CN103143052A - Medical collagen dressing as well as preparation method and use thereof - Google Patents
Medical collagen dressing as well as preparation method and use thereof Download PDFInfo
- Publication number
- CN103143052A CN103143052A CN2013100796435A CN201310079643A CN103143052A CN 103143052 A CN103143052 A CN 103143052A CN 2013100796435 A CN2013100796435 A CN 2013100796435A CN 201310079643 A CN201310079643 A CN 201310079643A CN 103143052 A CN103143052 A CN 103143052A
- Authority
- CN
- China
- Prior art keywords
- medical collagen
- dressing
- medical
- antimicrobial component
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a medical collagen dressing. The medical collagen dressing consists of medical collagen or medical collagen containing antibacterial ingredients and a substrate. The medical collagen dressing can be used for effectively protecting various wound surfaces caused by burn, trauma, operation, infection and the like, controlling the wound surface infection, keeping the wound surface moist, promoting the wound surface healing, increasing the skin nutrition, relieving pigmentation, relieving skin allergy and preventing scars. By verification of 100 or more clinical illness cases, the effective rate of the medical collagen dressing is 95% of higher.
Description
Technical field
The present invention relates to a kind of medical collagen dressing and its production and use.
Background technology
Clinically, for the various wound surface of protecting the reasons such as burn, wound, operation, infection to cause, control traumatic infection; keep wound surface moistening; wound healing often adopts various treatment means and product, but existing method and product are often unsatisfactory on therapeutic effect.
Summary of the invention
The object of the present invention is to provide a kind of formula reasonable, easy to prepare, medical collagen dressing that therapeutic effect is good and its production and use.
Technical solution of the present invention is:
A kind of medical collagen dressing is characterized in that: the one-tenth by following percentage by weight is grouped into:
Medical collagen or contain the medical collagen 1 ~ 100% of antimicrobial component
The substrate surplus.
Described medical collagen is the collagen protein powder of being made through enzymolysis, lyophilizing by Xenogenic acellular dermal matrix.
The described medical collagen that contains antimicrobial component is to be mixed by medical collagen and antimicrobial component, and the content of antimicrobial component is 0.1 ~ 0.5%; Described antimicrobial component is silver nitrate, silver oxide, hibitane, chitosan or contains iodine disinfectant.
The dosage form of dressing is powder, and medical collagen or the medical collagen content that contains antimicrobial component are 100%.
The dosage form of dressing is gel, and medical collagen or the medical collagen content that contains antimicrobial component are 1 ~ 50%, and surplus is host material, and substrate is that 2 ~ 3 compositions in polyvinyl alcohol, hydroxyethyl-cellulose, hydroxy methocel mix and form.
The dosage form of dressing is cream, and medical collagen or the medical collagen content that contains antimicrobial component are 1 ~ 50%, and surplus is host material, and substrate is grouped into by the one-tenth of following weight portion:
30 ~ 60 parts of glyceryl monostearates
80 ~ 120 parts of stearic acid
40 ~ 60 parts of white vaseline
130 ~ 180 parts of liquid paraffin
80 ~ 120 parts of glycerol
120 ~ 150 parts of tween 80s
350 ~ 550 parts of purified water.
The dosage form of dressing is the dosage form of applying ointment or plaster, and substrate is gauze or non-woven fabrics or PE nethike embrane.
A kind of preparation method of medical collagen dressing is characterized in that: medical collagen or the medical collagen that contains antimicrobial component are filled with in packaging bag or in plastic bottle, with ethylene oxide sterilizing or irradiation sterilization, be powder product;
Perhaps, with medical collagen or to contain the medical collagen of antimicrobial component miscible in substrate, fill after ethylene oxide sterilizing or irradiation sterilization, is gel or cream product in plastic tube;
Perhaps, with medical collagen or contain that the medical collagen of antimicrobial component is miscible to be packaged in aluminium foil bag in gauze or non-woven fabrics or PE nethike embrane substrate, after ethylene oxide sterilizing or irradiation sterilization, be the applicator product.
The application of a kind of medical collagen dressing in the goods of the various wound surface that preparation protection burn, wound, operation, infection cause.
The various wound surface that the present invention can effectively protect the reasons such as burn, wound, operation, infection to cause are controlled traumatic infection, keep wound surface moistening, wound healing, and increase skin-nourishing, and alleviate pigmentation, alleviate skin allergy, prevention of scar.Through 100 many cases clinical case checkings, effective percentage reaches more than 95%.
The invention will be further described below in conjunction with embodiment.
The specific embodiment
Embodiment 1:
Medical collagen or the medical collagen that contains antimicrobial component are filled with in packaging bag or in plastic bottle, with ethylene oxide sterilizing or irradiation sterilization, be powder product;
Described medical collagen be by Xenogenic acellular dermal matrix (preparation method of Xenogenic acellular dermal matrix is seen Chinese patent CN102580141A) through enzymolysis (adopt pepsin, trypsin or pancreatin, the consumption of enzyme be Xenogenic acellular dermal matrix weight 1% ~ 5%), the collagen protein powder made of lyophilizing.
The described medical collagen that contains antimicrobial component is to be mixed by medical collagen and antimicrobial component, and the content of antimicrobial component is 0.1 ~ 0.5%(example 0.1%, 0.3%, 0.5%); Described antimicrobial component is silver nitrate, silver oxide, hibitane, chitosan or contains iodine disinfectant.
During use, be laid in the wound surface surface.Through routine clinical case checking, effective percentage reaches more than 95%.
Embodiment 2:
With 1 ~ 50%(example 1%, 25%, 50%) medical collagen or to contain the medical collagen of antimicrobial component miscible in the substrate of surplus, fill after ethylene oxide sterilizing or irradiation sterilization, is the gel product in plastic tube; Substrate is that 2 ~ 3 compositions in polyvinyl alcohol, hydroxyethyl-cellulose, hydroxy methocel mix composition.
Described medical collagen be by Xenogenic acellular dermal matrix (preparation method of Xenogenic acellular dermal matrix is seen Chinese patent CN102580141A) through enzymolysis (adopt pepsin, trypsin or pancreatin, the consumption of enzyme be Xenogenic acellular dermal matrix weight 1% ~ 5%), the collagen protein powder made of lyophilizing.
During use, be laid in the wound surface surface.Through routine clinical case checking, effective percentage reaches more than 95%.
Embodiment 3:
With 1 ~ 50%(example 1%, 25%, 50%) medical collagen or to contain the medical collagen of antimicrobial component miscible in the substrate of surplus, fill after ethylene oxide sterilizing or irradiation sterilization, is the cream product in plastic tube; Matrix components is grouped into by the one-tenth of following weight portion:
30 ~ 60 parts of glyceryl monostearates (30 parts, 45 parts, 60 parts of examples)
80 ~ 120 parts of stearic acid (80 parts, 100 parts, 120 parts of examples)
40 ~ 60 parts of white vaseline (40 parts, 50 parts, 60 parts of examples)
130 ~ 180 parts of liquid paraffin (130 parts, 150 parts, 180 parts of examples)
80 ~ 120 parts of glycerol (80 parts, 100 parts, 120 parts of examples)
120 ~ 150 parts of tween 80s (120 parts, 135 parts, 150 parts of examples)
350 ~ 550 parts of purified water (350 parts, 450 parts, 550 parts of examples).
Described medical collagen be by Xenogenic acellular dermal matrix (preparation method of Xenogenic acellular dermal matrix is seen Chinese patent CN102580141A) through enzymolysis (adopt pepsin, trypsin or pancreatin, the consumption of enzyme be Xenogenic acellular dermal matrix weight 1% ~ 5%), the collagen protein powder made of lyophilizing.
During use, be laid in the wound surface surface.Through routine clinical case checking, effective percentage reaches more than 95%.
Embodiment 4:
With 1 ~ 50%(example 1%, 25%, 50%) medical collagen or contain that the medical collagen of antimicrobial component is miscible to be packaged in aluminium foil bag in the gauze or non-woven fabrics or PE nethike embrane substrate of surplus, after ethylene oxide sterilizing or irradiation sterilization, be the applicator product.
Described medical collagen be by Xenogenic acellular dermal matrix (preparation method of Xenogenic acellular dermal matrix is seen Chinese patent CN102580141A) through enzymolysis (adopt pepsin, trypsin or pancreatin, the consumption of enzyme be Xenogenic acellular dermal matrix weight 1% ~ 5%), the collagen protein powder made of lyophilizing.
During use, be laid in the wound surface surface.Through routine clinical case checking, effective percentage reaches more than 95%.
Claims (9)
1. medical collagen dressing, it is characterized in that: the one-tenth by following percentage by weight is grouped into:
Medical collagen or contain the medical collagen 1 ~ 100% of antimicrobial component
The substrate surplus.
2. medical collagen dressing according to claim 1 is characterized in that: described medical collagen is the collagen protein powder of being made through enzymolysis, lyophilizing by Xenogenic acellular dermal matrix.
3. medical collagen dressing according to claim 1 and 2 is characterized in that: the described medical collagen that contains antimicrobial component is to be mixed by medical collagen and antimicrobial component, and the content of antimicrobial component is 0.1 ~ 0.5%; Described antimicrobial component is silver nitrate, silver oxide, hibitane, chitosan or contains iodine disinfectant.
4. medical collagen dressing according to claim 1 and 2 is characterized in that: the dosage form of dressing is powder, and medical collagen or the medical collagen content that contains antimicrobial component are 100%.
5. medical collagen dressing according to claim 1 and 2, it is characterized in that: the dosage form of dressing is gel, medical collagen or the medical collagen content that contains antimicrobial component are 1 ~ 50%, surplus is host material, and substrate is 2 ~ 3 compositions mixing compositions in polyvinyl alcohol, hydroxyethyl-cellulose, hydroxy methocel.
6. medical collagen dressing according to claim 1 and 2 is characterized in that: the dosage form of dressing is cream, and medical collagen or the medical collagen content that contains antimicrobial component are 1 ~ 50%, and surplus is host material, and substrate is grouped into by the one-tenth of following weight portion:
30 ~ 60 parts of glyceryl monostearates
80 ~ 120 parts of stearic acid
40 ~ 60 parts of white vaseline
130 ~ 180 parts of liquid paraffin
80 ~ 120 parts of glycerol
120 ~ 150 parts of tween 80s
350 ~ 550 parts of purified water.
7. medical collagen dressing according to claim 1 and 2, it is characterized in that: the dosage form of dressing is the dosage form of applying ointment or plaster, substrate is gauze or non-woven fabrics or PE nethike embrane.
8. the preparation method of a medical collagen dressing claimed in claim 1 is characterized in that: medical collagen or the medical collagen that contains antimicrobial component are filled with in packaging bag or in plastic bottle, with ethylene oxide sterilizing or irradiation sterilization, be powder product;
Perhaps, with medical collagen or to contain the medical collagen of antimicrobial component miscible in substrate, fill after ethylene oxide sterilizing or irradiation sterilization, is gel or cream product in plastic tube;
Perhaps, with medical collagen or contain that the medical collagen of antimicrobial component is miscible to be packaged in aluminium foil bag in gauze or non-woven fabrics or PE nethike embrane substrate, after ethylene oxide sterilizing or irradiation sterilization, be the applicator product.
9. the application of medical collagen dressing claimed in claim 1 in the goods of the various wound surface that preparation protection burn, wound, operation, infection cause.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013100796435A CN103143052A (en) | 2013-03-13 | 2013-03-13 | Medical collagen dressing as well as preparation method and use thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013100796435A CN103143052A (en) | 2013-03-13 | 2013-03-13 | Medical collagen dressing as well as preparation method and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103143052A true CN103143052A (en) | 2013-06-12 |
Family
ID=48541551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2013100796435A Pending CN103143052A (en) | 2013-03-13 | 2013-03-13 | Medical collagen dressing as well as preparation method and use thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103143052A (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103357061A (en) * | 2013-06-24 | 2013-10-23 | 扬州辐照中心 | Production method of surgical dressing by irradiation sterilization |
| CN104721877A (en) * | 2015-03-18 | 2015-06-24 | 广州创尔生物技术股份有限公司 | Sterile collagen dressing and preparation method thereof |
| CN105363021A (en) * | 2015-11-13 | 2016-03-02 | 邢月军 | Gel for promoting wound healing |
| CN105983094A (en) * | 2015-02-09 | 2016-10-05 | 广州创尔生物技术股份有限公司 | Preparation method of sterile collagen liquid having bio-activity and preparation method of sterile collagen dressing having bio-activity |
| CN105985429A (en) * | 2015-02-09 | 2016-10-05 | 广州创尔生物技术股份有限公司 | Aseptic collagen liquid with biological activity and preparation method thereof |
| CN106146862A (en) * | 2015-03-31 | 2016-11-23 | 中南大学 | A kind of supermolecule heterozygosis hydrogel of antibiotic property and its preparation method and application |
| CN106421871A (en) * | 2016-09-29 | 2017-02-22 | 广州赛莱拉干细胞科技股份有限公司 | Atomizing type medicinal collagen dressing and preparing method thereof |
| CN109260503A (en) * | 2018-09-30 | 2019-01-25 | 振德医疗用品股份有限公司 | A kind of absorbing material and preparation method thereof, the dressing comprising the material |
| CN114848886A (en) * | 2022-06-08 | 2022-08-05 | 扬州卓和医用材料有限公司 | Absorbable hemostatic dressing |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1814778A (en) * | 2005-12-02 | 2006-08-09 | 成都佰乐金生物科技有限公司 | Method for preparing medical collagen protein powder |
| CN101108222A (en) * | 2006-07-17 | 2008-01-23 | 修涞贵 | Method of preparing traditional Chinese medicine unction formulated product for treating cervical erosion, colpitis |
| CN102228715A (en) * | 2011-06-10 | 2011-11-02 | 青岛明药堂医药科技开发有限公司 | Liquid dressing containing chitosan derivative and preparation method thereof |
| CN102535015A (en) * | 2011-12-14 | 2012-07-04 | 山东俊富非织造材料有限公司 | Biologically active compound non-woven fabric and production method thereof |
-
2013
- 2013-03-13 CN CN2013100796435A patent/CN103143052A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1814778A (en) * | 2005-12-02 | 2006-08-09 | 成都佰乐金生物科技有限公司 | Method for preparing medical collagen protein powder |
| CN101108222A (en) * | 2006-07-17 | 2008-01-23 | 修涞贵 | Method of preparing traditional Chinese medicine unction formulated product for treating cervical erosion, colpitis |
| CN102228715A (en) * | 2011-06-10 | 2011-11-02 | 青岛明药堂医药科技开发有限公司 | Liquid dressing containing chitosan derivative and preparation method thereof |
| CN102535015A (en) * | 2011-12-14 | 2012-07-04 | 山东俊富非织造材料有限公司 | Biologically active compound non-woven fabric and production method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 林海: "医用胶原蛋白粉剂及胶原基复合膜的研制与性能表征", 《CNKI优秀硕士学位论文全文库》 * |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103357061A (en) * | 2013-06-24 | 2013-10-23 | 扬州辐照中心 | Production method of surgical dressing by irradiation sterilization |
| CN105983094A (en) * | 2015-02-09 | 2016-10-05 | 广州创尔生物技术股份有限公司 | Preparation method of sterile collagen liquid having bio-activity and preparation method of sterile collagen dressing having bio-activity |
| CN105985429A (en) * | 2015-02-09 | 2016-10-05 | 广州创尔生物技术股份有限公司 | Aseptic collagen liquid with biological activity and preparation method thereof |
| CN104721877A (en) * | 2015-03-18 | 2015-06-24 | 广州创尔生物技术股份有限公司 | Sterile collagen dressing and preparation method thereof |
| CN104721877B (en) * | 2015-03-18 | 2017-09-22 | 广州创尔生物技术股份有限公司 | A kind of sterile collagen sticking dressing and preparation method thereof |
| CN106146862A (en) * | 2015-03-31 | 2016-11-23 | 中南大学 | A kind of supermolecule heterozygosis hydrogel of antibiotic property and its preparation method and application |
| CN106146862B (en) * | 2015-03-31 | 2018-09-25 | 中南大学 | A kind of supermolecule heterozygosis hydrogel of antibiotic property and its preparation method and application |
| CN105363021A (en) * | 2015-11-13 | 2016-03-02 | 邢月军 | Gel for promoting wound healing |
| CN106421871A (en) * | 2016-09-29 | 2017-02-22 | 广州赛莱拉干细胞科技股份有限公司 | Atomizing type medicinal collagen dressing and preparing method thereof |
| CN109260503A (en) * | 2018-09-30 | 2019-01-25 | 振德医疗用品股份有限公司 | A kind of absorbing material and preparation method thereof, the dressing comprising the material |
| CN114848886A (en) * | 2022-06-08 | 2022-08-05 | 扬州卓和医用材料有限公司 | Absorbable hemostatic dressing |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103143052A (en) | Medical collagen dressing as well as preparation method and use thereof | |
| US9839693B2 (en) | Anhydrous hydrogel composition and delivery system | |
| CN103191460B (en) | Chitosan-silicone dressing as well as preparation method and application thereof | |
| JP2017514866A5 (en) | ||
| CN103127543A (en) | Silicone dressing, and preparation method and use thereof | |
| WO2013108918A1 (en) | Pack cosmetic accommodating article, cosmetic pack, and manufacturing method for pack cosmetic | |
| IL273329A (en) | Modulation of heparin-binding epidermal growth factor activity for tympanic membrane healing | |
| CN105288700A (en) | Medical thermo-sensitive hydrogel dressing and preparation method thereof | |
| CN100522262C (en) | Composite function liquid wound dressing and its use | |
| CN103127544A (en) | Silver-containing chitosan dressing as well as preparation method and application thereof | |
| CN206761832U (en) | A kind of bandage with sterilizing function | |
| CN204016935U (en) | A kind of medical bio magnetic dressing pastes | |
| CN202505827U (en) | Hemostatic anti-inflammation antimicrobial applicator containing nano-silver | |
| CN105536041A (en) | Royal jelly acid containing antibacterial biological dressings as well as preparation method and application thereof | |
| AU2015268649B2 (en) | A composition and method of applying same & a composition that assists healing burns and wounds with antibacterial and anti-fungal actions | |
| CN104548184A (en) | Medical dressing with biological nourishment function, and preparation method thereof | |
| CN104001220B (en) | A kind of skin regeneration material and preparation method thereof | |
| CN103143051A (en) | Chitosan chlorhexidine dressing as well as preparation method and use thereof | |
| CN103285418A (en) | Novel biological antibacterial dressing aerosol based on large-area burn wound | |
| CN204050019U (en) | Hemostatic and antibacterial dressing plaster | |
| US10517989B1 (en) | Enhanced medical dressing apparatus, system, and method | |
| CN108042662A (en) | A kind of medicament for treating scald | |
| CN203763542U (en) | Collagen bandage | |
| CN202336084U (en) | Chitosan medical dressing product | |
| CN201389129Y (en) | Nano silver antibiotic band-aid |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20130612 |