CN103127428A - Chinese patent drug for treatment of gouty arthritis - Google Patents
Chinese patent drug for treatment of gouty arthritis Download PDFInfo
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- CN103127428A CN103127428A CN201310099358XA CN201310099358A CN103127428A CN 103127428 A CN103127428 A CN 103127428A CN 201310099358X A CN201310099358X A CN 201310099358XA CN 201310099358 A CN201310099358 A CN 201310099358A CN 103127428 A CN103127428 A CN 103127428A
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Abstract
The invention relates to a Chinese patent drug for treatment of gouty arthritis. The Chinese patent drug is prepared by semen coicis, rhizoma atractylodis, dioscorea and the like according to parts by weight, and has the beneficial effects that aiming at the three key factors causing gouty arthritis such as phlegm-damp, blood stasis and heat toxin, the Chinese patent drug adopts Chinese herbal medicine compound preparation having action of excreting dampness and reducing phlegm, promoting blood circulation to remove blood stasis, clearing and activating the channels and collaterals, diminishing inflammation and relieving pain, clearing away heat and toxic materials and removing uric acid, has reliable curative effects, can thoroughly cure the gouty arthritis, and has no toxic or side effect, and the gouty arthritis does not relapse for a long time; and if western medicine is adopted for treating gouty arthritis, the side effect is obvious, the gouty arthritis is easy to relapse, and the western medicine cannot be used for long time cure, while the Chinese patent drug has remarkable curative effect and is applicable to mass production, and a patient taking the drug has no discomfort.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of gouty arthritis, particularly a kind of Chinese medicine preparation of the treatment gouty arthritis made from herbal raw material.
Background technology
Gout is by the crystal dependency arthrosis due to monosodium urate salt (MSU) deposition, directly related with the hyperuricemia due to purine metabolic disturbance or underexcretion, refer in particular to acute characteristic arthritis and chronic gout stone disease, mainly comprise acute attack arthritis, tophus formation, tophus chronic arthritis, urate nephropathy and uric acid lithangiuria, joint deformity and renal insufficiency can appear in severe one.
In the Chinese medicine field, the name of gout starts from Zhu Danxi, Li Dongyuan, but the gout of the traditional Chinese medical science is the severe and migratory arthralgia of broad sense, and the gout of western medicine is " gouty arthritis " of the hyperuricemia that causes of purine metabolic disturbance.Primary disease occurs mainly with person in middle and old age, and body is partially fat, and history of drinking history is arranged more, over year, social materials is abundant due to nearly twenty or thirty, and living standards of the people improve day by day, diet and environment Fructus Citri tangerinae structure have had very large variation, and the artificial many of fat meat and fine grain delicious food are advanced in happiness, cause visceral dysfunction, ascending the clear and descending the turbid is had no right, and therefore stagnation of phlegm-damp in blood vessels, is difficult to letting out for a long time, tie mutually with blood, close and stay in passages through which vital energy circulates, the bone knot swells and ache, the tuberosity deformity, closing heat-transformation, the poly-poison that forms.
The treatment gout mainly adopts medicines such as oral " colchicine " " allopurinols " both at home and abroad at present, although these medicine effects are rapider, analgesic effect is fast, but serious side effect is arranged, particularly intestinal there is very large damage, and in a lot of situations, only otherwise be careful in one's diet, be easy to recurrence in 1 year; On the contrary, although the Chinese medicine curative effect is slow, heal rear effective, seldom have the situation of recurrence to occur in 1 year, and the toxic and side effects less of Chinese medicine, many patients begin to adopt treatment by Chinese herbs.
Safe and effective in order to seek, the Chinese medicine preparation that side effect is little, the patent No. 200610037537.0,200910220525.5,200810300845.7 etc. has all been announced medicine for the treatment of gouty arthritis separately and preparation method thereof, the medicine that these methods are made all has certain effect to relief of symptoms, but last curative effect all can not be satisfactory, be mainly speed and the disease radical cure aspect course for the treatment of, a lot of patients can be recurred again soon.
Summary of the invention
Technical problem to be solved by this invention is: for the deficiencies in the prior art, adopt prescription of one group of eliminating dampness and resolving phlegm, blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain and preparation method thereof, to provide a kind of curative effect reliable, without secondary toxic action, the Chinese patent medicine of the treatment gouty arthritis that does not recur for a long time.
For solving the problems of the technologies described above, the technical solution adopted in the present invention is a kind of Chinese patent medicine for the treatment of gouty arthritis, and is formulated by the crude drug of following weight portion: Semen Coicis 25-35 part, Rhizoma Atractylodis 10-14 part, Rhizoma Dioscoreae Septemlobae 30-40 part, Rhizoma Smilacis Glabrae 30-40 part, Caulis Lonicerae 25-35 part, Cortex Phellodendri 13-17 part, Fructus Forsythiae 25-35 part, Rhizoma Corydalis 13-17 part, Semen Persicae 13-17 part, Flos Carthami 5-7 part, Radix Cyathulae 13-17 part, Radix Cynanchi Paniculati 10-14 part, Radix Clematidis 17-23 part.
Preferred each crude drug amount ratio is: 30 parts of Semen Coiciss, 12 parts of Rhizoma Atractylodis, 35 parts of Rhizoma Dioscoreae Septemlobae, 35 parts of Rhizoma Smilacis Glabraes, 30 parts of Caulis Loniceraes, 15 parts of Cortex Phellodendris, 30 parts of Fructus Forsythiaes, 15 parts of Rhizoma Corydalis, 15 parts, Semen Persicae, 6 parts, Flos Carthami, 15 parts of Radix Cyathulaes, 12 parts of Radix Cynanchi Paniculatis, 20 parts of Radix Clematidis.
The preparation method of Chinese medicine preparation of the present invention be with each crude drug by above-mentioned formula proportion weighing, be ground to the fine powder of 0.10-0.12mm after oven dry, then make the watered pill of every 0.05g-0.1g.
During treatment, give the patient once oral 12g-20g, three times on the one, 10 days is a course for the treatment of, general one to three the course for the treatment of clinical cure; Period in a medicine ban on opium-smoking and the opium trade wine, light diet.
Though because existing medicine has certain effect to alleviating the gouty arthritis symptom, last curative effect all can not be satisfactory, can recur again soon; The inventor is through studying for a long period of time and putting into practice, think that the Etiological of gouty arthritis is: phlegm-damp, blood stasis, pyretic toxicity, mostly be greatly due to three factors bond each other, through saying: treatment must aim at the pathogenesis of disease, so should be turbid from eliminating dampness and resolving phlegm, the angle of blood circulation promoting and blood stasis dispelling, dredge the meridian passage, anti-inflammatory analgetic, heat-clearing and toxic substances removing carries out Zhi Genzhiben.
In prescription of the present invention, Semen Coicis is cool in nature, sweet in the mouth, light, but spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal; Rhizoma Atractylodis are warm in nature, and acrid in the mouth, hardship can be drying damp and strengthening spleen, and expelling wind and cold makes eye bright; Rhizoma Dioscoreae Septemlobae is flat, bitter in the mouth, but that dampness removing goes is turbid, wind expelling stagnation removing; Rhizoma Smilacis Glabrae is flat, and sweet in the mouth, light can detoxify, dehumidifying, sharp joint; So turbid with eliminating dampness and resolving phlegms such as Semen Coicis, Rhizoma Atractylodis, Rhizoma Dioscoreae Septemlobae, Rhizoma Smilacis Glabraes; Rhizoma Corydalis is warm in nature, acrid in the mouth, hardship, but promoting blood circulation to remove blood stasis, promoting the circulation of QI to relieve pain; Semen Persicae is flat, bitter in the mouth, sweet; But blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma; Flos Carthami is warm in nature, acrid in the mouth, but promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.Radix Cyathulae property is flat, sweet in the mouth, little hardship; But eliminating blood stasis and inducing menstruation, easing joint movement, inducing diuresis for treating stranguria syndrome; So with the blood circulation promoting and blood stasis dispelling such as Rhizoma Corydalis, Semen Persicae, Flos Carthami, Radix Cyathulae, dredge the meridian passage and anti-inflammatory analgetic; Caulis Lonicerae is cold in nature, sweet in the mouth, but heat-clearing and toxic substances removing, dispelling wind collateral dredging; Cortex Phellodendri is cold in nature, bitter in the mouth, but heat clearing and damp drying, and eliminating fire and detoxication is except the hectic fever due to YIN-deficiency clearind deficient heat; The Fructus Forsythiae cold nature, bitter in the mouth, but heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens; So with heat-clearing and toxic substances removing such as Caulis Lonicerae, Cortex Phellodendri, Fructus Forsythiaes; Radix Cynanchi Paniculati is warm in nature, and acrid in the mouth, but wind-expelling pain-stopping are antipruritic, invigorate blood circulation, and detoxifcation; Radix Clematidis is warm in nature, acrid in the mouth, salty, but expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, the loose hypochondriac lump; So with Radix Cynanchi Paniculati, the pain relieving of Radix Clematidis dispelling wind and removing obstruction in the collateral; Rhizoma Dioscoreae Septemlobae in the side, Rhizoma Smilacis Glabrae and Radix Clematidis adopt heavy dose of, and kinds of traditional Chinese medicines is through scientific composition, have that eliminating dampness and resolving phlegm is turbid, an effect of blood circulation promoting and blood stasis dispelling, dredge the meridian passage, anti-inflammatory analgetic, heat-clearing and toxic substances removing, and be main good to the therapeutic effect of arthromyodynia, severe and migratory arthralgia.
The inventor tests through Long-term clinical, has chosen 106 routine patients, the common single toe articulations digitorum manus of these patients, and the soldier is congestion and swelling pain so, and pain is acute gradually stings as tiger, and very repeatedly show effect light night in daytime, the diseases such as some heat that occurs together, headache; Often because of fatigue, eating and drinking too much at one meal, drink and affection of exogenous wind-cold etc. brings out; After some shows effect repeatedly, with tophus occurring between periarticular and auricle, helix and toe, phalanges; Check finds that uric acid increases, and some total white blood cells increases, and obvious gouty arthritis symptom is arranged; Male 98 examples wherein, female's 8 examples, age 35-73 year, 41.2 years old mean age, the course of disease 1 day-9 years, average 1.9 years; Invade metatarsophalangeal joints 80 examples, ankle joint 21 examples, knee joint 7 examples, Level of Serum Uric Acid 425~776 μ mol/L; The inventor is divided into two groups immediately with case in the clinical experiment process, one group is adopted medicine of the present invention, and matched group adopts colchicine to carry out the randomized controlled treatment experiment.It is a course for the treatment of that treatment group of the present invention adopts 10 days, and matched group adopts 5 days courses for the treatment of, all takes low purine, low fat, low caloric diet during treatment, drinks more water and prohibits against alcoholic drinks, tracing observation after treatment.
Criterion of therapeutical effect is with reference to State Administration of Traditional Chinese Medicine " traditional Chinese medical science disease Standardization of diagnosis and curative effect ".Cure: transference cure, lab testing are normal; Take a turn for the better: arthroncus disappearance, pain relief, lab testing is improved; Invalid: symptom and lab testing are unchanged.
Treat through the long-term case of collecting, statistical result is as follows: cure 35 examples in medication therapy groups 53 examples of the present invention, 15 examples that take a turn for the better, invalid 3 examples, cure rate 66.03%, total effective rate 94.33%, healing time is the longest 30 days, and is the shortest 5 days, average 11 days, the nothing recurrence that tracing observation was cured in 1 year afterwards, the only 7 example recurrences of improvement; Cure 41 examples in matched group 53 examples of employing colchicine, 11 examples that take a turn for the better, invalid 1 example, cure rate 77.36%, total effective rate 98.5%, healing time is the longest 10 days, and is the shortest 3 days, and average 7 days, 35 examples that have that tracing observation was cured in a year afterwards recurred, whole recurrences of improvement.Through check, two groups of cure rates and total effective rate difference all have significant (P<0.05), aspect treatment healing speed, treatment group is poorer than matched group, but prevent that in radical cure treatment aspect recurrence, the treatment group curative effect is better than matched group, and the secondary toxic action of matched group is very large, therefore, the present invention is fit to large-scale popularization.
The invention has the beneficial effects as follows the key reason phlegm-damp that produces for gouty arthritis, blood stasis, three factors such as pyretic toxicity, employing has that eliminating dampness and resolving phlegm is turbid, the compound Chinese medicinal preparation of blood circulation promoting and blood stasis dispelling, dredge the meridian passage, anti-inflammatory analgetic, heat-clearing and toxic substances removing, uricotelism, curative effect is reliable, effect a radical cure more thorough, without secondary toxic action, for a long time no longer the recurrence; And primary disease adopts western medicine, and side effect is very large, and easily recurrence, is difficult for adhering to treatment more, and it is distinguished to treat curative effect with the present invention, and after clothes for patients without any discomfort, be fit to large-scale production and use.
The specific embodiment
The invention will be further described below in conjunction with embodiment, and following examples are intended to illustrate the present invention rather than limitation of the invention further, should not limit protection scope of the present invention with this.
Embodiment 1.
Get Semen Coicis 2.5kg, Rhizoma Atractylodis 1.0 kg, Rhizoma Dioscoreae Septemlobae 3.0 kg, Rhizoma Smilacis Glabrae 3.0 kg, Caulis Lonicerae 2.5 kg, Cortex Phellodendri 1.3 kg, Fructus Forsythiae 2.5 kg, Rhizoma Corydalis 1.3 kg, Semen Persicae 1.3 kg, Flos Carthami 0.5 kg, Radix Cyathulae 1.3 kg, Radix Cynanchi Paniculati 1.0 kg, Radix Clematidis 1.7 kg, to grind to form the fine powder of 0.1mm after each crude drug oven dry, then make the watered pill of every 0.05g; Namely made the Chinese patent medicine watered pill for the treatment of gouty arthritis.
patient Mr. Zhang, 61 years old, the electric retired cadre of group of Qianjiang crow, live Qianjiang District Xia Ba road No. 345, on April 5th, 2007 is medical, the little joint congestion and swelling pain of both feet toe showed effect 3 years repeatedly, cause was often gone on business in 3 years, often eat and drink extravagantly, time sense toes swell and ache, because of busy, do not pay attention to, later on often after drinking or catching cold, be that pain exacerbates, red and swollen, at the uric acid 689umol/L that has a blood test of Qianjiang central hospital, be diagnosed as " gout ", take the medicines such as the third yellow acid, disease is slightly better, because stomach discomfort is withdrawn, rear because swelling and ache and increasing, be intermittently to take medicine, up to now, the left side of now having a medical check-up, right big toe congestion and swelling pain, with the watered pill that the present invention makes, the 15g that at every turn swallows three times on the one, treats two courses for the treatment of, treat after 3 days, a left side, right big toe congestion and swelling pain begins to alleviate, and after 15 days, pain disappears, and checks blood uric acid 325umol/L after 20 days again, follows up a case by regular visits to after 1 year, not recurrence again.
Embodiment 2.
Get Semen Coicis 3.0kg, Rhizoma Atractylodis 1.2kg, Rhizoma Dioscoreae Septemlobae 3.5kg, Rhizoma Smilacis Glabrae 3.5kg, Caulis Lonicerae 3.0kg, Cortex Phellodendri 1.5kg, Fructus Forsythiae 3.0kg, Rhizoma Corydalis 1.5kg, Semen Persicae 1.5kg, Flos Carthami 0.6kg, Radix Cyathulae 1.5kg, Radix Cynanchi Paniculati 1.2kg, Radix Clematidis 2.0kg, to grind to form the fine powder of 0.11mm after each crude drug oven dry, then make the watered pill of every 0.075g; Namely made the Chinese patent medicine watered pill for the treatment of gouty arthritis.
Patient Mr. Zhang, 37 years old, the Qianjiang worker of hydroelectric board, on August 23rd, 2010 is medical, and the often outbreak of swelling and ache of left big foot hallux toe is in the department of endocrinology diagnosis and treatment of Chongqing city-level hospital, be diagnosed as " gouty arthritis " oral administration western medicine, concrete medication is not quite clear, the symptom fashion time difference, after to take the Chinese herbal treatment effect an institute of traditional Chinese medicine again also undesirable, the watered pill made from the present invention, the 12g that once swallows three times on the one, treats a course for the treatment of; Treat after 2 days, left big toe congestion and swelling pain begins to alleviate, and after 7 days, pain disappears, and checks blood uric acid after 10 days normal again, after take again two courses for the treatment of, followed up a case by regular visits to 2 years, recurrence again.
Embodiment 3.
Get Semen Coicis 3.5kg, Rhizoma Atractylodis 1.4 kg, Rhizoma Dioscoreae Septemlobae 4.0 kg, Rhizoma Smilacis Glabrae 4.0 kg, Caulis Lonicerae 3.5 kg, Cortex Phellodendri 1.7 kg, Fructus Forsythiae 3.5 kg, Rhizoma Corydalis 1.7 kg, Semen Persicae 1.7 kg, Flos Carthami 0.7 kg, Radix Cyathulae 1.7 kg, Radix Cynanchi Paniculati 1.4 kg, Radix Clematidis 2.3 kg, to grind to form the fine powder of 0.12mm after each crude drug oven dry, then make the watered pill of every 0.1g; Namely made the Chinese patent medicine watered pill for the treatment of gouty arthritis.
Patient Hu Nvshi, 42 years old, the peasant, live two groups, dam village, the white Zhenping of Qianjiang District boat, on February 30th, 2011 is medical, and the little arthralgia of both hands toe shows effect April repeatedly, at Yi Jia village clinic by " arthritis " treatment, imitate not goodly, before 3 days, uric acid 746umol/L has a blood test, use above-mentioned formula, a 18g three times on the one, treats two courses for the treatment of; Treat after 3 days, the little arthralgia of both hands toe begins to alleviate, and after 10 days, pain disappears, and checks blood uric acid 330umol/L after 20 days again, recurrence was slightly arranged after 1 year, then use above-mentioned formula after one course for the treatment of, so far not recurrence.
Claims (2)
1. a Chinese patent medicine for the treatment of gouty arthritis, is characterized in that by the crude drug of following weight portion formulated: Semen Coicis 25-35 part, Rhizoma Atractylodis 10-14 part, Rhizoma Dioscoreae Septemlobae 30-40 part, Rhizoma Smilacis Glabrae 30-40 part, Caulis Lonicerae 25-35 part, Cortex Phellodendri 13-17 part, Fructus Forsythiae 25-35 part, Rhizoma Corydalis 13-17 part, Semen Persicae 13-17 part, Flos Carthami 5-7 part, Radix Cyathulae 13-17 part, Radix Cynanchi Paniculati 10-14 part, Radix Clematidis 17-23 part; Each crude drug is pressed the formula proportion weighing, be ground to the fine powder of 0.10-0.12mm after oven dry, then make the watered pill of every 0.05g-0.1g.
2. a kind of Chinese patent medicine for the treatment of gouty arthritis according to claim 1, is characterized in that preferred each crude drug amount ratio is: 30 parts of Semen Coiciss, 12 parts of Rhizoma Atractylodis, 35 parts of Rhizoma Dioscoreae Septemlobae, 35 parts of Rhizoma Smilacis Glabraes, 30 parts of Caulis Loniceraes, 15 parts of Cortex Phellodendris, 30 parts of Fructus Forsythiaes, 15 parts of Rhizoma Corydalis, 15 parts, Semen Persicae, 6 parts, Flos Carthami, 15 parts of Radix Cyathulaes, 12 parts of Radix Cynanchi Paniculatis, 20 parts of Radix Clematidis.
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CN104257779A (en) * | 2014-08-06 | 2015-01-07 | 蚌埠丰原涂山制药有限公司 | Gout-resisting pharmaceutical composition and preparation method of gout-resisting pharmaceutical composition |
CN104587316A (en) * | 2014-12-30 | 2015-05-06 | 广西中医药大学 | Anti-gout composition as well as preparation method and application thereof |
CN104689179A (en) * | 2015-03-25 | 2015-06-10 | 张金钟 | Traditional Chinese medicine composition for treatment of acute attack of gouty arthritis |
CN104887972A (en) * | 2015-07-03 | 2015-09-09 | 李军 | Traditional Chinese medicine external-use agent for treating gout and preparation method for traditional Chinese medicine external-use agent |
CN104888060A (en) * | 2015-07-03 | 2015-09-09 | 李军 | Traditional Chinese medicine medicament for treating gout |
CN104888061A (en) * | 2015-07-03 | 2015-09-09 | 李军 | Traditional Chinese medicine medicament for treating gout and preparation method for traditional Chinese medicine medicament |
CN104906467A (en) * | 2015-07-03 | 2015-09-16 | 李军 | Traditional Chinese medicine composition for treating gout and preparation method |
CN104906382A (en) * | 2015-07-03 | 2015-09-16 | 李军 | Traditional Chinese medicine external preparation for treating gout and preparation method |
CN106421523A (en) * | 2016-10-28 | 2017-02-22 | 扬州大学 | Traditional Chinese medicine compound for treating gout |
CN107929616A (en) * | 2017-12-18 | 2018-04-20 | 青岛大学 | A kind of external application drug paste composition for treating gout |
CN110755566A (en) * | 2019-12-02 | 2020-02-07 | 广东省中医院(广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院) | Traditional Chinese medicine composition and preparation and application thereof |
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CN104587316A (en) * | 2014-12-30 | 2015-05-06 | 广西中医药大学 | Anti-gout composition as well as preparation method and application thereof |
CN104587316B (en) * | 2014-12-30 | 2018-05-08 | 广西中医药大学 | Anti-gout composition and its preparation method and application |
CN104689179A (en) * | 2015-03-25 | 2015-06-10 | 张金钟 | Traditional Chinese medicine composition for treatment of acute attack of gouty arthritis |
CN104906467A (en) * | 2015-07-03 | 2015-09-16 | 李军 | Traditional Chinese medicine composition for treating gout and preparation method |
CN104888061A (en) * | 2015-07-03 | 2015-09-09 | 李军 | Traditional Chinese medicine medicament for treating gout and preparation method for traditional Chinese medicine medicament |
CN104888060A (en) * | 2015-07-03 | 2015-09-09 | 李军 | Traditional Chinese medicine medicament for treating gout |
CN104906382A (en) * | 2015-07-03 | 2015-09-16 | 李军 | Traditional Chinese medicine external preparation for treating gout and preparation method |
CN104887972A (en) * | 2015-07-03 | 2015-09-09 | 李军 | Traditional Chinese medicine external-use agent for treating gout and preparation method for traditional Chinese medicine external-use agent |
CN106421523A (en) * | 2016-10-28 | 2017-02-22 | 扬州大学 | Traditional Chinese medicine compound for treating gout |
CN107929616A (en) * | 2017-12-18 | 2018-04-20 | 青岛大学 | A kind of external application drug paste composition for treating gout |
CN110755566A (en) * | 2019-12-02 | 2020-02-07 | 广东省中医院(广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院) | Traditional Chinese medicine composition and preparation and application thereof |
CN110755566B (en) * | 2019-12-02 | 2021-09-24 | 广东省中医院(广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院) | Traditional Chinese medicine composition and preparation and application thereof |
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Application publication date: 20130605 |