CN103155945A - Retarding gas chlorine dioxide solid generating preparation - Google Patents
Retarding gas chlorine dioxide solid generating preparation Download PDFInfo
- Publication number
- CN103155945A CN103155945A CN2013101198250A CN201310119825A CN103155945A CN 103155945 A CN103155945 A CN 103155945A CN 2013101198250 A CN2013101198250 A CN 2013101198250A CN 201310119825 A CN201310119825 A CN 201310119825A CN 103155945 A CN103155945 A CN 103155945A
- Authority
- CN
- China
- Prior art keywords
- chlorine dioxide
- parts
- weight portion
- sodium
- dioxide gas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a retarding gas chlorine dioxide solid generating preparation, comprising the following components in parts by weight: 30-100 parts of chlorite of which the purity is 80%, 20-30 parts of ascorbic acid or sodium salt derivative, 5-20 parts of pH modifier, and 5-10 parts of embedding medium. The method comprises the steps of dissolving 30-100 parts of sodium chlorite into 100-300 parts of water solution in advance, adding 5-20 parts of pH modulator and evenly agitating; pelletizing 20-30 parts of ascorbic acid or sodium ascorbate by a wet process; and feeding 5-10 parts of embedding medium into a coating pan to coat, feeding coating granules prepared in advance into the solution, lightly oscillating to evenly disperse at the same time, and generating gas chlorine dioxide after 18-600 seconds. The retarding gas chlorine dioxide solid generating preparation is simple in preparation technology, strong in operability, low in price, good in stability, and convenient to store and transport and use, and can effectively ensure the safety of operating personnel.
Description
Technical field
The present invention relates to a kind of solid generation preparation of chlorine dioxide gas disinfection agent, specifically be a kind of response composite that Chlorine Dioxide Gas occurs that delays.
Background technology
Chlorine Dioxide Gas is as the wide spectrum of the latest generation of generally acknowledging in the world at present, efficient, safe A1 level disinfectant, get the nod in countries in the world, and be widely used in the fields such as food processing and fresh-keeping, the sterilization of pharmacy, hospital, public environment etc. and waste water treatment.Due to the lability of chlorine dioxide, be difficult for storing and transportation the way that existing solid pharmaceutical preparation preparation technology adopts original position to occur.Solid preparation of chlorine dioxide is a kind ofly can discharge ClO under certain operation condition
2The solid shape goods of gas.ClO
2The characteristics of solid pharmaceutical preparation are with low cost, operate relatively simply, be fit to the small-scale original position such as laboratory ClO occurs as required
2, therefore obtained using more and more widely.But this also brings a safety problem, owing to using ClO
2Solid pharmaceutical preparation needs the related personnel scene to operate.Gas ClO due to report employing at present
2The solid pharmaceutical preparation method, reaction is all instant the generation basically, and strong oxidizing property and high harmfulness in view of chlorine dioxide are absolutely necessary for Field Force's security protection, and the while requires very high for the skilled and order of accuarcy that operates, and security risk is higher.
Summary of the invention
The objective of the invention is to overcome the deficiency of conventional art, provide that a kind of preparation technology is easy, strong operability, security and stability are good, be convenient to the sluggish type Chlorine Dioxide Gas solid formulation formula that stores transportation and use.
To achieve these goals, the present invention takes following design.
The invention provides a kind of sluggish delayed-type Chlorine Dioxide Gas solid pharmaceutical preparation, it is composed as follows: it is comprised of following component: the chlorite 30-100 weight portion of purity 80%, ascorbic acid and sodium salt derivative 20-30 weight portion thereof, pH conditioning agent 5-20 weight portion, embedding medium 5-10 weight portion; 30-100 weight portion sodium chlorite is dissolved in the aqueous solution of 100-300 weight portion in advance, adds the pH adjusting agent of 5-20 weight portion, stir; First adopt wet method that 20-30 weight portion ascorbic acid or sodium ascorbate are granulated, drop into again 5-10 weight portion embedding medium and carry out dressing in coating pan, the coated granule that makes is in advance dropped in mentioned solution, slight vibration simultaneously is uniformly dispersed it, and the Chlorine Dioxide Gas 18-600 of generation generates Chlorine Dioxide Gas after second.
Wherein said pH adjusting agent is one or more composite forming that are selected from sodium sulphite, sodium carbonate, sodium bicarbonate and sodium hydroxide; Described embedding medium is one or more composite the forming in methylcellulose, ethyl cellulose, CMC and hydroxypropyl cellulose.Reaction is carried out in the aqueous solution, and reaction temperature is room temperature.
The above-mentioned functions component is added in a certain amount of aqueous solution with feeding sequence according to a certain percentage, can effectively regulate and control the time of origin of reaction in simple and rapid preparation Chlorine Dioxide Gas, the highest can sluggish 10min.This Chlorine Dioxide Gas generation preparation process is easy, the finished product stability and safety, by the delayed response time of origin, can play safety protection function for operating personnel, the Chlorine Dioxide Gas of generation can be advantageously used in the sterilization of health and epidemic prevention, water body purification and Biohazard Safety Equipment and medicine equipment etc.
But preparation technology of the present invention is easy, workable, cheap, good stability, be convenient to store transportation and use the delayed-type Chlorine Dioxide Gas solid formulation formula of effective guarantee operating personnel safety.
The present invention utilizes chlorite and ascorbic acid radical ion generation redox reaction to prepare target product---Chlorine Dioxide Gas, due to very exothermic in course of reaction, the Chlorine Dioxide Molecules that generates in the aqueous solution by continuous " vaporization " out can be directly used in the sterilization use of object or apparatus by collection or water conservancy diversion.
Description of drawings
Fig. 1 is the cross-sectional view of ascorbic acid or ascorbate dressing grain under drying regime;
Fig. 2 is the cross-sectional view of ascorbic acid or ascorbate dressing grain under solution state.
Embodiment
Utilize chlorite and the oxidation-reduction reaction of Vitamin C acid group in solution to prepare Chlorine Dioxide Gas.Its reaction mechanism more complicated, clearer and more definite studies show that (Ozawa, T. and Kwan, T., " Detoxification of chlorine dioxide (Cl0 at present
2) by Ascorbic Acid in Aqueous Solutions:ESR Studies, " Wat. Res. 21 (2); 229-231 (1987)) ascorbic acid (AsA) produces free radical intermediate product transition state (AFR) in solution, and disproportionated reaction further occurs generate hydroascorbic acid product (DAsA).Provide simultaneously the reaction of proton and sodium chlorite to generate Chlorine Dioxide Gas, product is except target product, and all the other are all chlorate solution and the water of low toxicity.
The present invention will be further described below in conjunction with accompanying drawing.Figure 1 shows that the cross-sectional view that ascorbic acid or sodium ascorbate dressing are granulated.Wherein the composition of inside particles is reactant ascorbic acid or sodium ascorbate 1; The particle skin is embedding medium layer 2, and its composition is composite the forming of one or more macromolecular materials in methylcellulose, ethyl cellulose, CMC and hydroxypropyl cellulose.Adding under aqueous solution state as shown in Figure 2, swelling occurs in outer field encapsulating layer 2 cellulosic material suctions, simultaneously inner effecting reaction composition Vitamin C salt 1 discharges gradually, and oxidation-reduction reaction occurs rapidly generates chlorine dioxide with chlorite in solution.Owing to discharging a large amount of heats in course of reaction, can promote product chlorine dioxide " vaporization ", overflow from reactant liquor rapidly, can be advantageously used in the sterilization of article surface and medicine equipment by collection or water conservancy diversion.
The preparation process of representational Chlorine Dioxide Gas of the present invention is as follows: first adopt wet method that raw material ascorbic acid or sodium ascorbate mixing certain proportion embedding medium are carried out granulating coated, make the dressing grain (B agent) that contains ascorbic acid or sodium ascorbate after drying; Again with appropriate sodium chlorite (technical grade, purity 80%
,The A agent) be dissolved in the aqueous solution of certain volume, add simultaneously appropriate pH adjusting agent, stir.The B agent is dropped in the above-mentioned solution that contains the A agent, and slight vibration simultaneously is uniformly dispersed it, begins timing this moment and be 0 constantly.Along with the prolongation solution of time of repose can be gradually flavescence, with time of beginning to produce bubble in solution as initial reaction time delay, the Chlorine Dioxide Gas concentration that generates simultaneously adopts GD80 chlorine dioxide Electrochemical Detection instrument (detectability 0-100 ppm, Shenzhen Cole's promise electronics technology Co., Ltd) to carry out observational measurement at the reaction bottle mouth position.
Form and actual performance for the ease of the material of understanding this formula, the present invention has attempted a series of different formulas that form, and now provides following specific embodiment to illustrate, but it should be understood that, these embodiment only are used for the purpose of explanation, and do not limit the scope of the invention.
Embodiment one to embodiment 12 (seeing the following form)
Table 1 embodiment one to embodiment 12
Claims (4)
1. delayed-type Chlorine Dioxide Gas solid generation preparation, it is characterized in that, it is comprised of following component: the chlorite 30-100 weight portion of purity 80%, ascorbic acid and sodium salt derivative 20-30 weight portion thereof, pH conditioning agent 5-20 weight portion, embedding medium 5-10 weight portion; 30-100 weight portion sodium chlorite is dissolved in the aqueous solution of 100-300 weight portion in advance, adds the pH adjusting agent of 5-20 weight portion, stir; First adopt wet method that 20-30 weight portion ascorbic acid or sodium ascorbate are granulated, drop into again 5-10 weight portion embedding medium and carry out dressing in coating pan, the coated granule that makes is in advance dropped in mentioned solution, slight vibration simultaneously is uniformly dispersed it, and the Chlorine Dioxide Gas 18-600 of generation generates Chlorine Dioxide Gas after second.
2. described Chlorine Dioxide Gas solid generation preparation according to claim 1, is characterized in that described pH adjusting agent is one or more composite forming that are selected from sodium sulphite, sodium carbonate, sodium bicarbonate and sodium hydroxide.
3. described Chlorine Dioxide Gas solid generation preparation according to claim 1, is characterized in that described embedding medium is one or more composite the forming in methylcellulose, ethyl cellulose, CMC and hydroxypropyl cellulose.
4. described Chlorine Dioxide Gas solid generation preparation according to claim 1 is characterized in that reaction carries out in the aqueous solution, temperature is room temperature.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310119825.0A CN103155945B (en) | 2013-04-09 | 2013-04-09 | Retarding gas chlorine dioxide solid generating preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310119825.0A CN103155945B (en) | 2013-04-09 | 2013-04-09 | Retarding gas chlorine dioxide solid generating preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103155945A true CN103155945A (en) | 2013-06-19 |
| CN103155945B CN103155945B (en) | 2014-12-31 |
Family
ID=48579873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310119825.0A Active CN103155945B (en) | 2013-04-09 | 2013-04-09 | Retarding gas chlorine dioxide solid generating preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103155945B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104719335A (en) * | 2015-03-13 | 2015-06-24 | 华阳新兴科技（天津）集团有限公司 | Chlorine dioxide controllable sustained release preparation |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1486611A (en) * | 2003-07-29 | 2004-04-07 | 上海三欧卫生科技有限公司 | Granulated CLO2 disinfectant and its production process |
| CN1829537A (en) * | 2003-07-29 | 2006-09-06 | 特里斯特尔有限公司 | Sterilant system |
| CN101658181A (en) * | 2008-08-28 | 2010-03-03 | 北京玉佳明三态离子科学研究院有限公司 | Method for manufacturing solid-phase media used to produce gaseous-liquid chlorine dioxide disinfectant |
| CN102160552A (en) * | 2011-02-22 | 2011-08-24 | 天津市华阳新兴科技有限公司 | Controlled-release coated chlorine dioxide disinfectant |
| CN102669176A (en) * | 2012-05-30 | 2012-09-19 | 吕永生 | Slow-release chlorine dioxide solid disinfectant |
| US8337717B2 (en) * | 2004-11-10 | 2012-12-25 | The United States Of America As Represented By The Secretary Of The Army | Process for producing aqueous chlorine dioxide for surface disinfection and decontamination |
-
2013
- 2013-04-09 CN CN201310119825.0A patent/CN103155945B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1486611A (en) * | 2003-07-29 | 2004-04-07 | 上海三欧卫生科技有限公司 | Granulated CLO2 disinfectant and its production process |
| CN1829537A (en) * | 2003-07-29 | 2006-09-06 | 特里斯特尔有限公司 | Sterilant system |
| US8337717B2 (en) * | 2004-11-10 | 2012-12-25 | The United States Of America As Represented By The Secretary Of The Army | Process for producing aqueous chlorine dioxide for surface disinfection and decontamination |
| CN101658181A (en) * | 2008-08-28 | 2010-03-03 | 北京玉佳明三态离子科学研究院有限公司 | Method for manufacturing solid-phase media used to produce gaseous-liquid chlorine dioxide disinfectant |
| CN102160552A (en) * | 2011-02-22 | 2011-08-24 | 天津市华阳新兴科技有限公司 | Controlled-release coated chlorine dioxide disinfectant |
| CN102669176A (en) * | 2012-05-30 | 2012-09-19 | 吕永生 | Slow-release chlorine dioxide solid disinfectant |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104719335A (en) * | 2015-03-13 | 2015-06-24 | 华阳新兴科技（天津）集团有限公司 | Chlorine dioxide controllable sustained release preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103155945B (en) | 2014-12-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105145626A (en) | Aroma type immobilized gel-like chlorine dioxide air cleanser | |
| ES2384594T3 (en) | Compositions, systems and / or methods involving chlorine dioxide ("ClO2") | |
| CN102669176A (en) | Slow-release chlorine dioxide solid disinfectant | |
| CN102246752A (en) | Effervescent disinfection tablet and preparation method thereof | |
| CN105347437B (en) | A kind of preparation method for wastewater treatment modified starch | |
| CN102379310A (en) | Unitary-package-reaction-type chlorine dioxide tablet and preparation method thereof | |
| TW200911287A (en) | Solid preparation for dialysis | |
| CN109890370B (en) | Agent A for hemodialysis | |
| CN110012913A (en) | A kind of compound disinfectant and preparation method thereof | |
| CN102283247A (en) | Veterinary disinfection powder and preparation method thereof | |
| Lukitowati et al. | Water Absorption of Chitosan, Collagen, and Chitosan/Collagen Blend Membranes Exposed to Gamma-Ray Irradiation: Water Absorption of the Membranes Exposed to Irradiation | |
| CN102001714A (en) | Effervescent tablet capable of purifying water quality and preparation method thereof | |
| CN103155945B (en) | Retarding gas chlorine dioxide solid generating preparation | |
| CN102379309A (en) | Binary-packaged reactive chlorine dioxide tablet and preparation method thereof | |
| Li et al. | Hybridization of carboxymethyl chitosan with bimetallic MOFs to construct renewable metal ion “warehouses” with rapid sterilization and long-term antibacterial effects | |
| CN1201660C (en) | Granulated CLO2 disinfectant and its production process | |
| CN105010389B (en) | A kind of slow released ClO 2 pulvis and preparation method thereof | |
| CN101480197B (en) | Stable type disinfecting liquid and method for producing the same | |
| CN103314956A (en) | Sustained-release solid ClO2 disinfectant and preparation method and application thereof | |
| JP4483406B2 (en) | Method for producing solid dialysis agent | |
| CN100591358C (en) | Method for preparing highly water-soluble cydiodine | |
| CN106489931A (en) | It is used as sodium chlorite gel and its preparation technology of disinfectant | |
| CN104784738B (en) | A kind of natural slow release multiple-effect medical sponge | |
| JP4626718B2 (en) | Solid dialysis agent | |
| CN102657173B (en) | Bromochlorohydantoin and DCDMH compound disinfection tablet and method for preparing same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |