CN103182043A - Externally applied traditional Chinese medicine for treating gynecologic inflammation and preparation method thereof - Google Patents
Externally applied traditional Chinese medicine for treating gynecologic inflammation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses an externally applied traditional Chinese medicine for treating gynecologic inflammation. The medicine is prepared from the following ingredients by weight: 18.3-21.7 parts of sophora flavescens, 14.2-15.8 parts of common cnidium fruit, 17.8-22.3 parts of cortex phellodendri, 13.8-16.2 parts of radix stemonae, 14.2-15.8 parts of cortex dictamni, 4.3-5.7 parts of Chinese prickly ash, and 9.1-10.8 parts of alum. The medicine is simple and reasonable in composition, and has the functions of clearing heat and promoting diuresis, promoting blood circulation to arrest pain, removing blood stasis and dispersing phlegm, and regulating menstruation and dredging collaterals. The invention further discloses a preparation method of the medicine, which comprises the following steps: drying each ingredient based on the weight part, crushing the ingredients into coarse powder of 250-850um or 10-50mesh, mixing uniformly, placing the mixed powder into a supersonic extractor, adding 70% ethanol to extract effective components so as to obtain the alcohol extract of the effective components, placing the extract still for 48-72h, taking and filtering alcohol precipitation supernatant, and recycling ethanol to obtain the concentrated extract of the effective components.
Description
Technical field
The invention belongs to the Chinese medicine preparation technical field, what relate generally to is a kind of medicine for the treatment of gynecological inflammation and preparation method thereof.
Background technology
Gynecological inflammation specifically comprises female vulva inflammation, vaginitis, cervicitis, pelvic inflammatory disease, adnexitis, urethritis, endometritis etc.Clinical diagnosis is seen with chronic more, normally because pathogenic microorganism (comprising microorganisms such as gonorrhea diplococcus, staphylococcus, streptococcus, Da Chang Rod bacterium, mycete, candidiasis, infusorian) has infected reason such as female sex organ corresponding site causes a disease, or because of puerperal, postoperative infection, or cause a disease because of unhygienic, unclean sexual intercourse in menstrual period or because of factors such as the inflammation of adjacent organs spread.
Chinese medicine thinks that the main pathogenesis of chronic gynecological inflammation is deficiency in origin and excess in superficiality.Generally based on the stasis of blood, heat secondly, wetly take second place again.Wound can cause wound and caused the stasis of blood the last ring of artificial abortion, puerperal; The consumption of losing blood in menstrual period, puerperal liquid or lochiostasis can cause in the stagnant heat gives birth to; Sexual intercourse is unclean, operation pollution etc. also can cause the rich knot of damp and hot heresy and QI and blood, amasss and forms the stasis of blood, and core pathology is in " stasis of blood ".Belong to the chronic refractory disease due to the long-term pathogenic factor (as heat, wet etc.).
Doctor trained in Western medicine adopts method treatments such as anti-inflammatory drug, regional perfusion, physiotherapy and operation more.In the therapeutic process, usually because patient's medication is lack of standardization, not thoroughly and without authorization drug withdrawal for the treatment of, so that outbreak repeatedly, protracted course of disease; Or because antibiotic long-term abuse easily causes the damage of the built-in organ of patient, can cause that also vaginal dysbacteriosis and immune function are low, as bring out side effect such as candidal vaginitis, bring difficulty more for the treatment of chronic gynecological inflammation; So the therapeutic effect for chronic gynecological inflammation is not good enough.The traditional Chinese medical science adopts composite treatments such as extract oral, regional perfusion, external application, acupuncture, and advantage is remarkable.Chinese medicine for oral administration heat-clearing and toxic substances removing, activating blood circulation to dissipate blood stasis and dredge the collateral, treating both the principal and secondary aspects of a disease, special effect; External Chinese medicine heat-clearing and toxic substances removing, dampness is antibiotic, and killing parasites for relieving itching is rapid-action, and side effect is little, but life-time service is the effective ways for the treatment of chronic pelvic inflammatory disease.
Summary of the invention
One of purpose of the present invention is to provide a kind of external Chinese patent medicine for the treatment of chronic gynecological inflammation, and this medicine reasonable recipe has the effect of clearing away heat-damp and promoting diuresis, promoting blood circulation and stopping pain, blood stasis-eliminating and stagnation-dissipating, regulating menstruation collateral dredging.Chronic gynecological inflammation to symptoms such as the vaginitis of damp invasion of lower energizer, pelvic inflammatory disease, adnexitis, cervicitis, the many pains of band is evident in efficacy.
Another object of the present invention provides a kind of preparation method for the treatment of the external used medicine of chronic gynecological inflammation.
The invention is for realizing one of goal of the invention, by the following technical solutions:
The external Chinese medicine for the treatment of gynecological inflammation of the present invention, made by following each component by weight:
Radix Sophorae Flavescentis 18.3-21.7, Fructus Cnidii 14.2-15.8, Cortex Phellodendri 17.8-22.3, Radix Stemonae 13.8-16.2, Cortex Dictamni 14.2-15.8, Pericarpium Zanthoxyli 4.3-5.7, Alumen 9.1-10.8.
Further, each component by weight is preferably:
Radix Sophorae Flavescentis 19.2-20.8, Fructus Cnidii 14.5-15.5, Cortex Phellodendri 18.8-21.2, Radix Stemonae 14.3-15.7, Cortex Dictamni 14.5-15.5, Pericarpium Zanthoxyli 4.6-5.4, Alumen 9.5-10.5.
Further, each component by weight is more preferably:
Radix Sophorae Flavescentis 19.6-20.5, Fructus Cnidii 14.8-15.1, Cortex Phellodendri 19.5-20.6, Radix Stemonae 14.7-15.2, Cortex Dictamni 14.8-15.1, Pericarpium Zanthoxyli 4.8-5.2, Alumen 9.8-10.2.
The external preparation method of Chinese medicine of the treatment gynecological inflammation of the invention:
Comprise will be by weight each component oven dry, make the step of coarse powder 250-850um or 24 orders-65 order, mixing; Powder is inserted in the supersound extraction device, add 70% ethanol extraction effective ingredient, make the step of effective ingredient alcohol extract; Left standstill 48-72 hour, and made the precipitate with ethanol supernatant; Filter, reclaim ethanol, make the step of effective ingredient concentrated extract.
Further, when making the effective ingredient alcohol extract, comprise that adding 5-7 doubly measures 70% soak with ethanol 0.5-1.0 hour of ingredients weight parts, continue to add 70% ethanol and doubly measure to 8-10, extracted 1.0-1.5 hour down at 45-55 ℃, collect the step of effective ingredient alcohol extract one.
Further, when making the effective ingredient alcohol extract, also comprise adding 70% ethanol that 5-7 doubly measures ingredients weight parts again, extracted 0.5-1.0 hour down at 45-55 ℃, collect the step of effective ingredient alcohol extract two.
Further, also comprise the step of the effective ingredient concentrated extract being made tincture, liniment, spray, ointment, powder preparation formulation.
In the composition of preparation medicine of the present invention, the characteristic of each component is as follows:
Radix Sophorae Flavescentis: bitter in the mouth, cold in nature; Go into liver, stomach, large intestine, urinary bladder channel.Heat clearing and damp drying, wind dispelling insecticide.Main damp-heat dysentery, have blood in stool, jaundice.Contain alkaloid: matrine, oxymatrine, multiple alkaloids such as N-oxidation sophocarpine.Its effective ingredient has effects such as beauty and skin care, antibiotic, antiinflammatory, diuresis, anti-cell poison, external curing skin pruritus; The noxious dampness skin infection.
Fructus Cnidii: acrid in the mouth hardship, warm in nature; Slightly poisonous; Return kidney channel.The detoxifcation parasite killing, dampness, dispel the wind.External treatment is used for vulval eczema, married woman's pudendal pruritus, trichomonal vaginitis, eczema scabies; The cold-damp leukorrhagia; The arthralgia chiefly caused by damp pathogen lumbago; Impotence due to deficiency of the kidney; The infertile dampness detoxifcation for oral administration of cold womb, relieving cough and asthma.Chemical constituent has the left-handed pinene of the volatile oil of containing and lactone etc. and Coumarins composition.Pharmacological action has antifungal, parasite killing anti-trichomonal, relievings asthma, expansion bronchus effect, antiallergic action, eliminate the phlegm, effect such as gonadotropic Effect, arrhythmia, local anesthetic action, antimutagenic.
Cortex Phellodendri: hardship, cold; Return kidney, bladder, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication is except the hectic fever due to YIN-deficiency clearind deficient heat.Be used for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Main berberine, jateorhizine, magnoflorine, phellodendrine, obacunone, obakulactone, the limonin etc. of containing; That pharmacological action has is antibiotic, antifungal, antitussive, blood pressure lowering, anti-trichomonal, anti-hepatitis, strengthen immunologic function, antiulcer action; In addition, kill mosquitos and flies, diuresis, stomach invigorating, external in addition and promote effects such as subcutaneous hemorrhage absorption.
The Radix Stemonae: sweet-bitter flavor, slightly warm in nature; Return lung meridian.Nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing.Be used for new chronic cough and cough pulmonary tuberculosis cough, pertussis; Outer head louse, body louse, enterobiasis, the pudendum Pruritus of being used for.Honey Radix Stemonae nourishing the lung to arrest cough.Be used for deficiency of YIN chronic cough.Various Radix Stemonae masters contain multiple bases, as (-)-Stemoninine, stemonidine, isostemonidine, former stemonidine etc.; In addition, still contain sugar, lipid, protein, ash and acetic acid, formic acid, malic acid, succinic acid, oxalic acid etc. effects such as pharmacological action has antitussive, eliminates the phlegm, resisting pathogenic microbes, insecticidal action, lax bronchial smooth muscle.
Cortex Dictamni: nature and flavor hardship, salty, cold; Return spleen channel, lung meridian, small intestine meridian, stomach warp, urinary bladder channel.Function heat clearing and damp drying, dispelling wind for relieving itching, detoxifcation.Be used for rubella, eczema, scabies, jaundice, damp and hot numbness due to the wind heat noxious dampness.Root contains dictamine, γ-.gamma.-fagarine, preceding .beta.-fagarine .beta.-fagarine, dictaminine .beta.-fagarine, limonin, cupreol Saponin etc.That pharmacological action has is antibiotic, strengthen uterus and intestinal smooth muscle contraction, antitumaous effect, effect such as analgesic; And the effect of influential cardiovascular system and blood: as excited heart, can make effect such as increase cardiac muscular tension, vasoconstrictive, antiarrhythmic effect, boost.
Pericarpium Zanthoxyli: acrid in the mouth, warm in nature; Slightly poisonous; Return spleen, stomach, kidney channel.Warming middle-JIAO to relieve pain, killing parasites for relieving itching.Be used for coldness and pain in the epigastrium, vomiting is had loose bowels, abdominal pain due to worm stagnation, ascariasis; External treatment eczema pruritus.Pericarpium Zanthoxyli fruit contains volatile oil such as limonene, cumic alcohol. also contain Mang geraniol, plant sterol and unsaturated fatty acid.Pharmacological action has effects such as resisting pathogenic microbes, antidiarrheal, anti-gastric-ulcer, anthelmintic, anesthesia, anti-stress myocardial damage.
Alumen: sour, puckery, cold; Return lung, spleen, liver, large intestine channel.Function: external detoxifcation parasite killing, dampness removing to stop itchin; Hemostasis antidiarrheal for oral administration is dispeled wind-phlegm.External treatment is used for eczema, scabies, { booth } discharging ear; The incessant chronic diarrhea that is used for for oral administration is had blood in stool, metrorrhagia, and epilepsy is gone mad.The dried Alumen removing dampness is held back skin ulcer, and hemostasisization is rotten.Be used for the eczema eczema, { booth } discharging ear, pudendal pruritus leukorrhagia, epistaxis bleeding from the gum, nose { breath } meat.Chemical analysis is aqueous sulfuric acid aluminum potassium [KAl (SO4) 212H2O].Pharmacological action has antibacterial action, anti-trichomonas vaginitis effect, the effect of coagulated protein, choleretic effect, local irritant effect, Thyme Extract.
This side forms, and is scientific and reasonable.Cortex Phellodendri, Radix Sophorae Flavescentis heat clearing and damp drying are monarch in the side, and Fructus Cnidii, the Radix Stemonae, Cortex Dictamni, Pericarpium Zanthoxyli, Alumen removing dampness and killing parasites are antipruritic, are the minister assistant altogether.All medicines share, and play heat clearing and damp drying altogether, the merit of killing parasites for relieving itching.
The technology of the ultrasonic extraction effective ingredient that adopts in the process for preparing medicine of the present invention be utilize that ultrasound wave produces special role such as accelerated particle motion, cavitation effect, vibration homogenize, come for material chemical constituent extraction process, with the new extractive technique of ingredient to extract quickly and efficiently.
Adopt this extractive technique, prepare medicine of the present invention, obvious with the traditional handicraft comparative advantages:
1, extraction efficiency height: the unique physical characteristic of ultrasound wave can be impelled plant cell tissue's breaking cellular wall or distortion, makes the Chinese medicine extracts active ingredients more abundant, and extraction ratio significantly improves than traditional handicraft and reaches 50-500%.
2, extraction time is short: the intensified by ultrasonic wave Chinese medicine extraction can obtain the optimum extraction rate at 24-40 minutes usually, and extraction time shortens more than 2/3 greatly than traditional method, and medical material raw material treating capacity is big.
3, the extraction temperature is low: the optimum temperature of supersound extraction Chinese crude drug has protective effect at 40-60 ℃ to effective ingredient in the medical material of case of thermal instability, facile hydrolysis or oxidation, simultaneously energy-conservation greatly energy consumption.
4, wide adaptability: the supersound extraction Chinese crude drug is not subjected to the restriction of compositional polarity, molecular weight size, is applicable to the extraction of most kind Chinese crude drugs and each constituents, and is applicable to multiple solvent.
5, extraction medicinal liquid impurity is few, and effective ingredient is easy to separate, purification.
6, extraction process operating cost is low, and overall economic efficiency is remarkable.
7, operation is simple, plant maintenance, easy maintenance.
The pharmacological research of medicine of the present invention:
Pharmacological research has confirmed that medicine of the present invention has following pharmacological action at present:
1, bacteriostasis: (seeing Table the external bacteriostasis laboratory test results of 1 medicine of the present invention)
Plate punch method experimental observation this product is to the external inhibition zone test (table 1) of 6 kinds of common pathogens
The result shows: medicine of the present invention has inhibitory action to 6 kinds of common chronic pelvic inflammatory disease pathogenic bacterium.Its sensitivity is followed successively by: enterococcus faecalis>beta hemolytic streptococcus>escherichia coli>staphylococcus aureus>bacteroides fragilis>Bacillus proteus.
The result shows: medicine of the present invention has bacteriostasis than wide spectrum to chronic gynecological inflammation common pathogen.
2, antiinflammatory action: cause mice ear with Oleum Tiglii, with medicine 5.0ml/kg of the present invention, 10.0ml/kg, 15.0ml/kg gastric infusion, observe the mice ear situation.
The result shows: medicine of the present invention can obviously suppress the mice ear degree, demonstrates antiinflammatory action.
3, skin irritation test: get 3 healthy rabbits that skin is intact, the hair of its spinal column both sides, back is removed 2.5cm*2.5cm respectively, draw medicine 1/2 diluent 0.5ml of the present invention again and directly be uniformly coated on the side skin of unhairing, then with the non-stimulated plastic foil covering of one deck and with stimulating immobilization with adhesive tape.The opposite side skin of unhairing is as blank.The time of applying ointment or plaster is 4hr.Being tried 1h, 24h behind the thing, 48h respectively at removal observes local skin and reacts.
The result shows: erythema and edema all do not appear in 3 rabbit, and integral mean value is 0, belong to nonirritant by " skin irritation strength grading ".
4, vaginal mucosa irritation experiment: the female white rabbit of same strain of select health for use, just growing up, body weight 2.0-2.5kg.Be divided into experimental group and matched group, 3 every group.Experimental group adopts medicine 1/2 diluent of the present invention, and matched group adopts normal saline.Last contamination back 24h.Adopt the aeroembolism method animal of conducting oneself in society, cut open the belly and take out complete vagina, vertically cut perusal experimental group and matched group rabbit vagina mucosa.
The result shows: rabbit vagina mucous membrane irritation reaction average integral is 0, belongs to nonirritant.
5, skin allergic reaction: select 48 of the intact Cavia porcelluss of skin for use, male and female half and half, body weight 200-300g.Be divided into experimental group, feminine gender and positive controls at random, 16 groups every group.24h is with unhairing in the 3cm*3cm scope of guinea pig back left side before test.Get the solution of induced concentration 0.5ml, directly be coated in the unhairing district, cover with non-stimulated plastic foil or oilpaper, again with non-stimulated immobilization with adhesive tape, continue 6h, 7d and 14d and in kind repeat.Last is induced back 14d, and the solution 0.5ml that excites concentration directly is coated in depilation district, right side, and with one deck plastic foil and non-stimulated immobilization with adhesive tape, that will apply ointment or plaster behind the 6h is tried the thing flush away.Observe dermoreaction behind 24h and the 48h, dermoreaction is marked.
The result shows: the sensitization rate is 0% in the test, does not see skin allergic reaction.
6, toxicity test: subcutaneous injection medicine of the present invention every other day once, continuously 21d puts to death laboratory animal.Observation experiment animal routine blood test, liver function, renal function and main organs histiocyte form.
The result shows: laboratory animal routine blood test, liver function, renal function are normal, and main organs histiocyte form does not have significant change, proves safety of medicine of the present invention.
Clinical observation:
Drug therapy damp heat downward flowing type pudendal pruritus disease 116 routine clinical observation brief summaries of the present invention
1, physical data
1.1 case source: all patients all are the court's clinic case over 3 years, totally 116 examples, 22~49 years old age, course of disease half a year~1 year.
1.2 case is selected
1.2.1 diagnostic criteria: formulate with reference to " Gynecology of Chinese Medicine " (1988 People's Press).
Diagnosis basis
1.2.1.1 pudendum is scratched where it itches, profuse leukorrhea, and yellow skin such as pus, or as foam water from washing rice sample, its gas is stench.
1.2.1.2 the visible pathogenic microorganism of lab testing.
1.2.1.3 the visible pudendum of gynecologial examination and the hyperemia of vagina flushing.
1.2.1.4 General Symptoms is visible vexedly sleeps less, bitter taste and be bored with, discomfort uncomfortable in chest, poor appetite,
Dialectical foundation:
This disease is many by insufficiency of the spleen resulting in production of dampness, damp invasion of lower energizer, or infect the disease worm, in worm-eaten the moon, then pudendum is scratched where it itches, damp invasion of lower energizer damages to appoint and is with two arteries and veins, the dirty then profuse leukorrhea of dirty liquid, and yellow skin such as pus, or as foam water from washing rice sample, its gas is stench, itches pain unbearably, disturbs and heart channel, then vexedly sleeps uneasy in either sitting or lying less.Contain in damp and hot, hinder in middle Jiao, then bitter taste and be bored with discomfort uncomfortable in chest, poor appetite.Yellow and greasy fur, wiry and frequent pulse.
1.2.2. get rid of the case standard:
1.2.2.1 get rid of other sexually transmitted disease (STD).
1.2.2.2 get rid of diseases such as trauma of vulva, serious erosion.
1.2.2.3 to multiple drug allergy person.
1.2.2.4 not medication in accordance with regulations can't be judged that curative effect or data are not congruent to affect the treatment and safety judgement person.
2. Therapeutic Method: external is coated with washes the affected part.
Pruritus vulvae, redness: a 10ml, 2 times on the one, be applied to the pudendum affected part, wash down after 15 minutes; Or add doubly warm boiled water dilution back bathing pudendum of 10-20.
Diseases such as vaginitis: a 20-40ml 2-4 time on the one, adds 10-20 and doubly washes the affected part with vaginal douche after the warm boiled water dilution.
3 observation indexs:
3.1 curative effect determinate standard
3.1.1 cure: transference cure, lab testing are repeatedly normal.
3.1.2 take a turn for the better: cardinal symptom and relevant lab testing have improvement.
3.1.3 do not heal: symptom and lab testing no change.
4.1 treatment back clinical efficacy: see Table 2.
Table 2 clinical control treatment curative effect (%)
From clinical control therapeutic outcome (table 2) as can be seen, medicine of the present invention is 94.8% for the treatment total effective rate of chronic gynecological inflammation.Wherein, cure rate 62.1%, improvement rate 32.8%, inefficiency 5.2%, general curative effect is remarkable.
4.2 untoward reaction: do not see obvious side reaction in the therapeutic process.
4.3 conclusion: Chinese medicine is thought insufficiency of the spleen resulting in production of dampness, and damp invasion of lower energizer, or infect the disease worm causes damp invasion of lower energizer to draw main cause for pudendal pruritus disease in worm-eaten the moon.So control the method with heat clearing and damp drying, killing parasites for relieving itching.The treatment of medicine of the present invention pair and the pudendal pruritus disease of damp invasion of lower energizer, instant effect, determined curative effect, side effect is little, by clinical observation, follow up a case by regular visits to feedback, adds up to efficient and reaches more than 90.0%.
The case case:
1, patient: grandson, woman, 41 years old, teacher.First visit on February 18 in 2009.
Patient's pudendum was itched nearly 1 year unbearably bitterly, the uncomfortable companion of lower abdomen lumbago, leucorrhoea grow in quantity, mucus shape.Haemorrhagia sub coitu, waist and sacrum pain, increase the weight of menstrual period.Gynecologial examination, cervical hypertrophy has polyp.Vexedly sleep less, then bitter taste and be bored with poor appetite.Yellow and greasy fur, wiry and frequent pulse.
Diagnosis: chronic cervicitis.
Treatment: medicine external of the present invention, each 30ml adds 10-20 and doubly washes the affected part with vaginal douche after the warm boiled water dilution every day 2 times, washes down 5 days courses for the treatment of after 15 minutes.
Two examine (on February 23rd, 2009)
All symptom complete obiterations of patient.After treatment 7 days was followed up a case by regular visits to 1 year, not recurrence again.
2, patient: field, woman, 32 years old, accounting.JIUYUE in 2010 first visit on the 22nd.
Medical history during treatment: the patient went to a doctor because of hypogastralgia in indistinct uncomfortable 4 years.Patient main suit's eumenorrhea, because the band pedestrian's stream of becoming pregnant adds removal of intrauterine device, postoperative is not gone uterine curettage entirely again because of artificial abortion, after this feels hypogastralgia gradually before 1 year, aggravate after having sexual intercourse or tired back, and lumbosacral aching pain is many with the leucorrhea amount, yellow skin, once used antibiotic therapy, bad during state of an illness fashion, delay is difficult
The main suit: hypogastralgia, lumbosacral aching pain is urinated puckery dysurea, and leucorrhea amount is many, yellow skin, frowziness, xerostomia, Mental fatigue, it is not good enough to sleep, and poor appetite, constipation with dry stool, dimly red tongue, yellow and thin fur, stringy and thready pulse, last menstrual period are JIUYUE in 2010 15 days.Pregnant 3 artificial abortions 2 produce 1 and deposit 1.
Gynecologial examination: the married formula of pudendum, pudendum is unobstructed, in see more yellow secretions; Cervix uteri is smooth, and the pain of act is arranged; Retroposition of uterus, matter is medium, and size is normal, and mild tenderness is movable good; The double accessory tenderness thickens into lumps.The pelvic cavity B ultrasonic: the uterus size is normal, and douglas cul-de-sac has hydrops.
Diagnosis: chronic pelvic inflammatory disease.
Treatment: medicine external of the present invention, each 40ml adds 10-20 and doubly washes the affected part with vaginal douche after the warm boiled water dilution every day 2 times, washes down 5 days courses for the treatment of after 15 minutes.
Two examine (on JIUYUE 27th, 2010) symptom obviously alleviates, and sleeps, and continues to give medicine of the present invention and treats with method, 5 days courses for the treatment of.
Three examine (on October 2nd, 2010) transference cure, and state of an illness recovery from illness is followed up a case by regular visits to and do not seen recurrence.
3, patient: the week certain, 43 years old, the workman.JIUYUE in 2011 first visit on the 11st.
Slight heating, hypogastric region weighs down the pain that expands, and is persistence.Leucorrhea amount showed increased, purulence band blood, frowziness, gynecologial examination: cervix uteri mouth purulent leukorrhea, lifting pain, body of uterus has mild tenderness.Lab testing sees that leukocyte raises neutrophilic leukocytosis.
Diagnosis: endometritis.
Treatment: give and medicine external of the present invention, each 20ml adds 10-20 and doubly washes the affected part with vaginal douche after the warm boiled water dilution every day 2 times, washes down 5 days courses for the treatment of after 20 minutes.
Two examine (on October 7th, 2010) symptom obviously alleviates, and sleeps, and continues to give medicine of the present invention and treats with method, 5 days courses for the treatment of.
Three examine (on October 12nd, 2010) transference cure, and state of an illness recovery from illness is followed up a case by regular visits to and do not seen recurrence.
Description of drawings
Fig. 1 is the invention pharmaceutical preparation schematic flow sheet;
The specific embodiment
Embodiment one
The external Chinese medicine medicine of the treatment gynecological inflammation of present embodiment, made by following each component by weight:
Radix Sophorae Flavescentis 20.5, Fructus Cnidii 15.1, Cortex Phellodendri 19.5, the Radix Stemonae 14.7, Cortex Dictamni 15.1, Pericarpium Zanthoxyli 4.8, Alumen 10.2.
Embodiment two
The external Chinese medicine medicine of the treatment gynecological inflammation of present embodiment, made by following each component by weight:
Radix Sophorae Flavescentis 19.6, Fructus Cnidii 14.8, Cortex Phellodendri 20.6, the Radix Stemonae 15.2, Cortex Dictamni 14.8, Pericarpium Zanthoxyli 5.2, Alumen 9.8.
Embodiment three
The external Chinese medicine medicine of the treatment gynecological inflammation of present embodiment, made by following each component by weight:
Radix Sophorae Flavescentis 20.0, Fructus Cnidii 15.0, Cortex Phellodendri 20.0, the Radix Stemonae 15.0, Cortex Dictamni 15.0, Pericarpium Zanthoxyli 5.0, Alumen 10.0.
The preparation method of the external Chinese medicine medicine of the treatment gynecological inflammation of above-described embodiment in conjunction with Fig. 1, is example with preparation lotion finished product,
At first the component of each weight portion is dried, is made coarse powder 250-850um or 24 orders-65 order, mixing; Powder is put into the supersound extraction device, and adding 5-7 doubly measures 70% soak with ethanol 30-60 minute of powder weight portion, continues to add 70% ethanol and doubly measures to 8-10, and extraction is 1.0-1.5 hour under 45-55 ℃, collection effective ingredient alcohol extract one; Add 5-7 again and doubly measure 70% ethanol, extracted 0.5-1.0 hour down at 45-55 ℃, collect effective ingredient alcohol extract two; Merge extracted twice liquid, low temperature 2-8 ℃ storage was left standstill 48-72 hour, made the precipitate with ethanol supernatant; Incline and get supernatant, filter, reclaim ethanol, make the effective ingredient concentrated extract.Add the purified water of 3-4 times of effective ingredient concentrated extract weight portion, mixing left standstill 24-36 hour, made the water precipitating supernatant; Incline and get supernatant, filter, add purified water to nearly full dose, regulate pH value to 3.5-5.5, standardize solution, fill namely gets the lotion finished product.
Dosage form selection can be made into dosage forms such as tincture, liniment, spray, ointment, powder based on lotion at concrete treatment, easy to use and carry.
The preparation technology of medicine of the present invention is final definite through studying, put into practice demonstration for many years repeatedly.Preparation technology as extracting solvent, adopts ultrasonic extraction (being also referred to as extraction) Chinese crude drug effective ingredient with 70% ethanol.With 70% ethanol as extracting solvent, wide adaptability, impurity is few, the finished product mouthfeel is limpid, color and luster is shinny.Ultrasonic extraction has extracts the unique advantage that temperature is low, extraction ratio is high, extraction time is short, is applicable to the extraction of Chinese crude drug and various animal and plant effective contents.With technology such as traditional water extract-alcohol precipitation relatively; extraction ratio improves 50%-100%; extraction time (minute) shorten more than 1/2; extract temperature and be reduced to 40-60 ℃; being more conducive to the protection of active ingredient, is to substitute traditional aqueous extraction-alcohol precipitation technology method to realize modern high technology means efficient, that the energy-saving and environmental protection formula is extracted.
Claims (7)
1. external Chinese medicine for the treatment of gynecological inflammation is characterized in that: made by following each component by weight:
Radix Sophorae Flavescentis 18.3-21.7, Fructus Cnidii 14.2-15.8, Cortex Phellodendri 17.8-22.3, Radix Stemonae 13.8-16.2, Cortex Dictamni 14.2-15.8, Pericarpium Zanthoxyli 4.3-5.7, Alumen 9.1-10.8.
2. the external Chinese medicine for the treatment of gynecological inflammation according to claim 1, it is characterized in that: each component by weight is preferably:
Radix Sophorae Flavescentis 19.2-20.8, Fructus Cnidii 14.5-15.5, Cortex Phellodendri 18.8-21.2, Radix Stemonae 14.3-15.7, Cortex Dictamni 14.5-15.5, Pericarpium Zanthoxyli 4.6-5.4, Alumen 9.5-10.5.
3. the external Chinese medicine for the treatment of gynecological inflammation according to claim 1 is characterized in that: each component by weight more preferably:
Radix Sophorae Flavescentis 19.6-20.5, Fructus Cnidii 14.8-15.1, Cortex Phellodendri 19.5-20.6, Radix Stemonae 14.7-15.2, Cortex Dictamni 14.8-15.1, Pericarpium Zanthoxyli 4.8-5.2, Alumen 9.8-10.2.
4. prepare the external preparation method of Chinese medicine of the described treatment gynecological inflammation of claim 1-3, it is characterized in that:
Comprise will be by weight each component oven dry, make the step of coarse powder 250-850um or 10 orders-50 order, mixing; Powder is inserted in the supersound extraction device, add 70% ethanol extraction effective ingredient, make the step of effective ingredient alcohol extract; Left standstill 48-72 hour, and made the precipitate with ethanol supernatant; Filter, reclaim ethanol, make the step of effective ingredient concentrated extract.
5. the external preparation method of Chinese medicine for the treatment of gynecological inflammation according to claim 4, it is characterized in that: when making the effective ingredient alcohol extract, comprise that adding 5-7 doubly measures 70% soak with ethanol 0.5-1.0 hour of ingredients weight parts, continue adding 70% ethanol doubly measures to 8-10, extracted 1.0-1.5 hour down at 45-55 ℃, collect the step of effective ingredient alcohol extract one.
6. the external preparation method of Chinese medicine for the treatment of gynecological inflammation according to claim 4, it is characterized in that: when making the effective ingredient alcohol extract, also comprise and add 70% ethanol that 5-7 doubly measures ingredients weight parts again, extracted 0.5-1.0 hour down at 45-55 ℃, collect the step of effective ingredient alcohol extract two.
7. the external preparation method of Chinese medicine for the treatment of gynecological inflammation according to claim 4 is characterized in that: also comprise the step of the effective ingredient concentrated extract being made tincture, liniment, spray, ointment, powder preparation formulation.
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CN103933441A (en) * | 2014-05-15 | 2014-07-23 | 刘善奎 | Traditional Chinese medicinal suppository for treating cervicitis and preparation method thereof |
CN104367738A (en) * | 2014-07-29 | 2015-02-25 | 天津泰源中草药技术开发有限公司 | Cell-energy skin-care liquid |
CN107684662A (en) * | 2017-08-22 | 2018-02-13 | 唐家婷 | A kind of health care of women waistband |
CN108186959A (en) * | 2018-03-26 | 2018-06-22 | 成都中医药大学 | A kind of pharmaceutical composition with antibacterial anti-inflammatory, desinsection itching-relieving action and preparation method thereof |
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CN101337040A (en) * | 2008-07-11 | 2009-01-07 | 丁绍余 | Gynecology lotion |
CN101361936A (en) * | 2008-09-18 | 2009-02-11 | 何进爱 | Traditional Chinese medicine combination of gynaecologic Shiyang washing lotion and preparation method thereof |
CN102000291A (en) * | 2010-11-02 | 2011-04-06 | 李永胜 | Liquid, powder, capsules and paste for preventing and treating gynecology |
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CN101337040A (en) * | 2008-07-11 | 2009-01-07 | 丁绍余 | Gynecology lotion |
CN101361936A (en) * | 2008-09-18 | 2009-02-11 | 何进爱 | Traditional Chinese medicine combination of gynaecologic Shiyang washing lotion and preparation method thereof |
CN102000291A (en) * | 2010-11-02 | 2011-04-06 | 李永胜 | Liquid, powder, capsules and paste for preventing and treating gynecology |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103933441A (en) * | 2014-05-15 | 2014-07-23 | 刘善奎 | Traditional Chinese medicinal suppository for treating cervicitis and preparation method thereof |
CN105497715A (en) * | 2014-05-15 | 2016-04-20 | 刘善奎 | Traditional Chinese medicine suppository for treating cervicitis |
CN104367738A (en) * | 2014-07-29 | 2015-02-25 | 天津泰源中草药技术开发有限公司 | Cell-energy skin-care liquid |
CN107684662A (en) * | 2017-08-22 | 2018-02-13 | 唐家婷 | A kind of health care of women waistband |
CN108186959A (en) * | 2018-03-26 | 2018-06-22 | 成都中医药大学 | A kind of pharmaceutical composition with antibacterial anti-inflammatory, desinsection itching-relieving action and preparation method thereof |
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