CN103239557B - Medicament for treating chronic eczema and production method of medicament - Google Patents

Abstract

The invention relates to a medicament for treating chronic eczema and a production method of the medicament. The current western medicine treatment mode of chronic eczema is mainly dependent on 4 types of medicaments, namely cortical hormone, an immunosuppressor, antihistamine and a moisturizing emollient. The western medicine treatment mode of the chronic eczema has a better curative effect, but has the defects of non-thorough treatment effect, easy relapse, large side effect and the like when being used for treating the chronic eczema. According to the medicament and the production method thereof, the medicament is produced from Sceptrocnide macrostachya Maxim, nidus vespae, radix sophorae flavescentis, tribulusterrestris, fructus cnidii, rehmannia root, red paeony root, moutan bark, cortex dictamni and dried alum, and an appropriate amount of medicament is dipped by a cotton swab to apply to affected parts. The medicament has the advantages of treatment of both symptoms and root causes, quick acting, good effect, low recurrence rate, less side effects, wide sources of raw materials, low cost and wide clinical application.

Description

A kind of medicine and manufacture method thereof for the treatment of chronic eczema

Technical field

The present invention relates to a kind of medicine, relate in particular to a kind of medicine and manufacture method thereof for the treatment of chronic eczema.

Background technology

1. chronic eczema sickness rate can be up to 10%～20% in developed country.The investigation demonstration that Inst. of Dermatology, Chinese Academy of Medical Sciences carries out the chronic eczema sickness rate of 7 years old to 20 years old population of adolescent of China, total prevalence rate is up to 0.69%, and China approximately has the puzzlement that is subject to chronic eczema over 2,300,000 teenager at present.Along with the quickening of Chinese Industrialization and modernization, can predict following chronic eczema will significantly increase at Chinese sickness rate as a kind of modern disease.

2. current chronic eczema western medical treatment mainly depends on the medicine of 4 kinds, is respectively 17-hydroxy-11-dehydrocorticosterone, immunosuppressant, hydryllin and humectants and emollients.Western medicine eczema curative effect is better, but in treatment, exist during chronic eczema treatment not thoroughly, the shortcoming such as easily recurrence, side effect be large.

Summary of the invention

The object of the present invention is to provide a kind ofly there is treating both the principal and secondary aspects of a disease, curative effect is fast, effective, relapse rate is low, few side effects, raw material is wide, cost is low, medicine and the manufacture method thereof of the treatment chronic eczema of clinical extensive utilization:

Treat a medicine for chronic eczema, it is comprised of effective ingredient and adjuvant, and raw material and the weight proportion of wherein making medicine are:

Herba Girardinlae Diversifoliae 15～30, Nidus Vespae 18～25, Radix Sophorae Flavescentis 5～15, Fructus Atriplicis Sibiricae 5～15, Fructus Cnidii 5～15, the Radix Rehmanniae 5～15, Radix Paeoniae Rubra 5～15, Cortex Moutan 5～15, Cortex Dictamni 5～15, dried Alumen 5～20.

Its optimization formula is: it is made the serve as reasons crude drug combination of following parts by weight of the raw material of medicine and weight proportion and makes:

Herba Girardinlae Diversifoliae 15～25, Nidus Vespae 18～20, Radix Sophorae Flavescentis 5～10, Fructus Atriplicis Sibiricae 5～10, Fructus Cnidii 5～10, the Radix Rehmanniae 5～10, Radix Paeoniae Rubra 5～10, Cortex Moutan 5～10, Cortex Dictamni 5～10, dried Alumen 5～15.

Its optimization formula is: it is made the serve as reasons crude drug combination of following parts by weight of the raw material of medicine and weight proportion and makes:

Herba Girardinlae Diversifoliae 20, Nidus Vespae 20, Radix Sophorae Flavescentis 10, Fructus Atriplicis Sibiricae 10, Fructus Cnidii 10, the Radix Rehmanniae 10, Radix Paeoniae Rubra 10, Cortex Moutan 10, Cortex Dictamni 10, dried Alumen 10.

Treat a medicine for chronic eczema, its manufacture method is:

(1) concentrated solution processed: weigh by weight ratio Herba Girardinlae Diversifoliae, Nidus Vespae, Fructus Atriplicis Sibiricae, Fructus Cnidii, the Radix Rehmanniae, Radix Paeoniae Rubra, Cortex Moutan, Cortex Dictamni, add up the water of 5～10 times of weight of dose, soak 0.25～1 hour, decoct 2～4 times, each 30～120min, will extract medicinal liquid and merge, and filter, be concentrated into volume and be 1.5～2.5 times of crude drug quality, standby;

(2) get load weighted Radix Sophorae Flavescentis by weight ratio, pulverize, cross 80～100 mesh sieves, sterilizing, standby;

(3) take 1～3% starch of the concentrated solution weight of (1) step, punching slurry, standby;

(4) mixed liquor processed: starch slurry and Lightyellow Sophora Root are mixed, add in the concentrated solution of step (1) gained, stir, standby;

(5) sterilized solution processed: load weighted dried Alumen adds the mixed liquor of step (4) gained by weight ratio, sterilizing is standby;

(6) measure the sterilized solution of step (5) gained, fill in sterilized environment, obtains.

5, a kind of medicine for the treatment of chronic eczema as claimed in claim 4, its manufacture method is:

(1) concentrated solution processed: weigh by weight ratio Herba Girardinlae Diversifoliae, Nidus Vespae, Fructus Atriplicis Sibiricae, Fructus Cnidii, the Radix Rehmanniae, Radix Paeoniae Rubra, Cortex Moutan, Cortex Dictamni, add up the water of 10 times of weight of dose, soak 1 hour, decoct 3 times, each 90min, will extract medicinal liquid and merge, filter, be concentrated into volume and be 1.5～2 times of crude drug quality,, standby;

(2) get load weighted Radix Sophorae Flavescentis by weight ratio, pulverize, cross 80 mesh sieves, sterilizing, standby;

(3) take 2% starch of the concentrated solution weight of (1) step, punching slurry, standby;

(4) mixed liquor processed: starch slurry and Lightyellow Sophora Root are mixed, add in the concentrated solution of step (1) gained, stir, standby;

(5) sterilized solution processed: load weighted dried Alumen adds the mixed liquor of step (4) gained by weight ratio, sterilizing is standby;

(6) measure the sterilized solution of step (5) gained, fill in sterilized environment, obtains.

Herba Girardinlae Diversifoliae: expelling wind and removing dampness, inducing diuresis and reducing edema.

Nidus Vespae: wind-expelling pain-stopping; Counteracting toxic substances detumescence; Killing parasites for relieving itching.

Radix Sophorae Flavescentis: heat clearing and damp drying, parasite killing, diuresis.

Fructus Atriplicis Sibiricae: suppressing the hyperactive liver resolving depression, dispelling pathogenic wind for improving eyesight.

Fructus Cnidii: warming the kidney to invigorate YANG, dampness, dispels the wind, parasite killing.

The Radix Rehmanniae: heat clearing away, promote the production of body fluid, moisturize, removing heat from blood, invigorate blood circulation.

Radix Paeoniae Rubra: invigorate blood circulation, removing heat from blood, detumescence, pain relieving.

Cortex Moutan: clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis.

Cortex Dictamni: heat clearing and damp drying, the removing toxic substances of dispeling the wind.

Dried Alumen: dampness, removing toxic substances, parasite killing.

The present invention is reasonably combined, learns from other's strong points to offset one's weaknesses, and Herba Girardinlae Diversifoliae expelling wind and removing dampness is antipruritic; The Radix Rehmanniae, Radix Paeoniae Rubra, the Cortex Moutan removing heat from blood that nourishes blood is nourshing Yin and drynsessmoistening prescription, is just answering the traditional Chinese medical science " to control wind and first control blood " theory; Cortex Dictamni, Nidus Vespae, Fructus Atriplicis Sibiricae, Fructus Cnidii, Radix Sophorae Flavescentis, dried Alumen dispelling wind for relieving itching, Nidus Vespae still has the effect of glucocorticoid sample.Full side's Herba Girardinlae Diversifoliae, the Radix Rehmanniae are monarch, and Radix Paeoniae Rubra, Cortex Moutan, Cortex Dictamni, Fructus Cnidii, Radix Sophorae Flavescentis, dried Alumen are minister, and Nidus Vespae is assistant, and Fructus Atriplicis Sibiricae is introduced Liver Channel for making.All medicines share, and play altogether the merit of the removing heat from blood that nourishes blood, nourshing Yin and drynsessmoistening prescription, dispelling wind for relieving itching.

The common sympton that the present invention relates to chronic eczema and be blood-deficiency and wind-dry type has: pruritus is immoderate, xerosis cutis desquamation, coarse shattered crack, seldom rotten to the corn flowing water, multipair title and limiting to, skin lesion has squama, knot blood crusts, large constipation; yellow urine, body of the tongue is partially red, white and thin fur or clean, wiry and frequent pulse.

Its pathogenic analysis: excessive because of seven emotions, cause heart-fire flourishing, inside disturb the heart-nutriment, secretly consume painstaking effort, blood deficiency domination of wind, is interwoven in skin, causes flesh natural fibre line of meat cervical carcinoma with cachexia, and skin ulcer rash stacks, thus there is pruritus immoderate, xerosis cutis desquamation, coarse shattered crack, skin lesion has squama, after scratching, ties blood crusts.Large constipation, yellow urine, body of the tongue is partially red, white and thin fur or clean, wiry and frequent pulses etc. resemble for deficiency of YIN-blood interior-heat.

Below provide clinical data

Treatment group man 72 examples, female's 78 examples, age (39.13 ± 11.45) year, the course of disease (5.38 ± 1.71) year; Matched group man 74 examples, female's 76 examples, age (40.00 ± 9.96) year, the course of disease (5.49 ± 1.55) year.Two groups in aspect comparisons such as sex, age, the course of disease, pruritus score, lichenization score, skin lesion integration and total marks, and no significant difference, has comparability.At 18～60 years old age, men and women does not limit.Get rid of acute subacute eczema patient; Be associated with the viscera diseases such as the middle severe heart, liver, lung, kidney; Be associated with the chronic diseases such as diabetes and cancer card medical history; Trimester of pregnancy, women breast-feeding their children; Following or above person of 65 one full year of life of 18 one full year of life of age; During treatment, arbitrarily end or change medicine and method person; Illiteracy, gestation or breast-feeding female, the known illness that is mentally ill, physical disabilities person.

Observation index and curative effect determinate standard: the self-symptom of observing treatment front and back is pruritus degree, skin lesion area, skin lesion form comprises erythema, pimple, lichenization, exfoliation.Efficacy evaluation is with pruritus, skin lesion area, skin lesion form, and the total mark of stadium weight coefficient calculates curative effect rate, and minute level Four is judged.Total mark=(erythra area integral+erythra Morphology score+pruritus degree integration) * stadium weight coefficient before and after treatment; Integration slip adopts nimodipine method, and computing formula is integration slip=[integration before (the rear total mark of total mark-treatment before treatment)/treatment] * 100%.Clinical recovery: skin lesion disappears completely, transference cure, integrated value reduces >=95%; Effective: skin lesion is most of to disappear, and symptom obviously alleviates, and 95%> integrated value reduces >=70%; Effective: skin lesion partly disappears, symptom makes moderate progress, and 70%> integrated value reduces >=50%; Invalid: skin lesion disappears not obvious, symptom does not alleviate or worsens on the contrary, and integrated value reduces less than 50%.

Therapeutic Method: by chronic eczema blood-deficiency and wind-dry type totally 300 examples, be divided at random each 150 examples for the treatment of group and matched group.Treatment group and matched group, all take nourishing blood to expel wind soup, ingredients: Radix Rehmanniae Preparata 12g, Radix Angelicae Sinensis 10g, Radix Paeoniae Alba 10g, Radix Salviae Miltiorrhizae 15g, Radix Gentianae Macrophyllae 10g, Radix Saposhnikoviae 10g, Periostracum Cicadae 5g, Radix Rehmanniae 30g, Semen Lini 9g, Cortex Dictamni 9g, Fructus Atriplicis Sibiricae 15g, Fructus Cnidii 9g orally.1 dose of day, decocting mixes minute 3 decoction being taken warmly 3 times.Treatment group external Chinese medicine preparation of the present invention, embrocates skin lesion place, the morning, noon and afternoon each 1 time.Matched group external carbamide ointment, 3 times/day.Be 4 weeks the course for the treatment of.Observe clinical symptoms change and clinical efficacy.

Statistical analysis technique: data input spss16.0 is analyzed.Measurement data data acquisition carries out descriptive statistics by mean ± standard deviation.Person checks with t to meet normal distribution, or t ' check, does not meet normal distribution non parametric tests.Enumeration data non parametric tests.

Result: treatment group total effective rate is 87.93%, matched group total effective rate is that 77.19%, two group of comparing difference has significant.And all without obvious adverse reaction.Conclusion: external Chinese medicine preparation of the present invention, has feature safely and effectively.In Table 1, table 2.

Two groups of patient clinical curative effects of table 1 blood-deficiency and wind-dry type comparison (%)

Group	n	Recovery from illness	Effective	Effectively	Invalid	Total effective rate (%)
							Treatment group	58	12	15	24	7	87.93
Matched group	57	5	11	28	13	77.19

Note: two groups of therapeutic effect relatively adopt rank test, difference have significant ( p< 0.05)

The cardinal symptom integral contrast that table 2 blood-deficiency and wind-dry type is two groups

Symptom	Group	n	Before treatment	After treatment
					Pruritus	Treatment group	58	2.79 ±0.31	1.12±0.82 **
?	Matched group	57	2.79 ±0.33	1.37±0.84 **
					Skin lesion integration	Treatment group	58	10.77 ±1.02	4.39±1.32 **#
?	Matched group	57	11.42 ±1.01	5.83±1.07 **
					Lichenization	Treatment group	58	2.91 ±0.25	1.01±0.15 **#
?	Matched group	57	2.71±0.16	1.78±0.28 **

Note: with before treatment relatively, difference have significant ( ^* p< 0.05, ^* p< 0.01); With matched group comparison, difference have significant ( ^# p< 0.05, ^## p< 0.01)

Clinical trial demonstration, it is evident in efficacy, especially the successful to chronic eczema.The features such as easy to use, onset rapidly, definite effect, safety be controlled, have no side effect.

The specific embodiment

Below in conjunction with concrete enforcement, the present invention will be further described, but example is not as limiting to the invention.

Embodiment mono-:

(1) get Herba Girardinlae Diversifoliae 15kg, Nidus Vespae 18kg, Fructus Atriplicis Sibiricae 5kg, Fructus Cnidii 5kg, Radix Rehmanniae 5kg, Radix Paeoniae Rubra 5kg, Cortex Moutan 5kg, the Cortex Dictamni 5kg of recipe quantity.Add water 365kg, soak 1 hour, decoct 3 times, each 90min.To extract medicinal liquid and merge, filter, be concentrated into 126 liters, standby;

(2) get the Radix Sophorae Flavescentis 5kg of recipe quantity, pulverize, cross 80 mesh sieves, sterilizing, standby;

(3) get starch 2.52Kg, punching slurry, standby;

(4) starch slurry and Lightyellow Sophora Root are mixed, add in the concentrated solution of step (1) gained, stir, standby;

(5) dried Alumen 5kg is added to the concentrated solution of step (4) gained, sterilizing, standby;

(6) measure the sterilized solution of step (5) gained, fill in sterilized environment, obtains.

With medical cotton stick, collect together and get the appropriate coating of this Chinese medicine preparation in affected part, every 4 hours 1 time.

Embodiment bis-:

(1) concentrated solution processed: weigh by weight ratio Herba Girardinlae Diversifoliae 20kg, Nidus Vespae 20kg, Fructus Atriplicis Sibiricae 10kg, Fructus Cnidii 10kg, Radix Rehmanniae 10kg, Radix Paeoniae Rubra 10kg, Cortex Moutan 10kg, Cortex Dictamni 10kg, the water of totalling dose 1000kg, soak 1 hour, decoct 3 times, each 90min, to extract medicinal liquid merges, filter, be concentrated into 200 liters, standby; Soak 1 hour, decoct 3 times, each 90min, will extract medicinal liquid and merge, and filter, and be concentrated into 250ml, standby;

(2) get load weighted Radix Sophorae Flavescentis 10kg by weight ratio, pulverize, cross 100 mesh sieves, sterilizing, standby;

(3) take starch 4Kg, punching slurry, standby;

(4) mixed liquor processed: starch slurry and Lightyellow Sophora Root are mixed, add in the concentrated solution of step (1) gained, stir, standby;

(5) sterilized solution processed: load weighted dried Alumen 10kg adds the mixed liquor of step (4) gained by weight ratio, sterilizing is standby;

(6) measure the sterilized solution of step (5) gained, fill in sterilized environment, obtains.With medical cotton stick, collect together and get external Chinese medicine preparation of the present invention, embrocate skin lesion place, the morning, noon and afternoon each 1 time.

Embodiment tri-:

(1) concentrated solution processed: weigh by weight ratio Herba Girardinlae Diversifoliae 30kg, Nidus Vespae 25kg, Fructus Atriplicis Sibiricae 15kg, Fructus Cnidii 15kg, Radix Rehmanniae 15kg, Radix Paeoniae Rubra 15kg, Cortex Moutan 15kg, Cortex Dictamni 15kg, the water of totalling dose 1200kg, soak 0.5 hour, decoct 2 times, each 120min, to extract medicinal liquid merges, filter, be concentrated into 290 liters, standby;

(2) get load weighted Radix Sophorae Flavescentis 15kg by weight ratio, pulverize, cross 100 mesh sieves, sterilizing, standby;

(3) take starch 5.8Kg, punching slurry, standby;

(4) mixed liquor processed: starch slurry and Lightyellow Sophora Root are mixed, add in the concentrated solution of step (1) gained, stir, standby;

(5) sterilized solution processed: load weighted dried Alumen 10kg adds the mixed liquor of step (4) gained by weight ratio, sterilizing is standby;

(6) measure the sterilized solution of step (5) gained, fill in sterilized environment, obtains.

Claims (5)

1. a medicine for the treatment of chronic eczema, is characterized in that: it is comprised of effective ingredient and adjuvant, and raw material and the weight proportion of wherein making medicine are:

Herba Girardinlae Diversifoliae 15～30, Nidus Vespae 18～25, Radix Sophorae Flavescentis 5～15, Fructus Atriplicis Sibiricae 5～15, Fructus Cnidii 5～15, the Radix Rehmanniae 5～15, Radix Paeoniae Rubra 5～15, Cortex Moutan 5～15, Cortex Dictamni 5～15, dried Alumen 5～20.

2. a kind of medicine for the treatment of chronic eczema as claimed in claim 1, is characterized in that: it is made the serve as reasons crude drug combination of following parts by weight of the raw material of medicine and weight proportion and makes:

Herba Girardinlae Diversifoliae 15～25, Nidus Vespae 18～20, Radix Sophorae Flavescentis 5～10, Fructus Atriplicis Sibiricae 5～10, Fructus Cnidii 5～10, the Radix Rehmanniae 5～10, Radix Paeoniae Rubra 5～10, Cortex Moutan 5～10, Cortex Dictamni 5～10, dried Alumen 5～15.

3. a kind of medicine for the treatment of chronic eczema as claimed in claim 1, is characterized in that: it is made the serve as reasons crude drug combination of following parts by weight of the raw material of medicine and weight proportion and makes:

Herba Girardinlae Diversifoliae 20, Nidus Vespae 20, Radix Sophorae Flavescentis 10, Fructus Atriplicis Sibiricae 10, Fructus Cnidii 10, the Radix Rehmanniae 10, Radix Paeoniae Rubra 10, Cortex Moutan 10, Cortex Dictamni 10, dried Alumen 10.

4. a kind of medicine for the treatment of chronic eczema described in claim 1,2 or 3, its manufacture method is:

(1) concentrated solution processed: weigh by weight ratio Herba Girardinlae Diversifoliae, Nidus Vespae, Fructus Atriplicis Sibiricae, Fructus Cnidii, the Radix Rehmanniae, Radix Paeoniae Rubra, Cortex Moutan, Cortex Dictamni, add up the water of 5～10 times of weight of dose, soak 0.25～1 hour, decoct 2～4 times, each 30～120min, will extract medicinal liquid and merge, and filter, be concentrated into volume and be 1.5～2.5 times of crude drug quality, standby;

(2) get load weighted Radix Sophorae Flavescentis by weight ratio, pulverize, cross 80～100 mesh sieves, sterilizing, standby;

(3) take 1～3% starch of the concentrated solution weight of (1) step, punching slurry, standby;

(4) mixed liquor processed: starch slurry and Lightyellow Sophora Root are mixed, add in the concentrated solution of step (1) gained, stir, standby;

(5) sterilized solution processed: load weighted dried Alumen adds the mixed liquor of step (4) gained by weight ratio, sterilizing is standby;

(6) measure the sterilized solution of step (5) gained, fill in sterilized environment, obtains.

5. a kind of medicine for the treatment of chronic eczema as claimed in claim 4, its manufacture method is:

(1) concentrated solution processed: weigh by weight ratio Herba Girardinlae Diversifoliae, Nidus Vespae, Fructus Atriplicis Sibiricae, Fructus Cnidii, the Radix Rehmanniae, Radix Paeoniae Rubra, Cortex Moutan, Cortex Dictamni, add up the water of 10 times of weight of dose, soak 1 hour, decoct 3 times, each 90min, will extract medicinal liquid and merge, filter, be concentrated into volume and be 1.5～2 times of crude drug quality,, standby;

(2) get load weighted Radix Sophorae Flavescentis by weight ratio, pulverize, cross 80 mesh sieves, sterilizing, standby;

(3) take 2% starch of the concentrated solution weight of (1) step, punching slurry, standby;

(4) mixed liquor processed: starch slurry and Lightyellow Sophora Root are mixed, add in the concentrated solution of step (1) gained, stir, standby;

(5) sterilized solution processed: load weighted dried Alumen adds the mixed liquor of step (4) gained by weight ratio, sterilizing is standby;

(6) measure the sterilized solution of step (5) gained, fill in sterilized environment, obtains.