CN103251883B - A kind of antineoplastic pharmaceutical compositions and preparation method thereof - Google Patents
A kind of antineoplastic pharmaceutical compositions and preparation method thereof Download PDFInfo
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Abstract
The object of the present invention is to provide the described Chinese medicine composition of a kind of Chinese medicine composition with antitumor action and preparation method thereof, be made up of medicated wine and Chinese medicine extract, medicated wine is that raw material is prepared from by crystal sugar, wild walnut skin, state's Folium Pini and pure grain wine; Chinese medicine extract is that raw material is prepared from by Radix Ginseng, Flos Caryophylli, Lignum Sappan, Semen Persicae, Ramulus Cinnamomi, Moschus, Rhizoma Curcumae Longae, Tabanus, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Myrrha, Rhizoma Cyperi, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Fructus Evodiae, Radix Et Rhizoma Rhei, Carapax Trionycis, rice vinegar.Chinese medicine extract of the present invention, as pharmaceutically active substance, can add medicine acceptable carrier when needing, and makes preparation according to the routine techniques of galenic pharmacy.Present invention also offers the application of described Chinese medicine composition in the medicine of preparation treatment tumor.Medicine in prescription of the present invention is coordinated to reach promoting the circulation of blood of invigorating blood circulation, disease eliminating powder junction mutually, tonification righting, pure and enter liver, hard masses softening and resolving, attacks and does not just hinder, effectively can cure tumor.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate to a kind of antineoplastic pharmaceutical compositions and preparation method thereof.
Background technology
Tumor refers to that body is under various tumorigenesis factor long term, and the regulation and control of the cellular gene expression of local organization are abnormal, thus lose the normal regulation of cell growth, causes the excessive reproduction of mutant and the neoplasm that formed.Malignant tumor refers to uncontrollable Malignant cellular growth and diffusion, and tissue infiltration is feature, and determines to meet through pathological examination the disease that " disease and Clasification " standard that health ministry announces belongs to the row of malignant tumor.Common as: pulmonary carcinoma, leukemia, osteosarcoma, liver tumor etc. all belong to malignant tumor.
Hepatocarcinoma refers to the tumor betiding liver, comprises primary hepatocarcinoma and secondary liver cancer two kinds, and mostly what the hepatocarcinoma of the daily theory of people referred to is primary hepatocarcinoma.Primary hepatocarcinoma is one of modal malignant tumor clinically, and according to recent statistics, liver cancer patient about 600,000 is newly sent out in the whole world every year, occupies the 5th of malignant tumor.Primary hepatocarcinoma can be divided into Hepatocellular carcinoma, intrahepatic cholangiocarcinoma and mixed carcinoma of liver by cell typing.
Tumor is a kind of physiological phenomenon and pathological symptom, for tumor, there is no specific drug both at home and abroad at present, the antitumor drug majority that market is sold is structure determination synthetic drug, they while killing off tumor cells to the epithelial cell of molecular marker for increased proliferation, as medullary cell, alimentary canal mucous membrane epithelial cell etc. all have major injury, to body vitals, after one's own heart, lung, kidney, nervous system etc. also have certain toxicity.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition with antitumor action and preparation method thereof.
Chinese medicine composition of the present invention, is made up of medicated wine and Chinese medicine extract, and described medicated wine is prepared from by the raw material of following weight portion: crystal sugar 0.1-2 kilogram, wild walnut skin 1-4 kilogram, state Folium Pini 2-6 kilogram, pure grain wine 8-14 kilogram; Described Chinese medicine extract is prepared from by the raw material of following weight portion: Radix Ginseng, Flos Caryophylli, Lignum Sappan, each 10--30 gram of Semen Persicae, Ramulus Cinnamomi, Moschus, Rhizoma Curcumae Longae, Tabanus, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Myrrha, Rhizoma Cyperi, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, each 2-15 gram of Rhizoma Chuanxiong, Radix Angelicae Sinensis 8-16 gram, Fructus Evodiae 1-5 gram, Radix Et Rhizoma Rhei 10-40 gram, Herba Leonuri 10-40 gram, Carapax Trionycis 20-100 gram, rice vinegar 50-1000 gram.
Preferably, described medicated wine is prepared from by the raw material of following weight portion: crystal sugar 0.5-1 kilogram, wild walnut skin 1.5-3 kilogram, state Folium Pini 3-5 kilogram, pure grain wine 10-12 kilogram.
According to one of embodiment of the present invention, described pure grain wine is the pure grain wine that market can buy.
Preferably, described pure grain wine is 34-42 degree pure grain wine.
Most preferred, described pure grain wine is 38 degree of pure grain wines.
Preferably, described Chinese medicine extract is prepared from by the raw material of following weight portion: Radix Ginseng, Flos Caryophylli, Lignum Sappan, each 15--20 gram of Semen Persicae, Ramulus Cinnamomi, Moschus, Rhizoma Curcumae Longae, Tabanus, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Myrrha, Rhizoma Cyperi, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, each 5-10 of Rhizoma Chuanxiong gram Radix Angelicae Sinensis 10-14 gram, Fructus Evodiae 2-3 gram, Radix Et Rhizoma Rhei 20-30 gram, Herba Leonuri 20-30 gram, Carapax Trionycis 50-70 gram, rice vinegar 200-500 gram.
The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is constant.Single medicinal material more than in composition, especially ministerial drug and adjuvant drug, also can be replaced by the suitable Chinese medicine with the identical property of medicine, its drug effect of the Chinese medicine composition after replacement is constant.
According to Chinese medicine composition of the present invention, the preparation method of medicated wine comprises the following steps:
Step 1 is cleaned: get various raw material in proportion and clean, dry for subsequent use;
Step 2 is concocted: by crystal sugar, wild walnut skin, and state's Folium Pini loads in glass drying oven jointly pours pure grain wine sealing 7-15 days into, filters, removes slag charge, to obtain final product.
According to Chinese medicine composition of the present invention, the preparation method of Chinese medicine extract comprises the following steps:
Step 1 is cleaned: get various raw material in proportion and clean, dry for subsequent use;
Step 2 is pulverized: Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Lignum Sappan, Radix Angelicae Sinensis, Ganoderma, Lignum Dalbergiae Odoriferae, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei, Herba Leonuri, turtle ' s carapace powder are broken into the long fritter of 3-5mm, again Herba Leonuri, Radix Et Rhizoma Rhei, Carapax Trionycis are ground into fine powder, sieve, obtain motherwort powder, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder, for subsequent use, Moschus list equipment use, Semen Persicae removes point;
Step 3 mixes and decocts: after Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Flos Caryophylli, Tabanus, Lignum Sappan, Semen Persicae, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Radix Angelicae Sinensis, Myrrha, Rhizoma Cyperi, Fructus Evodiae, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, Rhizoma Chuanxiong are put into vessel Homogeneous phase mixing, put in digester and add rice vinegar and heat to boiling, boil and within 15-20 minute, change slow fire receipts juice, juice receive dry after truce cooling air dry of drying in the air do, put again in digester after drying, add rice vinegar, dense endure receive juice cooling dry in the air air dry do, three times repeatedly, extract is obtained after drying, for subsequent use;
Step 4 levigation mixes with secondary: extract described in step 3 is ground into fine powder and sieves, and then mixs homogeneously with motherwort powder, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder and Moschus described in step 2, to obtain final product.
According to the preparation method of Chinese medicine composition of the present invention, the preparation method of described medicated wine comprises the following steps:
Step 1 is cleaned: get various raw material in proportion and clean, dry for subsequent use;
Step 2 is concocted: by crystal sugar, wild walnut skin, and state's Folium Pini loads in glass drying oven jointly pours pure grain wine sealing 7-15 days into, filters, removes slag charge, to obtain final product.
According to the preparation method of Chinese medicine composition of the present invention, the preparation method of described Chinese medicine extract comprises the following steps:
Step 1 is cleaned: get various raw material in proportion and clean, dry for subsequent use;
Step 2 is pulverized: Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Lignum Sappan, Radix Angelicae Sinensis, Ganoderma, Lignum Dalbergiae Odoriferae, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei, Herba Leonuri, turtle ' s carapace powder are broken into the long fritter of 3-5mm, again Herba Leonuri, Radix Et Rhizoma Rhei, Carapax Trionycis are ground into fine powder, sieve, obtain motherwort powder, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder, for subsequent use, Moschus list equipment use, Semen Persicae removes point;
Step 3 mixes and decocts: after Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Flos Caryophylli, Tabanus, Lignum Sappan, Semen Persicae, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Radix Angelicae Sinensis, Myrrha, Rhizoma Cyperi, Fructus Evodiae, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, Rhizoma Chuanxiong are put into vessel Homogeneous phase mixing, put in digester and add rice vinegar and heat to boiling, boil and within 15-20 minute, change slow fire receipts juice, juice receive dry after truce cooling air dry of drying in the air do, put again in digester after drying, add rice vinegar, dense endure receive juice cooling dry in the air air dry do, three times repeatedly, extract is obtained after drying, for subsequent use;
Step 4 levigation mixes with secondary: extract described in step 3 is ground into fine powder and sieves, and then mixs homogeneously with motherwort powder, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder and Moschus described in step 2, to obtain final product.
The present invention is by increasing the consumption of flavour of a drug, and raw material is fully pulverized, and concocts, and the means such as repeatedly boiling can effectively improve its drug effect.
Present invention also offers a kind of anti-tumor agent, using Chinese medicine extract of the present invention as pharmaceutically active substance, when needing, add medicine acceptable carrier, the preparation made according to the routine techniques of galenic pharmacy.
Pharmaceutically active substance in preparation can be 0.1-100%, and all the other are medicine acceptable carrier.Pharmaceutical preparation of the present invention, exists in a unit, and described unit dosage form refers to the unit of preparation, as every sheet of tablet, and every capsules of capsule, every bottle of oral liquid, granule every bag etc.
Preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, drop pill, capsule, oral liquid, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, injection, suppository, ointment, plaster, cream, spray, drop, patch.
Preferably, preparation of the present invention is peroral dosage form, as: capsule, granule, pill, powder, sublimed preparation, unguentum etc.
Most preferred, preparation of the present invention is capsule.
The application of Chinese medicine composition of the present invention in the medicine of preparation treatment tumor.
The application of Chinese medicine composition of the present invention in the medicine of preparation treatment liver tumor.
Described liver tumor refers to primary liver tumor and metastatic hepatic neoplasm.
Chinese medicine composition of the present invention, by medicated wine and Chinese medicine extract preparation with the use of, regulate the usage ratio of Chinese medicine extract and medicated wine according to conditions of patients.Medicated wine and Chinese medicine extract also can be used alone.
Adopt Chinese medicine composition of the present invention, by medicated wine and Chinese medicine extract or Chinese medicine extract preparation with the use of, prescription medicine is coordinated to reach promoting the circulation of blood of invigorating blood circulation mutually, disease eliminating powder junction, tonification righting, pure and enter liver, hard masses softening and resolving, attacks and does not just hinder, and effectively can cure tumor.
Clinical trial proves: liver tumor patient takes the Chinese medicine composition state of an illness of the present invention all to be had and alleviate in various degree, within 20-30 days, tumor body obviously reduces, within 3 months, substantially cure to half a year, in addition transfevent liver tumor and lung, stomach, hysteromyoma etc. are also had to the effect suppressing and reduce.
Detailed description of the invention
Be described below in detail embodiments of the invention, described embodiment is exemplary, only for explaining the present invention, and can not be interpreted as limitation of the present invention.
Embodiment 1
Medicinal liquor prescription: 0.1 kilogram, crystal sugar, wild walnut skin 1 kilogram, state's Folium Pini 2 kilograms, 34 degree of pure grain wines 8 kilograms;
Medicated wine preparation method:
Step 1 is cleaned: get above-mentioned raw material in proportion and clean, dry for subsequent use;
Step 2 is concocted: by crystal sugar, wild walnut skin, and state's Folium Pini loads in glass drying oven jointly to be poured pure grain wine into and seal 7 days, filters, removes slag charge, to obtain final product.
Chinese medicine extraction composition formula: Radix Ginseng, Flos Caryophylli, Lignum Sappan, each 10 grams of Semen Persicae, Ramulus Cinnamomi, Moschus, Rhizoma Curcumae Longae, Tabanus, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Myrrha, Rhizoma Cyperi, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, each 2 grams of Rhizoma Chuanxiong, Radix Angelicae Sinensis 8 grams, Fructus Evodiae 1 gram, Radix Et Rhizoma Rhei 10 grams, Herba Leonuri 10 grams, Carapax Trionycis 20 grams, rice vinegar 50 grams;
Chinese medicine extract preparation method:
Step 1 is cleaned: get above-mentioned raw material in proportion and clean, dry for subsequent use;
Step 2 is pulverized: Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Lignum Sappan, Radix Angelicae Sinensis, Ganoderma, Lignum Dalbergiae Odoriferae, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei, Herba Leonuri, turtle ' s carapace powder are broken into the long fritter of 3mm, again Herba Leonuri, Radix Et Rhizoma Rhei, Carapax Trionycis are ground into fine powder, sieve, obtain motherwort powder, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder, for subsequent use, Moschus list equipment use, Semen Persicae removes point;
Step 3 mixes and decocts: after Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Flos Caryophylli, Tabanus, Lignum Sappan, Semen Persicae, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Radix Angelicae Sinensis, Myrrha, Rhizoma Cyperi, Fructus Evodiae, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, Rhizoma Chuanxiong are put into vessel Homogeneous phase mixing, put in digester and add rice vinegar and heat to boiling, boil and within 15 minutes, change slow fire receipts juice, juice receive dry after truce cooling air dry of drying in the air do, put again in digester after drying, add rice vinegar, dense endure receive juice cooling dry in the air air dry do, three times repeatedly, extract is obtained after drying, for subsequent use;
Step 4 levigation mixes with secondary: extract described in step 3 is ground into fine powder and sieves, and then mixs homogeneously with motherwort powder, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder and Moschus described in step 2, to obtain final product.
Embodiment 2
Medicinal liquor prescription: 2 kilograms, crystal sugar, wild walnut skin 4 kilograms, state's Folium Pini 6 kilograms, 42 degree of pure grain wines 14 kilograms;
Medicated wine preparation method:
Step 1 is cleaned: get above-mentioned raw material in proportion and clean, dry for subsequent use;
Step 2 is concocted: by crystal sugar, wild walnut skin, and state's Folium Pini loads in glass drying oven jointly to be poured pure grain wine into and seal 10 days, filters, and removes slag charge, to obtain final product.
Chinese medicine extraction composition formula: Radix Ginseng, Flos Caryophylli, Lignum Sappan, each 30 grams of Semen Persicae, Ramulus Cinnamomi, Moschus, Rhizoma Curcumae Longae, Tabanus, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Myrrha, Rhizoma Cyperi, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, each 15 grams of Rhizoma Chuanxiong, Radix Angelicae Sinensis 16 grams, Fructus Evodiae 5 grams, Radix Et Rhizoma Rhei 40 grams, Herba Leonuri 40 grams, Carapax Trionycis 100 grams, rice vinegar 1000 grams;
Chinese medicine extract preparation method:
Step 1 is cleaned: get above-mentioned raw material in proportion and clean, dry for subsequent use;
Step 2 is pulverized: Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Lignum Sappan, Radix Angelicae Sinensis, Ganoderma, Lignum Dalbergiae Odoriferae, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei, Herba Leonuri, turtle ' s carapace powder are broken into the long fritter of 5mm, again Herba Leonuri, Radix Et Rhizoma Rhei, Carapax Trionycis are ground into fine powder, sieve, obtain motherwort powder, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder, for subsequent use, Moschus list equipment use, Semen Persicae removes point;
Step 3 mixes and decocts: after Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Flos Caryophylli, Tabanus, Lignum Sappan, Semen Persicae, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Radix Angelicae Sinensis, Myrrha, Rhizoma Cyperi, Fructus Evodiae, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, Rhizoma Chuanxiong are put into vessel Homogeneous phase mixing, put in digester and add rice vinegar and heat to boiling, boil and within 20 minutes, change slow fire receipts juice, juice receive dry after truce cooling air dry of drying in the air do, put again in digester after drying, add rice vinegar, dense endure receive juice cooling dry in the air air dry do, three times repeatedly, extract is obtained after drying, for subsequent use;
Step 4 levigation mixes with secondary: extract described in step 3 is ground into fine powder and sieves, and then mixs homogeneously with motherwort powder, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder and Moschus described in step 2, to obtain final product.
Embodiment 3
Medicinal liquor prescription: 0.5 kilogram, crystal sugar, wild walnut skin 1.5 kilograms, state's Folium Pini 3 kilograms, 38 degree of pure grain wines 11 kilograms;
Medicated wine preparation method:
Step 1 is cleaned: get above-mentioned raw material in proportion and clean, dry for subsequent use;
Step 2 is concocted: by crystal sugar, wild walnut skin, and state's Folium Pini loads in glass drying oven jointly to be poured pure grain wine into and seal 15 days, filters, and removes slag charge, to obtain final product.
Chinese medicine extraction composition formula: Radix Ginseng, Flos Caryophylli, Lignum Sappan, each 15 grams of Semen Persicae, Ramulus Cinnamomi, Moschus, Rhizoma Curcumae Longae, Tabanus, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Myrrha, Rhizoma Cyperi, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, each 5 grams of Rhizoma Chuanxiong, Radix Angelicae Sinensis 12 grams, Fructus Evodiae 2 grams, Radix Et Rhizoma Rhei 20 grams, Herba Leonuri 20 grams, Carapax Trionycis 50 grams, rice vinegar 200 grams;
Chinese medicine extract preparation method:
Step 1 is cleaned: get above-mentioned raw material in proportion and clean, dry for subsequent use;
Step 2 is pulverized: Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Lignum Sappan, Radix Angelicae Sinensis, Ganoderma, Lignum Dalbergiae Odoriferae, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei, Herba Leonuri, turtle ' s carapace powder are broken into the long fritter of 4mm, again Herba Leonuri, Radix Et Rhizoma Rhei, Carapax Trionycis are ground into fine powder, sieve, obtain motherwort powder, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder, for subsequent use, Moschus list equipment use, Semen Persicae removes point;
Step 3 mixes and decocts: after Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Flos Caryophylli, Tabanus, Lignum Sappan, Semen Persicae, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Radix Angelicae Sinensis, Myrrha, Rhizoma Cyperi, Fructus Evodiae, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, Rhizoma Chuanxiong are put into vessel Homogeneous phase mixing, put in digester and add rice vinegar and heat to boiling, boil and within 18 minutes, change slow fire receipts juice, juice receive dry after truce cooling air dry of drying in the air do, put again in digester after drying, add rice vinegar, dense endure receive juice cooling dry in the air air dry do, three times repeatedly, extract is obtained after drying, for subsequent use;
Step 4 levigation mixes with secondary: extract described in step 3 is ground into fine powder and sieves, and then mixs homogeneously with motherwort powder, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder and Moschus described in step 2, to obtain final product.
Embodiment 4
Medicinal liquor prescription: 1 kilogram, crystal sugar, wild walnut skin 3 kilograms, state's Folium Pini 5 kilograms, 38 degree of pure grain wines 12 kilograms;
Medicated wine preparation method:
Step 1 is cleaned: get above-mentioned raw material in proportion and clean, dry for subsequent use;
Step 2 is concocted: by crystal sugar, wild walnut skin, and state's Folium Pini loads in glass drying oven jointly to be poured pure grain wine into and seal 12 days, filters, and removes slag charge, to obtain final product.
Chinese medicine extraction composition formula: Radix Ginseng, Flos Caryophylli, Lignum Sappan, each 20 grams of Semen Persicae, Ramulus Cinnamomi, Moschus, Rhizoma Curcumae Longae, Tabanus, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Myrrha, Rhizoma Cyperi, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, each 10 grams of Rhizoma Chuanxiong, Radix Angelicae Sinensis 15 grams, Fructus Evodiae 5 grams, Radix Et Rhizoma Rhei 30 grams, Herba Leonuri 30 grams, Carapax Trionycis 70 grams, rice vinegar 300 grams;
Chinese medicine extract preparation method:
Step 1 is cleaned: get above-mentioned raw material in proportion and clean, dry for subsequent use;
Step 2 is pulverized: Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Lignum Sappan, Radix Angelicae Sinensis, Ganoderma, Lignum Dalbergiae Odoriferae, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei, Herba Leonuri, turtle ' s carapace powder are broken into the long fritter of 3mm, again Herba Leonuri, Radix Et Rhizoma Rhei, Carapax Trionycis are ground into fine powder, sieve, obtain motherwort powder, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder, for subsequent use, Moschus list equipment use, Semen Persicae removes point;
Step 3 mixes and decocts: after Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Flos Caryophylli, Tabanus, Lignum Sappan, Semen Persicae, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Radix Angelicae Sinensis, Myrrha, Rhizoma Cyperi, Fructus Evodiae, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, Rhizoma Chuanxiong are put into vessel Homogeneous phase mixing, put in digester and add rice vinegar and heat to boiling, boil and within 20 minutes, change slow fire receipts juice, juice receive dry after truce cooling air dry of drying in the air do, put again in digester after drying, add rice vinegar, dense endure receive juice cooling dry in the air air dry do, three times repeatedly, extract is obtained after drying, for subsequent use;
Step 4 levigation mixes with secondary: extract described in step 3 is ground into fine powder and sieves, and then mixs homogeneously with motherwort powder, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder and Moschus described in step 2, to obtain final product.
Embodiment 5
Example 1 gained Chinese medicine extract 25%, xylitol 48%, maltose 6%, 14% cyclodextrin, 7% calcium lactate is prepared soft capsule according to soft capsule common process and is namely obtained soft capsule.
Embodiment 6
Example 3 gained Chinese medicine extract, incapsulates, obtains capsule under room temperature is aseptic.
Embodiment 7
The Chinese medicine extract 75g microcrystalline Cellulose 37g micropowder silica gel 2.3g magnesium stearate 1.1g that [prescription] embodiment 4 obtains
[method for making] gets former, adjuvant mistake 100 mesh sieves respectively; Get extractum, microcrystalline Cellulose, mixing, with 60% appropriate amount of ethanol as binding agent soft material, cross 20 mesh sieve granules, 60 DEG C of dryings, take out, cross 30 mesh sieve granulate, add appropriate micropowder silica gel and magnesium stearate, mixing, tabletting, makes 1000, to obtain final product.
Test example
Case 1: turn round and look at certain, female, 39 years old.Within 2009, in first hospital ultrasonic examination finding, leftlobe of liver huge solid tumor mass 13.0*13.9*16.0cm size, form is irregular, obscure boundary, and in tuberosity sense, inner based on the low echo of substance, echo is mixed and disorderly, mixed and disorderly strong echo between substantive low echo nodules.The maximum clino-diagonal 10.8cm of right lobe of liver.The strong echo stove such as right lobe of liver visible 1.4*2.1*2.2cm, 1.6*1.7,1.8*1.9cm, form is irregular, and CT examination is liver multiple tumor, is diagnosed as hepatocarcinoma.After making a definite diagnosis the 9th day starts medication, and six hours once, and each 6 capsules (preparation method is shown in embodiment 6, the heavy 0.39-0.4g of every capsules), medicated wine morning and evening every day is each once, each 25-30g.Medication 6 days patient's private prosecution right flank distending pains alleviate, and within 15 days, without sense of discomfort, within one month 0 two days, check leftlobe of liver tumor body is 10.3*9.7*12.0cm, right lobe of liver 1.0*1.6*2.1cm, 1.4*1.3cm, 1.7*1.4cm.Medication 3 months leftlobe of liver are 3.9*4.2*6.1cm, and right lobe of liver can't see tumor body.Medication basic rehabilitation half a year.After 8 months, check returns to one's perfect health.
Case 2: Chen, man, 46 years old.March 17 calendar year 2001 is unenhanced at second hospital upper abdomen CT.Upper left abdomen display: 10*12cm agglomerate shadow, density unevenness in it, the upper bound and right lobe of liver are demarcated unclear, and the multiple brief summary nodular low-density stove of display in right lobe of liver, peritoneum structure shows brief summary nodular enlarged lymph node.CT diagnoses: upper left abdomen occupy-place.Consider lobus sinister liver ca and lobus dexter liver m.Hepatocarcinoma is diagnosed as at certain provincial hospital March 23 calendar year 2001.Do chemotherapy and can't stand vomiting 2 times, patient leaves hospital voluntarily.April 5 the same year starts to take medicine, and within every six hours, takes once, each 6, sooner or later each drink medicated wine half two.Medication 3 months 06 days check tumor bodies are little of 7.2*9.6cm.Peritoneum does not show.
Case 3: rope, man, 63 years old.2010 rectal cancer surgeries done in certain the People's Hospital of city, on March 17th, 2012 checks in this hospital: chest CT scans.Two lung marking are more, visible multiple brief summary nodular high density shadow in two lung field.Compare tuberosity slightly to increase with front CT sheet, visible enlarged lymph node shadow in vertical diaphragm.CT diagnoses: lung M, vertical diaphragm lymph enlargement.On March 21st, 2012 start, take capsule (preparation method is shown in embodiment 6), medication in every 6 hours once, each 6.On June 9th, 2012 checks.Above-mentioned hospital CT examination report: chest CT scans.Rectum Ca lung M checks: thorax almost symmetry, and two lung marking is clear, and inferior lobe of right lung shows two nodositas high density stoves, density unevenness, edge is shallow lobulated, shows no obvious abnormalities in remaining lung field, comparatively on March 17th, 2012, CT sheet had no significant change to focus, had no obvious enlarged lymph node in vertical diaphragm.On March 25th, 2013 checks again, CT examination finding: lung M checks: two lung is clear, and right lung is marched off into political wilderness and shown two soft tissue tuberosity stoves, and density is light, and border is still clear, has no enlarged lymph node in vertical diaphragm.Existing health is fine.Continue to take medicine.
Case 4: Zhao, female, 41 years old.On April 18th, 2011 haves a medical check-up and checks out multiple myomata, maximum 3.8*4.3cm, starts to take medicine every day 4 times on May 20th, 2011, each 6 capsules.JIUYUE in 2011 check tumor body on the 11st is obviously decreased to 1.4*1.8.
Claims (8)
1. a Chinese medicine composition, it is characterized in that, described Chinese medicine composition is made up of medicated wine and Chinese medicine extract, and its Chinese medicinal liquor is prepared from by the raw material of following weight portion: crystal sugar 0.1-2 kilogram, wild walnut skin 1-4 kilogram, state Folium Pini 2-6 kilogram, pure grain wine 8-14 kilogram; Chinese medicine extract is prepared from by the raw material of following weight portion: Radix Ginseng, Flos Caryophylli, Lignum Sappan, each 10--30 gram of Semen Persicae, Ramulus Cinnamomi, Moschus, Rhizoma Curcumae Longae, Tabanus, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Myrrha, Rhizoma Cyperi, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, each 2-15 gram of Rhizoma Chuanxiong, Radix Angelicae Sinensis 8-16 gram, Fructus Evodiae 1-5 gram, Radix Et Rhizoma Rhei 10-40 gram, Herba Leonuri 10-40 gram, Carapax Trionycis 20-100 gram, rice vinegar 50-1000 gram;
Wherein, the preparation method of described medicated wine comprises the following steps:
Step 1 is cleaned: get various raw material in proportion and clean, dry for subsequent use;
Step 2 is concocted: by crystal sugar, wild walnut skin, and state's Folium Pini loads in glass drying oven jointly pours pure grain wine sealing 7-15 days into, filters, removes slag charge, to obtain final product;
The preparation method of described Chinese medicine extract comprises the following steps:
Step 1 is cleaned: get various raw material in proportion and clean, dry for subsequent use;
Step 2 is pulverized: Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Lignum Sappan, Radix Angelicae Sinensis, Ganoderma, Lignum Dalbergiae Odoriferae, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei, Herba Leonuri, turtle ' s carapace powder are broken into the long fritter of 3-5mm, again Herba Leonuri, Radix Et Rhizoma Rhei, Carapax Trionycis are ground into fine powder, sieve, obtain motherwort powder, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder, for subsequent use, Moschus list equipment use, Semen Persicae removes point;
Step 3 mixes and decocts: after Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Flos Caryophylli, Tabanus, Lignum Sappan, Semen Persicae, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Radix Angelicae Sinensis, Myrrha, Rhizoma Cyperi, Fructus Evodiae, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, Rhizoma Chuanxiong are put into vessel Homogeneous phase mixing, put in digester and add rice vinegar and heat to boiling, boil and within 15-20 minute, change slow fire receipts juice, juice receive dry after truce cooling air dry of drying in the air do, put again in digester after drying, add rice vinegar, dense endure receive juice cooling dry in the air air dry do, three times repeatedly, extract is obtained after drying, for subsequent use;
Step 4 levigation mixes with secondary: extract described in step 3 is ground into fine powder and sieves, and then mixs homogeneously with motherwort powder, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder and Moschus described in step 2, to obtain final product.
2. Chinese medicine composition as claimed in claim 1, it is characterized in that, described medicated wine is prepared from by the raw material of following weight portion: crystal sugar 0.5-1 kilogram, wild walnut skin 1.5-3 kilogram, state Folium Pini 3-5 kilogram, pure grain wine 10-12 kilogram.
3. Chinese medicine composition as claimed in claim 2, it is characterized in that, described pure grain wine is 34-42 degree pure grain wine.
4. Chinese medicine composition as claimed in claim 1, it is characterized in that, described Chinese medicine extract is prepared from by the raw material of following weight portion: Radix Ginseng, Flos Caryophylli, Lignum Sappan, each 15--20 gram of Semen Persicae, Ramulus Cinnamomi, Moschus, Rhizoma Curcumae Longae, Tabanus, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Myrrha, Rhizoma Cyperi, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, each 5-10 of Rhizoma Chuanxiong gram Radix Angelicae Sinensis 10-14 gram, Fructus Evodiae 2-3 gram, Radix Et Rhizoma Rhei 20-30 gram, Herba Leonuri 20-30 gram, Carapax Trionycis 50-70 gram, rice vinegar 200-500 gram.
5. the preparation method of Chinese medicine composition as claimed in claim 1, it is characterized in that, the preparation method of described medicated wine comprises the following steps:
Step 1 is cleaned: get various raw material in proportion and clean, dry for subsequent use;
Step 2 is concocted: by crystal sugar, wild walnut skin, and state's Folium Pini loads in glass drying oven jointly pours pure grain wine sealing 7-15 days into, filters, removes slag charge, to obtain final product;
The preparation method of described Chinese medicine extract comprises the following steps:
Step 1 is cleaned: get various raw material in proportion and clean, dry for subsequent use;
Step 2 is pulverized: Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Lignum Sappan, Radix Angelicae Sinensis, Ganoderma, Lignum Dalbergiae Odoriferae, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei, Herba Leonuri, turtle ' s carapace powder are broken into the long fritter of 3-5mm, again Herba Leonuri, Radix Et Rhizoma Rhei, Carapax Trionycis are ground into fine powder, sieve, obtain motherwort powder, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder, for subsequent use, Moschus list equipment use, Semen Persicae removes point;
Step 3 mixes and decocts: after Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Flos Caryophylli, Tabanus, Lignum Sappan, Semen Persicae, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Radix Angelicae Sinensis, Myrrha, Rhizoma Cyperi, Fructus Evodiae, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, Rhizoma Chuanxiong are put into vessel Homogeneous phase mixing, put in digester and add rice vinegar and heat to boiling, boil and within 15-20 minute, change slow fire receipts juice, juice receive dry after truce cooling air dry of drying in the air do, put again in digester after drying, add rice vinegar, dense endure receive juice cooling dry in the air air dry do, three times repeatedly, extract is obtained after drying, for subsequent use;
Step 4 levigation mixes with secondary: extract described in step 3 is ground into fine powder and sieves, and then mixs homogeneously with motherwort powder, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder and Moschus described in step 2, to obtain final product.
6. an anti-tumor agent, is characterized in that, using the Chinese medicine extract described in any one of claim 1-4 as pharmaceutically active substance, adds medicine acceptable carrier when needing, the preparation made according to the routine techniques of galenic pharmacy.
7. anti-tumor agent as claimed in claim 6, it is characterized in that, the dosage form of described preparation comprises: tablet, drop pill, capsule, oral liquid, suck agent, granule, electuary, pill, powder, sublimed preparation, suspensoid, powder, injection.
8. the application of Chinese medicine composition described in claim 1 in the medicine of preparation treatment tumor.
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| EP3441076A4 (en) * | 2016-04-07 | 2019-12-04 | Beijing Lu De Kai Qi Co., Ltd. | Pharmaceutical product for treating tumor and combined immune defect, and preparation and application thereof |
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| CN106692871A (en) * | 2016-09-21 | 2017-05-24 | 深圳市得道中医馆管理有限责任公司 | Traditional Chinese medicine composition, preparation method thereof and application of traditional Chinese medicine composition in liver cancer treatment |
| CN115700276A (en) * | 2022-11-25 | 2023-02-07 | 广西农科环保科技有限公司 | Formula and preparation method of black soldier fly and ginseng nutritional wine |
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| CN101338266A (en) * | 2007-07-02 | 2009-01-07 | 李德文 | Walnut wine and brewing method |
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