CN103243032A - Sake candida and fermentation method thereof - Google Patents
Sake candida and fermentation method thereof Download PDFInfo
- Publication number
- CN103243032A CN103243032A CN2012100302784A CN201210030278A CN103243032A CN 103243032 A CN103243032 A CN 103243032A CN 2012100302784 A CN2012100302784 A CN 2012100302784A CN 201210030278 A CN201210030278 A CN 201210030278A CN 103243032 A CN103243032 A CN 103243032A
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- Prior art keywords
- acid
- candida
- candida sake
- substratum
- sake
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- 238000000034 method Methods 0.000 title claims description 35
- 238000000855 fermentation Methods 0.000 title abstract description 19
- 230000004151 fermentation Effects 0.000 title abstract description 19
- 241000222120 Candida <Saccharomycetales> Species 0.000 title abstract description 5
- 150000007520 diprotic acids Chemical class 0.000 claims description 31
- 241001530515 Candida sake Species 0.000 claims description 29
- 239000002253 acid Substances 0.000 claims description 25
- 150000001335 aliphatic alkanes Chemical class 0.000 claims description 14
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 12
- 229910052799 carbon Inorganic materials 0.000 claims description 10
- -1 n-dodecane hydrocarbon Chemical class 0.000 claims description 10
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 10
- 239000004215 Carbon black (E152) Substances 0.000 claims description 9
- 229930195733 hydrocarbon Natural products 0.000 claims description 9
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 8
- 239000004202 carbamide Substances 0.000 claims description 8
- 239000000758 substrate Substances 0.000 claims description 8
- 229940041514 candida albicans extract Drugs 0.000 claims description 7
- 239000012138 yeast extract Substances 0.000 claims description 7
- 229940094933 n-dodecane Drugs 0.000 claims description 6
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 4
- 239000001888 Peptone Substances 0.000 claims description 4
- 108010080698 Peptones Proteins 0.000 claims description 4
- 240000008042 Zea mays Species 0.000 claims description 4
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 4
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- 235000005822 corn Nutrition 0.000 claims description 4
- 235000019319 peptone Nutrition 0.000 claims description 4
- 125000001477 organic nitrogen group Chemical group 0.000 claims description 3
- 229910002651 NO3 Inorganic materials 0.000 claims description 2
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims description 2
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 claims description 2
- 108010009736 Protein Hydrolysates Proteins 0.000 claims description 2
- 235000019764 Soybean Meal Nutrition 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 229910021529 ammonia Inorganic materials 0.000 claims description 2
- 235000011114 ammonium hydroxide Nutrition 0.000 claims description 2
- 150000003863 ammonium salts Chemical class 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 239000004455 soybean meal Substances 0.000 claims description 2
- 230000001580 bacterial effect Effects 0.000 abstract description 20
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 108090000623 proteins and genes Proteins 0.000 description 14
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 11
- 239000002609 medium Substances 0.000 description 11
- 239000000126 substance Substances 0.000 description 11
- 238000010586 diagram Methods 0.000 description 10
- 239000000203 mixture Substances 0.000 description 10
- 239000000243 solution Substances 0.000 description 9
- 238000011218 seed culture Methods 0.000 description 8
- 238000005303 weighing Methods 0.000 description 8
- 241000894006 Bacteria Species 0.000 description 7
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 239000003513 alkali Substances 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 6
- 239000001963 growth medium Substances 0.000 description 6
- 150000002632 lipids Chemical class 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 230000001954 sterilising effect Effects 0.000 description 6
- 238000004659 sterilization and disinfection Methods 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 241000222178 Candida tropicalis Species 0.000 description 5
- 108091028043 Nucleic acid sequence Proteins 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 101150053659 POX4 gene Proteins 0.000 description 4
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- 230000008901 benefit Effects 0.000 description 4
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- 238000000576 coating method Methods 0.000 description 4
- YCOZIPAWZNQLMR-UHFFFAOYSA-N pentadecane Chemical compound CCCCCCCCCCCCCCC YCOZIPAWZNQLMR-UHFFFAOYSA-N 0.000 description 4
- 239000002504 physiological saline solution Substances 0.000 description 4
- 238000003822 preparative gas chromatography Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 239000007858 starting material Substances 0.000 description 4
- 239000006228 supernatant Substances 0.000 description 4
- WGTYBPLFGIVFAS-UHFFFAOYSA-M tetramethylammonium hydroxide Chemical compound [OH-].C[N+](C)(C)C WGTYBPLFGIVFAS-UHFFFAOYSA-M 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 239000008272 agar Substances 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 238000012856 packing Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- BGHCVCJVXZWKCC-UHFFFAOYSA-N tetradecane Chemical compound CCCCCCCCCCCCCC BGHCVCJVXZWKCC-UHFFFAOYSA-N 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 101150033406 CYP52A12 gene Proteins 0.000 description 2
- 101100161762 Candida tropicalis POX5 gene Proteins 0.000 description 2
- 101100168396 Debaryomyces hansenii CYP52A12 gene Proteins 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 2
- 238000010170 biological method Methods 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- TVIDDXQYHWJXFK-UHFFFAOYSA-N dodecanedioic acid Chemical compound OC(=O)CCCCCCCCCCC(O)=O TVIDDXQYHWJXFK-UHFFFAOYSA-N 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 238000012262 fermentative production Methods 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 239000002655 kraft paper Substances 0.000 description 2
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 230000035800 maturation Effects 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 150000007518 monoprotic acids Chemical class 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 239000002689 soil Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 239000008399 tap water Substances 0.000 description 2
- 235000020679 tap water Nutrition 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- QFGCFKJIPBRJGM-UHFFFAOYSA-N 12-[(2-methylpropan-2-yl)oxy]-12-oxododecanoic acid Chemical compound CC(C)(C)OC(=O)CCCCCCCCCCC(O)=O QFGCFKJIPBRJGM-UHFFFAOYSA-N 0.000 description 1
- HCUZVMHXDRSBKX-UHFFFAOYSA-N 2-decylpropanedioic acid Chemical compound CCCCCCCCCCC(C(O)=O)C(O)=O HCUZVMHXDRSBKX-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 101100433727 Caenorhabditis elegans got-1.2 gene Proteins 0.000 description 1
- 108090000201 Carboxypeptidase B2 Proteins 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 101100168397 Debaryomyces hansenii CYP52A13 gene Proteins 0.000 description 1
- 239000004831 Hot glue Substances 0.000 description 1
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 1
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
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- 238000002479 acid--base titration Methods 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- DCAYPVUWAIABOU-UHFFFAOYSA-N alpha-n-hexadecene Natural products CCCCCCCCCCCCCCCC DCAYPVUWAIABOU-UHFFFAOYSA-N 0.000 description 1
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- 150000001875 compounds Chemical class 0.000 description 1
- 239000010779 crude oil Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- SNRUBQQJIBEYMU-UHFFFAOYSA-N dodecane Chemical compound CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
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- 238000004108 freeze drying Methods 0.000 description 1
- 238000012268 genome sequencing Methods 0.000 description 1
- QQHJDPROMQRDLA-UHFFFAOYSA-N hexadecanedioic acid Chemical compound OC(=O)CCCCCCCCCCCCCCC(O)=O QQHJDPROMQRDLA-UHFFFAOYSA-N 0.000 description 1
- IIYFAKIEWZDVMP-UHFFFAOYSA-N linear paraffin C13 Natural products CCCCCCCCCCCCC IIYFAKIEWZDVMP-UHFFFAOYSA-N 0.000 description 1
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- 244000005700 microbiome Species 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
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- 229910052757 nitrogen Inorganic materials 0.000 description 1
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- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
Title | Proportioning |
Sucrose | 20g/L |
Corn steep liquor | 3g/L |
Yeast extract paste | 5g/L |
KH 2PO 4 | 8g/L |
Heavy wax | 50ml/L |
Urea (sterilization separately) | 3g/L |
Bacterial strain | The diprotic acid kind | Produce acid amount g/L |
CAT H4012 | Positive 12 carbon | 93.75 |
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210030278.4A CN103243032B (en) | 2012-02-10 | 2012-02-10 | Candida sake and fermentation process thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210030278.4A CN103243032B (en) | 2012-02-10 | 2012-02-10 | Candida sake and fermentation process thereof |
Publications (2)
Publication Number | Publication Date |
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CN103243032A true CN103243032A (en) | 2013-08-14 |
CN103243032B CN103243032B (en) | 2016-01-27 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201210030278.4A Active CN103243032B (en) | 2012-02-10 | 2012-02-10 | Candida sake and fermentation process thereof |
Country Status (1)
Country | Link |
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CN (1) | CN103243032B (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3550014A1 (en) * | 2018-04-04 | 2019-10-09 | Shanghai Cathay Biotech R&D Center Ltd. | Directed evolution of cyp52a12 gene and its use in dicarboxylic acid production |
CN110343675A (en) * | 2018-04-04 | 2019-10-18 | 上海凯赛生物技术研发中心有限公司 | The directed evolution of CYP52A12 gene and its application in binary acid production |
CN110684784A (en) * | 2018-07-06 | 2020-01-14 | 上海凯赛生物技术股份有限公司 | Long-chain dibasic acid with low content of monobasic acid impurities and production method thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1233658A (en) * | 1999-05-28 | 1999-11-03 | 清华大学 | Method for screening candida for high prodn. of long chain diacid |
CN1570124A (en) * | 2004-05-12 | 2005-01-26 | 上海凯赛生物技术研发中心有限公司 | Long chain normal dibasic acid production method |
CN101225411A (en) * | 2007-11-30 | 2008-07-23 | 中国科学院微生物研究所 | New method for biosynthetic production of mixed long-chain dibasic acid |
CN102191187A (en) * | 2011-04-01 | 2011-09-21 | 山东华星环保集团有限公司 | Candida lipolytica strain and method for preparing long chain dicarboxylic acid by using candida lipolytica strain |
-
2012
- 2012-02-10 CN CN201210030278.4A patent/CN103243032B/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1233658A (en) * | 1999-05-28 | 1999-11-03 | 清华大学 | Method for screening candida for high prodn. of long chain diacid |
CN1570124A (en) * | 2004-05-12 | 2005-01-26 | 上海凯赛生物技术研发中心有限公司 | Long chain normal dibasic acid production method |
CN101225411A (en) * | 2007-11-30 | 2008-07-23 | 中国科学院微生物研究所 | New method for biosynthetic production of mixed long-chain dibasic acid |
CN102191187A (en) * | 2011-04-01 | 2011-09-21 | 山东华星环保集团有限公司 | Candida lipolytica strain and method for preparing long chain dicarboxylic acid by using candida lipolytica strain |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3550014A1 (en) * | 2018-04-04 | 2019-10-09 | Shanghai Cathay Biotech R&D Center Ltd. | Directed evolution of cyp52a12 gene and its use in dicarboxylic acid production |
CN110343675A (en) * | 2018-04-04 | 2019-10-18 | 上海凯赛生物技术研发中心有限公司 | The directed evolution of CYP52A12 gene and its application in binary acid production |
US11091742B2 (en) | 2018-04-04 | 2021-08-17 | Cathay Biotech Inc. | Directed evolution of CYP52A12 gene and its use in dicarboxylic acid production |
CN110343675B (en) * | 2018-04-04 | 2023-05-12 | 上海凯赛生物技术股份有限公司 | Directed evolution of CYP52A12 gene and application thereof in dibasic acid production |
US11753629B2 (en) | 2018-04-04 | 2023-09-12 | Cathay Biotech Inc. | Directed evolution of CYP52A12 gene and its use in dicarboxylic acid production |
CN110684784A (en) * | 2018-07-06 | 2020-01-14 | 上海凯赛生物技术股份有限公司 | Long-chain dibasic acid with low content of monobasic acid impurities and production method thereof |
CN110684784B (en) * | 2018-07-06 | 2023-08-08 | 上海凯赛生物技术股份有限公司 | Long-chain dibasic acid with low content of monobasic acid impurity and production method thereof |
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Publication number | Publication date |
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CN103243032B (en) | 2016-01-27 |
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Effective date of registration: 20151106 Address after: 201203 Shanghai Zhangjiang hi tech park, 1690 No. 5 Cailun Road, building 4 floor Applicant after: CATHAY R&D CENTER Co.,Ltd. Applicant after: CATHAY INDUSTRIAL BIOTECH Ltd. Address before: 201203 Shanghai Zhangjiang hi tech park, 1690 No. 5 Cailun Road, building 4 floor Applicant before: CATHAY R&D CENTER Co.,Ltd. Applicant before: SHANDONG CATHAY BIOTECHNOLOGICAL MATERIAL Co.,Ltd. Applicant before: SHANGHAI CATHAY BIOTECHNOLOGY Co.,Ltd. Applicant before: CATHAY INDUSTRIAL BIOTECH Ltd. |
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