CN103301553B - Intravascular guidewire - Google Patents
Intravascular guidewire Download PDFInfo
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- CN103301553B CN103301553B CN201310165105.8A CN201310165105A CN103301553B CN 103301553 B CN103301553 B CN 103301553B CN 201310165105 A CN201310165105 A CN 201310165105A CN 103301553 B CN103301553 B CN 103301553B
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- Prior art keywords
- core component
- seal wire
- section
- wire according
- coil
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
- A61M2025/09058—Basic structures of guide wires
- A61M2025/09083—Basic structures of guide wires having a coil around a core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
- A61M2025/09058—Basic structures of guide wires
- A61M2025/09083—Basic structures of guide wires having a coil around a core
- A61M2025/09091—Basic structures of guide wires having a coil around a core where a sheath surrounds the coil at the distal part
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
- A61M2025/09133—Guide wires having specific material compositions or coatings; Materials with specific mechanical behaviours, e.g. stiffness, strength to transmit torque
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Materials For Medical Uses (AREA)
- Surgical Instruments (AREA)
Abstract
The present invention discloses a kind of seal wire used in medical operating, and the seal wire includes elongated guiding elements, and the guiding elements is dimensioned so as to insert in the body vessel of object.Guiding elements limits longitudinal axis and has tail end section and front end rigion.Front end rigion has the cross sectional dimensions reduced relative to the cross sectional dimensions of tail end section.Front end rigion includes the first core component and the second core component, and first core component includes the first material, and second core component includes the second material different from the first material and before the first core component.First material of the first core component has bigger rigidity relative to the rigidity of the second material of the second core component, so as to be advantageous to make front end rigion to advance and apply leading section reverse, and minimizes deformation simultaneously.First material of the first core component may include nickel cobalt evanohm or be alternatively stainless steel.Second material of the second core component may include NiTi or its alloy.
Description
Technical field
The present invention relates generally to a kind of endovascular device, and is helped more particularly to a kind of for example in neural blood vessel space
The intravascular guidewire of endovascular device is placed, so as to promote neural blood vessel diagnosis and/or therapeutic process.
Background technology
Intravascular guidewire be advanced through tortuous vascular system without it is undesirable deformation or knotting validity depend on
Consider in many factors and design.These factors especially include manufacture material, seal wire size and the application target of seal wire.Generally,
Balance must be realized in the torsional strength needed for providing, transverse strength, tensile strength and/or fracture strength, so as in complications
Easily and accurately it can be controlled and manipulate in vascular system.Due to needed for the narrow remote location through neural blood vessel space
Relatively small diameter, the seal wire for neural blood vessel endovascular surgeries faces other challenges.
The content of the invention
Therefore, the present invention relates to a kind of seal wire, the seal wire can enter the distal side for including neurovascular vascular system
Region, while there is enough torsions and lateral stiffness, enable to manipulate seal wire through tortuous region.It is also contemplated that
The distal end of seal wire has improved stretching and torsion entirety, and with the ability being easily bent in any direction.
According to one embodiment of the present of invention, a kind of seal wire used in medical operating, the seal wire includes elongated
Guiding elements, the guiding elements are dimensioned so as to insert in the body vessel of object.Guiding elements limits longitudinal axis
And there is tail end section and front end rigion.Front end rigion has the cross sectional dimensions reduced relative to the cross sectional dimensions of tail end section.Front end
Section includes the first core component and the second core component, and first core component includes the first material, the second core member
Part includes the second material different from the first material and before the first core component.First material of the first core component
Rigidity relative to the second material of the second core component has bigger rigidity, so as to be advantageous to make front end rigion advance and it is right
Leading section, which applies, to be reversed, and minimizes deformation simultaneously.First material of the first core component may include nickel-cobalt-evanohm or can
Alternative is stainless steel.Second material of the second core component may include Ni-Ti or its alloy.First core component can pass through
Such as welding procedure is joined directly to the second core component, welding procedure does not have any filler material.
Coil member can it is axially mounted on around guiding elements and be designed and sized to Longitudinal extending at least partly around
First core component and the second core component.Coil member may include first coil section and before first coil section second
Coil segment.First coil section may include that first coil material, and the second coil segment may include different from first coil material
Second coil method.First coil section can have the first torsional strength, and the second coil segment can have than the first torsional strength
The second big torsional strength.Second coil segment is required to bear bigger torque load, to compensate for example close to guiding elements
The cross sectional dimensions of the reduction of end.
Front end rigion may include at least two converging transitions being in tilted layout relative to longitudinal axis.In one embodiment, it is preceding
End section includes from the front side to caudal：Most distal section；The first converging transition for extending and being attached thereto from the first most distal section；It is tapered from first
Duan Yanshen and be attached thereto first substantially round section；The second converging transition for extending and being attached thereto from first substantially round section；
And second substantially round section for extending and being attached thereto from the second converging transition.In embodiments, the first core component is
The second core component is connected in two basic circle segments or the second core component is may be connected in the 3rd substantially round section.
Sleeve can be arranged on front end rigion it is at least most of on.The sleeve may include polyurethane and tungsten material.The sleeve is also
Curved distal end can be limited.
Brief description of the drawings
Embodiments of the invention will be more readily understood by referring to accompanying drawing, wherein：
Fig. 1 is according to the seal wire used in the meander region of patient vessel's system of the principle of the invention and the solid of conduit
Figure；
Fig. 2 is the stereogram of the separated part of Fig. 1 seal wire, which illustrates guiding elements, support spring and epitheca；
Fig. 3 is the sectional view of the front end rigion of the guiding elements of the seal wire in Fig. 1 and 2；
Fig. 4 is the sectional view along the guiding elements of Fig. 3 center lines 4-4 seal wires taken；
Fig. 5 is the sectional view along the guiding elements of Fig. 3 center lines 5-5 seal wires taken；And
Fig. 6 is the sectional view along the guiding elements of Fig. 3 center lines 6-6 seal wires taken.
Embodiment
In the following description, term " near " used herein and " remote " reference seal wire are in intraluminal relative position.Seal wire
" near " end or " tail " end extend into the outer guidewire sections near doctor of human body." remote " end or " preceding " end of seal wire are to put
In guidewire sections farthest away from inlet location in body lumen.
Seal wire disclosed by the invention is applied especially to neural blood vessel operation, but can also be used for any intervention, diagnoses and/or control
Operation is treated, the application of coronary vasodilator, peripheral vascular and stomach and intestine is also included in addition to neural blood vessel is applied.
In the following figures, the whole length of seal wire is not shown.The length of seal wire can according to intervention operation type and
Change, but seal wire normal length is between 30 to 400 centimetres (cm).For coronary vasodilator, peripheral vascular and neural blood vessel
The normal length of the seal wire of intervention can be from 170 to 300cm.These length allow using the rapid exchange system of standardization or through leading
Silk conduit system.The length of shaped distal tip also alterable, for example, the length from about 5 to about 80cm.
According to one embodiment of the present of invention, the maximum outside diameter of seal wire is about 0.008 inch to about 0.018 inch.These
Diameter needles are standards for the seal wire for example used in neural blood vessel operation.Other diameters are intended for cardiovascular, outer
In all blood vessels and gastrointestinal applications.The diameter of seal wire can keep relative constancy in most of guidewire length；However, front end or distal end
Comprising construction that is substantially tapered or narrowing with allow flexing and meanwhile allow by complications vascular system.
It now will be described in connection with the drawings each application mode of the present invention.It should be understood that for the present invention is better described, it is attached
Figure may not be to be drawn according to ratio.In addition, some accompanying drawings include amplification or deformation part, to show otherwise unobvious
Feature.
Referring now to Fig. 1, the tortuous vascular system for example in neural blood vessel space " n " is illustrated.For signal
Property purpose, zigzag path or meander region in such as neural blood vessel space " n " include big blood vessel " v1 " and smaller point
Branch vessel " v2 ", the branch vessel from closer to vascellum laterale with various angles (including being up to 90 degree or even greater than 90 degree) bifurcated
Or extension.
In Fig. 1, seal wire 10 of the invention is illustrated as in generally intervention path or microtubular 100.The microtubular
It is well known in the art.A kind of applicable microtubular is the United States Patent (USP) No.7,507,229 by Hewitt et al. joint applications
Enhanced microtubular disclosed in (entire contents are hereby incorporated by reference).Generally, microtubular 100 includes the He of handle 102
The hollow conduit component 104 extended from handle 102.Microtubular 100 defines longitudinal opening, and the longitudinal opening at least extends logical
Cross catheter component 104 for seal wire 10 by or receive.
Seal wire 10 includes actuator 12 and the guiding elements 14 extended from actuator 12.Actuator 12 can combine various features
(including handle, carriage etc.) is in order to the manipulation and/or movement of guiding elements 14.For example, actuator 12 can be used in blood
Translation and/or rotation guiding elements 14 during being placed in guard system.
Referring now to Fig. 2, the guiding elements 14 of seal wire 10 is illustrated and will be described in greater detail.The size of guiding elements 14 is fitted
In in insertion vascular system.Guiding elements 14 defines longitudinal axis " k " and with near-end or tail end section 16 and positioned at tail end section
Distal end or front end rigion 18 before 16.In fig. 2, the major lengthwise portion of proximal segment 16 is for ease of illustration eliminated.Tail end section
16 can generally circular cross section and the length with about 20cm to about 240cm.Tail end section 16 can have constant along its length
Cross sectional dimensions or diameter.
Referring to Fig. 2-3, the front end rigion 18 of guiding elements 14 is working tips or the end of seal wire 10, and define relative to
The cross sectional dimensions that the cross sectional dimensions of proximal segment 16 reduces.The whole length " L " (Fig. 2) of front end rigion 18 according to seal wire 10 most
Major diameter (such as diameter of proximal segment 16) and whole length scope can be from about 20cm to about 60cm.Front end rigion 18 may include multiple
Alternate tapered and circle segments, the multiple alternate tapered and circle segments generally from pole distal end portion or distal end proximally (i.e. to
Proximal segment 16) in cross sectional dimensions or diametrically increase.In Fig. 2-3 embodiment, front end rigion 18 includes：Most distal section 20；From
The first converging transition 22 that most distal section 20 extends and is attached thereto；First for extending and being attached thereto from the first converging transition 22 is substantially round
Shape section 24；The second converging transition 26 for extending and being attached thereto from first substantially round section 24；And extend from the second converging transition 26
And second substantially round section 28 be attached thereto.Front end rigion 18 may also include continuously extend from the second circle segments 28 it is the 3rd tapered
Section 30, and the 3rd circle segments 32 being connected with the 3rd converging transition 30.Can further alternately, front end rigion 18 may also include from
3rd circle segments 32 extend to the 4th converging transition 34 of front end rigion 16.As described respectively in the sectional view of Fig. 4,5 and 6, first,
Two and the 3rd circle segments 24,28,32 can limit the circular cross section with various diameters.Below for specific seal wire size
Each suitable diameter in first, second, and third circle segments 24,28,32 is provided.Converging transition 22,26,30 and 34 relative to
Longitudinal axis " k " tilts.Converging transition 22,26 can limit about 5 degree to about 30 degree of angle of relative longitudinal axis " k ".Converging transition
30th, 34 the bigger angle of relative longitudinal axis " k " can be limited, such as from about 20 degree to about 70 degree.
Most distal section 20 can limit various configurations.In Fig. 2-3 embodiment, most distal section 20 is flat, plane or band
The end of shape.But most distal section 20 can limit the shape of cross section of replacement, including circle, ellipse etc..It is further alternative,
Most distal section 20 can be by thermal finalization into various configurations, including linear arrangement.In one embodiment, by making most distal section 20 about
The duration of 500 DEG C to about 525 DEG C heating about 30 seconds to about 2 minutes, most distal section 20 are for example non-linear for holding by thermal finalization
Configuration, such as curve.Most distal section 20 is also provided with bending " J- hooks " (" j-hook ") well known in the art, or is performed the operation in intervention
It is preceding to be bent to by doctor " J- hooks " design.
According to embodiments of the invention, come with reference to Fig. 2 referring in particular to Fig. 3, front end rigion 18 is by with different mechanical properties
At least two core components of different core material are fabricated.For example, the first core component 36 is at least about the second circle segments
28 part and near-end to seal wire 10 or tail end section 16 proximally extend, and can surround whole tail end section 16.Second core
Element 38 (being determined in figure 3 by different grid lines) can surround second in the distal side of the first core component 36 or above
The remaining distal part of circle segments 28, the second converging transition 26, the first circle segments 24, the first converging transition 22 and most distal section 20.Such as
It is discussed in detail below, the first core component 36 and the second core component 38 link together at coupling position 40.
Second core component 38 may include shape memory or superelastic alloy or polymer.A kind of suitable shape memory closes
Golden (SMA) or superelastic metal are Nitinol (NiTi), and Nitinol is that a kind of nickel/titanium commercially available with various diameters or size closes
Gold.Superelastic alloy (such as NiTi) is more flexible, so as to efficiently comply with the tortuous vascular system run into while show
Go out favourable recovery capability.Such as NiTi shape memory or superelastic metal or polymer could be applicable to it is expected front end rigion 18
Application with predetermined curvature.Marmem including NiTi can thermal finalization be intended shape, straighten to be delivered to certain
Position, then discharge so that the heat set shape is presented.Other materials for the second core component 38 can be included by nickel, titanium and cobalt
The alloy of composition, it is commercially available by SAES the Smart Materials, Inc of the new Hartford in New York.
First core component 36 than the second core component 38 preferably by having bigger modulus of elasticity, torsion and/or transverse direction
Rigid more rigid material manufacture.In one embodiment, the first core component 36 is manufactured by MP35N (a kind of nickel cobalt (alloy)).
MP35N be it is a kind of by cold working, the nickel cobalt based alloy of (age hardenable) age-hardenable, its have intensity, toughness,
The combination of durability and corrosion resistance.MP35N typical component includes 35% nickel (Ni), 35% cobalt (Co), 20% chromium
(Cr) and 10% molybdenum (MO).By the seal wire of MP35N manufactures for example by the Fort Wayne Metals of state of Indiana Fort Wayne
Company is commercially available with various diameter dimensions.The first more rigid core component 36 enhances pushability and the torsion by vascular system
Square transporting, this will be described below.First core component 36 other be adapted to materials include stainless steel, titanium and its alloy,
And NiTi cobalt alloy, as described above.The characteristic of these materials can be changed by the use of added material, manufacturing process etc.
Become, to provide required transverse strength and rigidity, and then the desired characteristic of the first the above core component 36.
First core component 36 can be by various means (including link, weld, bond) in the second circle segments 28
The second core component 38 is attached at bond sites 40.In one embodiment, the first core component 36 passes through welding procedure (example
Such as laser or less radio-frequency (RF) welding procedure) it is fixed to the second core component 38.Desired welding procedure do not need filler or
Connecting material, thus provide during heating the first and second core components 36,38 be directly connected to or element coordinate.First He
Each end to be linked in second core component 36,38 can before part welding progress pickling with go the removal of impurity and/or
Edge.
First and second core components 36 and 38 are used with dual extension-compression modulus, rigid and/or anti-at front end rigion 18
Turn round intensity different materials, and combine front end rigion 18 part size, this be seal wire 10 pushability, transverse strength,
Moment of torsion transmission and flexible aspect provide very big benefit.For example, in one embodiment, the second core component 38 surrounds front end rigion
About the 10% of 18 whole length arrives about 20%.In embodiment, the second core component 38 can be from the extended distance of distalmost end 20 " m "
(Fig. 3), the distance " m " are about 10cm to about 20cm.Position or set at the distalmost end of front end rigion 18 and be smaller by rigid the
The two core components 38 relative increase length of more rigid first core component 36 (and/or in front end rigion 18) are added and drawn
Pushability of the component 12 in tortuous vascular system is led, moment of torsion transitivity is improved and minimizes distal side deformation, also simultaneously
Enough flexibilities are provided to adapt to the steering of the vascular system in neural blood vessel space.Listed in form below for various
The length of first and second core components 36,38 of seal wire size.
As described above, in the embodiment described by Fig. 2 and 3, the first and second core components 36,38 are circular second
Linked together at position 40 in section 28.It is contemplated that coupling position can be along the optional position of front end rigion 18, bag
Include for example along the second converging transition 26, the 3rd converging transition 30 or the 3rd circle segments 32 (such as at position 41), or be arranged to
For example linked together in the first circle segments 24 at position 43.
With continued reference to Fig. 2-3, front end rigion 18 also includes at least one of the coaxial installation of at least a portion around front end rigion 18
Coil, and epitheca 42.In embodiments, front end rigion 18 includes two coils, i.e., first or nearside coil segment 44 and is located at
Second before nearside coil segment 44 or distal side coil segment 46.Nearside coil segment 44 can be manufactured by multiple material, including be retouched above
The MP35N stated.The size of nearside coil segment 44 can extend with around the second circle segments 28 and the second partial converging transition 26.Closely
The diameter of the line of lateral coil section 44 can be from about 0.0009 inch to about 0.0025 inch, and be about in one embodiment
0.0012 inch.Nearside coil segment 44 can also have square-section or plane section.
Proximally coil segment 44 extends and surrounds the remainder of the front end rigion 18 of guiding elements 14 distal side coil segment 46.Far
Lateral coil section 46 can be manufactured by multiple material.In one embodiment, distal side coil segment 46 is by London Johnson-
The radiopaque biomedical material manufacture of Matthey companies markets, and provide 3 ranks, i.e. rank 1400 includes
86% palladium (Pd), 14% rhenium (Re), rank 1000 include 90% Pd, 10% Re, and rank 500 includes 95%
Pd, 5% Re.The line of distal side coil segment 46 has the diameter of the line more than nearside coil segment 44.In one embodiment, distal side
The diameter of coil segment 46 is about 0.0015 inch from about 0.0012 inch to about 0.0025 inch.Distal side coil segment 46 is also
With square-section or plane section.The radiopacity of distal side coil segment 46 can intervene perform the operation during by using for example into
As means (fluoroscopy) help to place front end rigion 18 in vascular system.
Nearside coil segment 44 and distal side coil segment 46 can be that front end rigion 18 provides transverse direction and/or reflexive support.At one
In embodiment, the transverse strength (or bending resistance) of distal side coil segment 46 is smaller than the transverse strength of nearside coil segment 44, so as to permit
Perhaps the flexing of the second core component 38 of front end rigion 18.The external diameter of nearside and distal side coil segment 44,46 can be closer to each other, and can be basic
It is equal with the diameter of the 3rd circle segments 32, to provide smooth transition.The construction of nearside and distal side coil segment 44,46 can be according to need
Change to provide different characteristics.In one embodiment, what nearside and distal side coil segment 44,46 can with difference or conversely
Direction winds or arranged around front end rigion 18.In embodiments, the phase of nearside and each coil in distal side coil segment 44,46
Adjacent circle is the relation (that is, not having space between adjacent windings circle) of contact.In one embodiment, nearside and distal side coil segment
44th, 46 can be connected in its interface.In addition, nearside and distal side coil segment 44,46 can be attached to guiding elements 14 along each position
Front end rigion 18.It can be attached by using realizations such as bonding, welding, solderings.Distal side coil segment 46 can pass through soldering processes or logical
Cross using adhesive (such as epoxy, cyanoacrylate adhesive or ultraviolet (UV) Photocurable adhesive) operationally
It is attached or secured to the distalmost end 20 of front end rigion 18.Soldering or attaching components are illustrated schematically as element 48 in figure 3.
Epitheca 42 encapsulates front end rigion 18 and nearside and distal side coil segment 44,46.Epitheca 42 can be by any suitable material
Manufacture.In one embodiment, epitheca 42 is polyurethane sleeve pipe, and the polyurethane sleeve pipe can be loaded or be not loaded with for example in microballon
The tungsten of mode.If being loaded with tungsten, epitheca 42 provides other radiopaque element for the front end rigion 18 of guiding elements 14.Epitheca
42 can pass through the hot forming on front end rigion 18 and nearside and distal side coil segment 44,46 of traditional heating forming technique.Epitheca 42 limits
Atraumatic arcuate front ends surface 50 has been determined to minimize the possibility damaged or wear vascular wall.In one embodiment,
The diameter of epitheca 42 is less than the near-end of guiding elements 14 or the diameter of tail end section 16, and then seamlessly transitting between offer part.
According to the principle of the present invention, the form being provided below determines the part of the front end rigion 18 for different seal wire sizes
Size range.In the form, D represents the percentage (%) for the diameter for accounting for tail end section 16, and L represents the designated length of part.
For example, the diameter of the first circle segments 24 can be about 10% to about the 30% of the diameter of tail end section 16, and about 10 are arrived with about 2 centimetres
Centimetre length.All scopes are all approximate.Preferred size for specific seal wire size can be the centre of specified range
Value.The change of these expectable sizes.First core component 36 is manufactured by MP35N, and the second core component 38 is by NiTi systems
Make.It is noted that the whole length of the first core component 36 can be from about 10 centimetres to about 40 centimetres, and the second core member
The whole length of part 38 can be from about 20 centimetres to about 290 centimetres.
Form
It is also contemplated that lubricant coating can be arranged on each part of the guiding elements 14 including epitheca 42.Close
Suitable lubricant coating includes such as polyvinylpyrrolidone (PVP), PEO, polyethylene glycol, fibre-forming polymer, hydrophilic suitable
The hydrophobic material of the water wetted material of anhydride maleique and such as silicones, PTFE or FEP.These coating generally uses impregnate
The mode of coating or spraying applies, and can use heat cure mode.For example, used for silicone coatings until about
70 degrees Celsius of solidification temperature, several Baidu can be needed for PTFE coatings., can be in whole seal wire or part in addition to lubricant coating
Apply bioactivity coatings on seal wire.These coatings may also be combined with such as heparin, hirudin and the like or other drugs
Material.The mode of these coating generally use immersion coatings applies.Bioactivity coatings are expected to have for preventing blood clotting
Or conduct drugs to privileged site.
Description above and accompanying drawing are used to various embodiments of the present invention be described, but do not limit the invention in any way
Scope.It will be apparent to one skilled in the art that without departing from the spirit and scope of the invention can be to this
Various modifications and variations can be made for invention.Therefore it is contemplated that various modifications and variations of the present invention are covered, as long as they fall into
In the range of appended claims and its equivalent.
Claims (20)
1. a kind of seal wire used in medical operating, the seal wire include：
Elongated guiding elements, the guiding elements are dimensioned so as to insert in the body vessel of object, guiding elements limit
Determine longitudinal axis and there is tail end section and front end rigion, front end rigion has the cross section reduced relative to the cross sectional dimensions of tail end section
Size, front end rigion include：
First core component, first core component are formed by the first material；With
Second core component, second core component different from the second material of the first material by forming and being located at the first core
Before element,
Wherein, the near-end of the second core component is joined directly to the distal end of the first core component and causes the second of the second core component
Material is joined directly to the first material of the first core component, and the first material of the first core component is relative to the second core component
The rigidity of the second material there is bigger rigidity, so as to be advantageous to make front end rigion to advance and apply leading section reverse, and
The deformation of the elongated guiding elements is minimized simultaneously.
2. seal wire according to claim 1, wherein the first material of the first core component includes nickel-cobalt-evanohm.
3. seal wire according to claim 1, wherein the first material of the first core component includes stainless steel.
4. seal wire according to claim 2, wherein the second material of the second core component includes Ni-Ti or Ni-Ti is closed
Gold.
5. seal wire according to claim 1, wherein the first core component is attached to the second core component by welding procedure,
Welding procedure does not have any filler material.
6. seal wire according to claim 1, the seal wire includes coil member, and the coil member is around the guiding elements
It is axially mounted on and be designed and sized to Longitudinal extending at least partly around the first core component and the second core component.
7. seal wire according to claim 6, wherein coil member include first coil section and before first coil sections
The second coil segment.
8. seal wire according to claim 7, wherein first coil section include first coil material, and the second coil segment bag
Include the second coil method different from first coil material.
9. seal wire according to claim 7, wherein first coil section have the first torsional strength, and the second coil segment tool
There is second torsional strength bigger than the first torsional strength.
10. seal wire according to claim 1, wherein front end rigion include at least two to be in tilted layout relative to longitudinal axis
Converging transition.
11. seal wire according to claim 10, wherein front end rigion include from the front side to caudal：
Most distal section；
The first converging transition for extending and being attached thereto from most distal section；
First substantially round section for extending and being attached thereto from the first converging transition；
The second converging transition for extending and being attached thereto from first substantially round section；And
Second substantially round section for extending and being attached thereto from the second converging transition.
12. seal wire according to claim 11, wherein the first core component is connected to second in second substantially round section
Core component.
13. seal wire according to claim 11, wherein the first core component is connected to second in the 3rd substantially round section
Core component, described 3rd substantially round section extends from the 3rd converging transition, and the 3rd converging transition prolongs from second substantially round section
Stretch.
14. seal wire according to claim 11, wherein most distal section limits one kind in polygonal cross-section or circular cross-section.
15. seal wire according to claim 11, wherein by making most distal section when 500 degree to 525 degree one section of heating continue
Between by most distal section thermal finalization be predetermined construction.
16. seal wire according to claim 15, wherein predetermined construction is generally arcuate in shape.
17. seal wire according to claim 1, the seal wire include installed in front end rigion it is at least most of on sleeve.
18. seal wire according to claim 17, its middle sleeve includes polyurethane and tungsten material.
19. seal wire according to claim 17, its middle sleeve limits the distal end of arc.
20. seal wire according to claim 6, wherein coil member engage with the first core component and the second core component.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/407,182 US10029076B2 (en) | 2012-02-28 | 2012-02-28 | Intravascular guidewire |
| US13/407,182 | 2012-02-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103301553A CN103301553A (en) | 2013-09-18 |
| CN103301553B true CN103301553B (en) | 2018-04-03 |
Family
ID=47826921
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310165105.8A Active CN103301553B (en) | 2012-02-28 | 2013-02-28 | Intravascular guidewire |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10029076B2 (en) |
| EP (1) | EP2633878B1 (en) |
| JP (2) | JP5925145B2 (en) |
| KR (1) | KR20130098935A (en) |
| CN (1) | CN103301553B (en) |
| BR (1) | BR102013004619A2 (en) |
| CA (1) | CA2806985C (en) |
| RU (1) | RU2013108351A (en) |
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| JP4917900B2 (en) | 2007-01-12 | 2012-04-18 | テルモ株式会社 | Intermediate member for guide wire and guide wire |
| JP2008237253A (en) | 2007-03-23 | 2008-10-09 | Terumo Corp | Guide wire |
| US20080269641A1 (en) | 2007-04-25 | 2008-10-30 | Medtronic Vascular, Inc. | Method of using a guidewire with stiffened distal section |
| JP5067845B2 (en) | 2007-06-22 | 2012-11-07 | 朝日インテック株式会社 | Medical guidewire |
| US20090076416A1 (en) | 2007-09-17 | 2009-03-19 | Medtronic Vascular, Inc. | Guidewire with Adjustable Core |
| US20090118675A1 (en) | 2007-11-02 | 2009-05-07 | Boston Scientific Scimed, Inc. | Elongate medical device with a shapeable tip |
| EP2158933B1 (en) | 2007-12-28 | 2012-03-21 | Terumo Kabushiki Kaisha | Guide wire |
| CA2793737A1 (en) | 2010-03-24 | 2011-09-29 | Shifamed Holdings, Llc | Intravascular tissue disruption |
-
2012
- 2012-02-28 US US13/407,182 patent/US10029076B2/en active Active
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2013
- 2013-02-22 CA CA2806985A patent/CA2806985C/en active Active
- 2013-02-25 EP EP13156588.9A patent/EP2633878B1/en active Active
- 2013-02-26 RU RU2013108351/14A patent/RU2013108351A/en not_active Application Discontinuation
- 2013-02-26 BR BRBR102013004619-1A patent/BR102013004619A2/en not_active IP Right Cessation
- 2013-02-27 JP JP2013037291A patent/JP5925145B2/en active Active
- 2013-02-28 CN CN201310165105.8A patent/CN103301553B/en active Active
- 2013-02-28 KR KR1020130021901A patent/KR20130098935A/en not_active Application Discontinuation
-
2014
- 2014-11-21 JP JP2014236214A patent/JP2015071055A/en not_active Withdrawn
-
2018
- 2018-06-22 US US16/015,727 patent/US20180296805A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1628874A (en) * | 2003-12-18 | 2005-06-22 | 泰尔茂株式会社 | Guide wire |
| CN101618249A (en) * | 2008-06-30 | 2010-01-06 | 泰尔茂株式会社 | Guide wire |
Also Published As
| Publication number | Publication date |
|---|---|
| US20180296805A1 (en) | 2018-10-18 |
| CA2806985A1 (en) | 2013-08-28 |
| CA2806985C (en) | 2016-06-28 |
| US10029076B2 (en) | 2018-07-24 |
| JP2015071055A (en) | 2015-04-16 |
| EP2633878B1 (en) | 2015-01-28 |
| US20130226033A1 (en) | 2013-08-29 |
| CN103301553A (en) | 2013-09-18 |
| RU2013108351A (en) | 2014-09-10 |
| KR20130098935A (en) | 2013-09-05 |
| JP2013176560A (en) | 2013-09-09 |
| BR102013004619A2 (en) | 2015-06-23 |
| JP5925145B2 (en) | 2016-05-25 |
| EP2633878A1 (en) | 2013-09-04 |
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