CN103191215B - Eye drops for treating conjunctivitis - Google Patents
Eye drops for treating conjunctivitis Download PDFInfo
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- CN103191215B CN103191215B CN201310117818.7A CN201310117818A CN103191215B CN 103191215 B CN103191215 B CN 103191215B CN 201310117818 A CN201310117818 A CN 201310117818A CN 103191215 B CN103191215 B CN 103191215B
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Abstract
The invention relates to eye drops for treating conjunctivitis, which have the effect of treating the conjunctivitis by washing eyes to achieve anti-inflammatory treatment. The eye drops for treating the conjunctivitis are the externally applied eye drops which are prepared from the following traditional Chinese medicine raw materials: 13-17 parts of common jujube bark, 13-17 parts of mulberry bark, 8-12 parts of herb of ramose scouring rush, 8-12 parts of swordlike atractylodes rhizome, 10-14 parts of chrysanthemum and 8-12 parts of feather cockscomb seed. According to the invention, 319 patients (408 eyes) with the acute conjunctivitis in a group are observed after being subjected to conjunctival sac washing treatment with the eye drops disclosed by the invention so that the eye drops are proved to have significant curative effects against acute bacterial conjunctivitis.
Description
Technical field
The invention belongs to human drugs manufacturing technology field, particularly treat the medicament for the eyes of conjunctivitis.
Background technology
Conjunctivitis (conjunctivitis) is the commonly encountered diseases of ophthalmology, but its sickness rate is not yet definite at present.Because most of conjunctiva directly contacts with extraneous, therefore be easily subject in surrounding the stimulation of infectious (as antibacterial, virus and chlamydia etc.) and non-infectious factor (wound, chemical substance and physical factor etc.), and the blood vessel of conjunctiva and lymphoid tissue are abundant, self and extraneous antigen easily make its sensitization.Be commonly called as pink eye disease.
Conjunctivitis is ephemeral infectious disease, occurs in summer and autumn well, and infectiousness is extremely strong, often can outbreak of epidemic.Conjunctivitis itself is general and not serious to eyesight influence, but when its inflammation involves cornea or leads to complications, can cause the infringement of vision, even blind.In addition, though what large defect is conjunctivitis be not, conjunctivitis is not the sole cause of " eye hyperemia ".Eye hyperemia, except conjunctivitis, also will consider it is eye Other diseases, as the alert news of the ophthalmics such as cornea broken skin, iritis, glaucoma, corneal ulcer or inside ofeye inflammation, and cannot general idea.
Current treatment means has:
1, rinse conjunctival sac: while having secretions in conjunctival sac, rinse, its effect is mainly clean, and abluent used should be nonirritant, dust head is normal saline, 2% ~ 3% boric acid solution or 1: 5000 ~ 1: 10000 mercuric chloride (or potassium permanganate) solution, rinses with undine.Flushing liquor must have suitable temperature.During flushing, upset eyelid, rinses conjunctival surface, with the upper and lower face of finger push, the secretions of fornix is also rushed out simultaneously, and head turns to homonymy simultaneously, avoids flushing liquor person who lives in exile Second eye.
2, local application: 1. antibacterials or antiviral eye drop: according to etiological diagnosis, select corresponding medicine.2. eye ointment: the drug level of eye ointment is high, long action time, is coated with before being applicable to sleep.3. caustic: caustic has very strong sterilizing power, also corrode conjunctiva textura epidermoidea and cause necrosis, as silver nitrate, during application, directly smear affected part simultaneously, can't touch cornea, conventional 0.5 ~ 1% silver nitrate, the eyelid that will overturn during eye drip, by eye drop in palpebral conjunctiva, after eye drip, slightly stop a moment, use normal saline flushing. or dip in a small amount of medicinal liquid with cotton swab, be applied to palpebral conjunctiva surface, use immediately normal saline flushing.For the many persons of acute stage secretions, effect is fine, but can not prolonged application.
3, whole body therapeutic: for serious conjunctivitis, as gonococcal conjunctivitis, trachoma etc., need treat in conjunction with systemic administration
In above-mentioned Therapeutic Method, especially will be less because give with topical treatment, simple and convenient the most frequently used, but medicine used is take Western medicine as main, as long as object is antiinflammatory, for conjunctivitis, easily causes recurrence.
Summary of the invention
The present invention seeks to invent a kind of medicament for the eyes for the treatment of conjunctivitis, by cleaning eye, reach the effect of anti-inflammatory treatment treatment conjunctivitis.
The medicament for the eyes for the treatment of conjunctivitis, it makes external medicament for the eyes with following raw material of Chinese medicine:
Cortex Jujubae 13-17, Cortex Mori 13-17, Herba Equiseti Hiemalis 8-12, Rhizoma Atractylodis 8-12, Flos Chrysanthemi 10-14, Semen Celosiae 8-12.
Preferential recommendation made external medicament for the eyes with following raw material of Chinese medicine: Cortex Jujubae 15, Cortex Mori 15, Herba Equiseti Hiemalis 10, Rhizoma Atractylodis 0, Flos Chrysanthemi 12, Semen Celosiae 10.
The each component effect of the present invention is as follows:
Cortex Jujubae---hemostasis, improving eyesight, control dysentery antidiarrheal, relieving cough and expelling phlegm;
Cortex Mori---eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema;
Herba Equiseti Hiemalis---dispelling wind heat, nebula removing film;
Rhizoma Atractylodis---expelling wind and dampness, invigorating the spleen to arrest diarrhea, cold expelling, block removing improving eyesight;
Flos Chrysanthemi---dispelling wind and heat pathogens, suppressing the hyperactive liver improving eyesight;
Semen Celosiae---liver heat removing and eyesight improving, nebula removing, for liver-heat conjunctival congestion, the nebula of looking unfamiliar film, blurring of vision, dizziness due to liver-fire.
The present invention adopts Cortex Jujubae, Semen Celosiae, Flos Chrysanthemi improving eyesight; Adopt Herba Equiseti Hiemalis, Rhizoma Atractylodis cold-dispelling, then use Cortex Mori inducing diuresis to remove edema, totally there is inflammation-dimishing and eye brightening effect, conjunctivitis is had to better therapeutic effect.
The present invention treats with collyrium irrigation of conjunctival sac of the present invention by observation group's 319 examples (408) acute conjunctivitis patient.Prove that collyrium of the present invention rinses evident in efficacy to acute bacterial conjunctivitis by sacculation film.
The specific embodiment
Formula 1: Cortex Jujubae 15, Cortex Mori 15, Herba Equiseti Hiemalis 10, Rhizoma Atractylodis 0, Flos Chrysanthemi 12, Semen Celosiae 10.
Formula 2: Cortex Jujubae 13, Cortex Mori 17, Herba Equiseti Hiemalis 8, Rhizoma Atractylodis 12, Flos Chrysanthemi 10, Semen Celosiae 12
Formula 3: Cortex Jujubae 17, Cortex Mori 13, Herba Equiseti Hiemalis 12, Rhizoma Atractylodis 8, Flos Chrysanthemi 14, Semen Celosiae 8.
After above-mentioned prescription drug cleans, extracting solution is made external medicament for the eyes water preparation.
Embodiment of the present invention treatment conjunctivitis 319 examples (408) clinical report
1 data and method
1.1 diagnosis and observation index, standards of grading diagnostic criteria are determined according to national higher medical education teaching material < < ophthalmology > > and < < ophthalmology pandect > >.Morbidity is anxious, and the course of disease is short; Consciously shed tears, foreign body sensation, burning sensation or the pain etc. of itching.Conjunctival congestion, secretions is many.Be first mucus, after be purulence, can there is subconjunctival hemorrhage.Cytolgical examination is polynucleosis.Observation index and standards of grading: observe patient's ophthalmalgia, shed tears, secretions, eyelid redness, palpebral conjunctiva hyperemia, totally 6 of bulbar conjunctiva hyperemia, are divided into 0,1 according to degree difference, 2,3 points of 4 grades.
1.2 physical data observation groups are conjunctivitis 319 examples (408), and the course of disease 1～2 day, all makes a definite diagnosis through the inspection of conjunctiva Scrape method before medication, do not use other drug treatment.
1.3 preparations of the present invention for Therapeutic Method observation group (according to formula 1 preparation) 20ml adds in 500ml normal saline solution, the about 100ml of irrigation of conjunctival sac eyes, every day 2 times.3 days courses for the treatment of, to observe eye symptom and sign and change, scoring every day record 1 time, finishes rear judgement curative effect the course for the treatment of.After January, follow up a case by regular visits to.
2 results
2.1 criterion of therapeutical effect recoveries from illness: symptom and sign all disappears; Effective: symptomatology disappears or cardinal symptom sign disappears; Effective: cardinal symptom sign disappears substantially; Invalid: each side symptom and sign is without improvement.
2.2 curative effect statistics
Fully recover 301, cure rate 74%; Effective 59, effective 45, invalid 3, total effective rate 99%.
Cardinal symptom after treatment simultaneously: the pain of itching, shed tears, secretions, eyelid redness, palpebral conjunctiva hyperemia, bulbar conjunctiva hyperemia etc. are basic to disappear.
After one month, participate in following up a case by regular visits to 290 examples (people) and only have 3 examples to have symptomatic recurrence, do not take to treat measure spontaneous recovery, all the other patients have no symptomatic recurrence.
3, conclusion
The present invention totally has inflammation-dimishing and eye brightening effect, by sacculation film, rinses evident in efficacy to acute bacterial conjunctivitis.
Claims (1)
1. the medicament for the eyes for the treatment of conjunctivitis, is characterized in that making external medicament for the eyes with following raw material of Chinese medicine: Cortex Jujubae 13-17, Cortex Mori 13-17, Herba Equiseti Hiemalis 8-12, Rhizoma Atractylodis 8-12, Flos Chrysanthemi 10-14, Semen Celosiae 8-12.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310117818.7A CN103191215B (en) | 2013-04-07 | 2013-04-07 | Eye drops for treating conjunctivitis |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310117818.7A CN103191215B (en) | 2013-04-07 | 2013-04-07 | Eye drops for treating conjunctivitis |
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| CN103191215A CN103191215A (en) | 2013-07-10 |
| CN103191215B true CN103191215B (en) | 2014-04-16 |
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| CN201310117818.7A Expired - Fee Related CN103191215B (en) | 2013-04-07 | 2013-04-07 | Eye drops for treating conjunctivitis |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104587076A (en) * | 2015-01-13 | 2015-05-06 | 青岛市中心医院 | Traditional Chinese medicine lotion for treating conjunctivitis |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101199685A (en) * | 2007-12-12 | 2008-06-18 | 叶志平 | Smoked washing medicament for treating chronicity conjunctivitis |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101199685A (en) * | 2007-12-12 | 2008-06-18 | 叶志平 | Smoked washing medicament for treating chronicity conjunctivitis |
Non-Patent Citations (2)
| Title |
|---|
| 孟青青等.过敏性结膜炎的治疗研究进展.《中国中医眼科杂志》.2012,第22卷(第6期), |
| 过敏性结膜炎的治疗研究进展;孟青青等;《中国中医眼科杂志》;20121231;第22卷(第6期);第446-449页 * |
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