CN103234595B - A kind of measuring method of capsule medicinal powder loading amount - Google Patents
A kind of measuring method of capsule medicinal powder loading amount Download PDFInfo
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- CN103234595B CN103234595B CN201310109155.4A CN201310109155A CN103234595B CN 103234595 B CN103234595 B CN 103234595B CN 201310109155 A CN201310109155 A CN 201310109155A CN 103234595 B CN103234595 B CN 103234595B
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Abstract
The present invention relates to a kind of measuring method of capsule medicinal powder loading amount, it is by putting into capsule the changeable airtight container of volume, keeping changing the air pressure of gas in container by applying the mode of outer force compresses or expansion vessel volume under the constant prerequisite of gas in container total amount, thereby calculating the volume of medicinal powder in capsule according to the change of this air pressure. The method is simple and easy to do, and implementation cost is low.
Description
Technical field
The present invention relates to a kind of measuring method of the volume of measuring non-pneumatic material, particularly measure the method for the medicinal powder content that loads in capsule.
Background technology
In pharmaceuticals industry field, due to the impact of the many factors such as stability and medicinal powder self-characteristic of capsule filling apparatus self, making in the production process of capsule the weight of institute's powder charge powder in it is that capsule grain heavily exists fluctuation, and for the medicine for the treatment of disease, the amount of contained drug in UD, be heavy just must being stabilized in a narrower scope of grain of every capsules, so pharmacy corporation can heavily carry out strict management and control and measurement to the grain of capsule, detects and reject a heavy undesirable defect ware.
The method of at present capsule being carried out to a remeasurement is mainly to utilize various mechanical balances, electronic balance or utilize the various weighing-appliances of weight sensor principle to carry out direct weighing measurement, but these modes all exist this many drawback. The weighing process of various mechanical balances, electronic balance all needs to operate manually, and drawback is: detection speed is slow, inefficiency, complex operation; Cannot realize on-line automatic weighing, can only be used for sampling observation, cannot realize capsule is carried out weighing by grain, the method, to the heavy monitoring dynamics of capsule grain and limited, still has a lot of the undesirable capsules of weight to be detected. Although and the various equipment operating efficiency of utilizing weight sensor principle significantly improves, can realize capsule is weighed by grain, also have its remarkable drawback: equipment precision, cost is very expensive, is unfavorable for promoting at pharmacy corporation; System complex, maintenance difficulties is large, and maintenance cost is high.
Summary of the invention
The object of this invention is to provide a kind of assay method of capsule medicinal powder loading amount, it can measure rapidly to batch capsule the content of capsule filling medicinal powder, and cost is very low.
To achieve these goals, the invention provides a kind of measuring method of capsule medicinal powder loading amount, comprise the following steps:
(a), choose the container of variable volume, capsule to be measured is inserted in this container, airtight container is also measured the original volume V1 of container, now the air pressure in container is that ambient pressure is P1, the air pressure of capsule to be measured is also P1;
(b), by the volume of outer force compresses or expansion vessel, make vessel volume reach V2, stop compression or the operation of expansion vessel, measure the air pressure P2 in container now, and the air pressure of capsule to be measured also reaches P2;
(c), calculate the volume V of medicinal powder in capsule according to formula V=(P2*V2-P1*V1)/(P2-P1)-V0, wherein, the volume that V0 is capsule housing.
Container is being applied to external force, compression or expansion vessel air pressure in container is increased or the process that reduces in, the air pressure in capsule also can be along with gas enters or spills and change from the gap of capsule shells, until with container in air pressure P2 balance. Change and meet Boyle's law and the unconverted principle of the volume of fixed substance according to gas volume, can measure the cumulative volume of capsule shells and medicinal powder, finally draw the volume of medicinal powder. Whole measuring process completes fast, and is simple and easy to implement.
Further, in step (c) afterwards, according to the density of the medicinal powder of the volume V of measured medicinal powder and precognition, can calculate the weight of medicinal powder, with the demand of more realistic application.
Advantage of the present invention is: by seal of vessel, by outer force compresses or expansion vessel, the gas gross in this process in container is constant, after vessel volume changes, its air pressure inside changes thereupon, calculate the medicinal powder loading amount in capsule according to final air pressure, the method is simple and easy to do, and implementation cost is low. Weigh compared with screening installation with weight sensor class, the requirement of the aspect such as sampling and processing difficulty and anti-interference of the measure of precision of the method to equipment, signal is all very low, also can be lower for the equipment cost of carrying out the method, and be convenient to safeguard, be beneficial at pharmacy corporation and promote the use of.
Detailed description of the invention
The present invention makes container internal gas pressure increase or reduce by compressing or expand the volume of the airtight container of placing capsule, and measure the medicinal powder content in capsule to be measured according to the air pressure change before and after in container, and the inside and outside volume of air of capsule forms the volume of container jointly in the housing volume of the volume of medicinal powder and capsule to be measured and container, the present invention is mainly that the principle of utilizing gas volume variation to meet Boyle's law is calculated the inside and outside volume of air of capsule, thereby records the medicinal powder volume in capsule according to formula. Below in conjunction with several embodiment, content of the present invention is described in detail.
Embodiment mono-:
Choose the changeable container of volume, it is flexible for example on container, having part wall at least, or cylinder etc. Capsule to be measured is put into container, airtight container, now the volume of container is initial value V1.
Exert pressure to the position such as elastic wall or piston of container and make the compressed V2 of being decreased to of volume of container by external force, gas in this process in container is compressed and air pressure rises gradually, compressed air can enter capsule by the gap between capsule utricule capsule cap, thereby the gas of capsule is also compressed, air pressure also can rise gradually, until with the same P2 that all rises to of air pressure in container.
Known according to Boyle's law: P1 (V1-V0-V)=P2 (V2-V0-V), wherein, V0 is the volume of the capsule housing learnt in advance itself, V represents the volume of medicinal powder in capsule, can draw thus: volume V=(P2*V2-P1*V1)/(the P2-P1)-V0 of medicinal powder in capsule, then can, according to the density of institute's powder charge powder in capsule, further calculate the weight of medicinal powder.
Embodiment bis-:
Similar to embodiment mono-, first should choose the changeable container of volume, capsule to be measured is put into this container, airtight container, now the volume of container is initial value V1.
Applying pulling capacity by external force to the position such as elastic wall or piston of container makes the volume expansion of container increase to V2, gas in this process in container thins out and air pressure declines gradually, the air of capsule also can spill by the gap between utricule capsule cap simultaneously, finally makes the air pressure of capsule and the same P2 that all drops in container.
Identical with embodiment mono-, known according to Boyle's law: P1 (V1-V0-V)=P2 (V2-V0-V), wherein, V0 is the volume of the capsule housing learnt in advance itself, V represents the volume of medicinal powder in capsule, just can calculate the volume of medicinal powder in capsule, then can, according to the density of institute's powder charge powder in capsule, further calculate the weight of medicinal powder according to formula V=(P2*V2-P1*V1)/(P2-P1)-V0 thus.
The difference of this embodiment and embodiment mono-is actual is shifting gears of vessel volume, the mode of embodiment mono-is the pressure rises that makes gas in container and capsule by the volume of compression container, and the mode of the present embodiment is by the volume of expansion vessel, the air pressure of gas in container and capsule to be declined. What in fact two kinds of modes were used is identical principle, i.e. Boyle's law.
In fact the disclosed method of the present invention is not limited to the measurement of the interior medicinal powder loading amount of capsule that is applied in field of medicaments, in fact also comprise the cubing of the non-pneumatic material of the similar structure in other field, i.e. the cubing of the inner non-pneumatic material that contains air. By changing the volume of container, the air pressure of the gas in container is changed, thereby according to this variation aeriferous volume in measurement of species again, and further extrapolate the volume of non-pneumatic material, even weight.
Above specific embodiment of the present invention is illustrated; but protection content of the present invention is not only limited to above embodiment, in affiliated technical field of the present invention, the common knowledge of a GPRS; just can, within the scope of its technology main idea, carry out diversified change.
Claims (2)
1. a measuring method for capsule medicinal powder loading amount, is characterized in that comprising the following steps:
(a), choose the container of variable volume, capsule to be measured is inserted in this container, airtight container is also measuredThe original volume V1 of container, now the air pressure in container is that ambient pressure is P1, the air pressure of capsule to be measuredAlso be P1;
(b), by the volume of external force compression container, make vessel volume reach V2, stop the behaviour of compression containerDo, measure the air pressure P2 in container now, and the air pressure of capsule to be measured also reaches P2;
(c), calculate medicinal powder in capsule according to formula V=(P2*V2-P1*V1)/(P2-P1)-V0Volume V, wherein, the volume that V0 is capsule housing.
2. method according to claim 1, is characterized in that: in step (c) afterwards, and according to measuredThe volume V of medicinal powder and the density of the medicinal powder of precognition, calculate the weight of medicinal powder.
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| CN201310109155.4A CN103234595B (en) | 2013-03-17 | 2013-03-17 | A kind of measuring method of capsule medicinal powder loading amount |
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| CN201310109155.4A CN103234595B (en) | 2013-03-17 | 2013-03-17 | A kind of measuring method of capsule medicinal powder loading amount |
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| CN103234595A CN103234595A (en) | 2013-08-07 |
| CN103234595B true CN103234595B (en) | 2016-05-18 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19651252A1 (en) * | 1996-12-10 | 1998-06-18 | Hamilton Bonaduz Ag | Method and device for determining the volume of a gas and / or the volume of a sample of solid and / or liquid material |
| CN2322128Y (en) * | 1998-01-26 | 1999-06-02 | 中华全国供销合作总社杭州茶叶研究所 | Instrument for measuring silkworm cocoon volume |
| CN101625234A (en) * | 2008-07-11 | 2010-01-13 | 柳州市圣诺化工有限责任公司 | System and method for measuring true volume of gathered-state substances with gaps |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8513586D0 (en) * | 1985-05-30 | 1985-07-03 | Int Research & Dev Co Ltd | Volume determination |
| DE4315455A1 (en) * | 1993-05-10 | 1994-11-17 | Merkel Wolfgang | Sorption gas pyknometer |
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2013
- 2013-03-17 CN CN201310109155.4A patent/CN103234595B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19651252A1 (en) * | 1996-12-10 | 1998-06-18 | Hamilton Bonaduz Ag | Method and device for determining the volume of a gas and / or the volume of a sample of solid and / or liquid material |
| CN2322128Y (en) * | 1998-01-26 | 1999-06-02 | 中华全国供销合作总社杭州茶叶研究所 | Instrument for measuring silkworm cocoon volume |
| CN101625234A (en) * | 2008-07-11 | 2010-01-13 | 柳州市圣诺化工有限责任公司 | System and method for measuring true volume of gathered-state substances with gaps |
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