CN103182048A - Oral medicine of huoyang kidney tonifying capsule for treatment of kidney yang deficiency syndrome and preparation method thereof - Google Patents

Abstract

The present invention relates to a medicine for treatment of kidney yang deficiency syndrome, and specifically relates to an oral medicine of huoyang kidney tonifying capsules for treatment of kidney yang deficiency syndrome which takes Chinese herbal medicine decoction pieces as raw materials. The sixteen raw materials include ginseng, cornua cervi pantotrichum, herba epimedii, fructus psoraleae, morinda officinalis, cynomorium songaricum, Chinese dodder seeds, herba cistanche, schisandra chinensis, radix salviae miltiorrhizae, radix ophiopogonis, polygala tenuifolia, rhizoma acori graminei, fructus amomi, radix achyranthis bidentatae, and liquorice. The medicine is prepared by thirteen steps of cleaning and selecting, washing and moistening, cutting, drying, extracting, concentrating, drying thick paste, crushing dry paste, mixing, granulating, filling in capsules, and packaging with an aluminum-plastic package and an outer package. By clinical observation, the medicine of the invention has the advantages of warming and invigorating kidney yang, high efficacy, convenience for taking, rich and available sources for medicines, easy acceptance for patients, safety, and no toxic side effects.

Description

A kind of oral medicine leaves of pulse plants sun capsule for tonifying kidney for the treatment of syndrome of deficiency of kidney-YANG and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of syndrome of deficiency of kidney-YANG, a kind of specifically is the oral medicine leaves of pulse plants sun capsule for tonifying kidney of the treatment syndrome of deficiency of kidney-YANG of feedstock production with the prepared slices of Chinese crude drugs, the invention still further relates to the preparation method of this medicine.

Background technology

Based on the deficiency syndrome of insufficiency of kidney-YANG, be the common clinical frequently-occurring disease, and have and increase trend year by year that the course of disease is long, with the passing of time delay causes kidney-jing deficiency to lose, and health is become thin, malaise, lassitude, sexual impotence, seminal emission, premature ejaculation, insomnia, dreaminess etc.Though the Chinese patent medicine of some treatment primary disease is arranged at present, because effect is not fairly obvious, has a strong impact on patient's body health.Leaves of pulse plants sun capsule for tonifying kidney can play tonify deficiency and set upright, kidney-reinforcing Yang-strengthening, and the effect of life lengthening, safe and reliable, have no side effect.

Summary of the invention

The objective of the invention is to provide a kind of oral medicine leaves of pulse plants sun capsule for tonifying kidney with treatment syndrome of deficiency of kidney-YANG of warming and recuperating the kidney-YANG.

Another object of the present invention provides the preparation method of the oral medicine leaves of pulse plants sun capsule for tonifying kidney of this treatment syndrome of deficiency of kidney-YANG.

The object of the present invention is achieved like this: this medicine is the medicament of being made by following raw materials by weight proportions:

30～50 parts of Radix Ginsengs, 20～40 parts in Cornu Cervi Pantotrichum, 30～50 parts of Herba Epimedii, 30～50 parts of Fructus Psoraleaes, 30～50 parts of Radix Morindae Officinaliss, 30～50 parts of Herba Cynomoriis, 30～50 parts of Semen Cuscutae, 30～50 parts of Herba Cistanches, 20～40 parts of Fructus Schisandrae Chinensis, 20～40 parts of Radix Salviae Miltiorrhizaes, 40～60 parts of Radix Ophiopogonis, 10～30 parts of Radix Polygalaes, 10～30 parts of Rhizoma Acori Graminei, 8～15 parts of Fructus Amomis, 30～50 parts of Radix Achyranthis Bidentataes, 10～30 parts in Radix Glycyrrhizae;

The weight proportion of described crude drug is :

30～40 parts of Radix Ginsengs, 20～30 parts in Cornu Cervi Pantotrichum, 30～40 parts of Herba Epimedii, 30～40 parts of Fructus Psoraleaes, 30～40 parts of Radix Morindae Officinaliss, 30～40 parts of Herba Cynomoriis, 30～40 parts of Semen Cuscutae, 30～40 parts of Herba Cistanches, 20～30 parts of Fructus Schisandrae Chinensis, 20～30 parts of Radix Salviae Miltiorrhizaes, 40～50 parts of Radix Ophiopogonis, 10～20 parts of Radix Polygalaes, 10～20 parts of Rhizoma Acori Graminei, 8～12 parts of Fructus Amomis, 30～40 parts of Radix Achyranthis Bidentataes, 10～20 parts in Radix Glycyrrhizae;

The weight proportion of described crude drug is :

40 parts of Radix Ginsengs, 30 parts in Cornu Cervi Pantotrichum, 40 parts of Herba Epimedii, 40 parts of Fructus Psoraleaes, 40 parts of Radix Morindae Officinaliss, 40 parts of Herba Cynomoriis, 40 parts of Semen Cuscutae, 40 parts of Herba Cistanches, 30 parts of Fructus Schisandrae Chinensis, 30 parts of Radix Salviae Miltiorrhizaes, 50 parts of Radix Ophiopogonis, 20 parts of Radix Polygalaes, 20 parts of Rhizoma Acori Graminei, 10 parts of Fructus Amomis, 40 parts of Radix Achyranthis Bidentataes, 20 parts in Radix Glycyrrhizae;

Above-mentioned each component is made medicine production method of the present invention is:

This process for preparing medicine by clean, wash profit, cutting, drying, extraction, concentrate, thick paste oven dry, dried cream powder are broken, mixing, granulation, capsule charge, aluminum-plastic packaged, 13 processing steps of outer package are finished.

When making this medicine, thick paste oven dry, dried cream powder are broken, mixing, granulation, capsule charge, aluminum-plastic packaged these posies be according to the GMP(Good Manufacturing Practice and Quality Control of Drug) requirement, reach and finish under the environmental requirement of D level (100,000 grades), the water of use reaches the requirement of purified water.

The present invention has treatment insufficiency of kidney-YANG curative effect height through clinical observation, instant effect, and taking convenience, safely, advantage such as have no side effect.

Function: warming and recuperating the kidney-YANG.

Cure mainly: be used for syndrome of deficiency of kidney-YANG, disease is seen physical weakness, physical fatigue and lassitude of spirit, and insomnia and dreamful sleep, dimly forgetful, soreness of the waist and knees, nocturia etc.

Usage and dosage: oral, one time 4～6,3 times on the one.

The clinical case visual report of medicine of the present invention

The oral medicine leaves of pulse plants sun capsule for tonifying kidney of this treatment syndrome of deficiency of kidney-YANG is Chinese medicine hard capsule preparation, this medical instrument has the effect of warming and recuperating the kidney-YANG, this product is observed by 140 routine clinical cases, this invention medicine has the curative effect height aspect the treatment syndrome of deficiency of kidney-YANG, taking convenience, the medicine source is rich and easy to get, the patient is acceptant, safely, advantage such as have no side effect.

One, case quantity

The clinical patients that this medicine is used for the treatment syndrome of deficiency of kidney-YANG is 140 examples

Case is selected

Male's 107 examples in 140 examples, women's 33 examples, the age, person was 18 years old, the maximum is 79 years old, 25 examples below 30 years old, 31 years old to 40 years old 46 examples, 41 to 50 years old 52 example, 51 to 60 years old 22 example, 5 examples more than 61 years old, 42 years old mean age, cadre's 69 examples wherein, workman's 49 examples, peasant's 15 examples, housework 7 examples, the elder of the course of disease is 8 years, the shortest person is 0.1 year, and average course of disease is 3 years.

Two, diagnostic criteria

1, " the dialectical reference standard of Chinese medicine deficiency-syndrome " execution of revising with reference to the whole nation, Zhengzhou in 1986 combination of Chinese and Western medicine deficiency syndrome and senile disease research academic conference.

2, case is selected (medical history and symptom):

All with ache of the spinal column, have a dizzy spell, spiritlessness and weakness, impotence and seminal emission, premature ejaculation and weak after being ill, old vital essence deficiency, it is that main clinical manifestation person all can classify the object of observation as that muscle power has insufficiency of kidney-YANG not as good as grade.

3, Therapeutic Method:

All observation cases of classifying as all fill symptom, sign and routine blood test, routine urinalysis by observing requirement, auxiliary examination projects such as liver function, symptom by heavy (+++), in (++), light (+) leaves of pulse plants sun capsule for tonifying kidney that medicine adopts lucky special Pharmaceutical (the distant pharmaceutical factory of pine, original name Siping City) to provide, each 4 are provided, every day three times clothes, 28 days is a course for the treatment of, and other relevant medicine of stopping using during the treatment finishes the back comprehensive review course for the treatment of, adopt the method for the treatment of front and back own control, data are carried out statistical procedures.

Three, observed result:

Clinical observation 140 routine patients, 81 examples of wherein fully recovering account for 57.8%, and produce effects 32 examples account for 22.9%, and 19 examples that take a turn for the better account for 13.6%, and invalid 8 examples account for 5.7%, and total effective rate is 94.3%.

Curative effect determinate standard:

1, recovery from illness: ache of the spinal column, the sexual impotence premature ejaculation, hyposexuality, symptoms such as spiritlessness and weakness all disappear.

2, produce effects: ache of the spinal column, the sexual impotence premature ejaculation, hyposexuality, symptoms such as spiritlessness and weakness all disappear, and the tongue arteries and veins is normal, and muscle power is recovered 3 of individual events with energy, produce effects+2 improvement, 4 produce effects+1 are invalid, 3+2 produce effects that take a turn for the better.

3, take a turn for the better: symptom takes a turn for the better, and 1 produce effects+2 improvement of individual event takes a turn for the better more than 3.

4, invalid: medication one course for the treatment of (30 days) back symptom no change or increase the weight of.

Four, usage and dosage:

Oral, one time 4～6,3 times on the one.

Five, conclusion:

Show through clinical 140 routine observed results, this product determined curative effect, total effective rate reaches 94.3%, and this invention medicine has the curative effect height in treatment aspect the syndrome of deficiency of kidney-YANG, and taking convenience, the medicine source is rich and easy to get, the patient is acceptant, safely, advantage such as have no side effect.

The specific embodiment

The preparation method of this medicine by be by clean, wash profit, cutting, drying, extraction, concentrate, a plurality of processing steps such as thick paste oven dry, dried cream powder are broken, mixing, granulation, capsule charge, aluminum-plastic packaged, outer package finish, every dress 0.32g.

At first choose crude drug Radix Ginseng 43.2 kg, Cornu Cervi Pantotrichum 32.4kg, Herba Epimedii 43.2kg by proportioning dosage, Fructus Psoraleae 43.2 kg, Radix Morindae Officinalis 43.2 kg, Herba Cynomorii 43.2 kg, Semen Cuscutae 43.2kg, Herba Cistanches 43.2kg, Fructus Schisandrae Chinensis 32.4kg, Radix Salviae Miltiorrhizae 32.4kg, Radix Ophiopogonis 54kg, Radix Polygalae 21.6kg, Rhizoma Acori Graminei 21.6kg, Fructus Amomi 10.8kg, Radix Achyranthis Bidentatae 43.2kg, Radix Glycyrrhizae 21.6kg, the foundation that the arrangement of Chinese crude drug is concocted: one one of Pharmacopoeia of the People's Republic of China version in 2010.

Concrete preparation method is:

1, crude drug clean, wash profit, cutting and drying:

Radix Ginseng: cutting;

Herba Epimedii: remove impurity, spray clear water, cutting, drying;

Fructus Psoraleae: remove impurity;

Radix Morindae Officinalis: remove impurity;

Herba Cynomorii: clean, run through cutting, drying;

Semen Cuscutae: remove impurity, cleaning, drying;

Herba Cistanches: remove impurity, wash profit, cutting, drying;

Fructus Schisandrae Chinensis: remove impurity;

Radix Salviae Miltiorrhizae: remove impurity and residual stem, wash profit, cutting, drying;

Radix Ophiopogonis: remove impurity, wash profit, drying;

Radix Polygalae: remove impurity, slightly wash, run through, cutting, drying;

Rhizoma Acori Graminei: remove impurity, wash profit, cutting, drying;

Fructus Amomi: remove impurity;

Radix Achyranthis Bidentatae: remove impurity, wash profit, remove residual reed head, cutting, drying;

Radix Glycyrrhizae: remove impurity, wash profit, cutting, drying;

The described profit process of washing is that Herba Cynomorii, Herba Cistanches are put into medicine-washing machine, uses circulating water to wash, to the no earth in medical material surface; Semen Cuscutae, Radix Ophiopogonis, Radix Salviae Miltiorrhizae, Radix Polygalae, Rhizoma Acori Graminei, Radix Achyranthis Bidentatae, Radix Glycyrrhizae are put into Turnround basket respectively in the wash pond, use circulating water to wash, to the no earth in medical material surface; Respectively Herba Cynomorii, Herba Cistanches are put into medicine processing device, add 8～10 ㎏ drinking waters, moisten to medicine permeable most.

Described cutting process be adopt reciprocating type medicine cutter, rotary medicine cutter respectively with Radix Ginseng,, Herba Cynomorii, Herba Cistanches, Radix Salviae Miltiorrhizae, Radix Polygalae, Rhizoma Acori Graminei, Radix Achyranthis Bidentatae, Radix Glycyrrhizae be cut into 0.4～2cm; Herba Epimedii spray clear water is cut into 0.4～2cm.

Described dry run is to put into heated-air circulation oven respectively that cutting is good Herba Epimedii, Herba Cynomorii, Herba Cistanches, Radix Salviae Miltiorrhizae, Radix Polygalae, Rhizoma Acori Graminei, Radix Achyranthis Bidentatae, Radix Glycyrrhizae, Semen Cuscutae, Radix Ophiopogonis, and the control temperature is at 80～100 ℃, and is stand-by behind the medicinal material drying.

2, extract, concentrate and the thick paste oven dry:

1., the Semen Cuscutae with after the weighing, Fructus Schisandrae Chinensis, Radix Ophiopogonis, Radix Morindae Officinalis, Fructus Psoraleae, Herba Epimedii, Herba Cynomorii, Herba Cistanches, Radix Salviae Miltiorrhizae, Radix Polygalae, Rhizoma Acori Graminei, Radix Achyranthis Bidentatae, the clean medical material of Radix Glycyrrhizae, be divided into two parts, it is stand-by to be ground into coarse powder with pulverizer respectively.

2., the coarse powder with Herba Epimedii, Herba Cynomorii, Herba Cistanches, Radix Salviae Miltiorrhizae, Radix Polygalae, Rhizoma Acori Graminei, Radix Achyranthis Bidentatae, Radix Glycyrrhizae, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Semen Cuscutae, Fructus Psoraleae, Radix Morindae Officinalis divides two material to drop in the multi-function extractor, every material adds 2 times of amounts of water (0.5 ton) and soaks after 40 minutes, add drinking water, being heated to boiling decocts, decoct 100～110 ℃ of temperature, steam pressure≤0.3Mpa, every material decocts three times, for the first time add 8 times of amounts of water (1.95 tons) drinking water, decocted 3 hours; For the second time add 8 times of amounts of water (1.95 tons), decocted 2 hours; Add 6 times of amounts of water (1.5 tons) for the third time, decocted 2 hours; Merge three times decoction liquor, filter, merging filtrate concentrates, control thickening temperature one is imitated 70～80 ℃, two imitate 70～80 ℃, and vacuum one is imitated 0.06～0.08MPa, and two imitate 0.06～0.08Mpa, steam pressure 0.06～0.10Mpa is concentrated into relative density 1.25～1.30(50 ℃) thick paste.

3., crude drug is pulverized: the Radix Ginseng after the weighing, Cornu Cervi Pantotrichum, Fructus Amomi are added to pulverize in the unit pulverize, be ground into 100 order fine powders, pulverizing back crude drug powder is packed in the clean cloth bag, the cloth bag of dress crude drug powder is put into clean stainless steel disc, sterilize cabinet at 105～110 ℃ with Chinese medicine, 30 minutes, sterilize under the conditions such as operating pressure≤0.2MPa; The sterilization back is convection drying in the sterilization cabinet, 75～85 ℃ of baking temperatures, 30 minutes drying times, operating pressure≤0.2MPa, vacuum 〉=0.07MPa.

4., vacuum drying: thick paste is put into clean stainless steel disc, and ointment thickness 2～3cm sends into vacuum drying oven then, dry steam pressure≤0.3MPa; Vacuum 0.06～0.08MPa; 60～80 ℃ of temperature; 10～12 hours drying times; Or thick paste put into the polypropylene material holding tray that is covered with silica gel plate, and ointment thickness 3～6cm sends in the box microwave vacuum dryer then, and control vacuum is 0.07～0.09MPa; 90～100 ℃ of baking temperatures; 2～4 hours drying times, dried dried cream is cooled to room temperature, is loaded in the clean canvas bag.

3, dried cream powder is broken: dried cream is pulverized with the pulverizing unit, pulverized the back and cross 100 eye mesh screens, pulverizing back medicated powder is packed in the stainless steel cask.

4, mix: the crude drug powder after will pulverizing and dried cream powder add in the efficient three-dimensional motion mixer and mix, and incorporation time 20 minutes during medicated powder is packed double-layer plastic bag or stainless steel cask into after mixing, is sent into semifinished product warehouse.

5, granulate:

1., the medicated powder gradation is added in the trough type mixing machine, it is an amount of to add 95% ethanol, mixes 10～15 minutes, makes soft material, is that the swing pelletizing machine of 20 purposes is made wet granular by screen cloth, carries out drying.

2., carry out drying with HighefficientFluidbeddrier, the control inlet temperature is 90～100 ℃, and 120～150 minutes drying times, dried granule carries out granulate.

3., to cross sieve aperture with pelletizing machine be that the screen cloth of 2.6mm carries out granulate, granule is packed into and is weighed in stainless steel cask or the double-layer plastic bag behind the granulate, changes the batch mixing post over to.

4., the dried granule that will make adds and carries out batch mixing in the efficient three-dimensional motion mixer, 900 rev/mins of motor revolutions, incorporation time 20 minutes is mixed the back granule and is packed in stainless steel cask or the double-layer plastic bag.

6, capsule charge, aluminum-plastic packaged: medicated powder is carried out filling with fully-automatic capsule filling machine, answer test run before the filling, set loading amount 0.32g/ grain, filling velocity is 800～900/minute, checks average loading amount.

Average loading quantity inspection: use the torsion balance weighing, each 10, every loading amount is controlled at 0.291 ~ 0.348g every average loading amount 0.32 ± 9.0%.

Adopt Aluminium-coating Packer to pack at last, 12 of every plates, heat-seal temperature are controlled about 190～210 ℃, 145～165 ℃ of plastic uptake temperature, 160～180 ℃ of typewriting heating, finish aluminum-plastic packaged after, carry out outer package again, finish whole process of preparation.

Claims (5)

1. oral medicine leaves of pulse plants sun capsule for tonifying kidney for the treatment of syndrome of deficiency of kidney-YANG, it is characterized in that: this medicine is the medicament of being made by following raw materials by weight proportions:

30～50 parts of Radix Ginsengs, 20～40 parts in Cornu Cervi Pantotrichum, 30～50 parts of Herba Epimedii,

30～50 parts of Fructus Psoraleaes, 30～50 parts of Radix Morindae Officinaliss, 30～50 parts of Herba Cynomoriis,

30～50 parts of Semen Cuscutae, 30～50 parts of Herba Cistanches, 20～40 parts of Fructus Schisandrae Chinensis,

20～40 parts of Radix Salviae Miltiorrhizaes, 40～60 parts of Radix Ophiopogonis, 10～30 parts of Radix Polygalaes,

10～30 parts of Rhizoma Acori Graminei, 8～15 parts of Fructus Amomis, 30～50 parts of Radix Achyranthis Bidentataes,

10～30 parts in Radix Glycyrrhizae.

2. a kind of oral medicine leaves of pulse plants sun capsule for tonifying kidney for the treatment of syndrome of deficiency of kidney-YANG according to claim 1, it is characterized in that: the weight proportion of described crude drug is :

30～40 parts of Radix Ginsengs, 20～30 parts in Cornu Cervi Pantotrichum, 30～40 parts of Herba Epimedii,

30～40 parts of Fructus Psoraleaes, 30～40 parts of Radix Morindae Officinaliss, 30～40 parts of Herba Cynomoriis,

30～40 parts of Semen Cuscutae, 30～40 parts of Herba Cistanches, 20～30 parts of Fructus Schisandrae Chinensis, 20～30 parts of Radix Salviae Miltiorrhizaes, 40～50 parts of Radix Ophiopogonis, 10～20 parts of Radix Polygalaes,

10～20 parts of Rhizoma Acori Graminei, 8～12 parts of Fructus Amomis, 30～40 parts of Radix Achyranthis Bidentataes,

10～20 parts in Radix Glycyrrhizae.

3. a kind of oral medicine leaves of pulse plants sun capsule for tonifying kidney for the treatment of syndrome of deficiency of kidney-YANG according to claim 1, it is characterized in that: the weight proportion of described crude drug is :

40 parts of Radix Ginsengs, 30 parts in Cornu Cervi Pantotrichum, 40 parts of Herba Epimedii, 40 parts of Fructus Psoraleaes,

40 parts of Radix Morindae Officinaliss, 40 parts of Herba Cynomoriis, 40 parts of Semen Cuscutae, 40 parts of Herba Cistanches,

30 parts of Fructus Schisandrae Chinensis, 30 parts of Radix Salviae Miltiorrhizaes, 50 parts of Radix Ophiopogonis, 20 parts of Radix Polygalaes,

20 parts of Rhizoma Acori Graminei, 10 parts of Fructus Amomis, 40 parts of Radix Achyranthis Bidentataes, 20 parts in Radix Glycyrrhizae.

4. the preparation method of an oral medicine leaves of pulse plants sun capsule for tonifying kidney for the treatment of syndrome of deficiency of kidney-YANG is characterized in that: this process for preparing medicine by clean, wash profit, cutting, drying, extraction, concentrate, thick paste oven dry, dried cream powder are broken, mixing, granulation, capsule charge, aluminum-plastic packaged, 13 processing steps of outer package are finished.

5. the preparation method of a kind of oral medicine leaves of pulse plants sun capsule for tonifying kidney for the treatment of syndrome of deficiency of kidney-YANG according to claim 4 is characterized in that:

Crude drug clean, wash profit, cutting and drying:

Radix Ginseng: cutting;

Herba Epimedii: remove impurity, spray clear water, cutting, drying;

Fructus Psoraleae: remove impurity;

Radix Morindae Officinalis: remove impurity;

Herba Cynomorii: clean, run through cutting, drying;

Semen Cuscutae: remove impurity, cleaning, drying;

Herba Cistanches: remove impurity, wash profit, cutting, drying;

Fructus Schisandrae Chinensis: remove impurity;

Radix Salviae Miltiorrhizae: remove impurity and residual stem, wash profit, cutting, drying;

Radix Ophiopogonis: remove impurity, wash profit, drying;

Radix Polygalae: remove impurity, slightly wash, run through, cutting, drying;

Rhizoma Acori Graminei: remove impurity, wash profit, cutting, drying;

Fructus Amomi: remove impurity;

Radix Achyranthis Bidentatae: remove impurity, wash profit, remove residual reed head, cutting, drying;

Radix Glycyrrhizae: remove impurity, wash profit, cutting, drying;

The described profit process of washing is that Herba Cynomorii, Herba Cistanches are put into medicine-washing machine, uses circulating water to wash, to the no earth in medical material surface; Semen Cuscutae, Radix Ophiopogonis, Radix Salviae Miltiorrhizae, Radix Polygalae, Rhizoma Acori Graminei, Radix Achyranthis Bidentatae, Radix Glycyrrhizae are put into Turnround basket respectively in the wash pond, use circulating water to wash, to the no earth in medical material surface; Respectively Herba Cynomorii, Herba Cistanches are put into medicine processing device, add 8～10 ㎏ drinking waters, moisten to medicine permeable most;

Described cutting process be adopt reciprocating type medicine cutter, rotary medicine cutter respectively with Radix Ginseng,, Herba Cynomorii, Herba Cistanches, Radix Salviae Miltiorrhizae, Radix Polygalae, Rhizoma Acori Graminei, Radix Achyranthis Bidentatae, Radix Glycyrrhizae be cut into 0.4～2cm; Herba Epimedii spray clear water is cut into 0.4～2cm;

Described dry run is to put into heated-air circulation oven respectively that cutting is good Herba Epimedii, Herba Cynomorii, Herba Cistanches, Radix Salviae Miltiorrhizae, Radix Polygalae, Rhizoma Acori Graminei, Radix Achyranthis Bidentatae, Radix Glycyrrhizae, Semen Cuscutae, Radix Ophiopogonis, and the control temperature is at 80～100 ℃, and is stand-by behind the medicinal material drying;

Two, extract, concentrate and the thick paste oven dry:

1., the Semen Cuscutae with after the weighing, Fructus Schisandrae Chinensis, Radix Ophiopogonis, Radix Morindae Officinalis, Fructus Psoraleae, Herba Epimedii, Herba Cynomorii, Herba Cistanches, Radix Salviae Miltiorrhizae, Radix Polygalae, Rhizoma Acori Graminei, Radix Achyranthis Bidentatae, the clean medical material of Radix Glycyrrhizae, be divided into two parts, it is stand-by to be ground into coarse powder with pulverizer respectively;

2., the coarse powder with Herba Epimedii, Herba Cynomorii, Herba Cistanches, Radix Salviae Miltiorrhizae, Radix Polygalae, Rhizoma Acori Graminei, Radix Achyranthis Bidentatae, Radix Glycyrrhizae, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Semen Cuscutae, Fructus Psoraleae, Radix Morindae Officinalis divides two material to drop in the multi-function extractor, every material adds 2 times of amounts of water (0.5 ton) and soaks after 40 minutes, add drinking water, being heated to boiling decocts, decoct 100～110 ℃ of temperature, steam pressure≤0.3Mpa, every material decocts three times, for the first time add 8 times of amounts of water (1.95 tons) drinking water, decocted 3 hours; For the second time add 8 times of amounts of water (1.95 tons), decocted 2 hours; Add 6 times of amounts of water (1.5 tons) for the third time, decocted 2 hours; Merge three times decoction liquor, filter, merging filtrate concentrates, control thickening temperature one is imitated 70～80 ℃, two imitate 70～80 ℃, and vacuum one is imitated 0.06～0.08MPa, and two imitate 0.06～0.08Mpa, steam pressure 0.06～0.10Mpa is concentrated into relative density 1.25～1.30(50 ℃) thick paste;

3., crude drug is pulverized: the Radix Ginseng after the weighing, Cornu Cervi Pantotrichum, Fructus Amomi are added to pulverize in the unit pulverize, be ground into 100 order fine powders, pulverizing back crude drug powder is packed in the clean cloth bag, the cloth bag of dress crude drug powder is put into clean stainless steel disc, sterilize cabinet at 105～110 ℃ with Chinese medicine, 30 minutes, sterilize under the conditions such as operating pressure≤0.2MPa; The sterilization back is convection drying in the sterilization cabinet, 75～85 ℃ of baking temperatures, 30 minutes drying times, operating pressure≤0.2MPa, vacuum 〉=0.07MPa;

4., vacuum drying: thick paste is put into clean stainless steel disc, and ointment thickness 2～3cm sends into vacuum drying oven then, dry steam pressure≤0.3MPa; Vacuum 0.06～0.08MPa; 60～80 ℃ of temperature; 10～12 hours drying times; Or thick paste put into the polypropylene material holding tray that is covered with silica gel plate, and ointment thickness 3～6cm sends in the box microwave vacuum dryer then, and control vacuum is 0.07～0.09MPa; 90～100 ℃ of baking temperatures; 2～4 hours drying times, dried dried cream is cooled to room temperature, is loaded in the clean canvas bag;

Three, dried cream powder is broken: dried cream is pulverized with the pulverizing unit, pulverized the back and cross 100 eye mesh screens, pulverizing back medicated powder is packed in the stainless steel cask;

Four, mix: the crude drug powder after will pulverizing and dried cream powder add in the efficient three-dimensional motion mixer and mix, and incorporation time 20 minutes during medicated powder is packed double-layer plastic bag or stainless steel cask into after mixing, is sent into semifinished product warehouse;

Five, granulate:

1., the medicated powder gradation is added in the trough type mixing machine, it is an amount of to add 95% ethanol, mixes 10～15 minutes, makes soft material, is that the swing pelletizing machine of 20 purposes is made wet granular by screen cloth, carries out drying;

2., carry out drying with HighefficientFluidbeddrier, the control inlet temperature is 90～100 ℃, and 120～150 minutes drying times, dried granule carries out granulate;

3., to cross sieve aperture with pelletizing machine be that the screen cloth of 2.6mm carries out granulate, granule is packed into and is weighed in stainless steel cask or the double-layer plastic bag behind the granulate, changes the batch mixing post over to; 4., the dried granule that will make adds and carries out batch mixing in the efficient three-dimensional motion mixer, 900 rev/mins of motor revolutions, incorporation time 20 minutes is mixed the back granule and is packed in stainless steel cask or the double-layer plastic bag;

Six, capsule charge, aluminum-plastic packaged: medicated powder is carried out filling with fully-automatic capsule filling machine, answer test run before the filling, set loading amount 0.32g/ grain, filling velocity is 800～900/minute, checks average loading amount;

Average loading quantity inspection: use the torsion balance weighing, each 10, every loading amount is controlled at 0.291 ~ 0.348g every average loading amount 0.32 ± 9.0%;

Adopt Aluminium-coating Packer to pack at last, 12 of every plates, heat-seal temperature are controlled about 190～210 ℃, 145～165 ℃ of plastic uptake temperature, 160～180 ℃ of typewriting heating, finish aluminum-plastic packaged after, carry out outer package again, finish whole process of preparation.