CN103170057B - Brain state supportive device and brain state support method - Google Patents
Brain state supportive device and brain state support method Download PDFInfo
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- CN103170057B CN103170057B CN201110431511.5A CN201110431511A CN103170057B CN 103170057 B CN103170057 B CN 103170057B CN 201110431511 A CN201110431511 A CN 201110431511A CN 103170057 B CN103170057 B CN 103170057B
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Abstract
The invention provides one and objectively can learn which kind of state is brain state be in, and can support to make it possible to brain state to be maintained at original state, or be transferred to brain state supportive device and the brain state support method of other state.Brain state supportive device has: stimulate and apply device, light detecting device, calculating part, detection unit and stimulation adjustment part, wherein calculating part is according to the optical information detected by light detecting device, calculates total hemoglobin variable quantity and oxygen exchange variable quantity; Detection unit applies device to human acupoint position with the signal of telecommunication of preset frequency applying stimulation by stimulating, the total hemoglobin variable quantity calculated according to calculating part and oxygen exchange variable quantity, judge whether human brain state is in relaxed mode, is absorbed in pattern and middle model; Stimulating adjustment part adjustment by stimulating the quantity of stimulus applying device and stimulate human acupoint position, making to maintain the brain state model judged by detection unit, or being transferred to other brain state model.
Description
Technical field
The present invention relates to brain state supportive device and the brain state support method for supporting human brain state, particularly relate to for utilizing near-infrared spectroscopy (NIRS, near-infraredspectroscopy) support to make it possible to brain state is maintained at relaxed mode, be absorbed in pattern, or be transferred to brain state supportive device and the brain state support method of other state.
Background technology
In the past, be in relaxation state to make brain state or be in the state that improve absorbed power, such as, massaging, acupuncture, or carrying out (below this technology being called prior art 1) such as sleeps.
In addition, following method is disclosed: to the whole process applied after outside stimulus before apply the outside stimulus as evaluation object for subjects in patent document 1, use near-infrared spectroscopy, measure the concentration change etc. of oxidized form hemoglobin and reduced form hemoglobin, afterwards, listen to subjective comfort when applying described outside stimulus, evaluate the appropriateness of outside stimulus for human body according to measured value and subjective comfort level.Refer at this near-infrared spectroscopy, faint near infrared ray (such as 680 ~ 1300 nanometers) is irradiated brain across skull from scalp, measures the oxidized form hemoglobin (Oxy-Hb in the blood in the brain surface (cerebral cortex) of the inner side of skull next-door neighbour; HbO
2) concentration change amount and reduced form hemoglobin (Deoxy-Hb; The method (below this technology being called prior art 2) of concentration change amount Hb).
Patent document 1: Japanese Unexamined Patent Publication 2002-177282 publication
Summary of the invention
In prior art 1, there are the following problems: cannot objectively learn by massage, acupuncture, sleep, in fact which kind of state is brain state be in.
In addition, there are the following problems: massaged or after acupuncture, if nervous or do other thing, its effect will disappear immediately and cannot continue.
Further, treatment is caused because acupuncture can make bodily injury, so there will be the situation having conflict concerning preliminary examination person.
In prior art 2, there are the following problems: although objectively can learn in fact which kind of state is brain state be in, cannot support to make brain state be maintained at original state, or be transferred to other state.
In addition, because do not have to use the oxygen of the oxygen consumption for judging brain to exchange index, so be difficult to correctly judge brain state.
The present invention makes to solve the problem, object is to provide one objectively to learn, and which kind of state is brain state be in, and can support to make brain state be maintained at original state, or be transferred to brain state supportive device and the brain state support method of other state.
Brain state supportive device of the present invention is characterised in that to have:
Stimulate applying unit, human acupoint position is stimulated with the signal of telecommunication of preset frequency;
Optical detecting unit, comprises the illuminating part predetermined position of human body being irradiated to light, and the light receiver that the light received from outgoing in human body carrying out detects; And
Apparatus main body, controls described stimulation applying unit and optical detecting unit, wherein
Described apparatus main body has: computing unit, identifying unit and stimulation adjustment unit, wherein this computing unit is according to the optical information detected by described optical detecting unit, calculate the total hemoglobin variable quantity as the variable quantity of oxidized form hemoglobin and the variable quantity sum of reduced form hemoglobin, and exchange variable quantity as the oxygen of the difference of the variable quantity of oxidized form hemoglobin and the variable quantity of reduced form hemoglobin; This identifying unit applies to stimulate with the signal of telecommunication of preset frequency to human acupoint position by described stimulation applying unit, thus the total hemoglobin variable quantity calculated according to described computing unit and oxygen exchange variable quantity, judge whether described human brain state is in relaxed mode, at least one pattern be absorbed in pattern and middle model; The adjustment of this stimulation adjustment unit is applied the quantity of stimulus stimulated with the signal of telecommunication of preset frequency to described human acupoint position by described stimulation applying unit, make to maintain the brain state model judged by described identifying unit, or be transferred to other brain state model.
The human acupoint position stimulated by described stimulation applying unit is such as left thumb target portion.
The position detected by described optical detecting unit is such as the prefrontal lobe of brain.
Described identifying unit can by stimulating with the signal of telecommunication of the 1st frequency described human acupoint position, and described total hemoglobin variable quantity increases, and described oxygen exchanges variable quantity when increasing, and judges that brain state is as relaxed mode; By stimulating with the signal of telecommunication of the 2nd frequency described human acupoint position, and described total hemoglobin variable quantity reduces, and described oxygen exchanges variable quantity when reducing, and judges that brain state is as absorbed pattern; Beyond these, be judged to be middle model.
Brain state can be maintained at relaxed mode by described stimulation adjustment unit, or when being transferred to relaxed mode, stimulates with the signal of telecommunication of the 1st frequency for described human acupoint position by predetermined space; Brain state is being maintained at absorbed pattern, or when being transferred to absorbed pattern, described human acupoint position is being stimulated by predetermined space with the signal of telecommunication of the 2nd frequency.
Described 1st frequency is such as 3Hz, and described 2nd frequency is such as 10Hz.
It is more than the quantity of stimulus of situation brain state being maintained at original pattern that described stimulation adjustment unit can carry out adjusting the situation making brain state to be transferred to other pattern.
Brain state support method of the present invention is characterized in that, makes the process of the apparatus main body performing described brain state supportive device.
Following effect can be reached according to the present invention:
(1) without the need to carrying out massaging, acupuncture, sleep etc., just can easily and in the short time, make the brain state oneself expected.
(2) objectively can learn which kind of state is brain state be in, and brain state can be maintained at original state, or be transferred to other state.Such as, when distracting thoughts are many in fatigue, or when distracting thoughts are many in agitation, when maybe cannot be absorbed in, if use the present invention brain state to be set to absorbed pattern, just can realize the brain state that absorbed power relatively improves.
In addition, when having to carry out work, when being judged to be relaxed mode by the present invention, forced branch extremely can be absorbed in pattern, otherwise, also can from absorbed mode shifts to relaxed mode.
Further, the state that absorbed power improves can also be extended, or make relaxation state elongated.
Accompanying drawing explanation
Fig. 1 is for illustrating the block diagram of the structure of the brain state supportive device involved by specific embodiments of the invention.
(A) of Fig. 2 is for illustrating the front view stimulating and apply device, (B) apply stimulating the key diagram that device is installed on the state of thumb for illustrating, (C) for illustrating the front view stimulating other the example applying device, (D) is for illustrating the key diagram that will other the example applying device stimulated to be installed on the state of thumb.
Fig. 3 is the flow chart of the work for illustration of the brain state supportive device involved by specific embodiments of the invention.
(A)-(C) of Fig. 4 is the key diagram of the setting for illustration of light detecting device.
Fig. 5 illustrates that the total hemoglobin variable quantity in prefrontal lobe when applying the electricity irritation of 3Hz to the adjacent central portion of the palmar side between left thumb first joint and second joint and oxygen exchange the curve chart of the change of variable quantity.
(A) of Fig. 6 is the key diagram of the change of the total hemoglobin variable quantity in prefrontal lobe during electricity irritation when visually representing that to apply before the electricity irritation of 3Hz quiet to the adjacent central portion of the palmar side between left thumb first joint and second joint and after applying, and (B) is the key diagram of the change of visually expression oxygen exchange variable quantity.
Fig. 7 illustrates that the total hemoglobin variable quantity in prefrontal lobe when applying the electricity irritation of 10Hz to the adjacent central portion of the palmar side between left thumb first joint and second joint and oxygen exchange the curve chart of the change of variable quantity.
(A) of Fig. 8 is the key diagram of the change of the total hemoglobin variable quantity in prefrontal lobe during electricity irritation when visually representing that to apply before the electricity irritation of 10Hz quiet to the adjacent central portion of the palmar side between left thumb first joint and second joint and after applying, and (B) is the key diagram of the change of visually expression oxygen exchange variable quantity.
Fig. 9 illustrates that the total hemoglobin variable quantity in prefrontal lobe when applying acupuncture stimulation to the adjacent central portion of the palmar side between left thumb first joint and second joint and oxygen exchange the curve chart of the change of variable quantity.
(A) of Figure 10 for when visually representing that to apply before acupuncture stimulation quiet to the adjacent central portion of the palmar side between left thumb first joint and second joint, apply acupuncture stimulates time and pin extract after the key diagram of change of the total hemoglobin variable quantity in prefrontal lobe, (B) is the key diagram of the change of visually expression oxygen exchange variable quantity.
Figure 11 represents the curve chart total hemoglobin variable quantity in prefrontal lobe outside right ring finger first joint to finger tip when neighbouring applying acupuncture stimulation and oxygen being exchanged to the change of variable quantity.
(A) of Figure 12 for visually represent to when to apply near outside right ring finger first joint to finger tip before acupuncture stimulation quiet, the key diagram of the change of the total hemoglobin variable quantity in prefrontal lobe when stimulating that applies acupuncture, (B) be the key diagram of the change visually representing oxygen exchange variable quantity.
Figure 13 is for illustrating the block diagram of the program involved by specific embodiments of the invention.
Reference numeral
1: brain state supportive device 2: stimulate and apply device 2a: stimulation unit 2b: strap 2c: velcro 3: light detecting device 3a: illuminating part 3b: light receiver 4: apparatus main body 5: input part 6: efferent 7: communication unit 8: storage part 9: control part 10: display part 11: speaker 12: printing portion 13: calculating part 14: detection unit 15: stimulate adjustment part 16: program
Detailed description of the invention
Referring to accompanying drawing, the specific embodiment of the present invention is described.Fig. 1 is for illustrating the block diagram of the structure of the brain state supportive device 1 involved by specific embodiments of the invention.
As shown in Figure 1, the brain state supportive device 1 involved by specific embodiments of the invention has: stimulate and apply device 2, be arranged at human acupoint position (such as left thumb target portion), stimulate this position with the signal of telecommunication of preset frequency; Light detecting device 3, there is the predetermined position (prefrontal lobe of such as brain) being arranged at human body, the illuminating part 3a (light-emitting component) of light is irradiated to this predetermined position, and the light receiver 3b (light receiving element) that the light received from outgoing in human body carrying out detects; And apparatus main body 4.
(A) of Fig. 2 is for illustrating the front view stimulating and apply device 2, (B) apply stimulating the key diagram that device 2 is installed on the state of thumb for illustrating, (C) for illustrating the front view stimulating other the example applying device 2, (D) is for illustrating the key diagram that will other the example applying device 2 stimulated to be installed on the state of thumb.
As shown in (A) and (B) of Fig. 2, stimulate and apply device 2 and have and connect with human acupoint position, for a pair stimulation unit 2a stimulating with the signal of telecommunication of preset frequency this position and keep stimulation unit 2a, the strap 2b being freely installed on finger etc. can be loaded and unloaded.
A pair stimulation unit 2a has the interval of about 3-10mm when such as pointing, as shown in (B) of Fig. 2, be set to stimulation target position S to clamp.The interval of stimulation unit 2a suitably sets according to human acupoint position.
Be provided with at the both ends of strap 2b such as velcro 2c (magic tape (registered trade mark)), by after finger on strap 2b volume is waited, velcro 2c is pasted mutually, stimulation can be applied device 2 and be set to be fixed on finger etc.
In addition, as shown in (C) and (D) of Fig. 2, longitudinal width of strap 2b can be made to broaden, a pair stimulation unit 2a is configured at spaced intervals on oblique direction.
Light detecting device 3 such as has the assembling band being installed on human body predetermined position, brings configured with separating predetermined space by one or more illuminating part 3a and light receiver 3b in this assembling.
Apparatus main body 4 controls to stimulate the work applying device 2 and light detecting device 3, and carries out the input and output of various data, computing and storage, has input part 5, efferent 6, communication unit 7, storage part 8 and control part 9.
Input part 5 inputs various data, such as, be keyboard, numeric keypad (ten key), mouse, badge card card reader and OCR (optical profile type character reader) etc.
Efferent 6 exports various data, has the display part 10 of the monitor, display etc. showing various data, exports the speaker 11 of voice data and prints the printing portion 12 of printer etc. of various data.
Communication unit 7 carries out the transmission and reception for the various data be connected with the communication network such as the Internet (data transmission network according to TCP/IP (TCP/IP)), LAN (LAN), such as, be modem, terminal adapter, router, DSU (DSU) etc.
Storage part 8 stores various data, comprises data base.
Control part 9 has: calculating part 13, detection unit 14 and stimulation adjustment part 15, wherein calculating part 13 is according to the optical information detected by light detecting device 3, calculate the total hemoglobin variable quantity as the variable quantity of oxidized form hemoglobin and the variable quantity sum of reduced form hemoglobin, and exchange variable quantity as the oxygen of the difference of the variable quantity of oxidized form hemoglobin and the variable quantity of reduced form hemoglobin; Detection unit 14 applies device 2 pairs of human acupoint positions with the signal of telecommunication of preset frequency applying stimulation by stimulating, thus the total hemoglobin variable quantity calculated according to calculating part 13 and oxygen exchange variable quantity, judge whether human brain state is in relaxed mode, at least one pattern be absorbed in pattern and middle model; Stimulating adjustment part 15 to adjust by stimulating the quantity of stimulus applying device 2 pairs of human acupoint positions and apply with the signal of telecommunication of preset frequency to stimulate, making to maintain the brain state model judged by detection unit 14, or being transferred to other brain state model.
Detection unit 14 is by stimulating with the signal of telecommunication of the 1st frequency (such as 3Hz) human acupoint position, and total hemoglobin variable quantity increases, and oxygen exchanges variable quantity when increasing, and judges that brain state is as relaxed mode; By stimulating with the signal of telecommunication of the 2nd frequency (such as 10Hz) human acupoint position, and described total hemoglobin variable quantity reduces, and described oxygen exchanges variable quantity when reducing, and judges that brain state is as absorbed pattern; Beyond these, be judged to be middle model.
Stimulate adjustment part 15 that brain state is being maintained at relaxed mode, or when being transferred to relaxed mode, human acupoint position is stimulated by predetermined space with the signal of telecommunication of the 1st frequency (such as 3Hz); And brain state is being maintained at absorbed pattern, or when being transferred to absorbed pattern, human acupoint position is stimulated by predetermined space with the signal of telecommunication of the 2nd frequency (such as 10Hz).
Adjustment part 15 is stimulated to carry out adjusting the situation making brain state to be transferred to other pattern more than the quantity of stimulus of situation brain state being maintained at original pattern.
In addition, for the numerical value of the frequency of the signal of telecommunication that stimulates for illustrating, this is not limited to.
Fig. 3 is the flow chart of the work for illustration of the brain state supportive device 1 involved by specific embodiments of the invention.
First, stimulation is applied device 2 and be arranged at human acupoint position (such as left thumb target portion) (step S1).
Next, light detecting device 3 is arranged at human body predetermined position (prefrontal lobe of such as brain) (step S2).
Next, the preparation (step S3) for judging brain state is carried out.
In this step S3, apply the stimulation 5-10 second of 3Hz, determine the minimum stimulus intensity that the skin of left thumb target portion feels slightly, apply the stimulation 5-10 second of 3Hz, determine the highest stimulus intensity of dermal sensation to pain of left thumb target portion, calculate centre 50% stimulus intensity that 3Hz stimulates according to the following formula.
Calculating=(minimum stimulus intensity+the highest stimulus intensity)/2 of centre 50% stimulus intensity that 3Hz stimulates
In addition, apply the stimulation 5-10 second of 10Hz, determine the minimum stimulus intensity that the skin of left thumb target portion feels slightly, apply the stimulation 5-10 second of 10Hz, determine the highest stimulus intensity of dermal sensation to pain of left thumb target portion, calculate centre 50% stimulus intensity that 10Hz stimulates according to the following formula.
Calculating=(minimum stimulus intensity+the highest stimulus intensity)/2 of centre 50% stimulus intensity that 10Hz stimulates
The voltage of maximal stimulus intensity settings electricity irritation, the value of electric current and carrying out.
Next, brain state (step S4) is judged by detection unit 14.At this, be defined as relaxed mode (R pattern) by left thumb target portion with the brain response of the stimulation gained of 3Hz, when this pattern, brains loosens and is in calm state.In addition, be defined as absorbed pattern (B-mode) by with the brain response of the stimulation gained of 10Hz, when being in this pattern, brains works, and is absorbed in power and faculty of understanding improves, and is in the state being suitable for learning etc.
In this step S4, the stimulation of the middle stimulus intensity 3Hz determined in abovementioned steps S2 is applied with the pattern that 30 seconds stimulate the stimulation in-30 seconds that stops for-30 seconds to stop for-30 seconds by left thumb target portion.
If do not reacted after within 30 seconds, stimulating, be then judged to be in strong R pattern.
If the reaction of R pattern, then judge it is the rudimentary of R pattern, or B-mode, middle model.
In addition, the stimulation of the middle stimulus intensity 10Hz determined in described step S2 applies with the pattern that 30 seconds stimulate the stimulation in-30 seconds that stops for-30 seconds to stop for-30 seconds by thumb target portion left.
If do not reacted after within 30 seconds, stimulating, be then judged to be in strong B-mode.
If B-mode reaction, then judge it is the rudimentary of B-mode, or R pattern, middle model.
Result of determination is shown in the display part 10 of monitor, display etc., or by speaker 11 by voice output.In addition, result of determination can also be printed by printing portion 12, or carries out data transmission by communication unit 7 via network.
Next, the adjustment (step S5) stimulating adjustment part 15 to carry out quantity of stimulus.
In this step S5, there is following situation: when 1) being judged to be B-mode by detection unit 14, be adjusted to the situation being transferred to R pattern; 2), when being judged to be R pattern by detection unit 14, the situation being maintained at R pattern is adjusted to; 3), when being judged to be B-mode by detection unit 14, the situation being maintained at B-mode is adjusted to; And 4) when being judged to be R pattern by detection unit 14, be adjusted to the situation being transferred to B-mode.
The selection of above any one situation can both be carried out via input part 5, and the adjustment of various situation is such as carried out as following.
1) situation of B → R (transfer)
The quantity of stimulus of 50% of the value of the 3Hz determined in step s3 stimulation is applied 60 seconds, has a rest 30 seconds, and then the quantity of stimulus of 75% is applied 60 seconds, have a rest 30 seconds.If be not transferred to R pattern, then further the quantity of stimulus of 100% is applied 60 seconds.
Like this quantity of stimulus is upgraded, and advance the transfer to R pattern.
2) situation of R → R (maintenance)
The quantity of stimulus of 25% of the value of the 3Hz determined in step s3 stimulation is applied 30 seconds, has a rest 30 seconds, and then the quantity of stimulus of 25% is applied 30 seconds, have a rest 30 seconds, the quantity of stimulus of 25% is applied 30 seconds.
Apply same stimulation like this intermittently, and maintain R pattern.
3) situation of B → B (maintenance)
The quantity of stimulus of 25% of the value of the 10Hz determined in step s3 stimulation is applied 30 seconds, has a rest 30 seconds, and then the quantity of stimulus of 25% is applied 30 seconds, have a rest 30 seconds, the quantity of stimulus of 25% is applied 30 seconds.
Apply same stimulation like this intermittently, and maintain B-mode.
4) situation of R → B (transfer)
The quantity of stimulus of 50% of the value of the 10Hz determined in step s3 stimulation is applied 60 seconds, has a rest 30 seconds, and then the quantity of stimulus of 75% is applied 60 seconds, have a rest 30 seconds.If be not transferred to B-mode, then further the quantity of stimulus of 100% is applied 60 seconds.
Like this quantity of stimulus is upgraded, and advance the transfer to B-mode.
In addition, the adjustment of above-mentioned quantity of stimulus is an example and is not limited thereto.
Next, in order to confirm that brain state supportive device 1 involved in the present invention is useful, the experiment undertaken by the present inventor is described.
In this experiment, (Shimadzu Seisakusho Ltd. manufactures: the detection and the record that FOIRE3000) have carried out corticocerebral Hb concentration to use near-infrared spectroscopic measurement device.
Hemoglobin be sampled as 70ms.
The hemoglobin recorded is oxidized form hemoglobin (oxy-Hb) and deoxidation (reduced form) hemoglobin (deoxy-Hb).
According to the variable quantity of this value, calculate total hemoglobin concentration variable quantity (total-Hb: the summation of oxidation and deoxidation) and oxygen concentration variable quantity (ScO according to following calculating formula
2), the index that the COE as brain reacts.
Total hemoglobin (concentration) variable quantity [Total hemoglobin]=[Oxyhemoglobin]+[Deoxyhemoglobin]
Oxygen exchanges (concentration) variable quantity (as one of inventor add the brain function index that rattan finds) [ScO
2]=[Oxyhemoglobin]-[Deoxyhemoglobin]
The functional parameter be even more important is, ScO
2minimizing=oxygen consumption, protoxydic position is even more important.
Total hemoglobin variable quantity represents the variation of the erythrocytic quantity in the voxel (voxel) in the photo measure region being clipped in irradiation and detector probe, if increased, represents that erythrocyte increases, if reduced, represents that erythrocyte reduces.
Oxygen exchanges variable quantity and represents that the oxygen concentration in blood capillary changes, if increased, means that Ink vessel transfusing oxygen increases, if reduced, means that endovascular oxygen reduces.Being meant to indicate that Ink vessel transfusing oxygen increases has supplied oxygen containing erythrocyte from tremulous pulse.Being meant to of endovascular hypoxia, represents that, because neurocyte consumes oxygen, the oxygen in blood capillary has been consumed.
Experimental result uses waveform display and reflection (mapping) to show these two kinds.Waveform display represents seasonal effect in time series change, and the integrated value of stimulation time is drawn by reflection display.
(A)-(C) of Fig. 4 is the key diagram of the setting for illustration of light detecting device 3.Light detecting device 3 configures with high-density probe arrangement, is configured to brodmann's area (Brodmann ' s Areas) 10th district (prefrontal lobe) shown in (A) of coverage diagram 4.
The illuminating part 3a of light detecting device 3 and light receiver 3b is with the interval configuration shown in (B) of Fig. 4, along configuring 3 illuminating part 3a and 3 light receiver 3b from right brain to left brain as shown in (C) of Fig. 4, measure the total hemoglobin variable quantity amounting to the measuring point at 5 places of 24ch-28ch and the change of oxygen exchange variable quantity.
Fig. 5 illustrates the curve chart exchanging the change of variable quantity when applying the electricity irritation of 3Hz to the adjacent central portion of the palmar side between left thumb first joint and second joint at the total hemoglobin variable quantity of prefrontal lobe and oxygen.At this, transverse axis is the time (s), and the longitudinal axis is variable quantity (mol/l), and stimulation time is 30 seconds.
(A) of Fig. 6 is the key diagram of the change of the total hemoglobin variable quantity in prefrontal lobe during electricity irritation when visually representing that to apply before the electricity irritation of 3Hz quiet to the adjacent central portion of the palmar side between left thumb first joint and second joint and after applying, and (B) is the key diagram of the change of visually expression oxygen exchange variable quantity.
Visible according to Fig. 5 and Fig. 6, under the electricity irritation of 3Hz, observed the change exchanged in the increase of large-scale total hemoglobin variable quantity and oxygen in the timing of the increase of variable quantity.Especially in prefrontal lobe, obviously assert and this change.
Fig. 7 illustrates that the total hemoglobin variable quantity in prefrontal lobe when applying the electricity irritation of 10Hz to the adjacent central portion of the palmar side between left thumb first joint and second joint and oxygen exchange the curve chart of the change of variable quantity.At this, transverse axis is the time (s), and the longitudinal axis is variable quantity (mol/l), and stimulation time is 30 seconds.
(A) of Fig. 8 for when visually representing that to apply before the electricity irritation of 10Hz quiet to the adjacent central portion of the palmar side between left thumb first joint and second joint with apply after electricity irritation time the key diagram of change of the total hemoglobin variable quantity in prefrontal lobe, (B) be the key diagram of the change of visually expression oxygen exchange variable quantity.
Visible according to Fig. 7 and Fig. 8, under the electricity irritation of 10Hz, observed the change exchanged in the minimizing of large-scale total hemoglobin variable quantity and oxygen in the timing of the minimizing of variable quantity.
When applying the signal of telecommunication of 3Hz and 10Hz respectively to left thumb target portion like this, be antipodal result, under 10Hz, suboxides occur at the oxygen metabolism of prefrontal lobe, blood flow then occurs under 3Hz to be increased and high oxidation.
In addition, implied the frequency depending on electricity irritation, prefrontal lobe changes sensitively, impacts cognitive function.
Next, as reference of comparing of the present invention, experiment when carrying out acupuncture stimulation is described.
Fig. 9 illustrates the curve chart exchanging the change of variable quantity when applying acupuncture stimulation to the adjacent central portion of the palmar side between left thumb first joint and second joint at the total hemoglobin variable quantity of prefrontal lobe and oxygen.
At this, transverse axis is the time (s), and the longitudinal axis is variable quantity (mol/l), and stimulation time is 180 seconds.
(A) of Figure 10 for when visually representing that to apply before acupuncture stimulation quiet to the adjacent central portion of the palmar side between left thumb first joint and second joint, apply acupuncture stimulates time and pin extract after the key diagram of change of the total hemoglobin variable quantity in prefrontal lobe, (B) is the key diagram of the change of visually expression oxygen exchange variable quantity.
Visible according to Fig. 9 and Figure 10, under acupuncture stimulation, from rotation starts 30 ~ 45 seconds, total hemoglobin variable quantity and oxygen exchange variable quantity all to be increased, and then continue afterwards to reduce, this is considered to the main efficacy results of acupuncture.
In addition, 10Hz produces and is identified close to the repeatability of the state of acupuncture stimulation than 3Hz.
Figure 11 illustrates the curve chart to exchanging the change of variable quantity outside right ring finger first joint to finger tip when neighbouring applying acupuncture stimulation at the total hemoglobin variable quantity of prefrontal lobe and oxygen.At this, transverse axis is the time (s), and the longitudinal axis is variable quantity (mol/l), and stimulation time is 180 seconds.
(A) of Figure 12 for visually represent to when to apply near outside right ring finger first joint to finger tip before acupuncture stimulation quiet, the key diagram of the change of the total hemoglobin variable quantity in prefrontal lobe when stimulating that applies acupuncture, (B) be the key diagram of the change visually representing oxygen exchange variable quantity.
Visible according to Figure 11 and Figure 12, when causing due to the rotatory stimulation of pin pain to strengthen, in a part for prefrontal lobe, change high oxidation into, blood flow reduces, obviously different from the brain response caused the stimulation of left thumb.
Figure 13 is for illustrating the block diagram of the program involved by specific embodiments of the invention.
As shown in figure 13, the program 16 involved by specific embodiments of the invention controls the apparatus main body 4 of the brain state supportive device 1 involved by specific embodiments of the invention, the process that the apparatus main body 4 making computer perform above-mentioned explanation carries out.
This program 16 both can be recorded on the recording mediums such as disk, CD-ROM, semiconductor memory, also can via downloaded.
The invention is not restricted to above-mentioned detailed description of the invention, in the scope of the technology item recorded in detail in the claims, various change can be had.Such as apparatus main body 4, special purpose device can be replaced with personal computer or information terminal apparatus etc.
Brain state supportive device 1 of the present invention and program 16 support to make it possible to brain state is maintained at relaxed mode, be absorbed in pattern for utilizing near-infrared spectroscopy (NIRS), or are transferred to other state.
Claims (4)
1. a brain state supportive device, is characterized in that having:
Stimulate applying unit, human acupoint position is stimulated with the signal of telecommunication of preset frequency;
Optical detecting unit, comprises illuminating part and light receiver, and this illuminating part irradiates light to the predetermined position of human body, and this light receiver receives the light from outgoing in human body and detects this light; And
Apparatus main body, controls described stimulation applying unit and optical detecting unit, wherein
Described apparatus main body has: computing unit, identifying unit and stimulation adjustment unit, wherein this computing unit is according to the optical information detected by described optical detecting unit, calculate the total hemoglobin variable quantity as the variable quantity of oxidized form hemoglobin and the variable quantity sum of reduced form hemoglobin, and exchange variable quantity as the oxygen of the difference of the variable quantity of oxidized form hemoglobin and the variable quantity of reduced form hemoglobin; This identifying unit applies to stimulate with the signal of telecommunication of preset frequency to human acupoint position by described stimulation applying unit, thus the total hemoglobin variable quantity calculated according to described computing unit and oxygen exchange variable quantity, judge whether the described brain state of human body is in relaxed mode, at least one pattern be absorbed in pattern and middle model; The adjustment of this stimulation adjustment unit is applied the quantity of stimulus stimulated with the signal of telecommunication of preset frequency to described human acupoint position by described stimulation applying unit, make to maintain the brain state model judged by described identifying unit, or be transferred to other brain state model,
Brain state is being maintained at relaxed mode by described stimulation adjustment unit, or when being transferred to relaxed mode, stimulates with the signal of telecommunication of the 1st frequency for described human acupoint position by predetermined space; Brain state is being maintained at absorbed pattern, or when being transferred to absorbed pattern, described human acupoint position is being stimulated by predetermined space with the signal of telecommunication of the 2nd frequency,
The value of described human acupoint position, the 1st frequency and the value of the 2nd frequency are determined, to make when the signal of telecommunication of the 1st frequency and the 2nd frequency is applied to the target portion of human acupoint respectively, be contrary result at the oxygen metabolism of prefrontal lobe, suboxides is there is under the stimulation of the 2nd frequency, and issue hemopoietic stream in the stimulation of the 1st frequency to increase and high oxidation
Described 1st frequency is 3Hz, and described 2nd frequency is 10Hz, and described human acupoint position is left thumb target portion.
2. brain state supportive device according to claim 1, is characterized in that:
The position detected by described optical detecting unit is the prefrontal lobe of brain.
3. brain state supportive device according to claim 1, is characterized in that:
Described identifying unit is by stimulating with the signal of telecommunication of the 1st frequency described human acupoint position, and described total hemoglobin variable quantity increases, and described oxygen exchanges variable quantity when increasing, and judges that brain state is as relaxed mode; By stimulating with the signal of telecommunication of the 2nd frequency described human acupoint position, and described total hemoglobin variable quantity reduces, and described oxygen exchanges variable quantity when reducing, and judges that brain state is as absorbed pattern; Beyond these, be judged to be middle model.
4. brain state supportive device according to claim 1, is characterized in that:
It is more than the quantity of stimulus of situation brain state being maintained at original pattern that described stimulation adjustment unit carries out adjusting the situation making brain state to be transferred to other pattern.
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| US5135468A (en) * | 1990-08-02 | 1992-08-04 | Meissner Juergen P | Method and apparatus of varying the brain state of a person by means of an audio signal |
| US6986747B2 (en) * | 2002-01-29 | 2006-01-17 | Johnson & Johnson Consumer Companies | Method of measuring the stress or relaxation level of a mammal |
| CN101044976A (en) * | 2006-03-31 | 2007-10-03 | 合世生医科技股份有限公司 | Method and apparatus for measuring blood pressure by using blood oxygen concentration and electrocardiograph |
| CN201147301Y (en) * | 2007-11-22 | 2008-11-12 | 河南华南医电科技有限公司 | Sleep respiratory disturbance detecting device |
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| JP2007167105A (en) * | 2005-12-19 | 2007-07-05 | Olympus Corp | Apparatus and method for evaluating mind-body correlation data |
| US20080269832A1 (en) * | 2007-04-26 | 2008-10-30 | The Hong Kong Polytechnic University | Device and method for sleep apnea management using SpO2 |
| US20090171164A1 (en) * | 2007-12-17 | 2009-07-02 | Jung Edward K Y | Methods and systems for identifying an avatar-linked population cohort |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5135468A (en) * | 1990-08-02 | 1992-08-04 | Meissner Juergen P | Method and apparatus of varying the brain state of a person by means of an audio signal |
| US6986747B2 (en) * | 2002-01-29 | 2006-01-17 | Johnson & Johnson Consumer Companies | Method of measuring the stress or relaxation level of a mammal |
| CN101044976A (en) * | 2006-03-31 | 2007-10-03 | 合世生医科技股份有限公司 | Method and apparatus for measuring blood pressure by using blood oxygen concentration and electrocardiograph |
| CN201147301Y (en) * | 2007-11-22 | 2008-11-12 | 河南华南医电科技有限公司 | Sleep respiratory disturbance detecting device |
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