CN103285331B - Traditional Chinese medicine for treating ovarian endometriosis cyst and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine for treating ovarian endometriosis cyst and a preparation method thereof. Each dose of the traditional Chinese medicine is prepared by the following sixteen components by weight ratio: 10-15 g of radix paeoniae rubra, 15-18 g of tangerine seed, 15-18 g of spina gleditsiae, 15-18 g of semen vaccariae, 15-18 g of fructus Liquidambaris, 15-18 g of bulb of thunberg fritillary, 20-30 g of concha ostreae, 20-30 g of sargentgloryvine stem, 20-30 g of field pennycress, 20-30 g of herba oldenlandiae, 10-15 g of common burreed rhizome, 10-15 g of rhizoma zedoariae, 2-3 g of sanguisuge, 15-18 g of rhizoma corydalis, 10-15 g of myrrh and 6-8 g of radix aucklandiae. The traditional Chinese medicine for treating ovarian endometriosis cyst overcomes the defects that the existing western medicines for treating ovarian endometriosis cyst have remarkable side effect and the existing Chinese patent drugs have limited efficacy, has the characteristics of remarkable effect and no side effect, and can effectively restrain the growth of ovarian endometriosis cyst and prevent postoperative recurrence.

Description

A kind ofly treat Chinese medicine of ovary type endometrial implantatior cyst and preparation method thereof

Technical field

The present invention relates to and a kind ofly treat Chinese medicine of ovary type endometrial implantatior cyst and preparation method thereof.

Background technology

Endometriosis is the position that the endometrial tissue with energy for growth appears at beyond cavity of uterus lining mucosa, and causes inner membrance to plant in the place of dystopy, attacks, cyclic hemorrhage repeatedly occurs, and causes lesion growth and occurs the disease of symptom.Wherein ovary type accounts for 17% ~ 44%.Ectopic Endometrium is under ovarian hormone effect, and generating period hemorrhage and increase when forming cyst gradually, is called ovary type endometrial implantatior cyst (chocolate cyst).Cyst is once be formed, Drug therapy is difficult to it to eliminate completely, even if pass through operative treatment, postoperatively also easily to recur, according to statistics, the postoperative average relapse rate of chocolate cyst of ovary relapse rate in 3 years that take drugless medication is 8 ~ 40%, and by pharmaceutical intervention, the ovary type chocolate cyst relapse rate of postoperative 1 year is about 10.61%.Therefore Drug therapy is quite important in ovarian endometriosis is postoperative.Existing use treatment with western clinical efficacy is better, but related side effect is more, as danazol, nemestran etc. can cause the increase of body weight and androgen to increase, the symptom such as menopause syndrome and osteoporosis that GnRH ~ a medicine can cause body inner estrogen level to reduce to cause, the endocrine function of severe jamming patient.And once drug withdrawal, symptom, the sign of patient will reappear, the serious quality of life affecting patient.And Chinese medicine is improving curative effect affirmative in clinical symptoms, the locally sign of patient, not only normal physiological function is not disturbed but also without obvious untoward reaction, two regulating action is played to the unbalance of organismic internal environment, there is the effect for the treatment of ovary type endometrial implantatior cyst and reduction Postoperative recurrent rate.Existing Chinese patent medicine also has special kind of carrying out treating for endometriosis, as DANER FUKANG JIANGAO etc., although have certain curative effect to improving dysmenorrhea symptom, they are strong to the elimination of ovary type endometrial implantatior cyst and postoperative prevention of recurrence specific aim, offer limited effectiveness.Therefore, exploitation has the main problem that the medicine improving ovary type endometrial implantatior cyst elimination factor and reduce Postoperative recurrent rate curative effect is further the postoperative ovarian endometriosis of Current therapeutic.

Summary of the invention

The object of this invention is to provide and a kind ofly treat Chinese medicine of ovary type endometrial implantatior cyst and preparation method thereof, the Western medicine side effect which overcoming existing treatment ovary type endometrial implantatior cyst is large, and the shortcoming of existing Chinese patent medicine offer limited effectiveness, there is successful and the feature of being free from side effects, there is effect of Xiao Disorder eliminating stagnation, blood-activating analgetic, clearing away heat-damp and promoting diuresis, can effectively suppress endometrial implantatior cyst to grow and prevention endometrial implantatior cyst postoperative recurrence.

Treat a Chinese medicine for ovary type endometrial implantatior cyst, this Chinese medicine of every agent is made up of ten Six-element medical materials of following part by weight: Radix Paeoniae Rubra 10 ~ 15g, Semen Citri Reticulatae 15 ~ 18g, Spina Gleditsiae 15 ~ 18g, Semen Vaccariae 15 ~ 18g, Fructus Liquidambaris 15 ~ 18g, Bulbus Fritillariae Thunbergii 15 ~ 18g, Concha Ostreae 20 ~ 30g, Caulis Sargentodoxae 20 ~ 30g, Herba Patriniae 20 ~ 30g, Herba Hedyotidis Diffusae 20 ~ 30g, Rhizoma Sparganii 10 ~ 15g, Rhizoma Curcumae 10 ~ 15g, Hirudo 2 ~ 3g, rhizoma corydalis 15 ~ 18g, Myrrha 10 ~ 15g, the Radix Aucklandiae 6 ~ 8g.Wherein select Radix Paeoniae Rubra, abnormal smells from the patient is bitter, cool in nature, has clots absorbing pain relieving, and the function of removing heat from blood detumescence, cures mainly hernia abdominal mass and gather, stomachache, dysmenorrhea; Its bitter in the mouth of Semen Citri Reticulatae, property are put down, and have the function of removing obstruction for relieving pain of regulating the flow of vital energy, and cure mainly hernia abdominal mass stomachache; Its acrid in the mouth of Spina Gleditsiae, warm in nature, there is the function of promoting blood circulation and detumescence evacuation of pus, cure mainly chronic pelvic inflammation; Its bitter in the mouth of Semen Vaccariae, property are flat, have promoting blood circulation to restore menstrual flow, the function of reducing swelling and alleviating pain, cure mainly dysmenorrhea carbuncle; Its bitter in the mouth of Fructus Liquidambaris, property are flat, have dispelling, collateral-activating, the function that diuretic stimulates the menstrual flow, cure mainly dysmenorrhea carbuncle; Its bitter in the mouth of Bulbus Fritillariae Thunbergii, cold in nature, there is removing heat-phlegm, the function of powder detoxifcation, cure mainly scrofula carbuncle; Its salty in the mouth of Concha Ostreae, cold nature, has resolving phlegm and softening hard masses, the function of removing damp-heat, cures mainly hernia abdominal mass and amasss block, wart disease tuberculosis; Its bitter in the mouth of Caulis Sargentodoxae, property are flat, have removing toxicity for eliminating carbuncles, promoting blood circulation and stopping pain, expelling wind and removing dampness; Cure mainly dysmenorrhea carbuncle; Its acrid in the mouth of Herba Patriniae, hardship, cold nature, has heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, and the function of stasis-dispelling and pain-killing cures mainly carbuncle and painful swelling warp; Its mildly bitter flavor of Herba Hedyotidis Diffusae, micro-sweet, cold nature, has the function of heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, inducing diuresis to remove edema, cures mainly carbuncle chronic pelvic inflammation; Its acrid in the mouth of Rhizoma Sparganii, hardship, property is put down, and has removing blood stasis circulation of qi promoting, the function of removing food stagnancy pain relieving, cures mainly lump in the abdomen mass in the abdomen; Its acrid in the mouth of Rhizoma Curcumae, hardship, warm in nature, there is circulation of qi promoting removing blood stasis, the function of removing food stagnancy pain relieving, cure mainly lump in the abdomen mass in the abdomen; Its salty in the mouth of Hirudo, hardship, property is put down, and has the function that removing blood stasis stimulates the menstrual flow, and cures mainly lump in the abdomen mass in the abdomen; Its acrid in the mouth of rhizoma corydalis, hardship, warm in nature, there is the function of promoting the circulation of QI pain relieving of invigorating blood circulation, cure mainly dysmenorrhea lump in the abdomen; Its bitter in the mouth of Myrrha, property are flat, have loose blood blood stasis removing, subduing swelling and relieving pain, cure mainly dysmenorrhea lump in the abdomen; Its acrid in the mouth of the Radix Aucklandiae, hardship, warm in nature, there is the function of promoting the circulation of QI to relieve pain, cure mainly stomachache hernia.Generally speaking Radix Paeoniae Rubra, Rhizoma Curcumae blood-activating analgetic, Xiao Disorder eliminating stagnation are monarch drug, Rhizoma Sparganii, Spina Gleditsiae, Concha Ostreae, Caulis Sargentodoxae, Herba Hedyotidis Diffusae blood circulation promoting and blood stasis dispelling, dispersing swelling and dissipating binds, eliminating damp-heat are ministerial drug, Semen Vaccariae, Fructus Liquidambaris, Hirudo, rhizoma corydalis, Myrrha, Bulbus Fritillariae Thunbergii, Herba Patriniae, Semen Citri Reticulatae strengthen monarch drug blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, dispersing accumulated pathogens to resolve the mass is adjuvant drug altogether, Radix Aucklandiae promoting the circulation of QI to relieve pain, and can injure one's stomach by all cold and cool medicines such as anti-Caulis Sargentodoxae, Herba Hedyotidis Diffusae, Herba Patriniae, be adjuvant.All medicines share, altogether the merit of Zou Xiao Disorder eliminating stagnation, blood-activating analgetic, clearing away heat-damp and promoting diuresis.Endometrial implantatior cyst can be effectively suppressed to grow and postoperative recurrence.

Every day decocted potion by this Chinese medicine, and secondary is decocted in every agent, and morning and evening service once is taken after the meal, and such explosive load design is suitable for, because drug effect can be made to give full play to.

This Chinese medicine before surgery or Post operation take, all can obtain good therapeutic effect.

Prepare this kind treat the Chinese medicines soup of ovary type endometrial implantatior cyst a method, specifically comprise the following steps: 1. by cold water soak about 15 ~ 25 minutes medicinal in other except the Radix Aucklandiae 15 kinds; 2. Concha Ostreae first adds decocting in water 10 ~ 15 minutes, add Radix Paeoniae Rubra, Semen Citri Reticulatae, Spina Gleditsiae, Semen Vaccariae, Fructus Liquidambaris, Bulbus Fritillariae Thunbergii, Caulis Sargentodoxae, Herba Patriniae, Herba Hedyotidis Diffusae, Rhizoma Sparganii, Rhizoma Curcumae, Hirudo, rhizoma corydalis, Myrrha totally 14 taste Chinese medicine and water again, after being boiled with high heat, use slow fire instead and decoct 20 ~ 30 minutes slowly, in time decocting to pre-selected amount of medication, drop into the Radix Aucklandiae with decocting 5 minutes.

Every agent Chinese medicine generally decocts secondary, and the second time time of decocting can be slightly short, and twice medicine soup merges to be taken, abundant effective component extracting.

In step 2. in, the water added during decoct medicinal herbs wants dipped powder 2 ~ 3 centimetres, ensures the enough water yield and dissolves Effective Component of Chinese Medicine.

Spice to be stirred in process of boiling medicine 2 ~ 3 times, Effective Component of Chinese Medicine is fully dissolved in water.

A kind of prepare this kind treat the Chinese medicine oral liquid of ovary type endometrial implantatior cyst method, specifically comprise the following steps: by Radix Paeoniae Rubra, Semen Citri Reticulatae, Spina Gleditsiae, Semen Vaccariae, Fructus Liquidambaris, Bulbus Fritillariae Thunbergii, Concha Ostreae, Caulis Sargentodoxae, Herba Patriniae, Herba Hedyotidis Diffusae, Rhizoma Sparganii, Rhizoma Curcumae, Hirudo, rhizoma corydalis, Myrrha, the Radix Aucklandiae medicinal soak by water of totally 16 taste, then filtered, concentrated, in the extracting solution of gained, add oral liquid commonly use auxiliaries and become oral liquid.

A kind of prepare this kind treat the Chinese medicinal capsule of ovary type endometrial implantatior cyst method, specifically comprise the following steps: the Hirudo of part and Myrrha are ground into fine powder, then extracting solution is obtained by remaining Hirudo and Myrrha and other medical material water extraction, alcohol extraction or super critical CO 2 technology method (water extraction, alcohol extraction or super critical CO 2 technology all belong to the conventional means of constituents extraction), extracting solution is concentrated, add prepare Hirudo, Myrrha fine powder, incapsulate after drying.

Detailed description of the invention

Machinery equipment:

Medicine-washing machine: XY-720 type, Nanjing Jian Pai drying equipment factory

Chinese medicine medicine processing device: RY1000-1 type, the normal grand pharmaceutical machine instrument factory in Changsha, Hunan

Reciprocating medicine cutter: WQY240 type, innovation plant equipment company limited of Jiangyin City

Band drier: DW-1.2-10 type, Heng Tai drying plant company limited of Jiangyin City

Multi-function extractor: EX-TE-03 type, Shanghai is along instrument experimental facilities company limited

Efficient centrifugal filter: G105 type, Jiangxi Ren Feng plant equipment company limited

Concentrator: TS-NS series, Shanghai is along instrument experimental facilities company limited

Measuring tank: Hangzhou Ke Hao Machinery Co., Ltd.

Large capacity refrigerated centrifuge: HF-2000R, Shanghai Bo Ling instrument and equipment company limited

Ultrasonic bottle washing machine: HSXP-K type, the permanent large ultrasonic Machinery Co., Ltd. in Jining

Far infrared sterilizing and drying case: 766 types, Kunming Nuo Jin Science and Technology Ltd.

Preparing tank: QGPYG, high light light industry and machinery company limited of Wenzhou City

Drenching mill: KF-12, Changsha Hong Wei pharmaceutical machine factory

Quick cooling sterilizing device: YXQ.WF21(22)-SZK, creates Hengyang Medical Devices Co., Ltd. of industry group

Heated-air circulation oven: CT-C series, Nanjing Tian Li pharmaceutical equipment company limited

Pulverizer: FWF-40 type, prosperous land, Jiangyin City chemical pharmaceutical equipment company limited

Trough type mixing machine: CH, Changsha Hong Wei pharmaceutical machine factory

Fully-automatic capsule filling machine: NJP-1200 type, Ruian Kai Xinlong pharmaceutical machine factory

Aluminum-plastic blister machine: DPP-140B type, Jinzhou Wan Hong package packing machine company limited

A kind of Chinese medicine for the treatment of ovary type endometrial implantatior cyst, this Chinese medicine of every agent is made up of ten Six-element medical materials of following part by weight, Radix Paeoniae Rubra 10 ~ 15g, Semen Citri Reticulatae 15 ~ 18g, Spina Gleditsiae 15 ~ 18g, Semen Vaccariae 15 ~ 18g, Fructus Liquidambaris 15 ~ 18g, Bulbus Fritillariae Thunbergii 15 ~ 18g, Concha Ostreae 20 ~ 30g, Caulis Sargentodoxae 20 ~ 30g, Herba Patriniae 20 ~ 30g, Herba Hedyotidis Diffusae 20 ~ 30g, Rhizoma Sparganii 10 ~ 15g, Rhizoma Curcumae 10 ~ 15g, Hirudo 2 ~ 3g, rhizoma corydalis 15 ~ 18g, Myrrha 10 ~ 15g, the Radix Aucklandiae 6 ~ 8g.This Chinese medicine before surgery or Post operation take.

Now provide embodiment to describe a kind of preparation method for the treatment of ovary type endometrial implantatior cyst Chinese medicine of the present invention in detail.

The formula of every this Chinese medicine of agent of following examples is as follows:

(unit: g)	Embodiment 1	Embodiment 2	Embodiment 3
				Radix Paeoniae Rubra	10	15	12
Semen Citri Reticulatae	15	18	17
				Spina Gleditsiae	15	18	16
Semen Vaccariae	15	18	17
				Fructus Liquidambaris	15	18	16
Bulbus Fritillariae Thunbergii	15	18	17
				Concha Ostreae	20	30	25
Caulis Sargentodoxae	20	30	25
				Herba Patriniae	20	30	25
Herba Hedyotidis Diffusae	20	30	25
				Rhizoma Sparganii	10	15	13
Rhizoma Curcumae	10	15	13
				Hirudo	2	3	2.5
Rhizoma corydalis	15	18	16
				Myrrha	10	15	13
The Radix Aucklandiae	6	8	7

Embodiment 1

Treat a Chinese medicine for ovary type endometrial implantatior cyst, the preparation process of its medicine soup is:

1. by cold water soak about 15 ~ 25 minutes medicinal in other except the Radix Aucklandiae 15 kinds;

2. Concha Ostreae first adds decocting in water 10 ~ 15 minutes, add Radix Paeoniae Rubra, Semen Citri Reticulatae, Spina Gleditsiae, Semen Vaccariae, Fructus Liquidambaris, Bulbus Fritillariae Thunbergii, Caulis Sargentodoxae, Herba Patriniae, Herba Hedyotidis Diffusae, Rhizoma Sparganii, Rhizoma Curcumae, Hirudo, rhizoma corydalis, Myrrha totally 14 taste Chinese medicines again, and powder 2 ~ 3 centimetres is crossed in the water logging that adds water, after being boiled with high heat, use slow fire instead and decoct 20 ~ 30 minutes slowly, spice to being stirred in process of boiling medicine 2 ~ 3 times, in time decocting to pre-selected amount of medication, dropping into the Radix Aucklandiae with decocting 5 minutes.

Every agent Chinese medicine generally can decoct secondary, and the second time time of decocting can be slightly short, is merged by twice medicine soup and takes.Decocting container, without ironware, should use marmite, enamel or stainless steel ware.Every day decocted potion by this Chinese medicine, and secondary is decocted in every agent, morning and evening service once, and generally clothes are advisable after the meal.

Embodiment 2

Treat a Chinese medicine for ovary type endometrial implantatior cyst, the preparation process of its oral liquid is:

One, the pre-treatment of Chinese crude drug

(1) medical material is chosen: Radix Paeoniae Rubra, Semen Citri Reticulatae, Spina Gleditsiae, Semen Vaccariae, Fructus Liquidambaris, Bulbus Fritillariae Thunbergii, Concha Ostreae, Caulis Sargentodoxae, Herba Patriniae, Herba Hedyotidis Diffusae, Rhizoma Sparganii, Rhizoma Curcumae, Hirudo, rhizoma corydalis, Myrrha, the Radix Aucklandiae are placed in respectively on sorting table, foreign peoples's medical material in removing medical material, as the grains of sand, soil block, damage by worms and non-medicinal effects, medical material after selection is respectively charged in clean container, weigh, hang up label, proceed to lower road sequence.

(2) medical material washing

Deliver between wash by the medical material chosen, open cock of water drain, after medicine-washing machine water tank filled with potable water, by the medical material chosen, point component of degree n n drops into medicine-washing machine charging aperture, different medical material Wash Separatelies.Clean medical material is respectively charged in clean container, hangs up label, to be dried.

(3) medical material infiltrates

Open the demulcen cover of medicine processing device, Radix Paeoniae Rubra after cleaning, Semen Citri Reticulatae, Spina Gleditsiae, Semen Vaccariae, Fructus Liquidambaris, Bulbus Fritillariae Thunbergii, Concha Ostreae, Caulis Sargentodoxae, Herba Patriniae, Herba Hedyotidis Diffusae, Rhizoma Sparganii, Rhizoma Curcumae, Hirudo, rhizoma corydalis, Myrrha, the Radix Aucklandiae are dropped in tank, close cover, opening vacuum valve makes vacuum to 0.08MPa, after 15 minutes, close vacuum valve, open water intaking valve, add water to dipped medical material surface 5 ~ 10cm, in impregnation process, vacuum degree control is at-0.06 ~-0.08Mpa.Afterwards, every 15 ~ 20 minutes, open vacuum valve once, open demulcen pot bottom valve simultaneously, medical material is soaked evenly, infiltrates and close vacuum valve after 2 hours, the medical material infiltrated is released, loads clean container, hang up label.

(4) cutting

Regulate reciprocating medicine cutter, after open drive is normal, medical material is delivered on medicine cutter conveyer belt respectively, is cut into the sheet of 2 ~ 8mm.Load in clean container, hang up label.

(5) dry

Open band drier, after being preheated to design temperature, medical material that will be dry is put on the conveyer belt of band drier respectively, carry out drying, Radix Paeoniae Rubra, Semen Citri Reticulatae, Spina Gleditsiae, Semen Vaccariae, Fructus Liquidambaris, Bulbus Fritillariae Thunbergii, Concha Ostreae, Caulis Sargentodoxae, Herba Patriniae, Herba Hedyotidis Diffusae, Rhizoma Sparganii, Rhizoma Curcumae, Hirudo, rhizoma corydalis baking temperature 70 ~ 80 DEG C, Myrrha, Radix Aucklandiae baking temperature 50 ~ 60 DEG C.Dried medical material is loaded clean container, weighs, hang up label.

Two, the extraction of Chinese crude drug

(1) extraction of oral liquid extracting solution

By Radix Paeoniae Rubra, Semen Citri Reticulatae, Spina Gleditsiae, Semen Vaccariae, Fructus Liquidambaris, Bulbus Fritillariae Thunbergii, Concha Ostreae, Caulis Sargentodoxae, Herba Patriniae, Herba Hedyotidis Diffusae, Rhizoma Sparganii, Rhizoma Curcumae, Hirudo, rhizoma corydalis, Myrrha, the Radix Aucklandiae totally 16 taste medical materials drop into multi-function extractors carry, and get the water adding medical material 5 times of weight, large reflux, extract, 4 hours (starting after boiling to clock), in leaching process, temperature controls at 98 ~ 100 DEG C, and steam pressure is not higher than 0.1Mpa.By medicinal liquid after efficient centrifugal filter filters, importing and being evaporated to relative density in concentrator is 1.24 ~ 1.26 (22 ~ 25 DEG C).

(2) precipitate with ethanol

Concentrated solution stirring is cooled to 14 ~ 16 DEG C, adds ethanol by measuring tank and make medicinal liquid alcohol content reach 70%, be just stirred to when adding ethanol and add after ethanol 30 minutes, precipitate with ethanol 48 hours (temperature controls below 16 DEG C).Precipitate with ethanol operation room temperature 18 ~ 26 DEG C, relative humidity 45 ~ 65%, clean rank 300,000 grades.

(3) medicinal liquid centrifugalize

After 60 ~ 90s reaches 18000rpm/min when large capacity refrigerated centrifuge running, open inlet valve, wait the liquid clarified flow out catch tray spigot joint after, the supernatant after centrifugal is put into clean liquid receiver, preservation of weighing after note sealing.Centrifugal process controls indoor temperature 18 ~ 26 DEG C, relative humidity 45 ~ 65%, clean rank 300,000 grades.

Three, preparation configuration and pouring process

Control temperature 18 ~ 26 DEG C in the operation room of clean area, relative humidity 45 ~ 65%, clean rank 100,000 grades, in clean area, carry out following operation:

(1) bottle washing procedure

A. bottle is selected: between depositing, get the Bottle and bottle cap needed for producing the same day, being placed in Revolving disc by propping up by bottle, putting neat, sorting out fragmentation, breach, breach, askew bottle defective work, record defective work number.Bottle place sent to laundry by qualified bottle.

B. wash bottle: connect ultrasonic bottle washing machine power supply, bottle is through twice recirculated water spray (spray pressure is 0.2MPa), compressed air dries up (drying up pressure is 0.3MPa), (flushing pressure is 0.2MPa) is rinsed again by a fresh purified water, after drying up finally by compressed air, proceed to far infrared sterilizing and drying case dry.

C. sterilizing-drying: open far infrared sterilizing and drying case on and off switch, keeps sterilising temp 260 DEG C, 30min, outlet blast 10Pa, entrance blast 8Pa.After sterilizing-drying, open conveyer belt switch and start active conveying bottle, bottle is proceeded to next procedure.

(2) preparation process

Accurately take oral liquid extracting solution, Mel, sodium citrate, take out oral liquid extracting solution 300ml, Mel 100g, sodium citrate 0.5g in preparing tank, fluid temperature is down to less than 60 DEG C, adds with the essence of ethanol dilution appropriate, and supplement purified water to dosing amount, filter, regulate pH value between 4.5 ~ 6.5, relative density is between 1.15 ~ 1.25, and this product is orange-yellow supernatant liquid, gas fragrance, taste is sweet.When fluid temperature is down to 30 ~ 40 DEG C, medicinal liquid is transported to filling and rolls process operations.

(3) operation is rolled in filling

Open drenching mill, regulate dosing pump loading amount to be 10.1 ± 0.1ml, carry out filling and roll.Filling checks loading amount and roll lid situation at the end of rolling operating process neutralization, fills with the semi-finished product sabot after rolling and leaks operation by pass-through box censorship.

(4) sterilizing leak detection operation

3 minutes leak detection time was set, leak detection vacuum-70Pa.Sterilizing is carried out, sterilising temp 105 DEG C, 30 minutes after leak detection.Then carry out, cleaning, 20 minutes time.After operation, when interior chamber pressure reduces to zero, taking-up of can opening the door, proceeds to transporting room.

(5) lamp inspection operation

Get semi-finished product to transporting room, check the name of an article, specification, quantity, lot number errorless after, the defective works such as foreign body, muddiness are sorted out in the range estimation of lamp inspection work, loading amount is not enough, compacting is not tight, by defective work process predetermined processing, certified products put into transporting room, often coil and all put into mark card, and indicate the name of an article, lot number, specification, quantity.

This Chinese medicine oral liquid consumption is a 10ml, one day three times, and wherein every 10ml oral liquid is relative to 81 ~ 98g of decoction pieces.

Embodiment 3

Treat a Chinese medicine for ovary type endometrial implantatior cyst, the preparation process of its capsule is:

One, the cleaning-drying of medical material

By Radix Paeoniae Rubra, Semen Citri Reticulatae, Spina Gleditsiae, Semen Vaccariae, Fructus Liquidambaris, Bulbus Fritillariae Thunbergii, Concha Ostreae, Caulis Sargentodoxae, Herba Patriniae, Herba Hedyotidis Diffusae, Rhizoma Sparganii, Rhizoma Curcumae, Hirudo, rhizoma corydalis, Myrrha, the Radix Aucklandiae, impurity selected by totally 16 taste Chinese medicines, go mouldy product etc., wash rapidly with clear water, and be cut into the section of 5 ~ 10cm, in 80 ~ 90 DEG C of dryings.

Two, sterilizing-drying is pulverized

Hirudo, Myrrha, the Radix Aucklandiae 3 taste medical material were put into 100 ~ 105 DEG C of sterilizings of quick cooling sterilizing device after 1 hour, and 65 ~ 75 DEG C of dryings in heated-air circulation oven, pulverize dried medical material pulverizer.

Three, extract

By Radix Paeoniae Rubra, Semen Citri Reticulatae, Spina Gleditsiae, Semen Vaccariae, Fructus Liquidambaris, Bulbus Fritillariae Thunbergii, Concha Ostreae, Caulis Sargentodoxae, Herba Patriniae, Herba Hedyotidis Diffusae, Rhizoma Sparganii, Rhizoma Curcumae, rhizoma corydalis, etc. 13 taste inventorys drop in multi-function extractors, the water extraction 2 hours that first time adds the water extraction 3 hours of 10 times of weight, second time adds 8 times of weight, third time adds the water extraction 1 hour of 8 times of weight.Gradation is filtered, and merges the extracting solution importing basin filtered.

Four, concentrated

By merge extracting solution in 65 DEG C ~ 75 DEG C, under vacuum-0.04 ~ 0.08Mpa, concentrating under reduced pressure becomes relative density is 1.25 ~ 1.30(60 DEG C of survey) thick paste.

Five, wet mixing

The thick paste of 13 tastes such as the Hirudo crushed in step 2, Myrrha, the Radix Aucklandiae 3 taste crude drug powder and Radix Paeoniae Rubra obtained in step 4 being placed in trough type mixing machine with rotating speed 24rpm/min mixes 30 ± 10min, carries out drying after stirring and evenly mixing.

Six, dry

Cream powder step 5 mixed is in 60 DEG C ~ 70 DEG C, vacuum drying oven, and vacuum-0.04 ~-0.08Mpa condition drying 50 ~ 60h, becomes extractum.Take out this extractum to break into pieces, after extractum block continues vacuum drying 10 ~ 12h, take out let cool to room temperature or close to room temperature time, proceed to pulverizing process.

Seven, pulverize

Dried extractum block is placed in pulverizer to pulverize.

Eight, always mix

Medicated powder step 7 crushed mixes 20 ± 5min in trough type mixing machine with the speed of 20rpm/min.

Nine, fill

Get the qualified medicated powder fully-automatic capsule filling machine of chemical examination and carry out filling, content uniformity controls at 0.4 × (1 ± 7%) g.Should keep negative relative with mistress between filling, dust is got rid of by dust exhaust apparatus, and temperature should control at 18 ~ 26 DEG C, and humidity should control 45 ~ 65%.

Ten, polishing

Get populated capsule administration product buffing machine and carry out polishing, remove the outer unnecessary powder of capsule shells, and select defective work.

11, bubble-cap

The setting capsule molding temperature of heating plate 130 DEG C ± 10 DEG C of aluminum-plastic blister machine, heated sealed temperature 140 DEG C ± 10 DEG C, gets qualified capsule aluminum-plastic blister machine and carries out bubble-cap.

12, pack

Press often box-packed 24 (or 48) packaging, sealing, labeling, and put into description in box, 200 boxes are a case, the in-built quality certification one.Joint sealing mouth, bale packing.

This Chinese medicinal capsule consumption be one time 6, one day three times, wherein 1 capsules is relative to decoction pieces 13.5 ~ 16.3g.

The clinical data of this Chinese medicine is as follows: take to 115 examples the ovary type endometriosis patient that this Chinese medicine treats and carry out clinical observation on the therapeutic effect, effective 81 examples, effective 25 examples, no effect 9, obvious effective rate 70.4%, effective percentage 92.17%.Patient takes average relapse rate in 3 years of this Chinese medicine at ovary type endometrial implantatior cyst Post operation and is about 11.7%.And use the effective percentage of existing Chinese medicine according to the literature between 80.16%, and relapse rate is between 16.15%.Visible, the effect that the curative effect of Chinese medicine of the present invention to ovary type endometrial implantatior cyst compares existing Chinese medicine is better, and relapse rate is lower.

Claims (9)

1. treat the Chinese medicine of ovary type endometrial implantatior cyst for one kind, it is characterized in that: every this Chinese medicine of agent is made up of ten Six-element medical materials of following part by weight, Radix Paeoniae Rubra 10 ~ 15g, Semen Citri Reticulatae 15 ~ 18g, Spina Gleditsiae 15 ~ 18g, Semen Vaccariae 15 ~ 18g, Fructus Liquidambaris 15 ~ 18g, Bulbus Fritillariae Thunbergii 15 ~ 18g, Concha Ostreae 20 ~ 30g, Caulis Sargentodoxae 20 ~ 30g, Herba Patriniae 20 ~ 30g, Herba Hedyotidis Diffusae 20 ~ 30g, Rhizoma Sparganii 10 ~ 15g, Rhizoma Curcumae 10 ~ 15g, Hirudo 2 ~ 3g, rhizoma corydalis 15 ~ 18g, Myrrha 10 ~ 15g, the Radix Aucklandiae 6 ~ 8g.

2. the Chinese medicine for the treatment of ovary type endometrial implantatior cyst according to claim 1, is characterized in that: every day decocted potion by this Chinese medicine, and secondary is decocted in every agent, and morning and evening service once is taken after the meal.

3. the Chinese medicine for the treatment of ovary type endometrial implantatior cyst according to claim 1, is characterized in that: this Chinese medicine before surgery or Post operation take.

4. prepare a method for the Chinese medicine of the described described treatment ovary type endometrial implantatior cyst of one of claims 1 to 3, the preparation process of its medicine soup is:

1. by cold water soak about 15 ~ 25 minutes medicinal in other except the Radix Aucklandiae 15 kinds;

2. Concha Ostreae first adds decocting in water 10 ~ 15 minutes, add Radix Paeoniae Rubra, Semen Citri Reticulatae, Spina Gleditsiae, Semen Vaccariae, Fructus Liquidambaris, Bulbus Fritillariae Thunbergii, Caulis Sargentodoxae, Herba Patriniae, Herba Hedyotidis Diffusae, Rhizoma Sparganii, Rhizoma Curcumae, Hirudo, rhizoma corydalis, Myrrha totally 14 taste Chinese medicine and water again, after being boiled with high heat, use slow fire instead and decoct 20 ~ 30 minutes slowly, in time decocting to pre-selected amount of medication, drop into the Radix Aucklandiae with decocting 5 minutes.

5. the method for the Chinese medicine of preparation treatment ovary type endometrial implantatior cyst according to claim 4, it is characterized in that: every agent Chinese medicine decocting secondary, the second time time of decocting can be slightly short, and twice medicine soup merges to be taken.

6. the method for the Chinese medicine of preparation treatment ovary type endometrial implantatior cyst according to claim 4, is characterized in that: in step 2. in, powder 2 ~ 3 centimetres is crossed in the water logging added during decoct medicinal herbs.

7. the method for the Chinese medicine of preparation treatment ovary type endometrial implantatior cyst according to claim 4, is characterized in that: will stir spice in process of boiling medicine 2 ~ 3 times.

8. prepare the method for the Chinese medicine for the treatment of ovary type endometrial implantatior cyst described in claim 1 or 3 for one kind, the preparation process of its oral liquid is: by Radix Paeoniae Rubra, Semen Citri Reticulatae, Spina Gleditsiae, Semen Vaccariae, Fructus Liquidambaris, Bulbus Fritillariae Thunbergii, Concha Ostreae, Caulis Sargentodoxae, Herba Patriniae, Herba Hedyotidis Diffusae, Rhizoma Sparganii, Rhizoma Curcumae, Hirudo, rhizoma corydalis, Myrrha, the Radix Aucklandiae medicinal soak by water of totally 16 taste, then filtered, concentrated, in the extracting solution of gained, add Mel, sodium citrate and appropriate amount of essence be mixed with oral liquid.

9. prepare the method for the Chinese medicine for the treatment of ovary type endometrial implantatior cyst described in claim 1 or 3 for one kind, the preparation process of its capsule is: the Hirudo of part and Myrrha are ground into fine powder, then residue Hirudo and Myrrha and other medical material water extraction, alcohol extraction or super critical CO 2 technology method are obtained extracting solution, extracting solution is concentrated, add prepare Hirudo, Myrrha fine powder, incapsulate after drying.