CN103181556B - Health food having effects of life cultivation and health preservation in spring and preparation method thereof - Google Patents
Health food having effects of life cultivation and health preservation in spring and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a health food, particularly to a health food for anti-fatigue and liver protection and nourishing in spring and a preparation method of the health food, and also relates to new application of the composition. The health food comprises radix astragali, Chinese wolfberry, spina date seed, upripe malt, Chinese date, ginger and rose. The health food formula not only has the traditional functions of regulating vital energy and blood of viscera of a human body and promoting the human body to conform to change rule of yin and yang in spring, but also has the modern effects of anti-fatigue, liver protection and immunity enhancement.
Description
Invention field
The present invention relates to a kind of health food and preparation method thereof being specially adapted to antifatigue in spring, protecting and nourishing liver, relate to the novelty teabag of said composition simultaneously.
Background technology
The present invention relates to modern health care and traditional Chinese medical science four seasons diet regimen field.
Spring " all things on earth is recovered, and yang-energy hair tonic, qi and blood is treated freely " and " spring answers liver " and human body easily send out the feature such as hepatopathy, epidemic disease; Spring, nourishment maintenance should be principle with " liver is protected in invigorating the spleen for benefiting qi and raising yang, happy qi and blood ", and namely solid protection defends gas, improved immunity of organisms to prevent the generation of many diseases; Happy qi and blood, strengthens fatigue resistance; Protecting and nourishing liver, prevents hepatopathy recurrence etc.
Tired also known as tired, be a kind of subjective uncomfortable sensation.But objectively under equal conditions, can be lost it and completes the normal activity or ability to work be originally engaged in.Physiological change: due to the accumulation of lactic acid and other metabolites, muscle tone declines, and exercise endurance reduces; Due to the accumulation of carbon dioxide, stimulate respiratory center, also can cause yawning.Every disease progression all can occur tired to certain phase, therefore tired disease can be caused a lot.Tired also known as tired be the discomfort of subjective a kind of fatigue and weak, feel fatigue is not specific symptoms, a lot of disease all can cause fatigue, current anti-fatigue medicament mainly contains ginseng, wilsonii, glossy ganoderma, royal jelly, atriphos (apt, vitamins etc., wherein vitamin to be absolutely necessary nutrient to body, is also have roborant more representational medicine.As adopted vitamin b1 and vitamin b6 to treat athletic fatigue state and electrocardiographic abnormality, have received good effect.Vitamin b12 is also very general as the application of a kind of strengthening medicine in sportsman, and strengthens the measure of muscle power as pre-games, can keep muscle power, improve a poor appetite and sleep, and prevent jerk.Take after exercise, can dispelling fatigue be accelerated.Vitamin c is also a kind of dispelling fatigue, strengthens the standing medicine of muscle power.The elderly uses the recovery for muscle power, and the improvement of overall physiological function has a lot of benefit.
Hepatic injury is the disease of clinical common harm humans health.Hepatic injury is exactly the invasion that liver is subject to extraneous factor, thus the liver damage caused.Hepatic injury is generally divided into infectious hepatic injury and chemical damage.Clinical and experiment all proves, traditional Chinese medicine has certain short regeneration and repair to hepatic injury.Use the experience of Chinese medicine compound prescription compatibility, preventing and treating the hepatic injury that some cause of disease causes is one both effective and practicable treatment thoughts.
Immunity is the defense mechanism of human body self, is human bioequivalence and any foreign matter (virus, bacterium etc.) eliminating external intrusion; Process is old and feeble, damage, the ability of mutant cell and virus infected cell in the own cells of dead, sex change and identification and handling body.Immunity or human bioequivalence and eliminating " dissident ", safeguard the critical function of homeostasis.Much research shows, much Chinese medicine has good regulating action to immunity of organism.
Diet regimen when four
Health preserving in four seasons is exactly the principle according to the traditional Chinese medical science " correspondence between man and universe ", according to the rule of Human Physiology reform of nature circle YIN YANG in four seasons change, initiatively take to comprise the multiple proper method such as rule of life, diet, motion, spirit, to improve the physiological fitness of body, farthest playing naturally treating of human body can, go after profits and advoid disadvantages, the object of reach illness prevention and fitness, promoting longevity.Wherein according to four time apolegamy suitable food, to reach salubrious method, i.e. four seasons dietary regimen.
In the clinical practice of the traditional Chinese medical science, medicine is relative with the division of food, because most of Chinese medicine can eat, medicine and the difference of food are different on a consumption, and the amount that toxic action is large is little, and the little amount of toxic action is large.Simultaneously for some foods with medicine and the double function of food, its medicine is also only its different objects used from the difference of food.Its side effect of food on ordinary meaning is little, has very large amount ranges, is mainly used in strengthening by means of tonics; And medicine has certain side effect, amount ranges is smaller, is mainly used in disease therapy.Some of them had both been had the food effect of allaying one's hunger by empirical evidence, had again the Chinese medicine of strong treatment disease effect, and because it has medicine food dual-use function, and have good security, what become diet regimen mainly selects object always.When four, diet regimen is then the principle according to the traditional Chinese medical science " integration of drinking and medicinal herbs " and " correspondence between man and universe ", draws the experience of the traditional Chinese medical science " four seasons health ", namely should " when the spring, summer, autumn and winter four, the difference change feed in season is seasonal nourishes medicine food, is referred to as four seasons diet and mends and be good for.
Four seasons diet regimen relates to " to eat as mending ", the empirical content such as " food get Qi Fa " and " eat and Time ".But about four time diet regimen a large amount of experiences only sporadically appear in successive dynasties medical book, and content is mainly concerned with the compatibility and incompatibility of drugs food that the four seasons use records, wherein and medicine feeding habits energy theoretical according to traditional Chinese medical science Health preserving in four seasons and the proposition of compound compatibility feature then little for the formula being specifically designed to Health preserving in four seasons.The various tea beverage that modern market has many nominals with health role, between can see as the four seasons use the Chinese medicine herbal tea (four seasons tea) that goes out of specialized designs, but its formula still lacks necessary traditional Chinese medicine scientific principle and the support of experiential basis, and it especially can not be provided to have the evidence of four seasons health care effectiveness.This series products is the bagged instant preparation belonging to crude drug that suitable boiling water brews and slightly fall apart also more, exist effective components utilising degree not high, use inconvenience and the problem such as mouthfeel is not good.
The traditional Chinese medical science is thought, as medicine, food also has its respective performance, comprise the content such as nature and flavor (fever and chills and warm and cool four gas and the bitter sweet pungent salty five tastes), Gui Jing, lifting sink-float, reinforcing and reducing methods, the food of different performance can produce different functions by different compatibility, the imbalance of body internal organs yang blood and qi can be corrected, play health care (prevention, body-building, rehabilitation etc.) effect.
Summary of the invention
One object of the present invention is openly a kind of new antifatigue, is particularly useful for the food of health care in spring, protecting and nourishing liver; Another object of the present invention is open a kind of new antifatigue and is applicable to the preparation method of food of health care in spring; One object of the present invention is also open a kind of new antifatigue and is applicable to the novelty teabag of food of health care in spring.
The bulk drug composition of health food of the present invention and proportioning following (by weight):
Health food preferred feedstock medicine proportioning of the present invention can be:
Health food preferred feedstock medicine proportioning of the present invention can also be:
Health food preferred feedstock medicine proportioning of the present invention can also be:
By practice of pharmacy, the invention described above health-care food composition can be added customary adjuvant and conventionally be prepared into various clinical formulation, comprise the formulation of oral formulations or parenterai administration.Said oral formulations is selected from the one in the middle of tablet, capsule, pill, granule, supensoid agent, dripping pill, liquid oral, brewed dose of bag.
Health food of the present invention also can add conventional health food excipient, as solvent, disintegrant, flavouring, anticorrisive agent, colouring agent etc.
The preparation method of health food extract of the present invention is following method:
Get ginger and rose adds 2-5 times of water gaging, water distillating extracting oil, collect volatile oil, for subsequent use; Get northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling to extract 1-3 time, each 0.5-1.5 hour, amount of water is respectively 6-10 doubly, filter, merging filtrate, during filtrate reduced in volume to 60 DEG C, relative density is 1 ~ 1.5, adds ginger and rose volatile oil mixes, drying under reduced pressure, dried cream powder is broken into fine powder.
The preparation method of health food extract of the present invention is preferably following method:
Get ginger and rose adds 3 times of water gagings, water distillating extracting oil, collect volatile oil, for subsequent use; Get northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling and extract 2 times, each 1 hour, amount of water is respectively 10 times, 8 times, filter, merging filtrate, during filtrate reduced in volume to 60 DEG C, relative density is 1.25 ~ 1.30, add ginger and rose volatile oil mixes, drying under reduced pressure, temperature≤70 DEG C, dried cream powder is broken into fine powder.
The preparation method of health food of the present invention is following method:
Get ginger and rose adds 2-5 times of water gaging, water distillating extracting oil, collect volatile oil, for subsequent use; Get northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling to extract 1-3 time, each 0.5-1.5 hour, amount of water is respectively 6-10 doubly, filter, merging filtrate, during filtrate reduced in volume to 60 DEG C, relative density is 1 ~ 1.5, the dextrin adding 50-100 weight portion mixes, drying under reduced pressure, temperature≤70 DEG C, dried cream powder is broken into fine powder, adds 95% ethanol and makes softwood, and 14 mesh sieves are granulated, dry, temperature≤70 DEG C, the whole grain of 12 mesh sieve, obtains particle; Get ginger and rose volatile oil to add 1-3 times amount ethanol and mix, add in particle, the dolomol adding 0.3-1 weight portion mixes, place 1-4 hour, add customary adjuvant and be conventionally prepared into one in the middle of tablet, capsule, pill, granule, supensoid agent, dripping pill, liquid oral, brewed dose of bag.
The preparation method of health food of the present invention is preferably following method:
Get ginger and rose adds 3 times of water gagings, water distillating extracting oil, collect volatile oil, for subsequent use; Get northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling and extract 2 times, each 1 hour, amount of water is respectively 10 times, 8 times, filter, merging filtrate, during filtrate reduced in volume to 60 DEG C, relative density is 1.25 ~ 1.30, the dextrin adding 72.4 weight portions mixes, drying under reduced pressure, temperature≤70 DEG C, dried cream powder is broken into fine powder, adds 95% ethanol and makes softwood, and 14 mesh sieves are granulated, dry, temperature≤70 DEG C, the whole grain of 12 mesh sieve, obtains particle; Get ginger and rose volatile oil to add 1 times amount ethanol and mix, add in particle, the dolomol adding 0.5 weight portion mixes, place 2 hours, add customary adjuvant and be conventionally prepared into one in the middle of tablet, capsule, pill, granule, supensoid agent, dripping pill, liquid oral, brewed dose of bag.
The present invention relates to a kind of health food, particularly a kind of for spring antifatigue, the health food of protecting and nourishing liver and preparation method, relate to the novelty teabag of said composition simultaneously.This health food is made up of northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus, date, ginger and rose.Health food of the present invention has antifatigue, protecting and nourishing liver and strengthens the effect of immunity.
Following experimental example and embodiment are used for further illustrating but are not limited to the present invention.
Experiment of the present invention all adopts following material.
Medicine: in health preserving tea in spring (extract by preparation in embodiment 11), 10g particle/sky, is provided by Beijing University of Chinese Medicine's state key Academic Area " Pharmacology of Chinese medicine Formulae, lot number: 20100305.DDB, Zhejiang Medicine Co produces, lot number: 20090303; Domperidone Tablets, Jiangxi Jie Zhong biochemistry corporation,Ltd. produces, lot number: 200808006275; Bolus for reinforcing middle-jiao and replenishing qi, Henan Province Wanxi Pharmacy Stock Co., Ltd produces, lot number: 080905; Content of Tablet of Levamisole Hydrochloride, Shandong Kernel and Hall Pharmaceutical Industry Co., Ltd., lot number: 100105.
Reagent: barium sulphide, Shanghai Zhuo Rui Chemical Co., Ltd.; DNCB, Beijing Xing Fu fine chemistry research institute, lot number: 20091102; Sheep blood, system in Beijing Jing along animal-breeding center, the Xiushan Mountain, SRBC (face the used time with brine 3 times, through 2000rpm 10 minutes packed red cells, then press desired concn and dilute); Complement: fresh cavy at least 3 pooled serums through SRBC (10: 1) in 4 DEG C absorb 30 minutes rearmounted less than-20 DEG C for subsequent use; Dou Shi reagent, Bioengineering Research Institute is built up in Nanjing.Incomplete 1640 (Sigma); Hyclone (Hyclone), ConA (Sigma); LPS (Sigma), MTT (Sigma); 0.01NHCL-10%SDS, dual anti-, Tris-NH4Cl, PBS, 75% ethanol.
Animal: Kunming mouse, 20-24g, male and female dual-purpose; Balb/c mouse, 18-22g, female.Cavy, 200 ± 20g, female.
Instrument: 754-spectrophotometer; Olympus-400 type automatic clinical chemistry analyzer; High speed freezing centrifuge; ELIASA; Microscope; CO2 constant incubator.
experimental example 1spring, health preserving tea was to mouse endurance and anti-stress effect
1 gets above-mentioned experiment material
2 methods
2.1 impacts on mouse swimming time
Temperature 18-25 DEG C; Humidity: 55-65% (same afterwards).Getting body weight is 18-22g mouse 50, male and female half and half, be divided at random normal group, bolus for reinforcing middle-jiao and replenishing qi group (positive group 4.68g/kg), health preserving tea little, in, heavy dose of group (1.30,2.60,5.20g particle/kg, calculate by body surface area, be equivalent to 1,2,4 times of people's consumption 10g particle/sky).Each group of according to dosage gastric infusion, continuous 7 days, normal group gave isometric(al) distilled water, after last administration 30 minutes, mouse tail heavy burden 2g (being about 7% of body weight) puts water went swimming, and observing mouse swimming and exhaust the dead time to power, is mouse swimming time.
2.2 affected the mouse oxygen deficit tolerance time-to-live
Getting body weight is 18-22g mouse 50, be divided at random normal group, bolus for reinforcing middle-jiao and replenishing qi group, health preserving tea little, in, heavy dose of group, each group of according to dosage gastric infusion, continuous 7 days, normal group gives isometric(al) distilled water, after last administration 30 minutes, each group of mouse is put into respectively the 200ml wide-mouth bottle filling soda lime, timing immediately, observes the mouse survival time.
2.3 statistical procedures: data all adopt
represent, compare between the group between multiple sample and adopt one-way analysis of variance (one-way ANOVA), carry out SNK-Q inspection and carry out Chi-square Test.Total data adopts SPSS13.0 software to process.
3 results
3.1 spring health preserving tea endurance and anti-stress effect
3.1.1 on the impact of mouse swimming time
The results are shown in Table 1.
Table 1 health preserving tea in spring affects mouse swimming time
With normal group ratio, * P < 0.05.
From table 1, successive administration is after 7 days, in positive group, spring health preserving tea, a large amount of group can obviously increase the mice burden swimming time, its positives group and a large amount of groups has significant with normal group than difference, spring health preserving tea by 1.30,2.60,5.20g particle/kg (calculates by body surface area, be equivalent to 1,2,4 times of people's consumption 10g particle/sky) give mouse stomach administration 7 days, can significantly increase the mice burden swimming time, have the trend extending mouse Hypoxia under normal pressure.
3.1.2 on the impact of mouse Hypoxia under normal pressure
The results are shown in Table 2.
Table 2 health preserving tea in spring affects mouse Hypoxia under normal pressure
From table 2, than Normal group, successive administration is after 7 days, and the Hypoxia under normal pressure of each administration group mouse is all shown in increase in various degree, but no significant difference (P > 0.05).
experimental example 2spring, health preserving tea was to the protective effect of acute liver damage
1 gets above-mentioned experiment material
2 methods
Getting body weight is 18-22g mouse 60, male and female half and half, be divided at random normal group, model group, positive group (DDB group), health preserving tea little, in, heavy dose of group, respectively organize according to dosage gastric infusion, normal group gives isometric(al) distilled water, continuous 7 days.Last administration is after 30 minutes, the carbon tetrachloride peanut oil solution 0.1ml/10g body weight of each mouse lumbar injection 0.2% except normal group, fasting can't help water after 18 hours, plucked eyeball and got blood, adopted Olympus-400 type automatic clinical chemistry analyzer to measure AST, ALT content.
Statistical procedures: data all adopt
represent, compare between the group between multiple sample and adopt one-way analysis of variance (one-way ANOVA), carry out SNK-Q inspection and carry out Chi-square Test.Total data adopts SPSS13.0 software to process.
3 results
The results are shown in Table 3.
Table 3 health preserving tea in spring is to the protective effect of acute liver
With normal group ratio, * P < 0.05; With model group ratio, Δ P < 0.05.
From table 3, after the carbon tetrachloride peanut oil solution of lumbar injection 0.2%, AST, ALT that modeling is respectively organized obviously increase, and have significant with normal group than difference, and model success is described.Successive administration 7 carries out the serum AST of each administration group mouse prevented, ALT all obviously reduces, and its positives group, a large amount of group and model group ratio, difference has significant.Illustrate that spring, health preserving tea had certain protective effect to acute liver damage.
Experimental example 3 health preserving tea in spring is on the impact of immune function of mice
1 gets above-mentioned experiment material
2 methods
2.1 serum hemolysin determination methods
Balb/c mouse is divided at random small dose group (1.55g/kg), middle dosage group (3.1g/kg) and left-handed group (5mg/kg), often group 10.Each group of mouse peritoneal injection 20%SRBC 0.2ml/ only, after immune 1h, gives corresponding medicine through gavage, every every day each administration 0.4ml, once a day, blank group fills with equivalent distilled water.Administration after 7 days mouse pluck eyeball and get blood, separation of serum, serum SPSS is diluted 500 times afterwards for measuring.
Hemolytic reaction: add diluted serum 1ml, 5%SRBC 0.5ml, 10% complement 1ml in reaction tube successively, put 37 DEG C of water bath with thermostatic control inside holding 30 minutes, then move to cessation reaction in ice bath, centrifugal 5 minutes of 1500rpm, get supernatant 1ml and add Dou Shi reagent 3ml, shake up placement 10 minutes.Getting each sample adds in 96 orifice plates, every hole 200ul.Absorbance is surveyed in 540nm wavelength with ELIASA.
SRBC HD50 value: get 5%SRBC 0.25ml and add Dou Shi liquid to 4ml, add in 96 orifice plates and survey absorbance, be absorbance during SRBC HD50 used in experiment.Sample cell HD50 value HC50 is calculated as follows: absorbance × extension rate during the serum HC50=sample absorbance value/SRBC HD50 of every mouse.
2.2 lymphocyte proliferation assay
Balb/c mouse is divided at random small dose group (1.55g/kg), middle dosage group (3.1g/kg) and left-handed group (5mg/kg), often group 10.4 groups of mouse lose hair or feathers at mouse web portion fixed position 3cm × 1cm area with barium sulphide starch mixture in experiment for first 1 day, warm water cleaning.Test the 1st, 2 day (sensitization phase) in mouse web portion depilation position painting 1%DNCB, every day 1 time, each 20ul, 3rd, 4,5 days not coatings, 6th day (sending out quick the phase) brings out dermatitis in the left hard of hearing painting 20ul 0.5%DNCB of mouse, and auris dextra back of the body painting 1: 1 acetone glycerol 20ul compares.Before the 1st coating, 2h starts to gavage relative medicine, every mouse each administration 0.4ml every day, and every day 1 time, continuous use 5 days, brings out front 2h on the 6th day and bring out each gastric infusion of rear 4h 1 time.After bringing out 24h, after each group mouse plucks eyeball execution, get spleen immediately and prepare splenocyte suspension.
Prepare splenocyte suspension: in ice bath, spleen is placed on 200 eye mesh screens, add complete 1640 liquid a little, squeeze out splenocyte gently.Through Tris-NH4Cl lysed erythrocyte, after PBS washes twice, carry out cell count.Observing living cells with 0.4% Trypan Blue during cell count should more than 90%.Splenocyte suspension is made into 107/ml concentration.
Added by splenocyte in 96 orifice plates, every hole 100ul, each sample repeats 3-4 hole.Stimulate during T cell propagation and add ConA (5ug/ml), stimulate during B cell proliferation and add LPS (10ug/mI).Put into 37 DEG C of 5%CO2 incubators, cultivate 72 hours.Stop cultivating first 6 hours, every hole adds 5mg/ml MTT solution, stops adding 0.01NHCL-10%SDS when cultivating, and puts 37 DEG C and spends the night.Absorbance is surveyed in 570nm wavelength with ELIASA.
2.3 statistical procedures: data all adopt
represent, compare between the group between multiple sample and adopt one-way analysis of variance (one-way ANOVA), carry out SNK-Q inspection and carry out Chi-square Test.Total data adopts SPSS13.0 software to process.
3 results
3.3 spring health preserving tea on the impact of immune function of mice
3.3.1 spring, health preserving tea was on the impact of mouse humoral immune function
The results are shown in Table 4.
Table 4 health preserving tea in spring is on the impact of mice serum hemolysin
With normal group ratio, * P < 0.05.
From table 4, compare to Normal group, low dose of and heavy dose of group and levamisol group mouse the HD50 value of health preserving tea in spring is all shown in and raises in various degree, wherein small dose group is without significant difference, and levamisol and heavy dose of group difference all have significant (P < 0.05).
3.3.2 spring, health preserving tea was on the impact of mouse cell immunologic function
The results are shown in Table 5.
Table 5 health preserving tea in spring is on the impact of mouse T, B cell proliferation
With Normal group ratio, * P < 0.05, * * P < 0.01.
As shown in Table 5, compare with Normal group, spring, health preserving tea small dose group was bred all in increasing in various degree with the beer spoiled bacteria that heavy dose of group rat stimulates through ConA, and wherein heavy dose of difference of organizing has significant (P < 0.05); Spring health preserving tea small dose group and the propagation the monarch and his subjects of spleen bone-marrow-derived lymphocyte that stimulate through LPS of levamisol group rat increase in various degree, its difference all has significant (P < 0.01 or P < 0.05).Spring, health preserving tea mouse was by 1.55 and 3.11 particles/kg mouse stomach administration, can significantly improve through the mice serum hemolysin level of sheep red blood cell immunity and delayed allergy mice spleen T, the B lymphocyte proliferation through dinitrofluorobenzene induction.
Following embodiment all can realize the effect of above-mentioned experimental example.
embodiment 1granule
North stilbene 3kg fruit of Chinese wolfberry 2kg spina date seed 1.33kg Fructus Hordei Germinatus 2kg
Date 0.67kg ginger 0.67kg rose 0.33kg
Above seven tastes, get ginger and rose adds 3 times of water gagings, water distillating extracting oil, collect volatile oil, for subsequent use; Get northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling and extract 2 times, each 1 hour, amount of water is respectively 10 times, 8 times, filter, merging filtrate, filtrate reduced in volume (temperature≤70 DEG C) to relative density is 1.25 ~ 1.30 (60 DEG C of surveys), add dextrin 7.24kg to mix, drying under reduced pressure (temperature≤70 DEG C), dried cream powder is broken into fine powder, adds 95% ethanol and makes softwood, 14 mesh sieves are granulated, dry (temperature≤70 DEG C), the whole grain of 12 mesh sieve, obtains particle; Get ginger and rose volatile oil to add 1 times amount ethanol and mix, add in particle, add 0.05kg dolomol and mix, place 2 hours, pack, 5g/ bag, to obtain final product.
embodiment 2capsule
North stilbene 1500g fruit of Chinese wolfberry 1000g spina date seed 665g Fructus Hordei Germinatus 1000g
Date 335g ginger 335g rose 165g
Above seven tastes, get ginger and rose adds 3 times of water gagings, water distillating extracting oil, collect volatile oil, for subsequent use; Get northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling and extract 2 times, each 1 hour, amount of water is respectively 10 times, 8 times, filter, merging filtrate, filtrate reduced in volume (temperature≤70 DEG C) to relative density is 1.25 ~ 1.30 (60 DEG C of surveys), gets ginger and rose volatile oil and adds after 1 times amount ethanol mixes, encapsulated, every containing extract 0.5g.Or it is directly encapsulated to be ground into fine powder with crude drug.
embodiment 3 tablet
North stilbene 22kg fruit of Chinese wolfberry 28kg spina date seed 18kg Fructus Hordei Germinatus 12kg date
4kg ginger 9kg rose 4kg dextrin 90kg stearic acid
Magnesium 0.4kg
Above seven tastes, get ginger and rose adds 3 times of water gagings, water distillating extracting oil, collect volatile oil, for subsequent use, get northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling extract 2 times, each 1 hour, amount of water is respectively 10 times, 8 times, filter, merging filtrate, filtrate reduced in volume (temperature≤70 DEG C) to relative density is 1.25 ~ 1.30 (60 DEG C of surveys), add dextrin to mix, drying under reduced pressure (temperature≤70 DEG C), dried cream powder is broken into fine powder, add 95% ethanol and make softwood, granulate with 16-20 mesh sieve, after flinging to alcohol taste, in 60 DEG C of oven dryings, after drying, the whole grain of 14 mesh sieve, add dolomol to mix, particle is crossed 60 mesh sieves, in fine powder, add ginger and rose volatile oil (1 times amount ethanol dissolves) mix, again this fine powder is added the mixing of former particle, place 24 hours in closed container, after volatile oil is evenly distributed, calculate sheet weight, compressing tablet, or dressing, obtain.
embodiment 4tablet
North stilbene 22kg fruit of Chinese wolfberry 28kg spina date seed 18kg Fructus Hordei Germinatus 12kg date
4kg ginger 9kg rose 4kg
Above seven tastes, get ginger and rose adds 3 times of water gagings, water distillating extracting oil, collect volatile oil, for subsequent use; After getting northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling extraction, technique makes tablet routinely.
embodiment 5capsule
North stilbene 1500g fruit of Chinese wolfberry 1000g spina date seed 665g Fructus Hordei Germinatus 1000g date 335g ginger 335g rose 165g
Above seven tastes, get ginger and rose adds 3 times of water gagings, water distillating extracting oil, collect volatile oil, for subsequent use; After getting northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling extraction, technique makes capsule routinely.
embodiment 6pill
North stilbene 1500g fruit of Chinese wolfberry 1000g spina date seed 665g Fructus Hordei Germinatus 1000g date 335g ginger 335g rose 165g
Above seven tastes, get ginger and rose adds 3 times of water gagings, water distillating extracting oil, collect volatile oil, for subsequent use; After getting northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling extraction, technique makes pill routinely.
embodiment 7granule
North stilbene 3kg fruit of Chinese wolfberry 2kg spina date seed 1.33kg Fructus Hordei Germinatus 2kg
Date 0.67kg ginger 0.67kg rose 0.33kg
Above seven tastes, get ginger and rose adds 3 times of water gagings, water distillating extracting oil, collect volatile oil, for subsequent use; After getting northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling extraction, technique makes granule routinely.
embodiment 8supensoid agent
North stilbene 3kg fruit of Chinese wolfberry 2kg spina date seed 1.33kg Fructus Hordei Germinatus 2kg
Date 0.67kg ginger 0.67kg rose 0.33kg
Above seven tastes, get ginger and rose adds 3 times of water gagings, water distillating extracting oil, collect volatile oil, for subsequent use; After getting northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling extraction, technique makes supensoid agent routinely.
embodiment 9dripping pill
North stilbene 22kg fruit of Chinese wolfberry 28kg spina date seed 18kg Fructus Hordei Germinatus 12kg date
4kg ginger 9kg rose 4kg
Above seven tastes, get ginger and rose adds 3 times of water gagings, water distillating extracting oil, collect volatile oil, for subsequent use; After getting northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling extraction, technique makes dripping pill routinely.
embodiment 10oral liquid
North stilbene 38kg fruit of Chinese wolfberry 12kg spina date seed 12kg Fructus Hordei Germinatus 28kg
Date 9kg ginger 4kg rose 2kg.
Above seven tastes, get ginger and rose adds 3 times of water gagings, water distillating extracting oil, collect volatile oil, for subsequent use; After getting northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling extraction, technique makes oral liquid routinely.
the preparation of embodiment 11 present composition extract
Get ginger and rose adds 3 times of water gagings, water distillating extracting oil, collect volatile oil, for subsequent use; Get northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling and extract 2 times, each 1 hour, amount of water is respectively 10 times, 8 times, filter, merging filtrate, during filtrate reduced in volume to 60 DEG C, relative density is 1.25 ~ 1.30, adds ginger and rose volatile oil mixes, drying under reduced pressure, dried cream powder is broken into fine powder.
the preparation of embodiment 12 present composition extract
North stilbene 22kg fruit of Chinese wolfberry 28kg spina date seed 18kg Fructus Hordei Germinatus 12kg date
4kg ginger 9kg rose 4kg
Get ginger and rose adds 4 times of water gagings, water distillating extracting oil, collect volatile oil, for subsequent use; Get northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling and extract 3 times, each 1.2 hours, amount of water is 7 times respectively respectively, filter, merging filtrate, filtrate reduced in volume is 1.4 to relative density, adds ginger and rose volatile oil mixes, drying under reduced pressure, dried cream powder is broken into fine powder.
the preparation of embodiment 13 present composition extract
North stilbene 38kg fruit of Chinese wolfberry 12kg spina date seed 12kg Fructus Hordei Germinatus 28kg
Date 9kg ginger 4kg rose 2kg.
Get ginger and rose adds 5 times of water gagings, water distillating extracting oil, collect volatile oil, for subsequent use; Get northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling and extract 3 times, each 1 hour, amount of water is respectively 10 times, 8 times, 8 times, filter, merging filtrate, filtrate reduced in volume is 1.45 to relative density, adds ginger and rose volatile oil mixes, drying under reduced pressure, dried cream powder is broken into fine powder.
embodiment 14granule
North stilbene 3kg fruit of Chinese wolfberry 2kg spina date seed 1.33kg Fructus Hordei Germinatus 2kg
Date 0.67kg ginger 0.67kg rose 0.33kg
Get ginger and rose adds 3 times of water gagings, water distillating extracting oil, collect volatile oil, for subsequent use; Get northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling and extract 2 times, each 1 hour, amount of water is respectively 10 times, 8 times, filters, merging filtrate, during filtrate reduced in volume to 60 DEG C, relative density is 1.25 ~ 1.30, add ginger and rose volatile oil mixes, drying under reduced pressure, temperature≤70 DEG C, dried cream powder is broken into fine powder, adds customary adjuvant and makes granule.
embodiment 15granule
North stilbene 38kg fruit of Chinese wolfberry 12kg spina date seed 12kg Fructus Hordei Germinatus 28kg
Date 9kg ginger 4kg rose 2kg.
Get ginger and rose adds 3 times of water gagings, water distillating extracting oil, collect volatile oil, for subsequent use; Get northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling and extract 2 times, each 1 hour, amount of water is respectively 10 times, 8 times, filters, merging filtrate, during filtrate reduced in volume to 60 DEG C, relative density is 1.25 ~ 1.30, add ginger and rose volatile oil mixes, drying under reduced pressure, temperature≤70 DEG C, dried cream powder is broken into fine powder, adds customary adjuvant and makes granule.
embodiment 16granule
North stilbene 22kg fruit of Chinese wolfberry 28kg spina date seed 18kg Fructus Hordei Germinatus 12kg date
4kg ginger 9kg rose 4kg
Above seven tastes, get ginger and rose adds 3 times of water gagings, water distillating extracting oil, collect volatile oil, for subsequent use; Get northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling and extract 2 times, each 1 hour, amount of water is respectively 10 times, 8 times, filter, merging filtrate, filtrate reduced in volume (temperature≤70 DEG C) to relative density is 1.25 ~ 1.30 (60 DEG C of surveys), add dextrin 7.24kg to mix, drying under reduced pressure (temperature≤70 DEG C), dried cream powder is broken into fine powder, adds 95% ethanol and makes softwood, 14 mesh sieves are granulated, dry (temperature≤70 DEG C), the whole grain of 12 mesh sieve, obtains particle; Get ginger and rose volatile oil to add 1 times amount ethanol and mix, add in particle, add 0.05kg dolomol and mix, place 2 hours, pack, 5g/ bag, to obtain final product.
Claims (6)
1. for spring anti-disease labor, protecting and nourishing liver a health food, it is characterized in that this food is made up of following raw material medicaments:
The preparation method of described health food is following method:
Get ginger and rose adds 3 times of water gagings, water distillating extracting oil, collect volatile oil, for subsequent use; Get northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling and extract 2 times, each 1 hour, amount of water is respectively 10 times, 8 times, filter, merging filtrate, during filtrate reduced in volume to 60 DEG C, relative density is 1.25 ~ 1.30, add ginger and rose volatile oil mixes, drying under reduced pressure, temperature≤70 DEG C, dried cream powder is broken into fine powder; Or
Get ginger and rose adds 3 times of water gagings, water distillating extracting oil, collect volatile oil, for subsequent use; Get northern stilbene, the fruit of Chinese wolfberry, spina date seed, Fructus Hordei Germinatus and date boiling and extract 2 times, each 1 hour, amount of water is respectively 10 times, 8 times, filter, merging filtrate, during filtrate reduced in volume to 60 DEG C, relative density is 1.25 ~ 1.30, the dextrin adding 72.4 weight portions mixes, drying under reduced pressure, temperature≤70 DEG C, dried cream powder is broken into fine powder, adds 95% ethanol and makes softwood, and 14 mesh sieves are granulated, dry, temperature≤70 DEG C, the whole grain of 12 mesh sieve, obtains particle; Get ginger and rose volatile oil to add 1 times amount ethanol and mix, add in particle, the dolomol adding 0.5 weight portion mixes, place 2 hours, add customary adjuvant and be conventionally prepared into one in the middle of tablet, capsule, pill, granule, supensoid agent, dripping pill, liquid oral, brewed dose of bag.
2. health food as claimed in claim 1, is characterized in that this food is made up of following raw material medicaments:
3. health food as claimed in claim 1, is characterized in that this food is made up of following raw material medicaments:
4. health food as claimed in claim 1, is characterized in that this food is made up of following raw material medicaments:
5. the health food as described in as arbitrary in claim 1-4, is characterized in that getting this healthy food material medicine and adds customary adjuvant and conventionally prepare one in the middle of tablet, capsule, pill, granule, supensoid agent, liquid oral, brewed dose of bag.
6. the health food as described in as arbitrary in claim 1-4 for the preparation of spring antifatigue, protecting and nourishing liver health food in application.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1074616A (en) * | 1993-02-12 | 1993-07-28 | 北京康力天然保健品研究所 | The health nutrient composition and method of making the same that helps sleeping |
| CN101133879A (en) * | 2006-08-31 | 2008-03-05 | 天津雪赢世纪专利技术有限公司 | Soup for replenishing vigour |
| CN101822746A (en) * | 2009-03-04 | 2010-09-08 | 北京因科瑞斯医药科技有限公司 | Chinese medicinal composition with function of enhancing immunity and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3298214B2 (en) * | 1992-03-27 | 2002-07-02 | 大正製薬株式会社 | Liquid for internal use |
| KR20020087298A (en) * | 2001-05-15 | 2002-11-22 | 김원규 | Tonic composition comprising wild ginseng as main ingredient |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1074616A (en) * | 1993-02-12 | 1993-07-28 | 北京康力天然保健品研究所 | The health nutrient composition and method of making the same that helps sleeping |
| CN101133879A (en) * | 2006-08-31 | 2008-03-05 | 天津雪赢世纪专利技术有限公司 | Soup for replenishing vigour |
| CN101822746A (en) * | 2009-03-04 | 2010-09-08 | 北京因科瑞斯医药科技有限公司 | Chinese medicinal composition with function of enhancing immunity and preparation method thereof |
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