of abdominal muscle is arranged, the numeration of leukocyte in the blood and neutrophilia; Ultrasound diagnosis can find that gallbladder enlargement, cyst wall thicken, and visible calculus gets lodged in the cervical region of gallbladder.
At present, the medicine that is used for the treatment of acute cholecystitis is more, such as magnesium sulfate, belladonna mixture, cephalosporins such as Ceftriaxone zinacef etc., but exist curative effect unstable, take effect slow, side effect large, the easy deficiency such as recurrence.
Summary of the invention
The technical problem to be solved in the present invention is: for solving the deficiencies in the prior art, the invention provides a kind of Chinese medicine composition for the treatment of acute cholecystitis and preparation method thereof, that the present invention has is evident in efficacy, instant effect, be difficult for recurrence, the simple advantage of preparation method.
A kind of Chinese medicine composition for the treatment of acute cholecystitis is made by the crude drug of following weight portion: Herba Pteridis creticae 12-24 part, Herba Artemisiae Scopariae 12-24 part, Flos Lonicerae 12-24 part, Radix Et Rhizoma Rhei 12-24 part, Cortex Moutan 9-15 part, Herba Lysimachiae 9-15 part, Radix Paeoniae Rubra 9-15 part, Radix Bupleuri 5-13 part, Radix Astragali 5-13 part, Rhizoma Coptidis 5-13 part, Rhizoma Polygoni Cuspidati 5-13 part, Herba Taraxaci 5-13 part, Fructus Forsythiae 5-13 part, Pericarpium Citri Reticulatae Viride 5-13 part, Fructus Aurantii Immaturus 3-7 part, Ramulus Cinnamomi 3-7 part, Cortex Magnoliae Officinalis 3-7 part, Rhizoma Corydalis 3-7 part, Endothelium Corneum Gigeriae Galli 3-7 part, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 3-7 part, Radix Glycyrrhizae 3-7 part.
The Chinese medicine composition of described treatment acute cholecystitis is made by the crude drug of following weight portion: 18 parts of Herba Pteridis creticaes, 18 parts of Herba Artemisiae Scopariaes, 18 parts of Flos Loniceraes, 18 parts of Radix Et Rhizoma Rhei, 12 parts of Cortex Moutans, 12 parts of Herba Lysimachiaes, 12 parts of Radix Paeoniae Rubra, 9 parts of Radix Bupleuri, 9 parts of the Radixs Astragali, 9 parts of Rhizoma Coptidis, 9 parts of Rhizoma Polygoni Cuspidati, 9 parts of Herba Taraxacis, 9 parts of Fructus Forsythiaes, 9 parts on Pericarpium Citri Reticulatae Viride, 5 parts of Fructus Aurantii Immaturuss, 5 parts of Ramulus Cinnamomi, 5 parts of Cortex Magnoliae Officinalis, 5 parts of Rhizoma Corydalis, 5 parts of Endothelium Corneum Gigeriae Galli, 5 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 5 parts in Radix Glycyrrhizae.
The preparation method of the Chinese medicine composition of described treatment acute cholecystitis is: make according to a conventional method decoction, concentrated pill or concentrated capsule by described Chinese medicine composition.
Usage and consumption: Chinese medicine composition of the present invention divides and takes for 3 times take decoction as main 1 pair of every day, early, middle and late respectively taking 1 time, and 5 days is 1 course for the treatment of, general 1-3 can cure the course for the treatment of; Also can be made into concentrated pill or concentrated capsule.
The beneficial effect that the present invention compared with prior art has is: the present invention is under Traditional Chinese medical theory and clinical experience guidance, choose each crude drug and proportioning thereof, have that heat clearing away is soothing the liver, detoxicating, relieving inflammation, warm in the function of QI invigorating, cholagogic and lithagogue, realize the purpose for the treatment of acute cholecystitis; That the present invention has is evident in efficacy, instant effect, be difficult for recurrence, the simple advantage of preparation method, and through clinical verification, it is 94% that the present invention treats the acute cholecystitis effective percentage.
The specific embodiment
Embodiment 1:
A kind of Chinese medicine composition for the treatment of acute cholecystitis is made by the crude drug of following weight portion: 18 parts of Herba Pteridis creticaes, 18 parts of Herba Artemisiae Scopariaes, 18 parts of Flos Loniceraes, 18 parts of Radix Et Rhizoma Rhei, 12 parts of Cortex Moutans, 12 parts of Herba Lysimachiaes, 12 parts of Radix Paeoniae Rubra, 9 parts of Radix Bupleuri, 9 parts of the Radixs Astragali, 9 parts of Rhizoma Coptidis, 9 parts of Rhizoma Polygoni Cuspidati, 9 parts of Herba Taraxacis, 9 parts of Fructus Forsythiaes, 9 parts on Pericarpium Citri Reticulatae Viride, 5 parts of Fructus Aurantii Immaturuss, 5 parts of Ramulus Cinnamomi, 5 parts of Cortex Magnoliae Officinalis, 5 parts of Rhizoma Corydalis, 5 parts of Endothelium Corneum Gigeriae Galli, 5 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 5 parts in Radix Glycyrrhizae.
The preparation method of the Chinese medicine composition of described treatment acute cholecystitis is: make according to a conventional method decoction, concentrated pill or concentrated capsule by described Chinese medicine composition.
Embodiment 2:
A kind of Chinese medicine composition for the treatment of acute cholecystitis is made by the crude drug of following weight portion: 12 parts of Herba Pteridis creticaes, 12 parts of Herba Artemisiae Scopariaes, 12 parts of Flos Loniceraes, 12 parts of Radix Et Rhizoma Rhei, 9 parts of Cortex Moutans, 9 parts of Herba Lysimachiaes, 9 parts of Radix Paeoniae Rubra, 5 parts of Radix Bupleuri, 5 parts of the Radixs Astragali, 5 parts of Rhizoma Coptidis, 5 parts of Rhizoma Polygoni Cuspidati, 5 parts of Herba Taraxacis, 5 parts of Fructus Forsythiaes, 5 parts on Pericarpium Citri Reticulatae Viride, 3 parts of Fructus Aurantii Immaturuss, 3 parts of Ramulus Cinnamomi, 3 parts of Cortex Magnoliae Officinalis, 3 parts of Rhizoma Corydalis, 3 parts of Endothelium Corneum Gigeriae Galli, 3 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 3 parts in Radix Glycyrrhizae.
The preparation method of the Chinese medicine composition of described treatment acute cholecystitis is: make according to a conventional method decoction, concentrated pill or concentrated capsule by described Chinese medicine composition.
Embodiment 3:
A kind of Chinese medicine composition for the treatment of acute cholecystitis is made by the crude drug of following weight portion: 24 parts of Herba Pteridis creticaes, 24 parts of Herba Artemisiae Scopariaes, 24 parts of Flos Loniceraes, 24 parts of Radix Et Rhizoma Rhei, 15 parts of Cortex Moutans, 15 parts of Herba Lysimachiaes, 15 parts of Radix Paeoniae Rubra, 13 parts of Radix Bupleuri, 13 parts of the Radixs Astragali, 13 parts of Rhizoma Coptidis, 13 parts of Rhizoma Polygoni Cuspidati, 13 parts of Herba Taraxacis, 13 parts of Fructus Forsythiaes, 13 parts on Pericarpium Citri Reticulatae Viride, 7 parts of Fructus Aurantii Immaturuss, 7 parts of Ramulus Cinnamomi, 7 parts of Cortex Magnoliae Officinalis, 7 parts of Rhizoma Corydalis, 7 parts of Endothelium Corneum Gigeriae Galli, 7 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 7 parts in Radix Glycyrrhizae.
The preparation method of the Chinese medicine composition of described treatment acute cholecystitis is: make according to a conventional method decoction, concentrated pill or concentrated capsule by described Chinese medicine composition.
Experimental example:
(1) clinical data: the present invention treats acute cholecystitis patient 35 examples altogether, male 9 examples wherein, and women 26 examples, the age is 35-63 year.
(2) Therapeutic Method: Chinese medicine composition of the present invention divides and takes for 3 times take decoction as main 1 pair of every day, early, middle and late respectively taking 1 time, and 5 days is 1 course for the treatment of, also can be made into concentrated pill or concentrated capsule.
(3) the standard of curative effect evaluation:
Cure: transference cure, lab testing is normal;
Take a turn for the better: symptom is clearly better, and lab testing is improved;
Do not heal: symptom is without improving or increasing the weight of.
(4) therapeutic outcome: the present invention treats acute cholecystitis patient 35 examples altogether, through 1-3 course of therapy, cures 29 examples, accounts for 83%, and 4 examples that take a turn for the better account for 11%, and 2 examples that do not heal account for 6%, and effective percentage is 94%, has no any side effect.
(5) model case:
1, Cui so-and-so, the woman, 41 years old, upper right abdomen constant pain, paroxysmal increases the weight of, to shoulder radiation, with bitter taste, feel sick, vomiting and heating, body temperature 38.8 degree, the gallbladder area tenderness, 0.6 centimetre of ultrasound diagnosis gallbladder wall thickness is diagnosed as acute cholecystitis; Take Chinese medicine composition of the present invention and take a turn for the better 1 course for the treatment of, cure 2 courses for the treatment of, follows up a case by regular visits to not recurrence in 2 years.
2, Lee so-and-so, the woman, 60 years old, upper right abdomen and right rib pain, with feel sick, heating etc., be diagnosed as acute cholecystitis through blood testing and ultrasound diagnosis; Take Chinese medicine composition of the present invention and take a turn for the better 1 course for the treatment of, cure 3 courses for the treatment of, follows up a case by regular visits to and do not recur half a year.
3, Lee so-and-so, the man, 55 years old, upper right abdomen pain, body temperature 39 degree, yellow urine, stool a couple of days does not separate, the lower abdomen tension of abdominal muscle is diagnosed as acute cholecystitis through blood testing and ultrasound diagnosis; Take Chinese medicine composition of the present invention and take a turn for the better 1 course for the treatment of, cure 2 courses for the treatment of, follows up a case by regular visits to not recurrence in 1 year.

Claims (3)

1. Chinese medicine composition for the treatment of acute cholecystitis, it is characterized in that: the crude drug by following weight portion is made: Herba Pteridis creticae 12-24 part, Herba Artemisiae Scopariae 12-24 part, Flos Lonicerae 12-24 part, Radix Et Rhizoma Rhei 12-24 part, Cortex Moutan 9-15 part, Herba Lysimachiae 9-15 part, Radix Paeoniae Rubra 9-15 part, Radix Bupleuri 5-13 part, Radix Astragali 5-13 part, Rhizoma Coptidis 5-13 part, Rhizoma Polygoni Cuspidati 5-13 part, Herba Taraxaci 5-13 part, Fructus Forsythiae 5-13 part, Pericarpium Citri Reticulatae Viride 5-13 part, Fructus Aurantii Immaturus 3-7 part, Ramulus Cinnamomi 3-7 part, Cortex Magnoliae Officinalis 3-7 part, Rhizoma Corydalis 3-7 part, Endothelium Corneum Gigeriae Galli 3-7 part, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 3-7 part, Radix Glycyrrhizae 3-7 part.
2. the Chinese medicine composition for the treatment of acute cholecystitis according to claim 1, it is characterized in that: the crude drug by following weight portion is made: 18 parts of Herba Pteridis creticaes, 18 parts of Herba Artemisiae Scopariaes, 18 parts of Flos Loniceraes, 18 parts of Radix Et Rhizoma Rhei, 12 parts of Cortex Moutans, 12 parts of Herba Lysimachiaes, 12 parts of Radix Paeoniae Rubra, 9 parts of Radix Bupleuri, 9 parts of the Radixs Astragali, 9 parts of Rhizoma Coptidis, 9 parts of Rhizoma Polygoni Cuspidati, 9 parts of Herba Taraxacis, 9 parts of Fructus Forsythiaes, 9 parts on Pericarpium Citri Reticulatae Viride, 5 parts of Fructus Aurantii Immaturuss, 5 parts of Ramulus Cinnamomi, 5 parts of Cortex Magnoliae Officinalis, 5 parts of Rhizoma Corydalis, 5 parts of Endothelium Corneum Gigeriae Galli, 5 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 5 parts in Radix Glycyrrhizae.
3. the preparation method of the Chinese medicine composition for the treatment of acute cholecystitis according to claim 1 and 2 is characterized in that: make according to a conventional method decoction, concentrated pill or concentrated capsule by claim 1 or 2 described Chinese medicine compositions.
CN201310288461.9A 2013-07-10 2013-07-10 Traditional Chinese medicinal composition for treating acute cholecystitis and preparation method thereof Expired - Fee Related CN103316174B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201310288461.9A CN103316174B (en) 2013-07-10 2013-07-10 Traditional Chinese medicinal composition for treating acute cholecystitis and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201310288461.9A CN103316174B (en) 2013-07-10 2013-07-10 Traditional Chinese medicinal composition for treating acute cholecystitis and preparation method thereof

Publications (2)

Publication Number Publication Date
CN103316174A true CN103316174A (en) 2013-09-25
CN103316174B CN103316174B (en) 2015-01-21

Family

ID=49185407

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201310288461.9A Expired - Fee Related CN103316174B (en) 2013-07-10 2013-07-10 Traditional Chinese medicinal composition for treating acute cholecystitis and preparation method thereof

Country Status (1)

Country Link
CN (1) CN103316174B (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103638190A (en) * 2013-12-03 2014-03-19 刘东彦 Traditional Chinese medicine for treating acute cholecystitis
CN104491207A (en) * 2015-01-15 2015-04-08 王金强 Cholangitis heat clearing inflammation diminish drug and preparation
CN104491255A (en) * 2014-12-08 2015-04-08 黄平县兴且民族民间中草医药科学发展有限责任公司 Traditional Chinese medicine preparation for treating acute cholecystitis
CN104758462A (en) * 2015-04-26 2015-07-08 李福军 Medicine for treating acute cholecystitis
CN105663486A (en) * 2016-04-27 2016-06-15 烟台市蓝洋之草医药生物科技有限公司 Application of traditional Chinese medicine preparation to preparation of medicine for treating acute cholecystitis
CN105726810A (en) * 2016-04-27 2016-07-06 烟台市蓝洋之草医药生物科技有限公司 Chinese herbal preparation for treating acute cholecystitis
CN107050282A (en) * 2017-04-19 2017-08-18 李玉姣 A kind of Chinese medicine preparation for being used to treat cholecystitis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1253013A (en) * 1999-10-25 2000-05-17 车兴泉 Medicine for treating hepatism and its preparing process
CN1390585A (en) * 2002-07-12 2003-01-15 李俊琦 Chinese medicine for detoxication purpose and its preparing process
CN1593601A (en) * 2004-07-12 2005-03-16 张成军 Chinese medicinal composition for cholecystitis and preparing method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1253013A (en) * 1999-10-25 2000-05-17 车兴泉 Medicine for treating hepatism and its preparing process
CN1390585A (en) * 2002-07-12 2003-01-15 李俊琦 Chinese medicine for detoxication purpose and its preparing process
CN1593601A (en) * 2004-07-12 2005-03-16 张成军 Chinese medicinal composition for cholecystitis and preparing method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
丁彩霞,顾勤: "慢性胆囊炎中医临床研究概况", 《辽宁中医药大学学报》 *
中华中医药学会脾胃病分会: "胆囊炎中医诊疗共识意见", 《中国中西医结合杂志》 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103638190A (en) * 2013-12-03 2014-03-19 刘东彦 Traditional Chinese medicine for treating acute cholecystitis
CN103638190B (en) * 2013-12-03 2015-11-25 刘东彦 The Chinese medicine for the treatment of acute cholecystitis
CN104491255A (en) * 2014-12-08 2015-04-08 黄平县兴且民族民间中草医药科学发展有限责任公司 Traditional Chinese medicine preparation for treating acute cholecystitis
CN104491207A (en) * 2015-01-15 2015-04-08 王金强 Cholangitis heat clearing inflammation diminish drug and preparation
CN104758462A (en) * 2015-04-26 2015-07-08 李福军 Medicine for treating acute cholecystitis
CN104758462B (en) * 2015-04-26 2016-01-06 美亚药业海安有限公司 A kind of powder for the treatment of acute cholecystitis
CN105663486A (en) * 2016-04-27 2016-06-15 烟台市蓝洋之草医药生物科技有限公司 Application of traditional Chinese medicine preparation to preparation of medicine for treating acute cholecystitis
CN105726810A (en) * 2016-04-27 2016-07-06 烟台市蓝洋之草医药生物科技有限公司 Chinese herbal preparation for treating acute cholecystitis
CN107050282A (en) * 2017-04-19 2017-08-18 李玉姣 A kind of Chinese medicine preparation for being used to treat cholecystitis

Also Published As

Publication number Publication date
CN103316174B (en) 2015-01-21

Similar Documents

Publication Publication Date Title
CN103316174B (en) Traditional Chinese medicinal composition for treating acute cholecystitis and preparation method thereof
CN103386086B (en) Traditional Chinese medicine composition for treating dysmenorrhea and preparation method thereof
CN103341004B (en) Chinese medicine composition for treating delayed menstrual cycle
CN103908640A (en) Traditional Chinese medicinal composition for treating liver cirrhosis
CN103083476B (en) Traditional Chinese medicine for treating acute mastitis
CN102430071B (en) Medicament for treating herpes zoster
CN103356968B (en) Traditional Chinese medicine composition for treating endometriosis
CN102895606A (en) Analgesic balm and preparation method thereof
CN103446554A (en) Traditional Chinese medicine composition for treating scapulohumeral periarthritis
CN104623362A (en) Traditional Chinese medicine composition for treating depression
CN102526635B (en) Medicament for treating premenstrual stress syndrome and preparation method thereof
CN104000893A (en) Traditional Chinese medicine oral liquid for treating rhinitis
CN103784804A (en) Pharmaceutical composition for treating benign prostatic hyperplasia
CN103585591A (en) Traditional Chinese medicine for treating gallstones
CN103341153B (en) Traditional Chinese medicine composition for treating raynaud disease
CN102872369A (en) Traditional Chinese medicine composition for varicella treatment
CN103356932B (en) A kind of pharmaceutical composition for the treatment of vulva squamous epithelial hyperplasia
CN102416146B (en) Chinese medicinal composition for treating amenorrhea
CN103845620A (en) Traditional Chinese medicine for treating raynaud disease
CN103550679A (en) Traditional Chinese medicine formula for treatment of lithangiuria
CN102716244B (en) Vietnamese sophora root Chinese medicine preparation for treating headache and preparation method of same
CN101658652A (en) Chinese medicinal preparation for treating chronic appendicitis
CN104162043A (en) Traditional Chinese medicine used for treatment of allergic nodular cutaneous vasculitis
CN104173933A (en) Traditional Chinese medicine composition for treating depressive disorder
CN103656123A (en) Traditional Chinese medicine composition for treating epididymitis

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C41 Transfer of patent application or patent right or utility model
CB03 Change of inventor or designer information

Inventor after: Liu Yongjuan

Inventor after: Liu Zhiwei

Inventor before: Zhu Kelan

COR Change of bibliographic data
TR01 Transfer of patent right

Effective date of registration: 20160810

Address after: 262700 Weifang, Shouguang City, Shandong Province, the holy city street, No. 40

Patentee after: Liu Yongjuan

Address before: 233000 Anhui Province, Bengbu City Economic Development Zone Jingshan Road No. 558 Building 1 unit 9 jinau Washington District 501 room

Patentee before: Zhu Kelan

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20150121

Termination date: 20160710

CF01 Termination of patent right due to non-payment of annual fee