CN103211957B - Alcohol relieving and liver protecting composition and application thereof - Google Patents
Alcohol relieving and liver protecting composition and application thereof Download PDFInfo
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- CN103211957B CN103211957B CN201310157072.2A CN201310157072A CN103211957B CN 103211957 B CN103211957 B CN 103211957B CN 201310157072 A CN201310157072 A CN 201310157072A CN 103211957 B CN103211957 B CN 103211957B
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- liver
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- bulbus allii
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- 239000000203 mixture Substances 0.000 title claims abstract description 38
- 210000004185 liver Anatomy 0.000 title claims abstract description 33
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims abstract description 27
- 230000002633 protecting effect Effects 0.000 title claims abstract description 23
- RXUWDKBZZLIASQ-UHFFFAOYSA-N Puerarin Natural products OCC1OC(Oc2c(O)cc(O)c3C(=O)C(=COc23)c4ccc(O)cc4)C(O)C(O)C1O RXUWDKBZZLIASQ-UHFFFAOYSA-N 0.000 claims abstract description 16
- HKEAFJYKMMKDOR-VPRICQMDSA-N puerarin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=C(O)C=CC(C2=O)=C1OC=C2C1=CC=C(O)C=C1 HKEAFJYKMMKDOR-VPRICQMDSA-N 0.000 claims abstract description 16
- 239000003814 drug Substances 0.000 claims abstract description 14
- 231100000753 hepatic injury Toxicity 0.000 claims abstract description 12
- 206010067125 Liver injury Diseases 0.000 claims abstract description 3
- 208000007848 Alcoholism Diseases 0.000 claims description 26
- 201000007930 alcohol dependence Diseases 0.000 claims description 26
- 239000002775 capsule Substances 0.000 claims description 8
- 238000002481 ethanol extraction Methods 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 6
- 239000002671 adjuvant Substances 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 17
- 239000002994 raw material Substances 0.000 abstract description 5
- 240000002234 Allium sativum Species 0.000 abstract description 4
- 235000004611 garlic Nutrition 0.000 abstract description 4
- 229940079593 drug Drugs 0.000 abstract description 2
- 239000000469 ethanolic extract Substances 0.000 abstract 1
- 239000012467 final product Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 241000699670 Mus sp. Species 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 238000010998 test method Methods 0.000 description 5
- 238000000605 extraction Methods 0.000 description 4
- 230000037396 body weight Effects 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 238000003304 gavage Methods 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 208000005584 Alcoholic Intoxication Diseases 0.000 description 2
- 241001529936 Murinae Species 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000001476 alcoholic effect Effects 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 210000005228 liver tissue Anatomy 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 241000234282 Allium Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000222336 Ganoderma Species 0.000 description 1
- 241000234280 Liliaceae Species 0.000 description 1
- 244000046146 Pueraria lobata Species 0.000 description 1
- 235000010575 Pueraria lobata Nutrition 0.000 description 1
- 240000006394 Sorghum bicolor Species 0.000 description 1
- 235000011684 Sorghum saccharatum Nutrition 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 239000003673 groundwater Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000002443 hepatoprotective effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007102 metabolic function Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- HBYYJIPCYANMBX-BAOOBMCLSA-M sodium;[(3s,4r,5r)-3,4,5-trihydroxy-2-oxo-6-phosphonooxyhexyl] hydrogen phosphate Chemical compound [Na+].OP(=O)(O)OC[C@@H](O)[C@@H](O)[C@H](O)C(=O)COP(O)([O-])=O HBYYJIPCYANMBX-BAOOBMCLSA-M 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses an alcohol relieving and liver protecting composition which comprises the components in percentage by weight as follows: 20-45% of puerarin and 55-80% of garlic, wherein the garlic is preferably a garlic ethanol extract. The invention further discloses application of the composition in preparing medicines for treating and preventing liver injury. The composition disclosed by the invention is easy in obtaining of the raw materials and low in cost, has remarkable alcohol relieving and liver protecting effect, and is less in side effect and safe and stable in efficacy.
Description
Technical field
The present invention relates to a kind of compositions for relieving alcoholism and protecting the liver.
Background technology
In China, Chinese liquor has become a kind of culture, along with the raising of people's living standard and the development of society, no matter entertain or public affair reception in friend's party, commercial affairs, all can not keep from drink.But too much drinks, great threat can be caused to healthy, no matter be to stomach or liver or other organs, of great impact, because gastrorrhagia, alcoholic liver etc. that insobriety causes are more and more.
Radix Puerariae (Radix Puerariae) is legume pueraria lobata, is a kind of plant of common medicine-food two-purpose.Modern pharmacology research shows, Radix Puerariae has the hepatocellular regeneration capacity of raising, recover normal liver function, promote bile secretion, prevent fat from piling up at liver, and can enhance metabolism, strengthen liver detoxification function, prevent ethanol to the effect of the damage of liver, flavones ingredient puerarin (puerarin) wherein plays Main Function especially, so people are applied to medicine or the health product of relieving alcoholism and protecting the liver.But, still there is various problem in the medicine relieved the effect of alcohol reported at present or health product.
Such as, publication No. is the Chinese patent application of 102106876A, discloses a kind of antialcoholism capsule containing Fructose Diphosphate sodium, puerarin and Ganoderma spore powder with cellular wall broken, and this antialcoholism capsule exists that cost of material is high, complicated process of preparation and the problem of less effective.Such as publication No. is the Chinese patent application of CN101874857A again, discloses a kind of liver-protecting white spirit containing Radix Puerariae, Fructus Lycii, Fructus Crataegi and Fructus Chaenomelis, and this liver-protecting white spirit exists the more more complicated and problem of less effective of raw material.In addition, also have a lot of report adopting Radix Puerariae or puerarin to carry out the compositions of compatibility, they also often exist, and raw material be more, not easily acquisition, complex manufacturing technology, cost are higher, the problem of less effective.Because all medicines are the same with ethanol, generally all need to carry out metabolism through liver, if composition is too complicated, the burden of liver can be increased on the contrary, the effect of relieving alcoholism and protecting the liver is had a greatly reduced quality, and very multicomponent pharmacology is not yet clear, the interaction especially after compatibility is also indefinite for healthy impact, there is potential danger.
Bulbus Allii (Allium sativum L) is Liliaceae allium, its underground bulb conventional.Garlicin wherein has had report to can be used for relieving the effect of alcohol, but its effect needs to be improved further.
Summary of the invention
One of goal of the invention of the present invention is: for above-mentioned Problems existing, provides a kind of definite effect, instant effect, side effect is little, relieving alcoholism and protecting the liver compositions that cost is low.
The technical solution used in the present invention is such: a kind of relieving alcoholism and protecting the liver compositions, is made up of the component of following weight percentage ratio:
Puerarin 20-45%
Bulbus Allii 55%-80%.
Above-mentioned weight ratio is dry weight, and in each component, biodiversity content is below 1%.
Inventor is found by great many of experiments: puerarin and Bulbus Allii adopt suitable ratio to coordinate, and can produce synergistic function for relieving alcoholism and protecting the liver.
As preferably: described Bulbus Allii is Bulbus Allii ethanol extraction.
Further research shows: extracted by ethanol by raw material Bulbus Allii, remove the part aqueous composition in Bulbus Allii, refining effective ingredient wherein, makes relieving alcoholism and protecting the liver effect more definite, also further mitigate the metabolism burden of liver, enhance the metabolic function of liver.
Extracting method is: after being smashed to pieces by Bulbus Allii, adds aquiferous ethanol and soaks, and can be aided with ultrasonic acceleration and extract, can be aided with heating simultaneously, but heating-up temperature should not higher than 60 DEG C, and in order to improve extraction efficiency, extraction time can control, at 2 hours, then to filter, concentrated, dry, to obtain final product.
Further: the ethanol extraction of described Bulbus Allii ethanol extraction to be volumetric concentration be 20%-55%.
Inventor finds further, and volumetric concentration is the Bulbus Allii extract of the ethanol extraction of 20%-55%, and the effect removing water soluble ingredient is better, and active constituent content is wherein higher.
Goal of the invention two of the present invention, is the application providing above-mentioned composition, is included in for the preparation of the application in the medicine for the treatment of hepatic injury, and for the preparation of the application in the medicine of preventing liver injury.
As preferably: described hepatic injury is the hepatic injury because ethanol causes.
As preferably: add pharmaceutically acceptable adjuvant and make capsule.Make capsule agent to take and carry all very convenient, and cost is lower.
As preferably: add pharmaceutically acceptable adjuvant and make tablet.Making tablets carries all very convenient, and cost is lower.
In sum, owing to have employed technique scheme, the invention has the beneficial effects as follows: raw material is simple and easy to get, with low cost; There is significant relieving alcoholism and protecting the liver effect, and few side effects, drug effect safety and stability.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in detail.
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with embodiment, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
Embodiment 1:
A kind of relieving alcoholism and protecting the liver compositions, is made up of following component:
Puerarin 20g, Bulbus Allii 80g; Mix homogeneously and get final product.
Embodiment 2:
A kind of relieving alcoholism and protecting the liver compositions, is made up of the component of following weight percentage ratio:
Puerarin 32g, Bulbus Allii 68g; Mix homogeneously and get final product.
Embodiment 3:
A kind of relieving alcoholism and protecting the liver compositions, is made up of the component of following weight percentage ratio:
Puerarin 40g, Bulbus Allii 60g; Mix homogeneously and get final product.
Embodiment 4:
A kind of relieving alcoholism and protecting the liver compositions, is made up of the component of following weight percentage ratio:
Puerarin 45g, Bulbus Allii 55g; Mix homogeneously and get final product.
Embodiment 5:
A kind of relieving alcoholism and protecting the liver compositions, is made up of the component of following weight percentage ratio:
Puerarin 32g, Bulbus Allii 68g, Bulbus Allii wherein adopts volumetric concentration to carry out the Bulbus Allii extract extracted than the ethanol being 50%, adopts spray-dired method to carry out drying after extraction and isolation; Then mix homogeneously with puerarin and get final product.
Embodiment 6:
A kind of relieving alcoholism and protecting the liver compositions, is made up of the component of following weight percentage ratio:
Puerarin 45g, Bulbus Allii 55g, Bulbus Allii wherein adopts volumetric concentration to carry out the Bulbus Allii extract extracted than the ethanol being 55%, adopts spray-dired method to carry out drying after extraction and isolation; Then mix homogeneously with puerarin and get final product.
The compositions of above-described embodiment 1-6, can adopt the ordinary skill in the art to be prepared into capsule or tablet.
Embodiment 7 mice relieving alcoholic intoxication is tested
This test employing publication number is the test method that the embodiment 1 of the embodiment part of the Chinese patent application of 102727571A is recorded, wherein
Test specimen comprises: experimental group 1-6(is respectively the relieving alcoholism and protecting the liver compositions obtained by the embodiment of the present application 1-6); Experimental control (the wherein Medicament for Alcoholism obtained by embodiment 1 of the embodiment part of " matched group 1 " Chinese patent application that is 102727571A for publication number, " matched group 2 " is negative control, i.e. normal saline gavage, " matched group 3 " is the Medicament for Alcoholism only containing Radix Puerariae, and " matched group 4 " is only containing the Medicament for Alcoholism adopting volumetric concentration to make than the Bulbus Allii extract that the ethanol being 50% carries out extracting);
Subjects: the Red Star strong, colourless liquor distilled from sorghum of 56 °, Hongxing Co., Ltd. Beijing; SPF level male mice 200, body weight 20 ± 2g;
Test method: be divided into 10 groups of (1-6 group relieving alcoholism and protecting the liver compositionss respectively obtained by gavage the embodiment of the present application 1-6 at random, 7th group is aforesaid " matched group 1 ", 8th group is aforesaid " matched group 2 ", 9th group is aforesaid " matched group 3 ", 10th group is aforesaid " matched group 4 ") often organize 20, except the 8th group, the groundwater increment of every mouse test sample is 0.2mg/10g body weight by dry weight basis, all the other and publication number are that the test method that the embodiment 1 of the embodiment part of the Chinese patent application of 102727571A is recorded is the same, the tolerance time obtained and hold time as shown in table 1:
Table 1 mice relieving alcoholic intoxication result of the test: (unit of time is min)
As can be seen from Table 1, the compositions that the application obtains, compared with independent Radix Puerariae or Bulbus Allii extract, and compared with publication number compositions disclosed in the Chinese patent application of 102727571A, has unforeseeable excellent effect of relieving the effect of alcohol.
Embodiment 8 anti-acute alcohol liver loss test
Test specimen is the same with the above embodiments 7, subjects is the male alcoholic hepatic injury mice of SPF level 200, body weight 20 ± 2g, be divided into 10 groups at random, the wherein compositions of 1-6 group difference administration the embodiment of the present application 1-6, the Medicament for Alcoholism obtained by embodiment 3 of the embodiment part of the 7th group of Chinese patent application that administration publication number is 102727571A, 8th group is negative control, i.e. normal saline gavage, 9th group is the Medicament for Alcoholism of administration only containing Radix Puerariae, 10th group is that administration is only containing the Medicament for Alcoholism adopting volumetric concentration to make than the Bulbus Allii extract that the ethanol being 50% carries out extracting, all the other test methods and publication number are that the test method that the embodiment 3 of the embodiment part of the Chinese patent application of 102727571A is recorded is consistent, testing program difference is wherein: except the 8th group, the dosage of every mouse test sample every day is all by the standard of 600mg/kgbw, the mice serum ALT finally recorded, AST is active, CHOL and TG content is as shown in table 2, SOD in the murine liver tissue recorded, GSH is active and MDA content is as shown in table 3,
Table 2 mice serum ALT, AST are active, CHOL and TG content, and wherein CHOL unit is (mg/dL), and TG unit is (mmol/L)
SOD, GSH activity and MDA content in table 3 murine liver tissue, wherein SOD unit is (U/mg pro), and GSH unit is (mg/g pro), and MDA unit is (n mol/mg pro)
As can be seen from table 2, table 3, the compositions that the application obtains, compared with independent Radix Puerariae or Bulbus Allii extract, and compared with publication number compositions disclosed in the Chinese patent application of 102727571A, has unforeseeable excellent hepatoprotective effect.
Embodiment 9 clinical trial
Choose 50 male volunteers, require: average at least drink Chinese liquor 2L weekly, and have a drinking amount at least more than 500ml, be divided into two groups at random, often organize 25 people, one group adopts placebo, the capsule that the compositions that another group adopts the embodiment of the present application 5 to prepare is made, take after drinking at every turn, Time of Administration is 3 months, after 3 months, take in the group of placebo and have 20 people to have hepatic injury in various degree, and in the group of the capsule that the compositions taking the embodiment of the present application 5 preparation is made, 2 people are only had to have slight hepatic injury, prove that the relieving alcoholism and protecting the liver effect of the compositions of the application is obvious.
Claims (7)
1. a relieving alcoholism and protecting the liver compositions, is characterized in that, is made up of the component of following weight percentage ratio:
Puerarin 20-45%
Bulbus Allii 55%-80%, described Bulbus Allii is Bulbus Allii ethanol extraction.
2. relieving alcoholism and protecting the liver compositions as claimed in claim 1, is characterized in that: the ethanol extraction of described Bulbus Allii ethanol extraction to be volumetric concentration be 20%-55%.
3. the application of compositions according to claim 2 in the medicine for the preparation for the treatment of hepatic injury.
4. compositions according to claim 2 is for the preparation of the application in the medicine of preventing liver injury.
5. the application as described in claim 3 or 4, is characterized in that: described hepatic injury is the hepatic injury because ethanol causes.
6. the application as described in claim 3 or 4, is characterized in that: add pharmaceutically acceptable adjuvant and make capsule.
7. the application as described in claim 3 or 4, is characterized in that: add pharmaceutically acceptable adjuvant and make tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310157072.2A CN103211957B (en) | 2013-05-02 | 2013-05-02 | Alcohol relieving and liver protecting composition and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310157072.2A CN103211957B (en) | 2013-05-02 | 2013-05-02 | Alcohol relieving and liver protecting composition and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103211957A CN103211957A (en) | 2013-07-24 |
| CN103211957B true CN103211957B (en) | 2015-01-28 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106109873A (en) * | 2016-07-22 | 2016-11-16 | 赵月 | Liver-protecting combination is used for the application preventing or treating in the medicine of fatty liver in preparation |
| CN107509907A (en) * | 2017-10-18 | 2017-12-26 | 山西琪尔康翅果生物制品有限公司 | A kind of solid beverage with preventing alcoholic liver injury |
| CN108464996A (en) * | 2018-04-28 | 2018-08-31 | 乌林奇 | A kind of targeting adjusts pharmaceutical composition and its application of gene |
| CN108421027A (en) * | 2018-05-07 | 2018-08-21 | 深圳润邦之家生物科技有限公司 | A kind of relieving alcoholism and protecting liver product |
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2013
- 2013-05-02 CN CN201310157072.2A patent/CN103211957B/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 《大蒜油与大蒜素对急性乙醇性肝损伤预防作用比较》;曾涛;《毒理学杂志》;20080630;第22卷(第3期);197-198 * |
| 《葛根解酒含片的开发研制》;常亮等;《食品工业》;20101231(第1期);24-25 * |
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| CN103211957A (en) | 2013-07-24 |
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