CN103284815A - 3D-printing fast forming method of nano composite degradable bone repair material - Google Patents
3D-printing fast forming method of nano composite degradable bone repair material Download PDFInfo
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- CN103284815A CN103284815A CN2013101838651A CN201310183865A CN103284815A CN 103284815 A CN103284815 A CN 103284815A CN 2013101838651 A CN2013101838651 A CN 2013101838651A CN 201310183865 A CN201310183865 A CN 201310183865A CN 103284815 A CN103284815 A CN 103284815A
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Abstract
The invention relates to the field of bone repair material production, in particular to a 3D-printing fast forming method of nano composite degradable bone repair material. The method includes: designing a personal bone repair material 3D-structure model by computer-assisted design software; importing the designed 3D-structure model to a 3D printer; placing the synthetized nano composite degradable bone repair material on the 3D printer; and starting the 3D printer to print the bone repair material layer by layer. The method has the advantages that the personal bone repair material is printed with the 3D printer, the problem that the traditional production method fails in forming special shapes with high precision is solved, the bone repair material has better effect of repairing bones at special parts, the precision is higher, and the method is more applicable to clinical applications.
Description
Technical field
The present invention relates to the bone renovating material preparation field, more specifically, relate to a kind of 3 D-printing rapid shaping preparation method of nano combined degradable bone renovating material.
Background technology
Bone is being born the important duty of vital movement as the histoorgan of human body maximum, but also the easiest cause damaged.Bone is damaged to be clinically commonly encountered diseases, also is one of difficult problem of orthopaedics therapy.There is every year the damaged patient of millions of osseous tissues to be treated surgically.In the such populous nation of China, annual because of orthopaedic diseases such as trauma fracture, spinal column degenerative disease and tumor, bone tuberculosis due to vehicle accident and the production safety accident according to estimates, cause the damaged or dysfunction patient of bone to surpass 3,000,000 people.Bone is transplanted has become the graft that has the call that is only second to blood transfusion.And how to find better osseous tissue renovating material, solving damaged this difficult medical problem of bone has become the common pursuit of the numerous scientists in the whole world and tireless research power.
It is the damaged main method for the treatment of bone that bone is transplanted.Desirable bone graft substitute should possess following condition: excellent biological compatibility, bone conduction and bone-inducting active arranged, has certain support strength, can biodegradation, and degradation speed is coordinated mutually with new osteogenesis.Autologous bone transplanting has above-mentioned osteanagenesis condition, is still the damaged goldstandard for the treatment of bone at present.But autologous bone transplanting exists the bone amount limited, but also can increase wound, and operating time prolongs, and it is damaged and for district's pain etc. to get behind the bone residual bone.Though homogeneous allogenic bone has the conduction ossification, new bone creeping substitution process is slow, and the nonunion rate is high relatively, can cause rejection, and the pathophoresis possibility is arranged, so extensive use is restricted.In order to overcome the shortcoming of above-mentioned two class bone-grafting materials, be devoted to study at present the artificial synthesis bone with good osteogenic ability always and substitute biomaterial.With respect to from body and allogenic bone transplantation, bone tissue engineer is that the large scale bone defect repair of tool potentiality substitutes solution, can provide than the better selectivity of present conventional transplant operation, reduce stress shielding and blood vessel injury, and osteopenia and the generation of fracture again.The artificial bone repair materials is having the important function of not replacing in the bone transplant operation now, seeks the focus that the bone renovating material with good biological characteristic is orthopaedics research always.Although various bone renovating material numerous and complicated in the world now do not have a kind ofly can very ideally substitute people's bone so far.
And as bone renovating material, polylactic acid has excellent biological compatibility and biodegradable, it is a class biodegradation material of FDA (FDA (Food and Drug Adminstration)) approval, it has mechanical strength, elastic modelling quantity and hot formability preferably, can satisfy the requirement as cell growing carrier material in fields such as the regeneration of bone tissue engineer and cartilaginous tissue and reparation substantially.And being degraded to lactic acid in human body is normal carbohydrate metabolism product in the body, enters tricarboxylic acid cycle, and its final catabolite is water (H2O) and carbon dioxide (CO2), thus can not assemble at vitals, nontoxic, harmless to human body.Though polylactic acid has excellent biological compatibility and degradable absorbability, has following problem simultaneously: the one, the catabolite slant acidity easily causes non-infectious inflammation; The 2nd, not enough as its mechanical strength of bone renovating material and intensity retention time.Therefore, single poly-lactic acid material is used and is restricted, and corresponding composite study is more and more noticeable.With seemingly polylactic acid-based, also there is similar problem in other bone rehabilitation polymer commonly used (as the polycaprolactone of polyesters, polyglycolic acid, polylactide-co-Acetic acid, hydroxy-, bimol. cyclic ester random copolymer etc. and polyamino acid esterification derivatives such as polyglutamic acid, poly-aspartate).
Because corresponding to different people, the composite concentration of the shape that its bone is damaged, size, material etc. are all different, the technology of present stage also can't be at the synthetic different bone renovating material of different situations.
Summary of the invention
The present invention provides a kind of 3 D-printing rapid shaping preparation method that can prepare the nano combined degradable bone renovating material with personalized bone renovating material for overcoming the described at least a defective of above-mentioned prior art.
For solving the problems of the technologies described above, technical scheme of the present invention is as follows:
A kind of 3 D-printing rapid shaping preparation method of nano combined degradable bone renovating material comprises the steps:
Utilize the computer aided design software design to have personalized bone renovating material 3 d structure model;
The 3 d structure model that designs is imported in the three-dimensional printer;
Synthetic good nano combined degradable bone renovating material is placed on the three-dimensional printer;
Start three-dimensional printer and finish the printing shaping successively of bone renovating material.
The present invention utilizes three-dimensional printer to print the bone renovating material with personalization, overcome the difficult problem that the traditional preparation process method can not realize special shape and precision, bone reparation to privileged sites has better effect, and accuracy is higher, is more suitable in clinical practice.
In the such scheme, utilize computer aided design software design to have in the step of personalized bone renovating material 3 d structure model according to human body is different and repair the bone renovating material 3 d structure model that the position is designed to given shape, specific standard, specific dimensions.The present invention can repair the bone renovating material that ad hoc structure is designed at the position according to human body is different, and the bone that can be good at adapting to the different people different parts is damaged, for clinical bone reparation provides quick, personalized solution.
In the such scheme, nano combined degradable bone renovating material adopts nanometer hydroxyapatite and degradable bone rehabilitation polymer to be composited.The present invention utilizes nanometer hydroxyapatite and the degradable bone rehabilitation polymer of using always to be composited, and has more excellent biological compatibility and repairing effect.
In the such scheme, nanometer hydroxyapatite is the polymer-hydroxyapatite nano compound that is combined into the variable concentrations ratio according to the difference of human body different parts bone component with the compound of degradable bone rehabilitation polymer.
In the such scheme, described degradable bone rehabilitation polymer comprises a kind of in polylactic acid, polycaprolactone, polyglycolic acid, polylactide-co-Acetic acid, hydroxy-, bimol. cyclic ester random copolymer and the polyamino acid esterification derivative.
In the such scheme, according to the different positions of repairing of human body, utilize the polymer-hydroxyapatite nano compound of variable concentrations ratio to carry out the gradient printing when three-dimensional printer is printed bone renovating material, adapt with the bone component with used position.The present invention is by being equipped with the polymer-hydroxyapatite nano compound of variable concentrations ratio, thereby prepare the repair materials with gradient at three-dimensional printer, make in same bone renovating material, the compound concentration of the degradable bone rehabilitation polymer of its each several part and hydroxyapatite nano is different, makes the performance of this bone renovating material can mate bone better and repairs speed.
In the such scheme, the complex method of nanometer hydroxyapatite and degradable bone rehabilitation polymer is: under the condition that is higher than degradable bone rehabilitation polymer glass transition temperature or melt temperature, by mechanicals efforts nano-hydroapatite particles is mixed in the matrix of degradable bone rehabilitation polymer into.
Compared with prior art, the beneficial effect of technical solution of the present invention is:
(1) in the present invention, the bone renovating material three dimensional structure can personalized design, and the printing of in the 3 D-printing process, adopting successively, can prepare the bone renovating material of given shape, overcome the difficult problem that the traditional preparation process method can not realize special shape, bone reparation to privileged sites has better effect, is more suitable in clinical practice, and can provides quick, personalized scheme for clinical.
(2) the present invention utilize the 3 D-printing rapid shaping technique prepare bone renovating material have simple to operate, shaping speed is fast, the part accuracy height, forming process is pollution-free etc. a bit.
(3) the present invention is by being equipped with the polymer-hydroxyapatite nano compound of variable concentrations ratio, thereby prepare the repair materials with gradient at three-dimensional printer, make in same bone renovating material, the compound concentration of the degradable bone rehabilitation polymer of its each several part and hydroxyapatite nano is different, makes the performance of this bone renovating material can mate bone better and repairs speed.
(4) nano combined degradable bone renovating material of the present invention is to be composited at nano level hydroxyapatite with degradable bone rehabilitation polymer commonly used and crystalline size control, this composite has improved physics and chemistry and the mechanical property of degradable bone rehabilitation polymer and hydroxyapatite, the good biocompatibility and the degradable absorbability that not only have bone rehabilitation polymer commonly used, simultaneously also have the good biological activity of hydroxyapatite, bone conductibility, make the bone renovating material of preparing have excellent repairing effect more.
Description of drawings
Fig. 1 is the flow chart of the 3 D-printing rapid shaping preparation method specific embodiment of a kind of nano combined degradable bone renovating material among the present invention.
Fig. 2 is the sketch map of printing simple solid bone screw in the specific embodiment of the invention 3, wherein Fig. 2 a is tomograph directly perceived, Fig. 2 b is the view that has been converted to the engineering drawing form, and Fig. 2 c is the photo in kind of the simple solid bone screw that prints with three-dimensional printer.
Fig. 3 is the sketch map of printing complicated hollow bone screw in the specific embodiment of the invention 4, wherein Fig. 3 a is tomograph directly perceived, Fig. 3 b is the view that has been converted to the engineering drawing form, and Fig. 3 c is the photo in kind of the complicated hollow bone screw that prints with three-dimensional printer.
Fig. 4 is the sketch map of printing the bone fishplate bar in the specific embodiment of the invention 5, and wherein Fig. 4 a is tomograph directly perceived, and Fig. 4 b is the view that has been converted to the engineering drawing form, and Fig. 4 c is the photo in kind of the bone fishplate bar that prints with three-dimensional printer.
Fig. 5 is the sketch map of printing alternate model bone fishplate bar in the specific embodiment of the invention 5, and wherein Fig. 5 a is tomograph directly perceived, and Fig. 5 b is the view that has been converted to the engineering drawing form, and Fig. 5 c is the photo in kind of the bone fishplate bar that prints of three-dimensional printer.
Fig. 6 is the sketch map of printing osseous tissue engineering stephanoporate stent material in the specific embodiment of the invention 6, wherein Fig. 6 a is tomograph directly perceived, Fig. 6 b is the view that has been converted to the engineering drawing form, and Fig. 6 c is the photo in kind of the osseous tissue engineering stephanoporate stent material that prints with three-dimensional printer.
The specific embodiment
Accompanying drawing only is used for exemplary illustration, can not be interpreted as the restriction to this patent;
For better explanation present embodiment, some parts of accompanying drawing have omission, amplify or dwindle, and do not represent the size of actual product;
To those skilled in the art, in the accompanying drawing some known features and explanation thereof may to omit be understandable.
Below in conjunction with drawings and Examples technical scheme of the present invention is described further.
Embodiment 1
As shown in Figure 1, be the flow chart of the 3 D-printing rapid shaping preparation method specific embodiment of a kind of nano combined degradable bone renovating material among the present invention.Referring to Fig. 1, the concrete steps of the 3 D-printing rapid shaping preparation method of a kind of nano combined degradable bone renovating material of present embodiment comprise:
S101. utilize the computer aided design software design to have personalized bone renovating material 3 d structure model; Wherein, computer aided design software can adopt solidworks software, can certainly adopt other can realize the software of above-mentioned functions.
S102. the 3 d structure model that designs is imported in the three-dimensional printer;
S103. will synthesize good nano combined degradable bone renovating material places on the three-dimensional printer;
S104. start three-dimensional printer and finish the printing shaping successively of bone renovating material.
The present invention adopts the 3 D-printing technology in the quick molding method, carries out the molding preparation of bone renovating material by computerized control system.Use quick three-dimensional to print rapid shaping technique and have advantages such as simple to operate, that shaping speed is fast, part accuracy is high, forming process is pollution-free, compare with traditional forming method of bone renovating material, the 3 D-printing technology is a kind of technology based on the three-dimensional computer image, use the 3 D-printing rapid shaping technique to prepare bone renovating material, not only can print the personalized bone renovating material with given shape, and can make up the baroque supporting structure of external morphology, be easy to realize the control of apparent size, be more suitable in clinical practice.
In specific implementation process, step S101 utilizes the computer aided design software design to have personalized bone renovating material 3 d structure model, is the bone renovating material 3 d structure model that is designed to given shape, specific standard, specific dimensions according to the different reparation of human body position.This personalized design can be better and coupling human body bone defect, for clinical bone reparation provides quick, personalized solution.
In specific implementation process, the nano combined degradable bone renovating material of present embodiment adopts nanometer hydroxyapatite and degradable bone rehabilitation polymer to be composited.Degradable bone rehabilitation polymer is degradable bone rehabilitation polymer commonly used, as, can adopt a kind of in polylactic acid, polycaprolactone, polyglycolic acid, polylactide-co-Acetic acid, hydroxy-, bimol. cyclic ester random copolymer and the polyamino acid esterification derivative; Polyamino acid esterification derivative such as polyglutamic acid, poly-aspartate etc.This composite has improved physics and chemistry and the mechanical property of degradable bone rehabilitation polymer and hydroxyapatite, the good biocompatibility and the degradable absorbability that not only have bone rehabilitation polymer commonly used, simultaneously also have the good biological activity of hydroxyapatite, bone conductibility, make the bone renovating material of preparing have excellent repairing effect more.
In specific implementation process, nanometer hydroxyapatite and degradable bone rehabilitation polymer compound can adopt following method to realize: under the condition that is higher than degradable bone rehabilitation polymer glass transition temperature or melt temperature, by mechanicals efforts nano-hydroapatite particles is mixed in the matrix of degradable bone rehabilitation polymer into.
In specific implementation process, in order to adapt with use position bone component, nanometer hydroxyapatite is the polymer-hydroxyapatite nano compound that is combined into the variable concentrations ratio according to the difference of human body different parts bone component with the compound of degradable bone rehabilitation polymer.When three-dimensional printer is printed bone renovating material, repair the position and utilize the polymer-hydroxyapatite nano compound of variable concentrations ratio to carry out the gradient printing according to human body is different, make in same bone renovating material, the compound concentration of the degradable bone rehabilitation polymer of its each several part and hydroxyapatite nano is different, makes the performance of this bone renovating material can mate bone better and repairs speed.
Below in conjunction with concrete embodiment technical scheme of the present invention is further detailed.
Embodiment 2
In the present embodiment, degradable bone rehabilitation polymer adopts polylactic acid, adopts melt-blending process to prepare the composite of polylactic acid and nanometer hydroxyapatite below:
Nano-hydroapatite particles is added in the polylactic acid, and blend under the condition that is higher than 120～150 ℃ of polylactic acid glass transition temperatures relies on mechanicals efforts to be advanced in the polylactic acid matrix nano-hydroapatite particles is compound.
Embodiment 3
Present embodiment is realized the preparation of simple solid bone screw, and concrete steps are as follows:
(1) design of simple solid bone screw three dimensional structure
Utilize simple solid bone screw 3 d structure model of computer aided design software solidworks design, shown in Fig. 2 a; During design simple solid bone screw 3 d structure model is carried out the personalization configuration, be set to respectively as the parameter with simple solid bone screw: screw diameter is designed to 8mm, and screw length is designed to 40mm, and pitch is designed to 2mm, and the depth of thread is designed to 1.5mm.
The simple solid bone screw 3 d structure model that designs is saved as the file of STL form, shown in Fig. 2 b, be the simple solid bone screw sketch map of engineering drawing form shown in the file of STL form.
(2) printing shaping of simple solid bone screw
The simple solid bone screw stl file that designs is imported the control software of three-dimensional printer, generate mimeograph documents.The nano combined degradable bone renovating material that is ready to print usefulness places on the three-dimensional printer, starts three printers and carries out the printing of gradient successively.Printing is finished and can be obtained simple solid bone screw, shown in Fig. 2 c.
Embodiment 4
Present embodiment is realized the preparation of complicated hollow bone screw, and concrete steps are as follows:
(1) design of complicated hollow bone screw three dimensional structure
At first adopt the 3 d structure model of a complicated hollow bone screw of CASE(Computer Aided Software Engineering) solidworks design, shown in Fig. 3 a; The parameters of complicated hollow bone screw can be set to respectively during design: screw diameter is designed to 8mm, and screw length is designed to 40mm, and pitch is designed to 2mm, and the depth of thread is designed to 1.5mm.Wherein the mid portion of screw is the flat configuration that does not have screw thread, and that the main part of bone screw is designed to is hollow, and hollow parts is a cylinder that diameter is 1mm.
The complicated hollow bone screw 3 d structure model that designs is saved as the file of STL form, shown in Fig. 3 b, for converting the simple solid bone screw sketch map of engineering drawing form to.
(2) printing shaping of complicated hollow bone screw
The complicated hollow bone screw stl file that designs is imported the control software of three-dimensional printer, generate mimeograph documents.The nano combined degradable bone renovating material that is ready to print usefulness in advance is placed on the tram of three-dimensional printer, starts three-dimensional printer and carry out successively gradient and print.Printing is finished and can be obtained designed good complicated hollow bone screw.Shown in Fig. 3 c, the picture in kind of the complicated hollow bone screw that prints for three-dimensional printer.
Embodiment 5
Present embodiment is realized the preparation of bone fishplate bar, and concrete steps are as follows:
(1) three dimensional structure of bone fishplate bar design
At first adopt the 3 d structure model of a bone fishplate bar of CASE(Computer Aided Software Engineering) solidworks design, shown in Fig. 4 a; And the 3 d structure model of this bone fishplate bar saved as the file of STL form, shown in Fig. 4 b, for Fig. 4 a converts view behind the engineering drawing form to.
(2) the 3 D-printing molding of bone fishplate bar
The bone fishplate bar stl file that designs is imported in the control software of three-dimensional printer, generate mimeograph documents.Be placed on the tram of 3 D-printing being ready to nano combined degradable bone renovating material that 3 D-printing uses in advance, start three-dimensional printer and print.Print procedure finishes to obtain designed bone fishplate bar.The in kind visible Fig. 4 c that prints.
Wherein, bone fishplate bar sketch map shown in Figure 5 is and utilizes the bone fishplate bar of the alternate model of present embodiment design, and it has the external form different with bone fishplate bar shown in Figure 4, and is the same with bone fishplate bar shown in Figure 4, all for the bone fishplate bar model of extremity.
Embodiment 6
Present embodiment is realized the preparation of osseous tissue engineering stephanoporate stent material, and concrete steps are as follows:
(1) three dimensional structure of osseous tissue engineering stephanoporate stent material design
At first adopt the three dimensional structure of an osseous tissue engineering stephanoporate stent material of CASE(Computer Aided Software Engineering) solidworks design, shown in Fig. 6 a; And this threedimensional model saved as the STL formatted file, shown in Fig. 6 b.
(2) printing shaping of osseous tissue engineering stephanoporate stent material
The osseous tissue engineering stephanoporate stent material stl file that designs is imported in the control software of three-dimensional printer, generate mimeograph documents.Be placed on the tram of 3 D-printing being ready to nano combined degradable bone renovating material that 3 D-printing uses in advance, start three-dimensional printer and print.Print procedure finishes to obtain designed osseous tissue engineering stephanoporate stent material.The in kind visible Fig. 6 c that prints.
The corresponding same or analogous parts of same or analogous label;
That describes position relation in the accompanying drawing is used for only being used for exemplary illustration, can not be interpreted as the restriction to this patent;
Obviously, the above embodiment of the present invention only is for example of the present invention clearly is described, and is not to be restriction to embodiments of the present invention.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here need not also can't give all embodiments exhaustive.All any modifications of doing within the spirit and principles in the present invention, be equal to and replace and improvement etc., all should be included within the protection domain of claim of the present invention.
Claims (7)
1. the 3 D-printing rapid shaping preparation method of a nano combined degradable bone renovating material is characterized in that, comprises the steps:
Utilize the computer aided design software design to have personalized bone renovating material 3 d structure model;
The 3 d structure model that designs is imported in the three-dimensional printer;
Synthetic good nano combined degradable bone renovating material is placed on the three-dimensional printer;
Start three-dimensional printer and finish the printing shaping successively of bone renovating material.
2. the 3 D-printing rapid shaping preparation method of nano combined degradable bone renovating material according to claim 1, it is characterized in that, utilize computer aided design software design to have in the step of personalized bone renovating material 3 d structure model according to human body is different and repair the bone renovating material 3 d structure model that the position is designed to given shape, specific standard, specific dimensions.
3. the 3 D-printing rapid shaping preparation method of nano combined degradable bone renovating material according to claim 1 is characterized in that, nano combined degradable bone renovating material adopts nanometer hydroxyapatite and degradable bone rehabilitation polymer to be composited.
4. the 3 D-printing rapid shaping preparation method of nano combined degradable bone renovating material according to claim 3, it is characterized in that nanometer hydroxyapatite is the polymer-hydroxyapatite nano compound that is combined into the variable concentrations ratio according to the difference of human body different parts bone component with the compound of degradable bone rehabilitation polymer.
5. the 3 D-printing rapid shaping preparation method of nano combined degradable bone renovating material according to claim 3, it is characterized in that described degradable bone rehabilitation polymer comprises a kind of in polylactic acid, polycaprolactone, polyglycolic acid, polylactide-co-Acetic acid, hydroxy-, bimol. cyclic ester random copolymer and the polyamino acid esterification derivative.
6. the 3 D-printing rapid shaping preparation method of nano combined degradable bone renovating material according to claim 5, it is characterized in that, when printing bone renovating material, three-dimensional printer repairs positions according to the human body difference, utilize the polymer-hydroxyapatite nano compound of variable concentrations ratio to carry out the gradient printing, adapt with the bone component with used position.
7. according to the 3 D-printing rapid shaping preparation method of each described nano combined degradable bone renovating material of claim 3 to 6, it is characterized in that, the complex method of nanometer hydroxyapatite and degradable bone rehabilitation polymer is: under the condition that is higher than degradable bone rehabilitation polymer glass transition temperature or melt temperature, by mechanicals efforts nano-hydroapatite particles is mixed in the matrix of degradable bone rehabilitation polymer into.
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Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104207861A (en) * | 2014-09-03 | 2014-12-17 | 吉林大学 | Manufacturing process of digital custom-made skeleton implant |
| CN104385586A (en) * | 2014-09-23 | 2015-03-04 | 四川理工学院 | Method for obtaining carbon black microscopic morphology enlarging entity through 3D printing |
| CN104552951A (en) * | 2015-01-06 | 2015-04-29 | 彭晓领 | 3D printing preparation method of polymeric gradient material |
| CN104800896A (en) * | 2015-04-20 | 2015-07-29 | 东华大学 | Human body-absorbable and enhancement-type bone fixation structure material 3D printed with FDM (fused deposition modeling) technology and preparation method thereof |
| CN104905899A (en) * | 2014-03-11 | 2015-09-16 | 江阴瑞康健生物医学科技有限公司 | External fixation support formed through 3D printing and used for personalized orthopedic and manufacturing method thereof |
| CN105013011A (en) * | 2015-07-22 | 2015-11-04 | 青岛尤尼科技有限公司 | 3D (three-dimensional) bioprinting preparation method for tissue engineering meniscus scaffold |
| CN105031737A (en) * | 2014-12-03 | 2015-11-11 | 北京印刷学院 | 3D printed digital artificial bone and preparation method thereof |
| CN105232179A (en) * | 2015-08-27 | 2016-01-13 | 华南理工大学 | Rapid prototyping preparation method of implant material of plastic surgery |
| CN105561394A (en) * | 2014-10-29 | 2016-05-11 | 四川大学华西医院 | Method of manufacturing three-dimensional nano composite stent for bone tissue engineering through selective laser sintering technology |
| CN106137480A (en) * | 2016-08-10 | 2016-11-23 | 青岛三帝生物科技有限公司 | Prepare method and the alimentary stent of alimentary stent based on 3D printing |
| CN106178124A (en) * | 2016-07-13 | 2016-12-07 | 华南理工大学 | A kind of degradable macromolecule network/calcium phosphate bone cement composite bone repairing material and preparation method and application |
| CN106344214A (en) * | 2016-08-29 | 2017-01-25 | 中国人民解放军第三军医大学第三附属医院 | Method for preparing implantable bone grafts by de-organification and 3D printing of animal bones |
| CN106474566A (en) * | 2016-10-19 | 2017-03-08 | 深圳市艾科赛龙科技股份有限公司 | A kind of 3D printing PCL/HAp composite and preparation method thereof, purposes, Method of printing |
| CN107009612A (en) * | 2017-06-07 | 2017-08-04 | 珠海天威飞马打印耗材有限公司 | The forming method of the threedimensional model of threedimensional model and rejected region |
| CN107929807A (en) * | 2017-11-28 | 2018-04-20 | 东华大学 | The compound polycaprolactone material of strontium-doped hydroxyapatite and its preparation and application |
| CN108904103A (en) * | 2018-05-30 | 2018-11-30 | 中国科学院深圳先进技术研究院 | A kind of method and apparatus preparing heterogeneous bone renovating material |
| CN109010924A (en) * | 2018-07-10 | 2018-12-18 | 扬州大学 | The preparation method of BMP2-PLA/HAP composite material bone repairing support |
| CN110694117A (en) * | 2018-07-10 | 2020-01-17 | 北京化工大学 | Completely degradable bone repair material and preparation method thereof |
| CN113827777A (en) * | 2021-09-26 | 2021-12-24 | 青岛大学附属医院 | Three-dimensional porous composite scaffold material and preparation method thereof |
| CN114940971A (en) * | 2022-06-24 | 2022-08-26 | 中山大学 | Method for constructing high-activity cartilage tissue based on Faraday wave |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943801A (en) * | 2006-11-01 | 2007-04-11 | 华中科技大学 | A gradient laminated composite supporting frame material based on bionic structures and its preparation method |
| CN101032430A (en) * | 2007-04-13 | 2007-09-12 | 中国人民解放军第三军医大学第一附属医院 | Method for preparing integrated frame fabrication of cartilage of tissue-engineered bone having function interface |
| CN101528158A (en) * | 2006-08-21 | 2009-09-09 | 21世纪国际新技术株式会社 | Bone model, bone filler and process for producing bone filler |
-
2013
- 2013-05-17 CN CN2013101838651A patent/CN103284815A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101528158A (en) * | 2006-08-21 | 2009-09-09 | 21世纪国际新技术株式会社 | Bone model, bone filler and process for producing bone filler |
| CN1943801A (en) * | 2006-11-01 | 2007-04-11 | 华中科技大学 | A gradient laminated composite supporting frame material based on bionic structures and its preparation method |
| CN101032430A (en) * | 2007-04-13 | 2007-09-12 | 中国人民解放军第三军医大学第一附属医院 | Method for preparing integrated frame fabrication of cartilage of tissue-engineered bone having function interface |
Non-Patent Citations (10)
| Title |
|---|
| JIHUA LI等: "Computer-Aided Design and Manufacturing and Rapid Prototyped Nanoscale Hydroxyapatite/Polyamide (n-HA/PA) construction for Condylar Defect Caused by Mandibular Angle Ostectomy", 《AESTH PLAST SURG》 * |
| K.F.LEONG等: "Solid freeform fabrication of three-dimensional scaffolds for engineering replacement tissues and organs", 《BIOMATERIALS》 * |
| SAMAR JYOTI KALITA等: "Development of controlled porositypolymer-ceramic composite scaffolds via fused deposition modeling", 《MATERIALS SCIENCE AND ENGINEERING C》 * |
| 何叶松等: "利用快速成型技术制造仿真人颅脑骨骼模型", 《中国医科大学学报》 * |
| 张欣等: "纳米羟基磷灰石及其复合物修复骨缺损的研究与应用", 《中国组织工程研究》 * |
| 杜江华: "羟基磷灰石/生物高分子复合材料的制备方法进展", 《中国组织工程研究与临床康复》 * |
| 柴岗等: "基于Micro-CT的三维打印组织工程骨建模技术", 《组织工程与重建外科杂志》 * |
| 许晓东: "面向快速成型技术高分子生物医学材料的研究", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 * |
| 郑雄飞等: "低温沉积制造壳聚糖-纳米羟基磷灰石支架", 《无机材料学报》 * |
| 魏学磊等: "计算机辅助成型技术制备骨组织工程支架的研究进展", 《中国修复重建外科杂志》 * |
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