CN103127357A - Traditional Chinese medicine composition used for treating kidney stone, and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition used for treating kidney stone, and preparation method and application thereof Download PDFInfo
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- 206010029148 Nephrolithiasis Diseases 0.000 title claims abstract description 40
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- 238000002360 preparation method Methods 0.000 title claims abstract description 16
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- 240000004670 Glycyrrhiza echinata Species 0.000 claims description 2
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- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
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- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 2
- 235000019202 steviosides Nutrition 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 12
- 210000003734 kidney Anatomy 0.000 abstract description 4
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- 239000004575 stone Substances 0.000 abstract description 2
- 240000008027 Akebia quinata Species 0.000 abstract 1
- 235000007756 Akebia quinata Nutrition 0.000 abstract 1
- 241000220457 Crotalaria Species 0.000 abstract 1
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- 240000005717 Dioscorea alata Species 0.000 abstract 1
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- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 abstract 1
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- LEVWYRKDKASIDU-QWWZWVQMSA-N D-cystine Chemical compound OC(=O)[C@H](N)CSSC[C@@H](N)C(O)=O LEVWYRKDKASIDU-QWWZWVQMSA-N 0.000 description 1
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- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
- 208000009911 Urinary Calculi Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229950005162 benexate Drugs 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- IAXUQWSLRKIRFR-SAABIXHNSA-N chembl2104696 Chemical compound C1C[C@@H](CNC(=N)N)CC[C@@H]1C(=O)OC1=CC=CC=C1C(=O)OCC1=CC=CC=C1 IAXUQWSLRKIRFR-SAABIXHNSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/43—Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
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- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
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Abstract
The invention provides a traditional Chinese medicine composition used for treating kidney stone. The composition is prepared by using the raw materials of, by weight: 50-70 parts of rust-colored crotalaria herb with root, 10-20 parts of dodder, 40-60 parts of downy rosemyrtle root, 10-20 parts of fiveleaf gynostemma herb, 15-25 parts of Himalayan teasel root, 10-20 parts of Japanese climbing fern spore, 30-50 parts of sevenlobed yam rhizome, 15-25 parts of fringed pind herb, 10-20 parts of spreading hedyotis herb, and 10-20 parts of licorice root. With the composition, a kidney stone treatment purpose is achieved through liver and kidney nourishing, heat clearing, dampness eliminating, stranguria dredging, and stone removing effects. The invention also discloses a preparation method and an application of the composition.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition that is used for the treatment of renal calculus and its preparation method and application.
Background technology
Renal calculus is one of common disease of urinary system, in every 20 people, just has one may suffer from renal calculus.Known renal calculus composition has tens of kinds.Usually calculus is divided into four large classes clinically: contain calcium calculus, Infective calculus, urate calculus and cystine stone.The cause of disease of renal calculus is a lot, and hereditary factors, metabolic factor, infectious factors, environmental factors, dietary factor, anatomical factors, medicine factor etc. are arranged.In renal calculus medication market share critical role, because the Chinese medicine side effect is little, determined curative effect is applicable to long-term prescription to Chinese medicine, has adapted to the easily characteristics of recurrence of renal calculus, and clinical practice is very extensive.People are in the urgent need to a kind of effective, own Chinese medicine composition that can be played the treatment renal calculus of good result by the most people confirmation.
Summary of the invention
Goal of the invention: in order to address the above problem, the object of the present invention is to provide a kind of Chinese medicine composition that is used for the treatment of renal calculus and its preparation method and application.
Technical scheme: the objective of the invention is to realize by following scheme:
A kind of Chinese medicine composition that is used for the treatment of renal calculus, it is prepared by the raw material of following parts by weight: Herba Crotalariae Ferrugineae 50-70 part, Semen Cuscutae 10-20 part, downy rosemyrtle root 40-60 part, Herb Gynostemmae Pentaphylli 10-20 part, Radix Dipsaci 15-25 part, Spora Lygodii 10-20 part, Rhizoma Dioscoreae Septemlobae 30-50 part, Herba Dianthi 15-25 part, Herba Hedyotidis Diffusae 10-20 part, Radix Glycyrrhizae 10-20 part.
The above-mentioned Chinese medicine composition that is used for the treatment of renal calculus, it is prepared by the raw material of following parts by weight: 60 parts of Herba Crotalariae Ferrugineaes, 15 parts of Semen Cuscutae, 50 parts of downy rosemyrtle roots, 15 parts of Herb Gynostemmae Pentaphylli, 20 parts of Radix Dipsacis, 40 parts of 15 parts of, Rhizoma Dioscoreae Septemlobae of Spora Lygodii, 20 parts of Herba Dianthis, 15 parts of Herba Hedyotidis Diffusaes, 15 parts, Radix Glycyrrhizae.
The above-mentioned Chinese medicine composition that is used for the treatment of renal calculus, described raw material add adjuvant and make oral liquid, tablet, capsule or granule after extracting.
The above-mentioned Chinese medicine composition that is used for the treatment of renal calculus, described adjuvant are one or more of dextrin, lactose, starch, sucrose, glucose, microcrystalline Cellulose, mannose, methylcellulose, hydroxypropyl cellulose, carboxymethyl cellulose and stevioside.
the above-mentioned preparation method that is used for the treatment of the Chinese medicine composition of renal calculus, it comprises the steps: to get Herba Crotalariae Ferrugineae, Semen Cuscutae, downy rosemyrtle root, Herb Gynostemmae Pentaphylli, Radix Dipsaci, Spora Lygodii, Rhizoma Dioscoreae Septemlobae, Herba Dianthi, the Cortex Eucommiae, licorice medicinal materials merges, decoct with water twice, collecting decoction, when being evaporated to 65 ℃, relative density is the extractum of 1.15-1.20, adding ethanol makes the percent by volume that contains the alcohol amount reach 75-85%, stir, standing, filter, when filtrate decompression is concentrated into 65 ℃, relative density is 1.25-1.30, and recovery ethanol, get concentrated solution, concentrated solution is added water and adjuvant is mixed with oral liquid, or with the concentrated solution spray drying, add adjuvant and make capsule, tablet, granule.
The above-mentioned preparation method that is used for the treatment of the Chinese medicine composition of renal calculus, in step, decocting condition is: the 8-12 that adds for the first time water and be medical material weight doubly measures, and decocts 1-2h, and the 6-10 that adds for the second time water and be medical material weight doubly measures, and decocts 1-2h.
The above-mentioned preparation method that is used for the treatment of the Chinese medicine composition of renal calculus, in step, the spray drying condition is: inlet temperature is 100-120 ℃, leaving air temp is 80-90 ℃, temperature of charge is 70-90 ℃, and atomizing pressure is the 0.2-0.4 MPa, and spray velocity is 5-10ml/s.
The above-mentioned application of Chinese medicine composition in the medicine of preparation treatment renal calculus that is used for the treatment of renal calculus.
Beneficial effect:
1, theory of Chinese medical science is thought, in we, Herba Crotalariae Ferrugineae, Semen Cuscutae, downy rosemyrtle root, Herb Gynostemmae Pentaphylli liver and kidney tonifying are monarch drug, Radix Dipsaci, Herba Hedyotidis Diffusae, eliminating damp-heat, Spora Lygodii, Rhizoma Dioscoreae Septemlobae, Herba Dianthi Tonglin Paishi, be ministerial drug altogether, Radix Glycyrrhizae is adjuvant, and all medicines are harmonious, play altogether liver and kidney tonifying, eliminating damp-heat, Tonglin Paishi effect, be used for the treatment of renal calculus.
2, Formulation of the present invention is reasonable, and compatibility is rigorous, through long-term clinical verification, determined curative effect.
3, the present invention consists of Chinese crude drug, is the pharmacopeia kind, have no side effect, and low price.
The specific embodiment
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following example, all technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
1, Preparation Example
embodiment 1: get Herba Crotalariae Ferrugineae 50g, Semen Cuscutae 20g, downy rosemyrtle root 40g, Herb Gynostemmae Pentaphylli 20g, Radix Dipsaci 15g, Spora Lygodii 10g, Rhizoma Dioscoreae Septemlobae 50g, Herba Dianthi 15g, Herba Hedyotidis Diffusae 20g, Radix Glycyrrhizae 10g medical material merges, decoct with water twice, adding for the first time water is 8 times of amounts of medical material weight, decoct 1h, adding for the second time water is 6 times of amounts of medical material weight, decoct 1h, collecting decoction, 0.07MPa, when being evaporated to 65 ℃ under 60-70 ℃, relative density is 1.10, adding 95% (v/v) ethanol makes the alcohol amount of containing reach 85% (v/v), stir, standing 24 hours, decompression filtrate recycling ethanol is also concentrated, filtrate is at 0.07MPa, when under 65 ℃ of conditions, concentrating under reduced pressure becomes to 65 ℃, relative density is 1.30, (condition is that inlet temperature is 120 ℃ to spray drying, leaving air temp is 100 ℃, temperature of charge is 90 ℃, atomizing pressure is 0.4 MPa, spray velocity is 10ml/s.), adding starch, mix homogeneously with the moistening of appropriate 80% (v/v) ethanol, soft material processed, is crossed 30 mesh sieves and is granulated, and in 70 ~ 80 ℃ of dryings, with 60 mesh sieve granulate, tabletting, sugar coating, packing, outer package, censorship is qualified, gets tablet.
embodiment 2: get Herba Crotalariae Ferrugineae 60g, Semen Cuscutae 15g, downy rosemyrtle root 50g, Herb Gynostemmae Pentaphylli 15g, Radix Dipsaci 20g, Spora Lygodii 15g, Rhizoma Dioscoreae Septemlobae 40g, Herba Dianthi 20g, Herba Hedyotidis Diffusae 15g, Radix Glycyrrhizae 15g medical material merges, decoct with water twice, adding for the first time water is 10 times of amounts of medical material weight, decoct 1.5h, adding for the second time water is 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, when being evaporated to 65 ℃ under 60-70 ℃, relative density is 1.15, adding 95% (v/v) ethanol makes the alcohol amount of containing reach 75% (v/v), stir, standing 24 hours, decompression filtrate recycling ethanol is also concentrated, filtrate is at 0.07MPa, when under 65 ℃ of conditions, concentrating under reduced pressure becomes to 65 ℃, relative density is 1.25, (condition is that inlet temperature is 100 ℃ to spray drying, leaving air temp is 80 ℃, temperature of charge is 80 ℃, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), adding dextrin etc., dry granulation is crossed 60 mesh sieves, and No. 1 capsule of packing into gets final product to get capsule.
embodiment 3: get 70 parts of Herba Crotalariae Ferrugineaes, 10 parts of Semen Cuscutae, 60 parts of downy rosemyrtle roots, 10 parts of Herb Gynostemmae Pentaphylli, 25 parts of Radix Dipsacis, 20 parts of Spora Lygodii, 30 parts of Rhizoma Dioscoreae Septemlobae, 25 parts of Herba Dianthis, 10 parts of Herba Hedyotidis Diffusaes, 20 parts of medical materials of Radix Glycyrrhizae merge, decoct with water twice, adding for the first time water is 12 times of amounts of medical material weight, decoct 2h, adding for the second time water is 10 times of amounts of medical material weight, decoct 2h, collecting decoction, 0.07MPa, when being evaporated to 65 ℃ under 60-70 ℃, relative density is 1.15, adding 95% (v/v) ethanol makes the alcohol amount of containing reach 75% (v/v), stir, standing 24 hours, decompression filtrate recycling ethanol is also concentrated, filtrate is at 0.07MPa, when under 65 ℃ of conditions, concentrating under reduced pressure becomes to 65 ℃, relative density is 1.25, (condition is that inlet temperature is 110 ℃ to spray drying, leaving air temp is 85 ℃, temperature of charge is 85 ℃, atomizing pressure is 0.3 MPa, spray velocity is 7.5ml/s.), add above-mentioned Benexate Hydrochloride, pulverize, then add suitable lactose, with the moistening of appropriate 80% (v/v) ethanol, soft material processed, cross 14 mesh sieves and granulate, 50-80 ℃ of drying, 60 order granulate get granule.
embodiment 4: get Herba Crotalariae Ferrugineae 60g, Semen Cuscutae 15g, downy rosemyrtle root 50g, Herb Gynostemmae Pentaphylli 15g, Radix Dipsaci 20g, Spora Lygodii 15g, Rhizoma Dioscoreae Septemlobae 40g, Herba Dianthi 20g, Herba Hedyotidis Diffusae 15g, Radix Glycyrrhizae 15g medical material merges, decoct with water twice, adding for the first time water is 10 times of amounts of medical material weight, decoct 1.5h, adding for the second time water is 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, when being evaporated to 65 ℃ under 60-70 ℃, relative density is 1.15, adding 95% (v/v) ethanol makes the alcohol amount of containing reach 75% (v/v), stir, standing 24 hours, decompression filtrate recycling ethanol is also concentrated, filtrate is at 0.07MPa, when under 65 ℃ of conditions, concentrating under reduced pressure becomes to 65 ℃, relative density is 1.25, add water and sucrose, be prepared into oral liquid.
2. the present invention treats the clinical research of renal calculus
2.1 the preparation of sample: press the preparation of oral liquid embodiment method, namely get Herba Crotalariae Ferrugineae 60g, Semen Cuscutae 15g, downy rosemyrtle root 50g, Herb Gynostemmae Pentaphylli 15g, Radix Dipsaci 20g, Spora Lygodii 15g, Rhizoma Dioscoreae Septemlobae 40g, Herba Dianthi 20g, Herba Hedyotidis Diffusae 15g, Radix Glycyrrhizae 15g medical material merges, decoct with water twice, adding for the first time water is 10 times of amounts of medical material weight, decoct 1.5h, adding for the second time water is 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, when being evaporated to 65 ℃ under 60-70 ℃, relative density is 1.15, adding 95% (v/v) ethanol makes the alcohol amount of containing reach 75% (v/v), stir, standing 24 hours, decompression filtrate recycling ethanol is also concentrated, filtrate is at 0.07MPa, when under 65 ℃ of conditions, concentrating under reduced pressure becomes to 65 ℃, relative density is 1.25, add water and sucrose, be prepared into 20 of oral liquids, every contains crude drug amount 13.25g.
2.2 choose renal calculus patient 30 examples, all be diagnosed as renal calculus through urinary system B ultrasonic or pyelography inspection. the vagoue pain of lumbus and abdomen or angor when all patient clinical main manifestations are outbreak, some patients were is with under mirror or gross hematuria, some patients were shows as urinate not smooth or pain, male l8 example, women's 12 examples; 25～42 years old age, average (35.50 ± 6.50) year; Course of disease 6d to 3.7 year, average 5.2 months; Make a definite diagnosis single renal calculus patient's 11 examples, two kidney complexity calculus patient 10 examples, two renal calculuss are accompanied hydronephrosis patients 9 examples simultaneously, calculus diameter 0.3cm*0.4cm-1.1cm*1.9cm.
2.3 give oral liquid of the present invention, each 2, advise patient's great quantity of water drinking every day 2 times, and do more jog, squat down, the activity such as jump, move down discharge in order to calculus.Treat and carry out the curative effect judgement after 1 month.
2.4 curative effect judgement is with reference to the curative effect judging standard of stranguria caused by urinary stone in " traditional Chinese medical science disease Standardization of diagnosis and curative effect ", produce effects refers to that after treatment the subjective symptoms such as patient's waist and belly dull pain disappears fully, and it is normal that urine examination recovers, and check urinary system B ultrasonic has no calculus, hydrops; Refer to that effectively patient's urine examination is normal, check urinary system B ultrasonic shows that renal calculus is narrow by the 1st, and has been down into proximal ureteral, and perhaps the existing part calculus of former multiple calculus is discharged; Invalid finger patient urine examination is normal, but the check of patient's subjective symptoms and urinary system B ultrasonic is all without improvement, and the renal calculus position is without movement, and hydronephrosis even increases the weight of without improvement.
2.5 in the routine patient of result 30, produce effects 16 examples, effective 9 examples, invalid 5 examples, total effective rate is 83.3%, illustrates that the present invention has good therapeutic effect to renal calculus.
Claims (8)
1. Chinese medicine composition that is used for the treatment of renal calculus, it is characterized in that, it is prepared by the raw material of following parts by weight: Herba Crotalariae Ferrugineae 50-70 part, Semen Cuscutae 10-20 part, downy rosemyrtle root 40-60 part, Herb Gynostemmae Pentaphylli 10-20 part, Radix Dipsaci 15-25 part, Spora Lygodii 10-20 part, Rhizoma Dioscoreae Septemlobae 30-50 part, Herba Dianthi 15-25 part, Herba Hedyotidis Diffusae 10-20 part, Radix Glycyrrhizae 10-20 part.
2. the Chinese medicine composition that is used for the treatment of renal calculus according to claim 1, it is characterized in that, it is prepared by the raw material of following parts by weight: 60 parts of Herba Crotalariae Ferrugineaes, 15 parts of Semen Cuscutae, 50 parts of downy rosemyrtle roots, 15 parts of Herb Gynostemmae Pentaphylli, 20 parts of Radix Dipsacis, 40 parts of 15 parts of, Rhizoma Dioscoreae Septemlobae of Spora Lygodii, 20 parts of Herba Dianthis, 15 parts of Herba Hedyotidis Diffusaes, 15 parts, Radix Glycyrrhizae.
3. the Chinese medicine composition that is used for the treatment of renal calculus according to claim 1 and 2, is characterized in that, described raw material adds adjuvant and makes oral liquid, tablet, capsule or granule after extracting.
4. the Chinese medicine composition that is used for the treatment of renal calculus according to claim 3, it is characterized in that, described adjuvant is one or more of dextrin, lactose, starch, sucrose, glucose, microcrystalline Cellulose, mannose, methylcellulose, hydroxypropyl cellulose, carboxymethyl cellulose and stevioside.
5. the described preparation method that is used for the treatment of the Chinese medicine composition of renal calculus of claim 1 or 2, it is characterized in that, it comprises the steps: to get Herba Crotalariae Ferrugineae, Semen Cuscutae, downy rosemyrtle root, Herb Gynostemmae Pentaphylli, Radix Dipsaci, Spora Lygodii, Rhizoma Dioscoreae Septemlobae, Herba Dianthi, Herba Hedyotidis Diffusae, licorice medicinal materials merges, decoct with water twice, collecting decoction, when being evaporated to 65 ℃, relative density is the extractum of 1.15-1.20, adding ethanol makes the percent by volume that contains the alcohol amount reach 75-85%, stir, standing, filter, when filtrate decompression is concentrated into 65 ℃, relative density is 1.25-1.30, and recovery ethanol, get concentrated solution, concentrated solution is added water and adjuvant is mixed with oral liquid, or with the concentrated solution spray drying, add adjuvant and make capsule, tablet, granule.
6. the preparation method that is used for the treatment of the Chinese medicine composition of renal calculus according to claim 5, is characterized in that, in step, decocting condition is: the 8-12 that adds for the first time water and be medical material weight doubly measures, decoct 1-2h, the 6-10 that adds for the second time water and be medical material weight doubly measures, and decocts 1-2h.
7. the preparation method that is used for the treatment of the Chinese medicine composition of renal calculus according to claim 5, it is characterized in that, in step, the spray drying condition is: inlet temperature is 100-120 ℃, leaving air temp is 80-90 ℃, temperature of charge is 70-90 ℃, and atomizing pressure is the 0.2-0.4 MPa, and spray velocity is 5-10ml/s.
8. the described application of Chinese medicine composition in the medicine of preparation treatment renal calculus that is used for the treatment of renal calculus of claim 1 or 2.
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| CN201310056331.2A CN103127357B (en) | 2013-02-22 | 2013-02-22 | Traditional Chinese medicine composition used for treating kidney stone, and preparation method and application thereof |
| KR1020140020379A KR101431788B1 (en) | 2013-02-22 | 2014-02-21 | A Chinese medicine composition and its preparation method and drug application in the treatment of kidney stones |
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Cited By (3)
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| CN104337872A (en) * | 2014-11-11 | 2015-02-11 | 黄雷 | Chinese medicinal formula for treating lithangiuria |
| CN104491619A (en) * | 2015-01-19 | 2015-04-08 | 王春东 | Calculus removing decoction for treating hydronephrosis caused by urinary calculus and preparation method thereof |
| CN106389976A (en) * | 2016-10-25 | 2017-02-15 | 广西大学 | Medicine for treating kidney stone and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104189470A (en) * | 2014-09-12 | 2014-12-10 | 梁英珍 | Health-care wine for tonifying kidney and strengthening yang and preparation method |
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| KR101431788B1 (en) | 2014-08-20 |
| CN103127357B (en) | 2014-04-16 |
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