CN103157040A - Pharmaceutical composition for treating multiple osteoenchondroma - Google Patents

Abstract

The invention discloses a pharmaceutical composition for treating multiple osteoenchondroma, which aims to solve the problem of treatment of multiple osteoenchondroma. The invention is characterized by comprising the following active pharmaceutical ingredients in parts by weight: lychee seed, poncirus bark, Trachelospermum jasminoides, retinervus luffae fructus, murraya jasminorage, tuckahoe, dried orange peel, kudzu root, Paris polyphylla, Aeschynomene indica, brown malt and charred rice sprout. The clinical experiment proves that the pharmaceutical composition for treating multiple osteoenchondroma has the characteristics of good curative effect and high safety, and is worthy of clinical application and popularization.

Description

A kind of pharmaceutical composition for the treatment of osteochondroma multiple

Technical field

The present invention relates to tumor medication field, be specifically related to a kind of pharmaceutical composition for the treatment of osteochondroma multiple.

Background technology

Osteochondroma belongs to benign bone tumour, claims again the bone wart, is apt to occur in the long bone of limbs metaphysis, and shape differs, and nerve compression symptom or joint function disturbance can occur.Osteochondroma is without special therapeutic method, and only at local discomfort, tumor is large and oppress surrounding tissue and produce symptom and growth and stop rear tumor and continue to increase time side and take excision.

Osteochondroma has single-shot and multiple two kinds, and the osteochondroma multiple tumor is tiny, often abnormal with skeleton development.Multiple because of it, so can't be controlled by operation, but, because osteochondroma multiple rises from metaphysis, if do not treated, often cause the skeleton development obstacle, and often cause long bone of limbs cripetura or deformity, of short and small stature.

Summary of the invention

Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the pharmaceutical composition of the treatment osteochondroma multiple that side effect is little.

The technical scheme that the present invention solves its technical problem is: a kind of pharmaceutical composition for the treatment of osteochondroma multiple is characterized in that being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts of Semen Litchis, 6 ~ 12 parts of Cortex Ponciri trifoliatae, 6 ~ 12 parts of Caulis Trachelospermis, 6 ~ 12 parts of Retinervus Luffae Fructuss, 1 ~ 5 part of Folium Et Cacumen Murrayae, 3 ~ 10 parts, Poria, 6 ~ 12 parts of Pericarpium Citri Reticulataes, 6 ~ 12 parts of Radix Puerariaes, 6 ~ 12 parts of Rhizoma Paridis, 3 ~ 10 parts of Folium Aeschynomense indicaes, 3 ~ 10 parts of Fructus Hordei Germinatus (parched to brown)s, 10 ~ 25 parts of Fructus Setariae Germinatus (parched to brown).

Chinese medicine of the present invention is that the raw material by following optimum weight part proportioning is prepared from: 20 parts of Semen Litchis, 10 parts of Cortex Ponciri trifoliatae, 10 parts of Caulis Trachelospermis, 10 parts of Retinervus Luffae Fructuss, 2 parts of Folium Et Cacumen Murrayae, 6 parts, Poria, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Radix Puerariaes, 10 parts of Rhizoma Paridis, 6 parts of Folium Aeschynomense indicaes, 6 parts of Fructus Hordei Germinatus (parched to brown)s, 20 parts of Fructus Setariae Germinatus (parched to brown).

Wherein said:

Semen Litchi is the dry mature seed of sapindaceous plant Fructus Litchi Litchi chinensis Sonn..Sweet, the micro-hardship of nature and flavor, temperature.Return liver, kidney channel.But the merit promoting QI to circulate and dispersing the agglomeration of the pathogens, cold-dispelling pain-relieving.

Cortex Ponciri trifoliatae is bark bits or the peel bits of rutaceae Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Poncirus tuifoliata (L.) Raf..The nature and flavor suffering; Temperature.Return liver; Kidney channel.But merit endogenous wind stopping relieving convulsion; Eleminating phlegm and freeing channels.Master stroke, body rigidity; flexion and extension negative; eye and mouth are oblique.

Poria is On Polyporaceae Poria Poriacocos(Schw.) the white part of Wolf sclerotium.Nature and flavor are sweet, light, flat.GUIXIN, lung, spleen, kidney channel.But the merit promoting diuresis to eliminate damp pathogen, spleen invigorating, reduce phlegm, mind tranquilizing and the heart calming.

Pericarpium Citri Reticulatae is the dry mature skin of rutaceae orange Citrus reticulata Blanco and variety thereof.Nature and flavor are bitter, hot, temperature.Return lung, spleen channel.But the merit regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.

Folium Aeschynomense indicae is the stem pith of leguminous plant Herba Aeschynonenes Indicae stem Aeschynomene indica L..Nature and flavor are bitter, flat.Attach to the lung and stomach meridians.Heat clearing away, diuresis, lactogenesis, improving eyesight.

Caulis Trachelospermi is the dry zone leaf rattan of apocynaceae plant trachelospermum jasminoide Trachelospermum jasminoides (Lindl.) Lem..Hardship, be slightly cold.GUIXIN, liver, kidney channel.But the merit dispelling wind and removing obstruction in the collateral, the removing heat from blood detumescence.

Radix Puerariae, the root that Radix Puerariae is the leguminous plant Pachyrhizua angulatus.Sweet, hot, flat.Enter spleen, the stomach warp.Merit can be induced sweat, rash, and relaxing muscles and tendons, promote the production of body fluid, antidiarrheal.

Rhizoma Paridis is the rhizome of liliaceous plant Rhizoma Paridis Paris polyphylla Sm..Hardship, be slightly cold.Enter Liver Channel.But the merit heat-clearing and toxic substances removing, detumescence, spasmolytic.

Retinervus Luffae Fructus is the vascular bundle of the dry mature fruit of cucurbitaceous plant Fructus Luffae Luffa cylindrica (L.) Roem..Sweet, flat.Return lung, stomach, Liver Channel.But the merit dredging collateral, invigorate blood circulation, and dispels the wind.

Folium Et Cacumen Murrayae is dried leaves and the band leaf twig of rutaceae Folium Et Cacumen Murrayae Murraya exotica L. and Murraya paniculata (L.) Jack. Murraya paniculata (L.) xJack.Hot, micro-hardship, temperature.The promoting flow of QI and blood dissipating blood stasis, relieving convulsion, removing toxic substances and promoting subsidence of swelling, Eradicates wind is active.

Fructus Hordei Germinatus (parched to brown),, fry to burnt brown according to the method for frying through the drying of germinateing for the mature fruit of grass Fructus Hordei Vulgaris Hordeum vulgare L., cools sieve dedust bits.Nature and flavor are sweet, flat.Return spleen, stomach warp.But the merit promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, move back newborn relieving distension.

Fructus Setariae Germinatus (parched to brown),, fry to burnt brown according to frying method through the drying of germinateing for the mature fruit of grass foxtail millet Setaria italica (L.) Beauv..Nature and flavor are sweet, temperature.Return spleen, stomach warp.Merit can help digestion and in, spleen benefiting and stimulating the appetite.

Composition principle: osteochondroma multiple is a kind of benign bone tumour, at present clinically without this sick medicine for the treatment of.The inventor is through the discovery of clinical research for many years, and the pathogeny of osteochondroma multiple is " the irregular division of chondo-epiphysial cells ", and draws prescription disclosed by the invention through repetition test deliberation checking.

Compared with prior art, the present invention has following characteristics.

1, prescription uniqueness: the inventor thinks that primary disease is that expectorant folder blood stasis forms, phlegm and blood stasis, and the glue work is for suffering from, and should invigorate blood circulation, eliminates the phlegm, eliminating stagnation, dredging collateral go forward side by side, and can improve the pathology present situation of the irregular division of osteochondroma multiple epiphysis ossification center's chondo-epiphysial cells; Avoid using the medicine of nourishing liver and kidney in side, especially avoid the product that use flesh and blood in love, it is abnormal that its reason is that such medicine can not improve skeletonization, on the contrary because " mending it not empty " causes accumulated heat in interior, promotes PD; So get Semen Litchi, Cortex Ponciri trifoliatae in side for monarch, Semen Litchi can enter the joint epiphysis, promoting QI to circulate and dispersing the agglomeration of the pathogens, cold-dispelling pain-relieving; Cortex Ponciri trifoliatae endogenous wind stopping relieving convulsion, eleminating phlegm and freeing channels, clinical former multiplex in apoplexy sequela, but the inventor experimental studies have found that, low dose of Cortex Ponciri trifoliatae water decoction or volatile oil all have protective effect for the chondo-epiphysial cells in cell culture; The capable loose power of described Semen Litchi is strong, and Cortex Ponciri trifoliatae is from expectorant from wind, the two cooperation, and constant breathing, reduce phlegm by endogenous wind stopping on the one hand and solve the problem of epiphysis skeletonization center island skeletonization inequality, can pass through on the other hand dredging collateral dissipating blood stasis alleviating pain, the alleviation clinical symptoms.

2, blood system medicine Caulis Trachelospermi, Retinervus Luffae Fructus, Folium Et Cacumen Murrayae, except the removing heat from blood and promoting blood circulation effect, all have the dredging collateral effect, and a medicine multiple-effect, contribute to reduce medicament categories and consumption, do not increase the Liver and kidney burden.

3, the reason spleen, with removing dampness, is cured the disease and is asked its source, so the present invention writes out a prescription, with Poria, Pericarpium Citri Reticulatae, coordinates the Cortex Ponciri trifoliatae dampness removing to reduce phlegm.

4, Radix Puerariae relaxing muscles and tendons, Rhizoma Paridis spasmolytic, Folium Et Cacumen Murrayae row are altered actively, and three medicine combineds effect are organized spasm in the hope of alleviating periarticular, reduce epiphysis periphery ligament tractive tension force, increase epiphysis stability.

5, prescription Kai Heyou road, get Folium Aeschynomense indicae department mechanism of qi and open entire in we; And the use of Fructus Hordei Germinatus (parched to brown) and Fructus Setariae Germinatus (parched to brown) is considered from interior tonifying the spleen gas.

6, medicine material consumption of the present invention is groped in a large number to sum up through the inventor and is drawn, each raw material consumption is for all to have curative effect preferably in the following weight parts scope: the Semen Litchi amount is larger, the inventor studies discovery, only has escalated dose Semen Litchi side drug effect to enter the joint epiphysis; In " China book on Chinese herbal medicine ", dosage of record Cortex Ponciri trifoliatae is 15 ~ 30g, and in this prescription, Cortex Ponciri trifoliatae be low dose, and its reason is, heavy dose is to treat apoplexy sequela, and in we, is solid protection cartilage proper splitting ossification.And the dosage of Folium Et Cacumen Murrayae is very little, reason be the Folium Et Cacumen Murrayae of middle heavy dose for narcotic analgesic, be that row alters actively and get the Folium Et Cacumen Murrayae effect in we, without heavy dose, slightly get final product.

The specific embodiment

Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.

Embodiment 1, the crude drug weight proportion: 20 parts of Semen Litchis, 10 parts of Cortex Ponciri trifoliatae, 6 parts, Poria, 10 parts of Pericarpium Citri Reticulataes, 6 parts of Folium Aeschynomense indicaes, 10 parts of Caulis Trachelospermis, 10 parts of Radix Puerariaes, 10 parts of Rhizoma Paridis, 12 parts of Retinervus Luffae Fructuss, 2 parts of Folium Et Cacumen Murrayae, 6 parts of Fructus Hordei Germinatus (parched to brown)s, 20 parts of Fructus Setariae Germinatus (parched to brown).

The preparation method of embodiment 1 is: Semen Litchi, Cortex Ponciri trifoliatae, Poria, Pericarpium Citri Reticulatae, Folium Aeschynomense indicae, Caulis Trachelospermi, Radix Puerariae, Rhizoma Paridis, Retinervus Luffae Fructus, Folium Et Cacumen Murrayae, Fructus Hordei Germinatus (parched to brown), Fructus Setariae Germinatus (parched to brown) mixing and water adding are decocted, get filtrate after 30 minutes, medicinal residues add water continuation decoction and get filtrate after 20 minutes, twice filtrate merges, and is divided into two parts of morning and evenings to take.

Embodiment 2, the crude drug weight proportion: 10 parts of Semen Litchis, 6 parts of Cortex Ponciri trifoliatae, 3 parts, Poria, 6 parts of Pericarpium Citri Reticulataes, 3 parts of Folium Aeschynomense indicaes, 6 parts of Caulis Trachelospermis, 6 parts of Radix Puerariaes, 6 parts of Rhizoma Paridis, 6 parts of Retinervus Luffae Fructuss, 1 part of Folium Et Cacumen Murrayae, 3 parts of Fructus Hordei Germinatus (parched to brown)s, 10 parts of Fructus Setariae Germinatus (parched to brown).

Embodiment 3, the crude drug weight proportion: 20 parts of Semen Litchis, 10 parts of Cortex Ponciri trifoliatae, 6 parts, Poria, 10 parts of Pericarpium Citri Reticulataes, 6 parts of Folium Aeschynomense indicaes, 10 parts of Caulis Trachelospermis, 10 parts of Radix Puerariaes, 10 parts of Rhizoma Paridis, 10 parts of Retinervus Luffae Fructuss, 2 parts of Folium Et Cacumen Murrayae, 6 parts of Fructus Hordei Germinatus (parched to brown)s, 20 parts of Fructus Setariae Germinatus (parched to brown).

Embodiment 4, the crude drug weight proportion: 30 parts of Semen Litchis, 12 parts of Cortex Ponciri trifoliatae, 10 parts, Poria, 12 parts of Pericarpium Citri Reticulataes, 10 parts of Folium Aeschynomense indicaes, 12 parts of Caulis Trachelospermis, 12 parts of Radix Puerariaes, 12 parts of Rhizoma Paridis, 12 parts of Retinervus Luffae Fructuss, 5 parts of Folium Et Cacumen Murrayae, 10 parts of Fructus Hordei Germinatus (parched to brown)s, 25 parts of Fructus Setariae Germinatus (parched to brown).

The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:

(1) Radix Puerariae, Cortex Ponciri trifoliatae, Folium Aeschynomense indicae coarse powder are extracted to volatile oil with vapor distillation respectively, and mixing for standby use after collecting;

(2) Fructus Setariae Germinatus (parched to brown), Fructus Hordei Germinatus (parched to brown) were pulverized to 150 mesh sieves, and became fine powder standby;

(3) Semen Litchi, Poria, Pericarpium Citri Reticulatae, Caulis Trachelospermi, Retinervus Luffae Fructus, Rhizoma Paridis, Folium Et Cacumen Murrayae mix and add 10 times of water yields, decoct with water 2 times, and each 1 hour, collecting decoction, standing; Then toward 95% the ethanol that adds 3 ~ 4 times of medicinal liquids in decocting liquid, standing 15 minutes, then with 3000rpm/min centrifugal 20 minutes, get precipitation, spray drying, draw just material;

(4) gained volatile oil in step 1 is sprayed in the first material of step 3 gained, add gained fine powder in step 2 to mix, cross 60 mesh sieves, encapsulated forming.

Can set every capsules is 0.5g.

Effective combination of said medicine, coordinate mutually, invigorates blood circulation, eliminates the phlegm, eliminating stagnation, dredging collateral, effectively reach the purpose for the treatment of osteochondroma multiple, and side effect is less.The above results is the clinical data sufficient proof, and interrelated data is as follows.

1 object and method.

1.1 object.

1.1.1 case is selected: in January, 2008 ~ 2012 a year December is diagnosed as osteochondroma multiple 90 examples, is the outpatient, is divided into matched group, decoction group and Capsules group.Matched group 30 examples, age 12 ~ 19(14.32 ± 4.71) year; Decoction group 30 examples, age 13 ~ 20(16.89 ± 6.09) year; Capsules group 30 examples, age 12 ~ 20(15.48 ± 6.11) year.Three groups of patients all have arthralgia or malaise symptoms in various degree, before treatment, on sex, age, the state of an illness, compare, the difference not statistically significant (P > 0.05), there is comparability.

1.1.2 diagnostic criteria: with reference to " osteopathia " (the 5th edition), all cases is all clarified a diagnosis according to medical history, physical examination, X-ray inspection, and cartilage oligomeric matrix albumen (COMP) detects all negative.

1.2 method.

1.2.1 Therapeutic Method: matched group is taked symptomatic treatment, exempts to bear a heavy burden, as arthralgia adopts ibuprofen oral.The decoction group is with gained decoction oral in the embodiment of the present invention 1,2 times/d.Capsules group is with gained capsule oral in the embodiment of the present invention 1,2g/ time, 2 times/d.Within 1 month, be 1 course for the treatment of, after 3 courses for the treatment of, add up curative effect.Capsules group continues by this therapeutic scheme treatment, and be 1 year total course for the treatment of, and matched group and Capsules group are carried out the X-ray check after 1 year.

1.2.2 observation item: carry out symptom main suit's record, carry out respectively the X-ray check when 3m and 12m, calculate the incidence rate of long bone of limbs cripetura or deformity.Definite method of long bone of limbs cripetura is comply with " osteopathia ", by a year growth ratio, contrasts this age bracket balanced growth ratio, as in extremity any one side year growth ratio be judged as and the long bone cripetura occurs lower than 10% of balanced growth ratio.

1.2.3 statistical analysis: SPSS 13.0 carries out statistical analysis.Measurement data is checked with t, the enumeration data chi-square criterion.

2 results.

2.1 clinical symptoms is improved relatively: after 3 courses for the treatment of, what the decoction group finally completed whole-course treatment is 22 examples, completion rate 73.33%, and the case that comes off is all owing to can not adhering to taking decoction.Three groups complete case and calculate arthralgia or the improvement of malaise symptoms curative effect, obvious effective rate is respectively: matched group 80.00%, decoction group 81.82%, Capsules group 80.00%, decoction group similar to matched group with Capsules group pain relief obvious effective rate (P > 0.05), that is to say that analgesic effect of the present invention and ibuprofen are suitable.

2.2 before and after treating, X-ray checks relatively (after treating 3 months): matched group 36.67% patient occurs that the tumor body becomes greatly or quantity increases, and the decoction group is 13.64%, and Capsules group is 16.67%.The bad progress incidence rate of Capsules group and decoction group is starkly lower than matched group (P<0.05).Illustrate that the present invention can control PD.

2.3 before and after treating, X-ray checks relatively (after treating 1 year): matched group 53.33% patient occurs that the tumor body becomes greatly or quantity increases, and Capsules group is 20.00%, and Capsules group is starkly lower than matched group (P<0.05).Long bone of limbs cripetura or deformity appear in matched group 36.67% patient, and Capsules group is 13.33%, and the incidence rate of the cripetura of Capsules group long bone of limbs or deformity is starkly lower than matched group (P<0.05).

2.4 adverse reaction rate relatively: matched group is 13.33%; The decoction group is 6.67%; Capsules group is 3.33%, is the property a crossed gastrointestinal upset.The adverse reaction rate of Capsules group and decoction group is starkly lower than matched group (P<0.05).

3. conclusion.

This result of study shows, takes decoction group of the present invention and Capsules group obvious effective rate apparently higher than matched group, and can prevent that the osteochondroma multiple state of an illness from further developing.Long-term taking medicine, contribute to reduce the incidence rate of long bone of limbs cripetura or deformity.

Claims (2)

1. a pharmaceutical composition for the treatment of osteochondroma multiple, is characterized in that being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts of Semen Litchis, 6 ~ 12 parts of Cortex Ponciri trifoliatae, 6 ~ 12 parts of Caulis Trachelospermis, 6 ~ 12 parts of Retinervus Luffae Fructuss, 1 ~ 5 part of Folium Et Cacumen Murrayae, 3 ~ 10 parts, Poria, 6 ~ 12 parts of Pericarpium Citri Reticulataes, 6 ~ 12 parts of Radix Puerariaes, 6 ~ 12 parts of Rhizoma Paridis, 3 ~ 10 parts of Folium Aeschynomense indicaes, 3 ~ 10 parts of Fructus Hordei Germinatus (parched to brown)s, 10 ~ 25 parts of Fructus Setariae Germinatus (parched to brown).

2. a kind of pharmaceutical composition for the treatment of osteochondroma multiple according to claim 1, is characterized in that being prepared from by the crude drug of following weight proportion: 20 parts of Semen Litchis, 10 parts of Cortex Ponciri trifoliatae, 10 parts of Caulis Trachelospermis, 10 parts of Retinervus Luffae Fructuss, 2 parts of Folium Et Cacumen Murrayae, 6 parts, Poria, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Radix Puerariaes, 10 parts of Rhizoma Paridis, 6 parts of Folium Aeschynomense indicaes, 6 parts of Fructus Hordei Germinatus (parched to brown)s, 20 parts of Fructus Setariae Germinatus (parched to brown).