CN103301388A - Traditional Chinese medicine composition for treating chronic gastrointestinal inflammation - Google Patents

Abstract

The invention aims at providing a traditional Chinese medicine composition for treating chronic gastrointestinal inflammation. The traditional Chinese medicine composition is prepared by repeated verification of a clinical test, and accords with the principle of the traditional Chinese medicine. The traditional Chinese medicine disclosed by the invention is started from dual health-care effects of nourishing the stomach and expanding the bowel, has the functions of clearing away heat and eliminating dampness, regulating flow of vital energy and relieving diarrhea, helping digestion, and relaxing the bowels and large intestines, has unique curative effects on various gastrointestinal diseases, has an incomparable magical effect of the modern medicine, and fundamentally removes the pain of a sufferer. The traditional Chinese medicine composition is characterized by being prepared from the following materials of fructus aurantii, caulis akebiae, myrobalan, peach kernel, flos sophorae, semen cannabis, atlas leaf, black false hellebore, agastache rugosus, raphanus sativus L, fructus amomi, anisodus luridus, conespike flemingia root, tonkin pepper herb, twocolor magnoliavine root and stem, rhizoma galangae, elecampane, ginseng flower, herba portulacae and root of three-nerved spicebush.

Description

A kind of Chinese medicine composition for the treatment of chronic gastroenteritis disease

Technical field

The present invention relates to the field of Chinese medicines, specifically a kind of Chinese medicine composition for the treatment of chronic gastroenteritis disease.

Background technology

Chronic gastroenteritis is gastric mucosa and intestinal mucosa inflammation.Modal is chronic superficial gastritis and chronic atrophic gastritis.Its main clinical manifestation is loss of appetite, epigastric discomfort and dull pain, belch, pantothenic acid, feel sick, vomiting etc.

Constipation is more to be seen.The feces amount is few, difficult defecation, and 1-2 time weekly, day person surplus idol has ten, thereby often use cathartic.Sometimes because anal sphincter shrinks, stool is pencil sample fine strip shape.The symptom of chronic gastroenteritis diarrhoea: every day 1 time or repeatedly.What have only early breaks out repeatedly defecation after meal, and all the other times can not have diarrhoea, and idol has time person surplus the diarrhoea 20 on the 1st.Diarrhoea does not occur in night, can not awaken because of defecate feeling, so do not disturb sleep, faecal incontinence does not take place yet, has a large amount of white or transparent mucus in some patient's the feces, even is mucus entirely.In the diarrhoea course of disease, the normal or constipation of defecation in a period often can appear, occur diarrhoea with normal just or the phenomenon that replaces mutually of constipation.

General treatment:

(1), active treatment pars oralis pharyngis focus of infection, the secretions that sputum, nasal mucus etc. do not carried disease germs is swallowed into stomach and is caused chronic gastritis.

(2), keep in high spirits: spirit depressing or hypertonicity and fatigue, cause the sphincter of pylorus dysfunction easily, bile reflux and chronic gastritis takes place.

A. due to weakness of spleen and stomach: plain body is insufficiency of the spleen, or eating and drinking without temperance, irregular diet, makes taste injured and weak, shows as gastral cavilty feeling of fullness distending pain, inappetence, abdominal distention after meal, fatigue and weakness, and treatment is with invigorating the spleen and regulating the stomach;

B. spleen-stomach deficiency-cold: insufficiency of the spleen heavier, spleen YANG deficiency, or voracious raw food, damage spleen sun causes yin-cold excessly, show as vague epigastralgia, gain happily temperature by, after meal alleviation of pain, pain of empty stomach is heavy, extremity are chilly, control with warming the spleen warming the stomach, relieving spasm to stop pain;

C. hyperactive liver-qi attacking the stomach: feelings will is not smooth, depressed rage impairing the liver, hyperactive liver-QI attacking the stomach, the mechanism of qi retardance, abnormal ascending-descending of QI shows as that stomach side of body distending pain, belch are frequent, alleviates after belch or the aerofluxus, or feels oppressed, pharyngeal symptom such as foreign body sensation arranged with susceptible to lose temper due to restlessness, sighing frequently uncomfortable in chest, cervical region.Treatment is with depressed liver-energy dispersing and QI regulating and stomach and alleviating pain.

The modal symptom of primary disease is stomach pain and feeling of repletion, sx especially after the meal, and pleasant on an empty stomach.Though each food-intake is few, feel satiety and uncomfortable, often with phenomenons such as belch, acid regurgitation, heartburn, nausea and vomiting, inappetence, dyspepsias.Since the feed less, dyspepsia, can produce malnutrition, become thin, anemia and weakness.Also with neurological symptom such as psychentonia, mood agitation, insomnia, cardiopalmus, forgetful etc., these phenomenons can increase the weight of the stomach symptom of chronic gastritis again to some patients conversely, form vicious cycle, make state of an illness complexity, are difficult for curing.

Traditional Chinese medical herbal treatment is clinical method commonly used, and its effect is also better, acts on traditional Chinese medical science taste and rules together, and the theory of its WEINAIAN can reach the purpose of healing.

Summary of the invention

The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of chronic gastroenteritis disease, form by clinic tests and repeated verification configuration, meet the theory of Chinese medicine.Drug regimen of the present invention is started with from nourishing the stomach, wide intestinal double health effect, clearing away heat and eliminating dampness, the antidiarrheal of regulating the flow of vital energy, be easy to digestion, the tonneau large intestine has unique curative effect to various gastrointestinal disease, the unrivaled effect of modern medicines is arranged, fundamentally cure gastrointestinal inflammation, removed patient's misery.

A kind of Chinese medicine composition for the treatment of chronic gastroenteritis disease is characterized in that, is made up of the raw material of following weight portion:

Fructus Aurantii 5-10 part, Caulis Akebiae 5-10 part, Fructus Chebulae 5-10 part, Semen Persicae 5-10 part, Flos Sophorae 5-10 part, Fructus Cannabis 1-6 part, Folium ailanthi 1-6 part, Rhizoma et radix veratri (Radix Rhizoma Veratri) 1-6 part, Herba Pogostemonis 1-6 part, Radix Raphani 1-6 part, Fructus Amomi 0.1-0.9 part, Rhizoma Scopoliae Japonicae 0.1-0.9 part, Herba Moghaniae fruticulosa 0.1-0.9 part, Herba Piperris Tonkinensis 0.1-0.9 part, Radix Schisandrae Bicoloris 0.1-0.9 part, Rhizoma Alpiniae Officinarum 1-6 part, Radix Aucklandiae 1-6 part, Flos Ginseng 1-6 part, Herba Portulacae 1-6 part, Radix Linderae 1-6 part;

Preparation method:

By formula proportion with the oven dry of above-mentioned Chinese medicine be ground into 300-400 purpose fine powder under 0-10 ℃ of temperature with ultrasound wave homogenize 10-30 minute, incapsulate behind the mix homogeneously and get product;

Instructions of taking: take with warm water half an hour ante cibum, takes 15g every day three times at every turn, warm water delivery service, and one month is a course for the treatment of, cure 2-3 courses for the treatment of.The avoid cold and uncooked food thing of pungent stimulation.

A kind of Chinese medicine composition for the treatment of chronic gastroenteritis disease is characterized in that, is made up of the raw material of following weight portion:

Fructus Aurantii 6-9 part, Caulis Akebiae 6-9 part, Fructus Chebulae 6-9 part, Semen Persicae 6-9 part, Flos Sophorae 6-9 part, Fructus Cannabis 2-5 part, Folium ailanthi 2-5 part, Rhizoma et radix veratri (Radix Rhizoma Veratri) 2-5 part, Herba Pogostemonis 2-5 part, Radix Raphani 2-5 part, Fructus Amomi 0.2-0.8 part, Rhizoma Scopoliae Japonicae 0.2-0.8 part, Herba Moghaniae fruticulosa 0.2-0.8 part, Herba Piperris Tonkinensis 0.2-0.8 part, Radix Schisandrae Bicoloris 0.2-0.8 part, Rhizoma Alpiniae Officinarum 2-5 part, Radix Aucklandiae 2-5 part, Flos Ginseng 2-5 part, Herba Portulacae 2-5 part, Radix Linderae 2-5 part.

A kind of Chinese medicine composition for the treatment of chronic gastroenteritis disease is characterized in that, is made up of the raw material of following weight portion:

8 parts of Fructus Aurantiis, 8 parts of Caulis Akebiaes, 8 parts of Fructus Chebulaes, 8 parts in Semen Persicae, 8 parts in Flos Sophorae, 4 parts of Fructus Cannabiss, 4 parts of Folium ailanthi, 4 parts of Rhizoma et radix veratri (Radix Rhizoma Veratri)s, 4 parts of Herba Pogostemoniss, 4 parts of Radix Raphanis, 0.5 part of Fructus Amomi, 0.5 part of Rhizoma Scopoliae Japonicae, 0.5 part of Herba Moghaniae fruticulosa, 0.5 part of Herba Piperris Tonkinensis, 0.5 part of Radix Schisandrae Bicoloris, 4 parts of Rhizoma Alpiniae Officinarums, 4 parts of the Radix Aucklandiae, 4 parts of Flos Ginseng, 4 parts of Herba Portulacaes, 4 parts of the Radixs Linderae.

The present invention relates to pharmacology and the property of medicine of Chinese medicine:

Fructus Aurantii:

[nature and flavor] hardship; Acid; Cold nature

[return through]: lung; Spleen; Liver; Stomach; Large intestine channel

[function cures mainly]: chest and diaphragm feeling of fullness; Distending pain over the hypochondrium; Accumulation of food in the stomach and intes tine due to indigestion; Distension and fullness in the abdomen; Heavy behind the dysentery; Proctoptosis; Uterine prolapse.

Caulis Akebiae:

[nature and flavor] bitter, be slightly cold; Go into heart channel, small intestine meridian, urinary bladder channel.　　

[function cures mainly] clearing away heart-fire, diuresis, the stimulating milk secretion of stimulating the menstrual flow.Be used for irritable feverish sensation in the chest, the sore throat pharyngalgia, dark coloured urine, five types of stranguria, edema, whole body spasm and pain, the amenorrhea breast is few.　

The Fructus Chebulae:

[meridian distribution of property and flavor] bitter in the mouth; Acid; Puckery; Property is put down.

[effect] astringes the lung; Astringing intestine to stop diarrhea; The therapeutic method to keep the adverse QI flowing downwards; Sore-throat relieving.

[curing mainly] chronic diarrhea; Chronic dysentery; Proctoptosis; The phlegmatic cough of breathing with cough; Chronic cough aphonia.

Semen Persicae:

Sweet flat, the bitter in the mouth of [meridian distribution of property and flavor] property is gone into lung, liver, large intestine channel;

[function cures mainly] has blood stasis removing and clots absorbing, moisturizes the effect of laxation; Control amenorrhea, dysmenorrhea, abdominal mass abdominal mass mass in the abdomen, traumatic injury, dryness of the intestine constipation.

Flos Sophorae: nature and flavor with return through: bitter in the mouth, be slightly cold.Return liver, large intestine channel.Function with cure mainly: cooling blood for hemostasis, blood pressure lowering.Be used for spitting blood, have blood in stool bleeding hemorrhoids, hematuria metrorrhagia, hypertension.Suitable amount used externally.Many parch to black that stop blooding are used; Expelling phlegm for arresting cough is given birth to usefulness more.

Fructus Cannabis:

[meridian distribution of property and flavor] sweet in the mouth, property is flat, returns spleen, stomach, large intestine channel,

[effect] loosening bowel to relieve constipation, moisturize parasite killing,

[clinical in name] has Fructus Cannabis core, stir-baked FRUCTUS CANNABIS core.

Folium ailanthi:

[return through] lung meridian

[chemical composition of Chinese materia medica]: leaf contains globulariacitrin (rutin), afzelin (afzelin), quercitrin (quercitrin), Isoquercitrin (isoquercitrin), nimbecetin (kaempferol), bark element (quercetin) and aminoacid (amino acid).

[effect]: heat clearing and damp drying; Parasite killing

[textual criticism]: come from Compendium of Material Medica section and belong to classification: Simarubaceae

[curing mainly]: damp and hot dysentery; Have loose bowels; Dysentery; Eczema; The skin ulcer scabies; Furuncle and phyma.

Rhizoma et radix veratri (Radix Rhizoma Veratri):

[effect] vomiting wind-phlegm by emesis, heat-clearing and toxic substances removing, parasite killing.

Wind-phlegm gushed during [curing mainly] controlled, the insane disease of acute infantile convulsion, and jaundice, chronic malaria is let out dysentery, headache, sore throat, breath, scabies, malignant boil.In addition, grind into powder with this product and to exosmose, the delousing effect is arranged.Eliminate the phlegm, emetic, parasite killing.Be used for wind-phlegm and stop up, epilepsy, malaria, fracture; Scabies is controlled in external, the fly eradication maggot.

[nature and flavor] toil, cold, poisonous.

1. " herbal classic ": " acrid in the mouth, cold.”

2. " not Lu ": " hardship is slightly cold, and is poisonous "

[return through] " Bencao Jingshu ": " lunar, the sufficient Yangming Channel of starting with." " book on Chinese herbal medicine is new again " " go into Liver Channel.”

Herba Pogostemonis: suffering, tepor.Return spleen, stomach, lung meridian.Function cures mainly: eliminating turbid pathogen with aromatics, the appetizing preventing or arresting vomiting is delivered expelling summer-heat.Be used for turbid damp obstructing in middle-JIAO, the vomiting of gastral cavity painful abdominal mass, the heat-damp in summer asthenia, uncomfortable in chest easypro, cold-damp is closed summer-heat, and stomachache is vomited and diarrhoea, nasosinusitis headache." kind reason Central Region turbid damp sputum is the fast stomach of being amusing, and vibrates clear positive quality goods for Herba Pogostemonis, delicate fragrance tepor." not Lu " controls the swollen person of edema due to wind pathogen poison, dispels turbid damp, and the self energy clear the course also.1. antifungic action 2. anti-leptospira act on the effect of 4. pairs of digestive system of 3. antivirus actions.

Radix Raphani:

Radix Raphani has another name called Radix Raphani, sieve clothes.

[Nature and flavor] Xin Gan, cold;

[return through ]Go into lung, stomach warp;

[function cures mainly] removing food stagnancy stagnates, the heat of reducing phlegm, the therapeutic method to keep the adverse QI flowing downwards, alleviating distention in middle-JIAO, detoxifcation.Control the food stagnation distension, phlegmatic cough aphonia is spitted blood, and epistaxis is quenched one's thirst, dysentery, migraine and general headache.

1. " not Lu ": " main sharp the five internal organs, beneficial rational diet gas." 2. Tang Materia Medica: " loose clothes and big gun boils and takes, the big therapeutic method to keep the adverse QI flowing downwards, and rapid digestion of food removes accumulation of phlegm in the hypochondrium; Give birth to and smash the juice clothes, main quenching one's thirst."

3. the Meng numerous: " bad odor in the five internal organs except the five internal organs apoplexy, is practiced in very sharp joint."

4. " four tones of standard Chinese pronunciation book on Chinese herbal medicine ": " ordinary person surfeits, and gives birth to and to chew just disappearing of pharynx, the also main lung haematemesis of coughing."

5. " feeding habits book on Chinese herbal medicine ": " sector-style gas, steam uncharms." " flower: make eye bright."

6. " Japan hanako materia medica ": " energy stopping coughing and removing phlegm; Controlling consumptive lung disease spits blood; Warming middle-JIAO, tonifying for the deficiency is controlled the thin cough of labor and Carnis caprae seu ovis, Carassius auratus and is cooked it."

7. " daily book on Chinese herbal medicine ": " the chest stuffiness relieving diaphragm, sharp defecation.Prepared food it, rapid digestion of food reduces phlegm; Give birth to and eat it, alleviating distention in middle-JIAO quenches the thirst."

8. Wang Ying " food book on Chinese herbal medicine ": " give birth to and smash clothes, control fasting dysentery."

9. " book on Chinese herbal medicine can be compiled ": " kill fishy smell, it is long-pending to control bean curd."

10. " detailed outline ": " main acid regurgitation, eliminate indigestion stagnates, alcoholic intoxication, dissipating blood stasis blood is very imitated.The end clothes are controlled five types of stranguria; The ball clothes are controlled nebulousurine; Fry in shallow oil soup foot bath gas; Drink juice is controled the inferior dysentery and aphonia, and sootiness is desired dead; Give birth to smash be coated with beat pounce on, burn."

⑾ " book on Chinese herbal medicine is looked for the truth ": " separate the Radix Aconiti Lateralis Preparata poison."

⑿ " occupying the diet spectrum with breath ": " control the cough with aphonia, all diseases of throat; Separate carbon monoxide poisoning, Fructus Solani melongenae poison.Ripe person's therapeutic method to keep the adverse QI flowing downwards and in, spleen reinforcing fortune food, born fluid is driven wind and cold, foul leukorrhea, damp fetal cultivation blood."

Fructus Amomi:

[nature and flavor] are warm in nature, acrid in the mouth,

During [function] circulation of qi promoting was transferred, stomach function regulating was amusing, and is applicable to that breast gastral cavity painful abdominal mass is vexed, and abdominal distention is eaten less, and since the stomachache that Deficiency and coldness of spleen and stomach causes have loose bowels etc.

Rhizoma Scopoliae Japonicae:

[meridian distribution of property and flavor] is warm in nature, flavor fiber crops: severe toxicity is arranged.Go into the heart, liver, lung meridian.

[function cures mainly] controls eating accumulation, dysphagia and regurgitation.

1. supplement to the Herbal: " QI invigorating is made light of one's life by commiting suicide, hard muscles and bones."

2. " Kangxu's investigate things of a little free time volume ": " property is warm, and the strengthening the spleen stomach is easy to digestion, does not tell well the person, and polyphagia is useful."

3. " property of medicine is examined ": " heat clearing away pathogenic wind expelling."

4. " detailed outline is picked up any lost article from the road ": " the tonneau large intestine, the dyspepsia that disappears is controlled dysphagia and regurgitation."

Herba Moghaniae fruticulosa:

[nature and flavor] little hardship is sweet, cold.Return through lung; Spleen channel

[function cures mainly] dehumidifying of bringing down a fever, the infantile malnutrition that disappears, cough-relieving.Control hyperpyrexia, flu, rheumatic arthritis, dysmenorrhea, infantile malnutrition, diarrhoea, dyspepsia.

Herba Piperris Tonkinensis:

[meridian distribution of property and flavor] suffering, temperature.

[function cures mainly] expelling wind and cold, eliminating stasis to stop pain.Be used for flu, bones and muscles pain due to rheumatism, treating swelling and pain by traumatic injury, dysmenorrhea, amenorrhea, cold syndrome of the stomach pain; Poisonous snake, centipete bite are controlled in external.

Radix Schisandrae Bicoloris:

Nature and flavor: hardship; Puckery; Warm in nature

Gui Jing: liver; The stomach warp

Function cures mainly: dredge the meridian passage; Spleen benefiting and stimulating the appetite.Main impairment caused by overstrain is taken off power; Extremity are tingle; Breast is vexed; Indigestion and loss of appetite.

Rhizoma Alpiniae Officinarum:

[meridian distribution of property and flavor] suffering, heat.Return spleen, stomach warp.

[function cures mainly] warming stomach for dispelling cold, pain relieving helps digestion.Be used for coldness and pain in the epigastrium, gastrofrigid vomiting, belch acid regurgitation.

The Radix Aucklandiae:

[nature and flavor] are warm in nature, acrid in the mouth, hardship,

[function] promoting the circulation of QI to relieve pain, warming middle-JIAO for easing the stomach is applicable to the intestines and stomach stagnation of QI, the stagnant caused abdominal and hypochondriac pain of chest and abdomen swelling and pain and liver and gall damp-heat and vomiting are had loose bowels, dysentery, pain in the abdomen is strict heavy, colic of cold type etc.

The Flos Ginseng:

[nature and flavor]: bitterness Hui Tian has the hot sweet taste of Radix Ginseng.

[function]: replenish human body vigour, regain one's strength, strengthen body immunity.

Herba Portulacae:

[meridian distribution of property and flavor] acid, cold; Return liver, large intestine channel.

[function cures mainly] is applicable to dysentery (it is half-dried partly rare to defecate), heat-clearing and toxic substances removing, cooling blood for hemostasis.Be used for toxic-heat and blood stasis, the carbuncle furuncle, eczema, erysipelas, snake bite and insect sting is had blood in stool, hemorrhoidal bleeding, metrostaxis.Modern times are used for the treatment of enteritis, acute arthritis, cystitis, urethritis, anusitis, bleeding hemorrhoids etc. mostly.Collective Notes to the Canon of Materia medica " Bencao Tujing " is come from textual criticism: Herba Portulacae, have another name called five elements' grass, and with its leaf green grass or young crops, obstruct redly, brightly yellowish, root is white, and son is deceived also.Cure mainly: the pyretic toxicity dysentery; Pyretic stranguria; Urine retention; Leucorrhea with red and white discharge; Metrorrhagia; Hemorrhoidal bleeding; Skin infection carbuncle furuncle; Erysipelas; Scrofula; Exudative dermatitis; Bald in vain." the southern regions of the Yunnan Province book on Chinese herbal medicine ": QI invigorating, clearing away summer-heat heat, the alleviating distention in middle-JIAO therapeutic method to keep the adverse QI flowing downwards, intestine moistening, removing food stagnancy stagnates, and parasite killing is treated the skin ulcer congestion and swelling pain.

The Radix Linderae:

[nature and flavor] acrid in the mouth, warm in nature. go into spleen, lung, kidney, urinary bladder channel.

[function cures mainly] is pleasant, dissipating depression of QI, cold expelling, pain relieving. and cure mainly: QI rising in reverse order chest and abdomen swelling and pain, dyspepsia do not disappear, food is told in regurgitation, colic of cold type, beriberi, frequent micturition.

The specific embodiment:

Embodiment 1, prescription:

Fructus Aurantii 5g, Caulis Akebiae 5g, Fructus Chebulae 5g, Semen Persicae 5g, Flos Sophorae 5g, Fructus Cannabis 1g, Folium ailanthi 1g, Rhizoma et radix veratri (Radix Rhizoma Veratri) 1g, Herba Pogostemonis 1g, Radix Raphani 1g, Fructus Amomi 0.1g, Rhizoma Scopoliae Japonicae 0.1g, Herba Moghaniae fruticulosa 0.1g, Herba Piperris Tonkinensis 0.1g, Radix Schisandrae Bicoloris 0.1g, Rhizoma Alpiniae Officinarum 1g, Radix Aucklandiae 1g, Flos Ginseng 1g, Herba Portulacae 1g, Radix Linderae 1g;

Preparation method:

By formula proportion with the oven dry of above-mentioned Chinese medicine be ground into 300-400 purpose fine powder under 0-10 ℃ of temperature with ultrasound wave homogenize 10-30 minute, incapsulate behind the mix homogeneously and get product;

Instructions of taking: take with warm water half an hour ante cibum, takes 15g every day three times at every turn, warm water delivery service, and one month is a course for the treatment of, cure 2-3 courses for the treatment of.The avoid cold and uncooked food thing of pungent stimulation.

Embodiment 2, prescription:

Fructus Aurantii 6g, Caulis Akebiae 6g, Fructus Chebulae 6g, Semen Persicae 6g, Flos Sophorae 6g, Fructus Cannabis 2g, Folium ailanthi 2g, Rhizoma et radix veratri (Radix Rhizoma Veratri) 2g, Herba Pogostemonis 2g, Radix Raphani 2g, Fructus Amomi 0.2g, Rhizoma Scopoliae Japonicae 0.2g, Herba Moghaniae fruticulosa 0.2g, Herba Piperris Tonkinensis 0.2g, Radix Schisandrae Bicoloris 0.2g, Rhizoma Alpiniae Officinarum 2g, Radix Aucklandiae 2g, Flos Ginseng 2g, Herba Portulacae 2g, Radix Linderae 2g.

Preparation method is identical with embodiment 1.

Embodiment 3, prescription:

Fructus Aurantii 8g, Caulis Akebiae 8g, Fructus Chebulae 8g, Semen Persicae 8g, Flos Sophorae 8g, Fructus Cannabis 4g, Folium ailanthi 4g, Rhizoma et radix veratri (Radix Rhizoma Veratri) 4g, Herba Pogostemonis 4g, Radix Raphani 4g, Fructus Amomi 0.5g, Rhizoma Scopoliae Japonicae 0.5g, Herba Moghaniae fruticulosa 0.5g, Herba Piperris Tonkinensis 0.5g, Radix Schisandrae Bicoloris 0.5g, Rhizoma Alpiniae Officinarum 4g, Radix Aucklandiae 4g, Flos Ginseng 4g, Herba Portulacae 4g, Radix Linderae 4g.

Preparation method is identical with embodiment 1.

Embodiment 4, prescription:

Fructus Aurantii 9g, Caulis Akebiae 9g, Fructus Chebulae 9g, Semen Persicae 9g, Flos Sophorae 9g, Fructus Cannabis 5g, Folium ailanthi 5g, Rhizoma et radix veratri (Radix Rhizoma Veratri) 5g, Herba Pogostemonis 5g, Radix Raphani 5g, Fructus Amomi 0.8g, Rhizoma Scopoliae Japonicae 0.8g, Herba Moghaniae fruticulosa 0.8g, Herba Piperris Tonkinensis 0.8g, Radix Schisandrae Bicoloris 0.8g, Rhizoma Alpiniae Officinarum 5g, Radix Aucklandiae 5g, Flos Ginseng 5g, Herba Portulacae 5g, Radix Linderae 5g.

Preparation method is identical with embodiment 1.

Embodiment 5, prescription:

Fructus Aurantii 10g, Caulis Akebiae 10g, Fructus Chebulae 10g, Semen Persicae 10g, Flos Sophorae 10g, Fructus Cannabis 6g, Folium ailanthi 6g, Rhizoma et radix veratri (Radix Rhizoma Veratri) 6g, Herba Pogostemonis 6g, Radix Raphani 6g, Fructus Amomi 0.9g, Rhizoma Scopoliae Japonicae 0.9g, Herba Moghaniae fruticulosa 0.9g, Herba Piperris Tonkinensis 0.9g, Radix Schisandrae Bicoloris 0.9g, Rhizoma Alpiniae Officinarum 6g, Radix Aucklandiae 6g, Flos Ginseng 6g, Herba Portulacae 6g, Radix Linderae 6g;

Preparation method:

By formula proportion with the oven dry of above-mentioned Chinese medicine be ground into 300-400 purpose fine powder under 0-10 ℃ of temperature with ultrasound wave homogenize 10-30 minute, incapsulate behind the mix homogeneously and get product;

Instructions of taking: take with warm water half an hour ante cibum, takes 15g every day three times at every turn, warm water delivery service, and one month is a course for the treatment of, cure 2-3 courses for the treatment of.The avoid cold and uncooked food thing of pungent stimulation.

Diagnostic point:

Morbidity is more anxious usually for nauseating, vomiting that gastroenteritis causes, does not slowly feel any better, and begins many abdominal discomforts, feels sick then, vomits.The abdominal part paroxysmal colic also has diarrhoea, every day number to tens of watery stools, yellow or yellow green contain a small amount of mucus.With in various degree heating, aversion to cold, headache etc.The minority case can cause dehydration and electrolyte disturbance, acidosis because of frequent vomiting and diarrhoea.

The pharmacology pharmacodynamic experiment:

1, acute toxicity test

The application mice carries out acute toxicity testing and shows: mice oral administration gavage Chinese medicine preparation capsule of the present invention, under 488.8g crude drug/kg dosage, the light activity minimizing appears in mice after the administration, recover normal about 1 hour, observed 7 days continuously after the administration, none animal dead, its overall health of patients, diet, to take the photograph water, urine and body weight gain all normal, and experimental result shows: the maximum dosage-feeding of mice oral administration gavage Chinese medicine preparation capsule of the present invention is 488.8g crude drug/kg/d (LD 50＞488.8g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; Press weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 4888 times of clinical patient.Point out this medicine acute toxicity low, clinical drug safety.

2, long term toxicity test

Select the SD rat for use, give variable concentrations (18.0,6.0, the Chinese medicine preparation of the present invention of 2.0g crude drug/kg), irritate stomach every day once, continuous 90 days, respectively organized 1/2 animal (male and female half and half) extremely that lives in 24 hours after the last administration, all the other 1/2 animals continuation observation, 2 all backs are extremely alive.Duration of test is observed outward appearance, general behavior, food ration, the body weight change of animal, after the administration 90 days and carry out hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) in 2 weeks of drug withdrawal and index inspections such as blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology.Result of the test shows: preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight gain be no abnormal variation all; Three dosage groups and matched group hematological examination, blood biochemical are learned, the urine biochemical analysis is all in normal range, do not have significant difference between group; Each is organized the main organs histopathological examination and shows no obvious abnormalities.The These parameters drug withdrawal is not seen change after 2 weeks yet.This test dosage is respectively 180,60,20 times of clinical medicine dose, according to result of the test Chinese medicine preparation of the present invention high, medium and low three dosage (18.0,6.0, the 2.0g crude drug/kg) administration in continuous 90 days does not have obvious influence to rat, no clear and definite toxicity target organ and sensitive indicator, the retardance toxic reaction is not seen in the convalescent period observation yet, points out the dosage safety of Chinese medicine preparation clinical practice of the present invention higher.

3, animal local excitation test:

The guinea pig skin hypersensitive test of preparation of the present invention and rat rectal application irritation test.The result shows: skin anaphylactic test, and high dose group 0.8g (medicated powder)/kg, low dose group 0.1g (medicated powder)/kg is equivalent to intend 20 times, 2.5 times of clinical people's consumption [0.04g (medicated powder)/kg] respectively, through the skin administration, there is no animal and produces allergy; Rectal application irritation test high dose group 5.0g (medicated powder)/kg, low dose group 3.2g (medicated powder)/kg, be equivalent to intend 125,80 times of clinical people's consumption respectively, in official hour, observe mucous membrane of rectum and all do not have phenomenons such as hyperemia, edema, histopathologic examination and blank group be no significant difference relatively, do not see and tangible irritative response occurs, every group of its overall health of patients of part animal of retaining, body weight, breathing, circulation, central nervous system and extremity activity etc., all Non Apparent Abnormality reactions.

Pharmacological experiment

1, experiment material

Available from the Shandong Experimental Animal Center, the cleaning level.

1.2 medicine and reagent: capsule of the present invention; Ranitidine capsule (Yan'an, Shanghai everything Pharmaceutical joint stock company limited, lot number: 040301); Glacial acetic acid (AR, Shantou City's brilliance laboratory); Dehydrated alcohol (AR, Yang Yuan chemical plant, Changshu City, Jiangsu).

1.3 statistical procedures is carried out date processing with Excel l software,

1.1 animal SD rat, the male and female dual-purpose, each group is all carried out the t check with matched group.

2 methods and result

2.1 to the gastrointestinal inflammatory effect of rat water logging irritability.

Get 50 of healthy rats, body weight 180 ± 20g, male and female half and half are divided into the basic, normal, high dosage group of capsule of the present invention (dosage is respectively: 2.75g/kg, 5.5g/kg and 1 lg/kg) at random by sex, body weight: ranitidine group (dosage is 200mg/kg) and distilled water matched group.10/group, all by 1.5ml/l00mg, every day, gastric infusion was 1 time, continuously 5d.After 3d irritated stomach, water 48h was can't help in fasting, and 1h is bound by rat on the plate after the last administration, immerses in 23 ± 0.5 ℃ of thermostatic water tanks sacrificed by decapitation behind the 18h, cut open the belly ligation pylorus and cardia.Get stomach and to gastric injecting normal saline 10ml.Place 10% formalin fixedly behind the 10min, cut along greater gastric curvature, wash away the gastric residue with normal saline, observe also evaluation gastrointestinal inflammation index.Assessment method: gland area the length of streak damage occurs greater than lmm person, measures its length, every mm meter 1 minute, and its width doubles greater than lmm person's score, and length and width were counted 0.5 fen all less than lmm, the score addition were the inflammation index of this Mus.The result shows that three dosage groups of capsule of the present invention all have obvious inhibitory action to the stress in rats gastrointestinal inflammation, compares P＜0.01 or 0.05 with matched group.See table 1 for details.

Table 1 capsule of the present invention is to the effect of rat water logging irritability gastroenteritis (x ± S)

2.2 rats acetic acid is burnt 40 of the effect healthy rats of type gastroenteritis, body weight 200 ± 20g, male and female half and half, fasting 24h, freely drink water, the ether light anaesthesia is opened the abdominal cavity under the aseptic technique, stomach is pulled out gently, cut an osculum at coat of the stomach, with internal diameter 5mm, the little glass-tube of long 3cm inserts gastric by otch, middle finger directes reach the glandular stomach portion of offside pylorus top, the little glass-tube of fastening injects glacial acetic acid 0.1ml with syringe in pipe, make with gastric mucosa and contact lmin, then with glacial acetic acid in the disinfecting cotton swab exhaustion pipe, remove glass-tube, sew up the incision, omentum majus covers hinders face, send stomach back to abdominal cavity, sew up, sterilization.The 2nd day rat of postoperative is divided into 5 groups at random by sex, body weight, before grouping and the medication, irritates stomach every day 1 time, successive administration 11d.Fasting 24h after the last administration, sacrificed by decapitation, cut open the belly ligation pylorus and cardia.Get stomach and to gastric injecting normal saline 10ml, place 10% formalin fixedly behind the l0min, cut along greater gastric curvature, wash away the gastric residue with normal saline, measure the inflammation area.As a result, three dosage groups of capsule of the present invention are burnt the type gastrointestinal inflammation to rats acetic acid all obvious inhibitory action, compares P＜0.0l with matched group.See table 2 for details.

Table 2 capsule of the present invention is to the gastrointestinal inflammatory effect of rat water logging irritability (x ± S)

2.3 40 of gastric analysis healthy rats, body weight 190 ± 20g, male and female half and half.Divide 5 groups at random by body weight, sex, grouping and medication are the same, continuous use 5 days.Water 48h is can't help in fasting before the art, behind the last administration 2h, and surgical ligation pylorus, sacrificed by decapitation behind the fasting taboo water 5h, the ligation cardia of cutting open the belly.Get stomach, collect gastric juice, centrifugal 10min (3000r/min) measures free acid, total acid, pepsin activity.The acid base neutralization titration method is adopted in gastric acidity determination, and determination of peptic activity adopts capillary glass-tube method (Mett method).The result shows that capsule high dose group of the present invention has obvious inhibitory action to the rat stomach proteinase activity, compares P＜0.05 with matched group.Also influential to gastric acid secretion.See Table 3.

Table 3 capsule of the present invention is to the effect of rat gastric secretion

Annotate: compare with matched group: * P＜0.05.

1 clinical data

1 clinical data

1.1 physical data is chosen altogether and is diagnosed as gastrointestinal inflammatory patient's 100 examples under the gastroscope, adopts the table of random number method to be divided into treatment group and matched group at random, two groups of each 50 examples, and wherein male 30 examples are organized in treatment, women 20 examples; 22-58 years old ages; Matched group man 33 examples, women 17 examples, at 21-59 years old ages, two groups of ages, sexes are learned processing by statistics, the difference not statistically significant (P〉0.05).

1.2 diagnostic criteria

1.2.1 Western medicine diagnose standard reference " internal medicine " " and " new Chinese medicine clinical research guideline " draft.(1) symptom and sign: the periodicity of prolonged and repeated generation, the chronic epigastrium pain of rhythmicity, the using basic medicine can be alleviated; Epigastrium has limitation deeply in tenderness; (2) auxiliary examination: see the active stage inflammation under the gastroscope, pathologic finding is not seen malignant cell.

1.2.2 the diagnostic criteria of traditional Chinese medical science syndrome of stagnation of liver qi and spleen deficiency is with reference to " the clinical research guideline of new Chinese medicine treatment syndrome of stagnation of liver qi and spleen deficiency ".Primary symptom: gastric abscess or side of body costalgia, abdominal distention, lack of appetite is indigestion and loss of appetite, and the loose stool is not well.Inferior disease: be in a very depressed state or being irritable and getting angry easily, sighing frequently, intestinal toot vow gas, stomachache is namely rushed down, and rushes down the back alleviation of pain, tongue fur is white or greasy, stringy pulse or thin.3 (gastral cavilty or side of body costalgia) indispensabilities of primary symptom, or 2 gastral cavilties of primary symptom or side of body costalgia indispensability), 2 of inferior diseases are namely diagnosable.

1.3 case is included in, and standard is all to meet two doctor's medical diagnosis on disease standards and TCM Syndrome Type diagnostic criterias and outside exclusion standard, and age person between 20-60 years old all can be used as and includes case in.Participate in the experimenter and all sign Informed Consent Form.

1.4 complication takes place and the person of undergoing surgery in 30 d in case exclusion standard (1) before test.(2) gastric ulcer of cause specific is arranged, as gastrinoma etc.(3) anemia of pregnant woman, women breast-feeding their children or may conceived person at period in a medicine.(4) there are other complication to affect the treatment to observe or to observing medicine the disease of taboo arranged.(5) excessive drinking, the person that maybe can not cooperate with the dietetic regulation smokes.(6) there are other organ serious diseases to need the medication treatment person.(7) not medication in accordance with regulations can't be judged that curative effect or data are not congruent to affect the treatment or safety judgement person.

2 Therapeutic Method

2.1 instructions of taking: take with warm water half an hour ante cibum, takes 15g every day three times at every turn, warm water delivery service, and one month is a course for the treatment of, cure 2-3 courses for the treatment of.The avoid cold and uncooked food thing of pungent stimulation.

3 observation of curative effect

3.I observation item (1) tcm syndrome (primary symptom, inferior disease) is observed its variation weekly.(2) time, number of times, degree, persistent period, the induced factor of side of body costalgia, abdominal distention outbreak.(3) relevant sign: blood pressure, pulse, body temperature, breathing, tongue, arteries and veins.(4) relevant physico-chemical examination: gastroscope, blood routine examination respectively check 1 time before and after the treatment.Check is 1 time after 1 year.

3.2 the general health check-up project of security inspection (1).(2) blood, urine, stool routine examination.(3) electrocardiogram, hepatic and renal function.

3.3 criterion of therapeutical effect

3.3.I gastroscopy effect criterion (I) clinical recovery: the inflammation complete obiteration, local mild hyperaemia does not have obvious edema.(2) produce effects: inflammation disappears substantially, still has obvious inflammation.(3) effective: the inflammation area dwindles more than 50%.(4) invalid: the inflammation area dwindles not as good as 50%.

3.3.2 therapeutic effect of syndrome criterion is formulated with reference to " new Chinese medicine clinical research guideline " l.Statistics doing well,improving integration (that primary symptom is divided is light, in, counted 3 minutes, 5 minutes, 7 minutes heavily respectively, inferior disease was counted respectively 1 minute, 2 minutes, 3 minutes, asymptomatic meter zero), namely check gastroscope after finishing for 1 course for the treatment of, the recent healing rate of statistics inflammation (recovery from illness and produce effects person are considered as healing, are designated as healing rate), total effective rate; Cure and followed up a case by regular visits in back 1 year, check gastroscope statistics inflammation relapse rate.

3.4 all The data SPSS12.0 statistical software statistics of statistical procedures, data relatively adopt x check and t check before and after the treatment, and group is asked relatively and analyzed with Ridit.

3.5 therapeutic outcome sees Table 1-3.

Healing rate compares (example) under table 1 liang group total effective rate and the gastroscope

Group	n	Recovery from illness	Produce effects	Effectively	Invalid	Total effective rate (%)	Healing rate (%)
								The treatment group	50	34	11	2	3	94	88
Matched group	50	26	12	5	7	86	86

The prompting of table 1 statistical analysis: healing rate compares under the gastrointestinal inflammatory total effective rate for the treatment of group and treatment of control group and the mirror, the equal not statistically significant of difference (P〉0.05).

Table 2 liang group tcm syndrome integration is (x ± s divides) relatively

Group	n	Before the treatment	After the treatment
				The treatment group	50	25．21±2．5	11．81±2．42
Matched group	50	24．41±1．34	12．51±2．54

The prompting of table 2 statistical analysis: treat preceding two groups of integration difference not statistically significants, compare before treating the two groups of integrations in back and treating, difference all has statistical significance (P＜0.01), and the two groups of integrations in treatment back compare, and difference has statistical significance (P＜0.05).

The inflammation relapse rate comparison (example) after 1 year of table 3 liang group

Group	n	Recurrence	Recovery from illness	Relapse rate (%)
					The treatment group	50	5	45	10
Matched group	50	9	41	18

The prompting of table 3 statistical analysis: treatment group relapse rate and matched group compare, and difference has statistical significance (P＜0.05).

Model case:

Case 1 :

Certain patient suffers from the long-term gastritis of bile reflux repeatedly, and eaten thing and just told on an empty stomach with regard to acid regurgitation morning, and Western medicine has been eaten a lot, all is to work as fashion, later again dying.Taken and reacted some act of violence when Chinese medicine preparation of the present invention is had the 3rd day, very uncomfortable in the morning stomach, think it to be degree of depth treatment, adhere to having taken a course for the treatment of again, when eating second course for the treatment of, felt in the stomach not so acid regurgitation, and eaten thing and think in the stomach that also very easily, sleep is also felt better.I have bought a course for the treatment of again and have consolidated.Drug withdrawal one day after than one day easily.Real feels that healthy beyond all else is important.

Case 2:

Open x, man, 45 years old.Clinical manifestation, stomach rises, and what inappetence felt sick, eaten what is vomitted, and is diagnosed as chronic gastroenteritis disease, takes a course for the treatment of, stomachache, stomach disappearances of rising, vomiting, the grade of feeling sick transference cure, the state of an illness heals entirely.

Case 3:

In xx, man, 22 years old.Suffer from chronic gastroenteritis.Clinical manifestation is stomachache, inappetence.Take this medicine after course for the treatment of, stomachache disappears, and appetite is recovered.

Case 4:

Lu xx, man, 35 years old.Suffer from chronic gastritis.Clinical manifestation is had a stomachache for a long time, and stomach rises, and appetite is depressed for a long time, take a course for the treatment of after, stomachache, the stomach disappearance of rising, the state of an illness heals entirely.

Case 5:

Strange x, man, 42 years old.Often suffer from diarrhoea.Be diagnosed as chronic gastroenteritis disease, clinical manifestation be mucus pus and blood shape just, stomachache.Take course for the treatment of of this preparation, the stool chemical examination is normal.

Case 6:

Hao xx, man, 20 years old.Suffer from chronic gastritis.Clinical manifestation is had a stomachache for a long time, and stomach rises, and appetite is depressed for a long time, takes a course for the treatment of, stomachache, and the stomach disappearance of rising, the state of an illness heals entirely.

Case 7:

In certain, the man, 46 years old, surplus patient's gastric abscess 10 year. increase the weight of two weeks.The patient is not smooth because of feelings will before two weeks, the gastric abscess outbreak, and gastral cavilty distension pain, two side of body distending pains, belch is done frequently.Diet is depressed, light red tongue. white and thin fur, stringy pulse.Canel barium meal contrast examination checks. prompting: gastroenteritis.Chinese medical discrimination. belong to the hepatic qi attacking stomach type.Give liver-smoothing, qi-regulating and stomach and alleviating pain Chinese medicine preparation of the present invention, the patient obeys after 5 doses, pain subtracts greatly, all diseases all alleviate. the patient obeys 30 doses altogether, checks through x line canel barium meal contrast examination. the prompting: stomach bull film is smooth.Patient's recovery from illness. follow up a case by regular visits to not recurrence in 1 year.

Claims (3)

1. a Chinese medicine composition for the treatment of chronic gastroenteritis disease is characterized in that, is made up of the raw material of following weight portion:

Fructus Aurantii 5-10 part, Caulis Akebiae 5-10 part, Fructus Chebulae 5-10 part, Semen Persicae 5-10 part, Flos Sophorae 5-10 part, Fructus Cannabis 1-6 part, Folium ailanthi 1-6 part, Rhizoma et radix veratri (Radix Rhizoma Veratri) 1-6 part, Herba Pogostemonis 1-6 part, Radix Raphani 1-6 part, Fructus Amomi 0.1-0.9 part, Rhizoma Scopoliae Japonicae 0.1-0.9 part, Herba Moghaniae fruticulosa 0.1-0.9 part, Herba Piperris Tonkinensis 0.1-0.9 part, Radix Schisandrae Bicoloris 0.1-0.9 part, Rhizoma Alpiniae Officinarum 1-6 part, Radix Aucklandiae 1-6 part, Flos Ginseng 1-6 part, Herba Portulacae 1-6 part, Radix Linderae 1-6 part;

Preparation method:

By formula proportion with the oven dry of above-mentioned Chinese medicine be ground into 300-400 purpose fine powder under 0-10 ℃ of temperature with ultrasound wave homogenize 10-30 minute, incapsulate behind the mix homogeneously and get product.

2. a kind of Chinese medicine composition for the treatment of chronic gastroenteritis disease according to claim 1 is characterized in that, is made up of the raw material of following weight portion:

Fructus Aurantii 6-9 part, Caulis Akebiae 6-9 part, Fructus Chebulae 6-9 part, Semen Persicae 6-9 part, Flos Sophorae 6-9 part, Fructus Cannabis 2-5 part, Folium ailanthi 2-5 part, Rhizoma et radix veratri (Radix Rhizoma Veratri) 2-5 part, Herba Pogostemonis 2-5 part, Radix Raphani 2-5 part, Fructus Amomi 0.2-0.8 part, Rhizoma Scopoliae Japonicae 0.2-0.8 part, Herba Moghaniae fruticulosa 0.2-0.8 part, Herba Piperris Tonkinensis 0.2-0.8 part, Radix Schisandrae Bicoloris 0.2-0.8 part, Rhizoma Alpiniae Officinarum 2-5 part, Radix Aucklandiae 2-5 part, Flos Ginseng 2-5 part, Herba Portulacae 2-5 part, Radix Linderae 2-5 part.

3. a kind of Chinese medicine composition for the treatment of chronic gastroenteritis disease according to claim 1 is characterized in that, is made up of the raw material of following weight portion:

8 parts of Fructus Aurantiis, 8 parts of Caulis Akebiaes, 8 parts of Fructus Chebulaes, 8 parts in Semen Persicae, 8 parts in Flos Sophorae, 4 parts of Fructus Cannabiss, 4 parts of Folium ailanthi, 4 parts of Rhizoma et radix veratri (Radix Rhizoma Veratri)s, 4 parts of Herba Pogostemoniss, 4 parts of Radix Raphanis, 0.5 part of Fructus Amomi, 0.5 part of Rhizoma Scopoliae Japonicae, 0.5 part of Herba Moghaniae fruticulosa, 0.5 part of Herba Piperris Tonkinensis, 0.5 part of Radix Schisandrae Bicoloris, 4 parts of Rhizoma Alpiniae Officinarums, 4 parts of the Radix Aucklandiae, 4 parts of Flos Ginseng, 4 parts of Herba Portulacaes, 4 parts of the Radixs Linderae.