CN103169824A - Traditional Chinese medicine composition for treating menoxenia infertility and application thereof - Google Patents
Traditional Chinese medicine composition for treating menoxenia infertility and application thereof Download PDFInfo
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- CN103169824A CN103169824A CN 201110440896 CN201110440896A CN103169824A CN 103169824 A CN103169824 A CN 103169824A CN 201110440896 CN201110440896 CN 201110440896 CN 201110440896 A CN201110440896 A CN 201110440896A CN 103169824 A CN103169824 A CN 103169824A
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Abstract
The invention provides a traditional Chinese medicine composition and application thereof. Particularly, the composition is prepared from the following raw materials in parts by weight: 20-50 parts of Codonopsis pilosula or radix salviae miltiorrhizae, 20-50 parts of raw radix astragali, 5-30 parts of Curculigo orchioides, 5-30 parts of dodder, 5-40 parts of cynomorium songaricum, 5-30 parts of wolfberry, 5-30 parts of photinia leaf and 5-30 parts of Japanese sweetflag. The traditional Chinese medicine composition has the function of promoting ovulation, and can effectively treat menoxenia infertility.
Description
Technical field
The present invention relates to the field of Chinese medicines.More specifically, the present invention relates to the Chinese medicine composition and uses thereof of menoxenia barrenness.
Background technology
The menoxenia barrenness refers to the long-term menstruation entanglement of women, and matrimonial cohabitation is more than 1 year, and the person that do not become pregnant that do not practise contraception is one of gynecological clinic commonly encountered diseases.
In Chinese traditional treatment, different times according to menstrual cycle, adopt that kidney tonifying is enriched blood, invigorating kidney, promoting blood circulation and kidney tonifying appoint in admittedly rushing-method of promoting blood flow to regulate menstruation carries out regulating menstruation, namely according to the method for " regulating menstruation need be transferred week ", periodically use by Chinese medicine, regulate the function of hypothalamus, hypophysis and hypothalamic pituitary ovarium axis, promote follicular development and ovulation.Therapeutic Method to the menoxenia barrenness in the successive dynasties document also has detailed description, writes in " Plain Questions innocent opinion in ancient times ": " woman seven years old, kidney qi is contained, and dental transition is sent out long; 27 and the menarche, conception vessel is logical, and taichong channel is contained, and regular menstrual cycle is therefore there is son ".Write in " clear Chen Xiuyuan ": " married woman's loss of fecundity is all by irregular menstruation; The method of seed all is among regulating menstruation ", " profit and loss of woman's sea of blood have the phase ", " the substances of producing primal life activities being essence ", the god of meaning " two essences fight mutually ", " two god fight mutually and close and be shaped ".Follicular development maturation and discharge are menstruation and Female Genital Endocrine physiological characteristics, and follicular development needs certain material base, and this basis and Chinese medicine it " essence " are with former.If follicular dysplasia, delay of maturation, follicular atresia etc. can cause delayed menstrual cycle, amount less, amenorrhea and infertile etc.Adopting the Artificial menstrual cycle with Chinese herbal medicine method is a kind of method that modern medical theory combines with tcm theory, and it presses the different phase of human body menstrual cycle, impels follicular development and reaches the purpose of regulating menstruation seed.
The Chinese Traditional Medicines commonly used for the treatment of menoxenia barrenness are Ramulus Cinnamomi Poria pills at present.
The composition of Ramulus Cinnamomi Poria pill is: Ramulus Cinnamomi (hot dissipating blood stasis is stagnant for warming the meridian circulation of qi promoting, the logical heart-yang of a surname), Poria (eliminating dampness by diuresis spleen invigorating), Cortex Moutan, Semen Persicae (blood circulation promoting and blood stasis dispelling, disease eliminating powder junction hold concurrently clearing away damp-heat) and the Radix Paeoniae Alba (relieving spasm to stop pain, in promoting the circulation of blood stagnant).
The main effect of Ramulus Cinnamomi Poria pill has: all medicines are played altogether and are built the capable water that activates yang, the merit of blood stasis dispelling eliminating mass, and the row blood circulation promoting and dispersing pathogen accumulation, the effect of removing blood stasis with potent drugs eliminating mass, all medicines share, and play altogether the effect of blood circulation promoting and blood stasis dispelling, slow elininating inflammation.Main pharmacodynamics is tested through modern medicine and is shown, this product has anticoagulant, reduces golden blood viscosity, alleviates the effects such as hysterospasm, analgesia, the energy blood circulation promoting and blood stasis dispelling, and slow note of the ancient Chinese piece that disappears is used for the treatment of gynecological's syndrome of blood stasis.
But the subject matter of Ramulus Cinnamomi Poria pill is:
This medicine is only applicable to the menoxenia barrenness due to blood-stasis internal-depression, and is limited for this disease curative effect due to the kidney qi virtual loss.This is that composition is take the blood circulation promoting and blood stasis dispelling collateral dredging as main (Semen Persicae, Cortex Moutan, Ramulus Cinnamomi), and is unhelpful to this disease patient due to the kidney qi virtual loss because Ramulus Cinnamomi Poria pill is complete square take blood circulation promoting and blood stasis dispelling as main.
And Ramulus Cinnamomi Poria pill is drops, although take conveniently, cost of manufacture is higher, so compare with other drug, the Ramulus Cinnamomi Poria pill price is comparatively expensive, and long-term menoxenia infertile patient is difficult to bear economically.
Therefore, the needs research and development are a kind of can overcome above-mentioned deficiency, the Chinese medicine composition of the treatment menoxenia barrenness that the scope of application is wider, more economical, curative effect is better.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition that can effectively treat the menoxenia barrenness.This Chinese medicine composition has ovulation effect, can effectively treat the menoxenia barrenness.
In a first aspect of the present invention, a kind of Chinese medicine composition is provided, said composition comprises the raw material that forms by following weight portion proportioning:
Party's Radix Salviae Miltiorrhizae, the 20-50 weight portion, preferably, the 25-35 weight portion, more preferably, 30 weight portions;
Radix Astragali, the 20-50 weight portion, preferably, the 25-35 weight portion, more preferably, 30 weight portions;
Rhizoma Curculiginis, the 5-30 weight portion, preferably, the 5-20 weight portion, more preferably, 10 weight portions;
Semen Cuscutae, the 5-30 weight portion, preferably, the 5-20 weight portion, more preferably, 10 weight portions;
Herba Cynomorii, the 5-40 weight portion, preferably, the 10-25 weight portion, more preferably, 15 weight portions;
Fructus Lycii, the 5-30 weight portion, preferably, the 5-20 weight portion, more preferably, 10 weight portions;
Folium Photiniae (Folium Photiniae serrulatae), the 5-30 weight portion, preferably, the 5-20 weight portion, more preferably, 10 weight portions; With
Rhizoma Acori Graminei, the 5-30 weight portion, preferably, the 5-20 weight portion, more preferably, 10 weight portions.
Preferably, the weight ratio of above-mentioned each raw material in Chinese medicine composition of the present invention is 3: 3: 1: 1: 1.5: 1: 1: 1.
In another aspect of this invention, provide the purposes of above-mentioned Chinese medicine composition on the medicine of preparation treatment menoxenia barrenness.
Compositions of the present invention can be routinely the method for Chinese medicine decocting directly be prepared into water decoction, every day potion, every natural gift 2-3 time are oral, 2 months is 1 course for the treatment of.
Compositions of the present invention also can with pharmaceutically acceptable carrier combinations, make conventional dosage form according to the pharmaceutical methods of routine, for example can be made into solid formulation, as powder, capsule, pill, tablet, Orally-disintegrating tablet etc., can also make liquid formulation, as suspensoid.
Party's Radix Salviae Miltiorrhizae of selecting in the present composition and Radix Astragali are monarch drug in this prescription, have the QI invigorating righting, the effect of building up resistance.
The Rhizoma Curculiginis of selecting in the present composition, Semen Cuscutae, Semen Astragali Complanati and Herba Cynomorii are ministerial drug, have reinforcing the kidney and supporting YANG, the effect that spermatogenesis consolidates.
The Fructus Lycii of selecting in the present composition is adjuvant drug, has the effect of yin nourishing spermatogenesis, treating YANG within YIN.
The Folium Photiniae (Folium Photiniae serrulatae) of selecting in the present composition and Rhizoma Acori Graminei have for making medicine the effect that drying is turbid, fragrance is amusing.
Above-mentioned medical material prescription of the present invention brings out the best in each other, the energy ovulation rate, thus effectively treat the menoxenia barrenness.
Other side of the present invention due to the disclosure of this paper, is apparent to those skilled in the art.In should be understood that within the scope of the present invention, above-mentioned each technical characterictic of the present invention and can making up mutually between specifically described each technical characterictic in below (eg embodiment), thus consist of new or preferred technical scheme.As space is limited, give unnecessary details no longer one by one at this.
Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment only to be used for explanation the present invention and be not used in and limit the scope of the invention.The experimental technique of unreceipted actual conditions in the following example carries out according to the normal condition in affiliated field usually.
The specific embodiment
1, drug regimen composition formula 1 of the present invention
The concrete formula (potion side) of a drug composition effective embodiment of the present invention is as follows:
2, drug regimen composition formula 2 of the present invention
The concrete formula (potion side) of another drug composition effective embodiment of the present invention is as follows:
3, drug regimen composition formula 3 of the present invention
The concrete formula (potion side) of another drug composition effective embodiment of the present invention is as follows:
In above-mentioned formula 1-3, each component is the key component of the described disease for the treatment of, can be according to the concrete state of an illness with the card plus-minus in the actual therapeutic process.Can add Cortex Cinnamomi 6g and Radix Morindae Officinalis 15g as yang deficiency person; Can add Radix Rehmanniae Preparata 15g and Herba Dendrobii 15g as deficiency of YIN person.
4, the preparation method of pharmaceutical composition of the present invention
The water decoction for preparing the Chinese medicine composition of above-mentioned different formulations by Chinese medicine decocting method conventional on the traditional Chinese medical science.
5, the treatment curative effect of pharmaceutical composition of the present invention
Now come O﹠A Chinese medicine composition of the present invention at the clinical efficacy aspect treatment menoxenia barrenness by following clinical trial.
Method: 32 routine woman in menstrual period dysfunctional Sterility patients are treated observation with the water decoction of aforementioned pharmaceutical compositions formula 3 of the present invention, observe the basal body temperature for the treatment of front and back, the variation of the aspects such as gonadal hormone.
Efficacy assessment standard: (1) ovulation: 1. the ultrasonoscopy change of follicular rupture appears in the B ultrasonic monitoring; 2. the BBT two-phase is periodically-varied; 3. Sterility patient is become pregnant.Meet 1. above+2. or 3. the person is judged as ovulation.(2) effective: as 1. to treat rear main follicular diameter greater than 15mm without follicular development person before the treatment; 2. raise 50% before treatment after the E2 treatment; 3. the clinical symptoms of following significantly alleviates, and vaginal secretions increases.Meet 1. above+3. or 2.+3. the person is judged as effectively.(3) invalid: before and after treatment, symptom and gonad function are without significant change.
Therapeutic Method and result: take the water decoction of the Chinese medicine composition composition formula 3 of the present invention of preparation as stated above for 32 routine woman in menstrual period dysfunctional Sterility patients, every day, potion, divided secondary oral, and 2 months is 1 course for the treatment of.After 1 course for the treatment of, detect this 32 routine patient's ovulation situation.Result shows, in 32 routine woman in menstrual period dysfunctional Sterility patients, ovulation rate reaches 75%, all has obviously before the patient's of normally ovulating serum follicle stimulating hormone (FSH), interstitialcellstimulating hormone (ICSH) (LH) and estradiol (E2) are treated and increases (FSH:p＜0.01; LH:P＜0.01; E2:p＜0.001).
Conclusion: above-mentioned clinical effectiveness shows, pharmaceutical composition of the present invention has ovulation effect, and its induced ovulation may be realized by too many levels, multipath comprehensive functions such as hypothalamus, hypophysis, ovaries, therefore can be used to treat the menoxenia barrenness.
All quote in this application as a reference at all documents that the present invention mentions, just as each piece document is quoted separately as a reference.Should be understood that in addition after having read foregoing of the present invention, those skilled in the art can carry out to the present invention change or the modification of various unsubstantialities, and these equivalent form of values fall within the protection domain that the application's appended claims limits equally.
Claims (5)
1. a Chinese medicine composition, is characterized in that, said composition contains the raw material that forms by following weight portion proportioning:
2. Chinese medicine composition as claimed in claim 1, is characterized in that, said composition contains the raw material that forms by following weight portion proportioning:
3. Chinese medicine composition as claimed in claim 1, is characterized in that, said composition contains the raw material that forms by following weight portion proportioning:
4. Chinese medicine composition as claimed in claim 1, is characterized in that, in this Chinese medicine composition, the weight ratio of each raw material is 3: 3: 1: 1: 1.5: 1: 1: 1.
5. the arbitrary described Chinese medicine composition of claim 1-4 is in the purposes for preparing on the medicine for the treatment of the menoxenia barrenness.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110440896 CN103169824A (en) | 2011-12-23 | 2011-12-23 | Traditional Chinese medicine composition for treating menoxenia infertility and application thereof |
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| CN 201110440896 CN103169824A (en) | 2011-12-23 | 2011-12-23 | Traditional Chinese medicine composition for treating menoxenia infertility and application thereof |
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| CN103169824A true CN103169824A (en) | 2013-06-26 |
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| CN 201110440896 Pending CN103169824A (en) | 2011-12-23 | 2011-12-23 | Traditional Chinese medicine composition for treating menoxenia infertility and application thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105943758A (en) * | 2016-06-27 | 2016-09-21 | 上海中医药大学附属岳阳中西医结合医院 | Traditional Chinese medicine composition for treating infertility and application of traditional Chinese medicine composition |
| CN106474296A (en) * | 2016-10-13 | 2017-03-08 | 上海市第七人民医院 | Chinese medicine composition and its application |
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2011
- 2011-12-23 CN CN 201110440896 patent/CN103169824A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105943758A (en) * | 2016-06-27 | 2016-09-21 | 上海中医药大学附属岳阳中西医结合医院 | Traditional Chinese medicine composition for treating infertility and application of traditional Chinese medicine composition |
| CN105943758B (en) * | 2016-06-27 | 2019-06-28 | 上海中医药大学附属岳阳中西医结合医院 | A kind of Chinese medicine composition that treating infertility and its application |
| CN106474296A (en) * | 2016-10-13 | 2017-03-08 | 上海市第七人民医院 | Chinese medicine composition and its application |
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Application publication date: 20130626 |